JPS6336826A - Solubilized composition - Google Patents
Solubilized compositionInfo
- Publication number
- JPS6336826A JPS6336826A JP61179192A JP17919286A JPS6336826A JP S6336826 A JPS6336826 A JP S6336826A JP 61179192 A JP61179192 A JP 61179192A JP 17919286 A JP17919286 A JP 17919286A JP S6336826 A JPS6336826 A JP S6336826A
- Authority
- JP
- Japan
- Prior art keywords
- solubilized
- amount
- basic amino
- surface active
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 150000001413 amino acids Chemical class 0.000 claims abstract description 12
- 239000002736 nonionic surfactant Substances 0.000 claims description 17
- 235000001014 amino acid Nutrition 0.000 abstract description 11
- 239000000126 substance Substances 0.000 abstract description 8
- 239000004094 surface-active agent Substances 0.000 abstract description 8
- 238000002156 mixing Methods 0.000 abstract description 7
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract description 2
- 229930064664 L-arginine Natural products 0.000 abstract description 2
- 235000014852 L-arginine Nutrition 0.000 abstract description 2
- 206010018910 Haemolysis Diseases 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 230000008588 hemolysis Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000007928 solubilization Effects 0.000 description 4
- 238000005063 solubilization Methods 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 230000003381 solubilizing effect Effects 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 235000009697 arginine Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical class C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は可溶化補助剤として塩基性アミノ酸を配合した
可溶化組成物に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a solubilization composition containing a basic amino acid as a solubilization aid.
本発明は、被可溶化物質が多すぎて非イオン性界面活性
剤単独添加では可溶化しきれず、系が曇っている場合、
塩基性アミノ酸を特定量配合することにより透明可溶化
系が得られること、又、安全性面でとくにポリオキシエ
チレン付加非イオン性界面活性剤は好まれないが、塩基
性アミノ酸を可溶化補助剤として添加することにより非
イオン性界面活性剤の添加量を低減できること、以上二
点の知見に基づく。In the present invention, when there are too many substances to be solubilized and it cannot be completely solubilized by adding a nonionic surfactant alone, and the system is cloudy,
A transparent solubilizing system can be obtained by blending a specific amount of basic amino acids, and although polyoxyethylene-added nonionic surfactants are not particularly preferred from a safety standpoint, basic amino acids can be used as solubilizing aids. Based on the above two findings, it is possible to reduce the amount of nonionic surfactant added by adding it as a nonionic surfactant.
可溶化組成物は、透明で見た目に美しく、純粋に見える
為、化粧品、食品、薬品、塗料、接着剤など各種業界で
商品として用いられる。Because solubilized compositions are transparent, aesthetically pleasing, and appear pure, they are used as commercial products in various industries such as cosmetics, foods, drugs, paints, and adhesives.
従来、可溶化組成物を得るには、一定量の界面活性剤と
くに非イオン性界面活性剤を用いて、水相中に被可溶化
物質例えば、油分、香料、油溶性薬剤等を透明に可溶化
させる方法をとっているが、非イオン住血活性剤の可溶
化量には限界があり、現在の様に被可溶化物質の種類、
量の配合がニーズの面で多様化している現状では、完全
に透明な可溶化組成物を得ることは、困難になってきた
。Conventionally, in order to obtain a solubilized composition, a certain amount of a surfactant, particularly a nonionic surfactant, is used to transparently transport substances to be solubilized, such as oils, fragrances, oil-soluble drugs, etc., into an aqueous phase. However, there is a limit to the amount of nonionic schistosactive agents that can be solubilized, and currently, the type of substance to be solubilized,
In the current situation where the amount formulation is diversified in terms of needs, it has become difficult to obtain a completely transparent solubilized composition.
又、非イオン性界面活性剤の代表である高級アルコール
のポリオキシエチレン付加エーテル型非イオン性界面活
性剤のようなポリオキシエチレン付加物は、経皮吸収力
が強く、溶血性があり、安全性面で使用量は出来る限り
抑えるのが世間一般の風潮となってきており、界面活性
剤量を減少させることが研究の対象になっている。In addition, polyoxyethylene adducts such as polyoxyethylene adducts of higher alcohols, which are typical nonionic surfactants, have strong transdermal absorption, are hemolytic, and are safe. It has become a general trend to reduce the amount of surfactants used as much as possible in terms of properties, and reducing the amount of surfactants is the subject of research.
本発明者らはこうした事ｔＦｆにかんがみ、上記の欠点
を解決すべく鋭意研究を重ねた結果、被可溶化物質が多
すぎて非イオン性界面活性剤だけでは可溶化しきれず系
が曇っている場合でも、さらに塩基性アミノ酸を特定量
配合したならば、系が完全透明で安定性が良好であるこ
とを見い出したつ又、安全性面でポリオキシエチレン付
加非イオン性界面活性剤は好まれないが、塩基性アミノ
酸を活性剤補助剤として添加すれば、透明系を得るため
の被可溶化物質に対する非イオン性界面活性剤の必要量
を大幅に減少させることができることを見い出し、この
知見に基づいて本発明を完成するに至った。In view of the above, the inventors of the present invention conducted extensive research to solve the above drawbacks, and found that there were too many substances to be solubilized, and the nonionic surfactant alone could not completely solubilize them, resulting in a cloudy system. Even in cases where a certain amount of basic amino acids were added, the system was found to be completely transparent and stable.However, polyoxyethylene-added nonionic surfactants are not preferred from a safety standpoint. have found that the addition of basic amino acids as an activator adjuvant can significantly reduce the amount of nonionic surfactant required for the substance to be solubilized to obtain a transparent system, and based on this knowledge, As a result, the present invention was completed.
すなわち本発明は、非イオン性界面活性剤と、塩基性ア
ミノ酸０，３〜５重量％とを配合することを特徴とする
可溶化組成物である。That is, the present invention is a solubilized composition characterized by blending a nonionic surfactant and 0.3 to 5% by weight of a basic amino acid.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明で用いられる非イオン性界面活性剤は従来用いら