JPS6339801A - Life prolongation by dehydration of living body at cryogenic temperature and refrigeration - Google Patents
Life prolongation by dehydration of living body at cryogenic temperature and refrigerationInfo
- Publication number
- JPS6339801A JPS6339801A JP18405486A JP18405486A JPS6339801A JP S6339801 A JPS6339801 A JP S6339801A JP 18405486 A JP18405486 A JP 18405486A JP 18405486 A JP18405486 A JP 18405486A JP S6339801 A JPS6339801 A JP S6339801A
- Authority
- JP
- Japan
- Prior art keywords
- cells
- human body
- dehydration
- freezing
- living
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000018044 dehydration Effects 0.000 title claims description 9
- 238000006297 dehydration reaction Methods 0.000 title claims description 9
- 238000005057 refrigeration Methods 0.000 title abstract description 4
- 230000035777 life prolongation Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 10
- 235000013305 food Nutrition 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 241001465754 Metazoa Species 0.000 claims abstract description 5
- 239000013078 crystal Substances 0.000 claims abstract description 5
- 230000006378 damage Effects 0.000 claims abstract description 4
- 238000001291 vacuum drying Methods 0.000 claims abstract 2
- 238000007710 freezing Methods 0.000 claims description 18
- 230000008014 freezing Effects 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 12
- 210000000056 organ Anatomy 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 5
- 230000007774 longterm Effects 0.000 claims description 3
- 244000005700 microbiome Species 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 210000002569 neuron Anatomy 0.000 claims description 2
- 210000005132 reproductive cell Anatomy 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000010257 thawing Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013611 frozen food Nutrition 0.000 description 1
- 230000006266 hibernation Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
【発明の詳細な説明】
人体を冷凍し保存して解凍蘇生する試みはアメリカで数
多く試みられたが失敗に帰しています。その原因は冷凍
保存中に氷の結晶が再結晶して無数の針のように成長し
て細胞を破壊してしまうことにあります。従って氷の結
晶が再結晶しない方法があれば成功する筈です。[Detailed Description of the Invention] Numerous attempts have been made in the United States to freeze, preserve, and thaw and resuscitate the human body, but all have failed. The reason for this is that during frozen storage, ice crystals recrystallize and grow like countless needles, destroying the cells. Therefore, if there is a way to prevent ice crystals from recrystallizing, it should be successful.
本案では従来の急速冷凍のように一４０Ｃより更に極低
温である一１３０Ｃ以下に急速冷凍することにより氷晶
の成長しない、生体細胞にとって安全な冷凍法を採用し
て、上記のような失敗のない人体冷凍保存後、解凍蘇生
の方法に関する発明です。In this project, we adopt a freezing method that is safe for living cells and does not cause the growth of ice crystals by rapid freezing to below -130C, which is even lower than -40C as in conventional quick freezing. This is an invention related to a method for thawing and resuscitating a human body after cryopreservation.
更に水分が凍結すると約９．１６％体積膨脹するため、
その圧力による細胞の損傷を防ぐため、冷凍直前に人体
を真空乾燥又は温風乾燥或いは高分子吸水体を用いて５
％ないし９％の脱水を行った後。Furthermore, when water freezes, it expands in volume by approximately 9.16%, so
In order to prevent cell damage caused by the pressure, the human body is vacuum-dried, warm-air-dried, or dried using a polymeric water-absorbing material for 50 minutes just before freezing.
After % to 9% dehydration.
−１３０ｔ：”以下に急速冷凍する方法を実施して細胞
破壊の原因を除去します。-130t: ”Use the following rapid freezing method to remove the cause of cell destruction.
冷凍しても細胞が破壊されない限り生命体は安全に保存
され、所定の長期間後、解凍し再び水分を５％ないし９
％、水中に浸漬することにより補給した後、ペースメー
カーや人工心肺を用いて確実に蘇生を行うことができま
す。As long as cells are not destroyed even when frozen, living organisms can be safely preserved, and after a predetermined long period of time, they are thawed and rehydrated to 5% to 9%.
%, after replenishment by immersion in water, resuscitation can be reliably performed using a pacemaker or heart-lung machine.
本実の人体の一１３０Ｃ以下の超急速冷凍と氷結の体積
膨張消去の組み合せにより半永久的に生命体を冬眠状態
に保存し、任意の期間経過後解凍。A combination of ultra-rapid freezing of a real human body at temperatures below 130C and the elimination of volumetric expansion during freezing preserves living organisms semi-permanently in a state of hibernation, and then thaws them after an arbitrary period of time.
蘇生を行う技術により人間は寿命の壁を打破り世代を超
えて生き永らえることが可能となり、何千年、何万年の
後の世界を見ることができます。The technology of resuscitation makes it possible for humans to break through the barrier of lifespan and survive beyond generations, allowing us to see the world thousands or tens of thousands of years in the future.
又２人体全体でなく部分的に例えば生殖細胞、血液、胎
児細胞、幼若細胞、各器管、各臓器、脳神経細胞その他
あらゆる細胞組織を生きたままと同じ状態で長期間完全
保存が可能で輸血や臓器移植その他あらゆる生体部分の
安全保存に活用できます。In addition, it is possible to completely preserve parts of the human body, such as reproductive cells, blood, fetal cells, immature cells, organs, organs, brain nerve cells, and all other cellular tissues, for long periods of time in the same state as they were in the living body. It can be used for blood transfusions, organ transplants, and the safe preservation of all living body parts.
更に本実の完全冷凍技術を応用してあらゆる動物・植物
の全体的２部分的な生体完全保存を行うことができ更に
カビ、酵母、バクテリア、ビールス等の微生物の長期冷
凍生命保存に活用できます。Furthermore, by applying Honjitsu's complete freezing technology, it is possible to completely preserve the whole and two parts of all animals and plants, and it can also be used for long-term frozen life preservation of microorganisms such as mold, yeast, bacteria, and viruses. .
本実−１３０Ｃ脱水冷凍技術を食品の冷凍に応用すれば
解凍後も生鮮状態と変らない風味と味覚を味わうことが
できて、冷凍物はまずいと云うことはなくなります。本
実はあらゆる食品の長期完全保存に利用できる優れた冷
凍技術です。If Honjitsu-130C dehydration freezing technology is applied to food freezing, you will be able to enjoy the same flavor and taste as fresh even after thawing, and frozen food will no longer be considered bad. In fact, it is an excellent freezing technology that can be used for long-term preservation of all types of food.
−１３０ｔｌｌ’の冷凍機は二元冷凍混合冷媒方式で容
易に経済的に冷凍保存でき又脱水も何等難しいものでは
なく、今後の業務用・家庭用冷凍機の主流を占めるもの
と予想します。The -130 tll' refrigerator uses a binary refrigeration mixed refrigerant system and can be easily and economically frozen and stored, and dehydration is not difficult at all, so we predict that it will become the mainstream of commercial and household refrigerators in the future.
本実脱水、−１３０Ｃ以下の冷凍法は、生命体を時間を
超え２世代を超えて半永久的に保存する決め手となり更
に理想的食品冷凍技術であり極めて有意義な発明です。Honjitsu's dehydration and freezing methods below -130C are the key to preserving living organisms semi-permanently for more than two generations, and are an ideal food freezing technology, making them extremely significant inventions.
Claims (1)
胞破壊を防ぐため−１３０℃以下に急速冷凍し保存する
に際し、冷凍直前に人体の水分を均一に５％ないし９％
を真空乾燥その他の方法で脱水した後、冷凍することに
より氷結による体細胞の容積膨脹による細胞の損傷を最
少限に防止する脱水極低温冷凍法。並びに任意の長期間
−１３０℃以下に保存後、解凍し水分を５％ないし９％
補充した後、蘇生を行うことを特長とする人体不老延命
法。 上記と同様の原理で人間の部分的生体細胞、例えば生殖
細胞、授精細胞、血液、骨髄液、胎児細胞、幼若細胞そ
の他人体の各細胞組織・各器管・人体各臓器・脳神経細
胞その他を５％ないし９％脱水後、−１３０℃以下に急
速冷凍保管し、所定の期間保管した後、解凍し５％ない
し９％水分を補給して蘇生させ、生殖その他輸血又は細
胞移植、臓器移植に活用することを特色とする人体部分
的長期完全保存法。 更に本案の原理を応用して総ての動物、植物その他微生
物の生体その他食品類を−１３０℃、５％ないし９％脱
水冷凍保存し、任意の長期間生命体を保存し、又は食品
の味覚を完全に保持する動物、植物微生物、食品類の脱
水、極低温完全保存法。[Scope of Claims] When freezing a human body, in order to prevent cell destruction due to recrystallization of ice crystals, the human body is rapidly frozen to -130°C or lower and stored, and immediately before freezing, the water content of the human body is uniformly reduced to 5% or 5%. 9%
A dehydration cryogenic freezing method that minimizes damage to cells due to volume expansion of somatic cells due to freezing by dehydrating them by vacuum drying or other methods and then freezing them. After storing at -130℃ or lower for any long period of time, thaw and reduce moisture to 5% to 9%.
A human life extension method that is characterized by resuscitation after replenishment. Using the same principle as above, human partial living cells, such as reproductive cells, fertilized cells, blood, bone marrow fluid, fetal cells, immature cells, and other human cell tissues, organs, human organs, brain nerve cells, etc. After 5% to 9% dehydration, the animal is stored in a deep freeze below -130°C, stored for a specified period of time, thawed, rehydrated by 5% to 9%, and resuscitated for reproduction, blood transfusion, cell transplantation, and organ transplantation. A method of long-term complete preservation of parts of the human body, which is characterized by the use of Furthermore, by applying the principles of this proposal, all living organisms such as animals, plants, microorganisms, and other foods can be frozen and preserved at -130℃ with 5% to 9% dehydration, and any living organisms can be preserved for a long period of time, or the taste of food can be improved. A complete cryogenic storage method for dehydration and cryogenic preservation of animals, plants, microorganisms, and foods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18405486A JPS6339801A (en) | 1986-08-05 | 1986-08-05 | Life prolongation by dehydration of living body at cryogenic temperature and refrigeration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18405486A JPS6339801A (en) | 1986-08-05 | 1986-08-05 | Life prolongation by dehydration of living body at cryogenic temperature and refrigeration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6339801A true JPS6339801A (en) | 1988-02-20 |
Family
ID=16146568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18405486A Pending JPS6339801A (en) | 1986-08-05 | 1986-08-05 | Life prolongation by dehydration of living body at cryogenic temperature and refrigeration |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6339801A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000072601A (en) * | 1998-08-31 | 2000-03-07 | Univ Kanagawa | Preservation of internal organ enucleated from mammalian |
-
1986
- 1986-08-05 JP JP18405486A patent/JPS6339801A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000072601A (en) * | 1998-08-31 | 2000-03-07 | Univ Kanagawa | Preservation of internal organ enucleated from mammalian |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mazur | Limits to life at low temperatures and at reduced water contents and water activities | |
| US4965185A (en) | Method for low-temperature preservation of embryos | |
| US5171660A (en) | Process of revitalizing cells and tissue prior to cryopreservation | |
| US4155331A (en) | Method for cryopreservation of multicellular organisms | |
| US3677024A (en) | Preservation and storage of biologic materials | |
| CA1310588C (en) | Method for cryopreserving heart valves | |
| US4008754A (en) | Process for the conservation of isolated organs and the like | |
| JPS62114901A (en) | Method of preserving and storing biological material | |
| Storey et al. | Cryomicroscopic analysis of freezing in liver of the freeze-tolerant wood frog | |
| CN111955535A (en) | Method for freezing oysters with assistance of ultrasonic waves | |
| Okamoto et al. | Successful sub-zero non-freezing preservation of rat lungs at− 2° C utilizing a new supercooling technology | |
| Ishine et al. | Transplantation of mammalian livers following freezing: vascular damage and functional recovery | |
| JPS6339801A (en) | Life prolongation by dehydration of living body at cryogenic temperature and refrigeration | |
| JP5039972B2 (en) | Cryopreservation method of cells or tissues | |
| Minor et al. | The effects of allopurinol and SOD on lipid peroxidation and energy metabolism in the liver after ischemia in an aerobic/anaerobic persufflation | |
| Grout et al. | Freezing of fruit and vegetables | |
| Robertson et al. | Studies on the Function Canine Heat: f the ixposed to Sub-Zero Temperatures | |
| RU2698903C1 (en) | Method for cryopreservation of biological objects with simultaneous homogeneous nucleation of crystals of ice and xenon clathrate | |
| US3219463A (en) | Process of dehydrofreezing foods | |
| Villalba et al. | Cryopreservation of human skin with propane-1, 2-diol | |
| JPS6049740A (en) | Method for preserving perishable food | |
| Toledo-Pereyra et al. | Organ freezing | |
| Jacob | Studies in organ preservation by actual freezing and reduction of the freezing point | |
| RU2022109075A (en) | METHOD FOR CRYOPRESERVATION OF CELLS, ORGANS, TISSUE AND ORGANISMS | |
| JP3211890U (en) | Biological tissue or cell storage device |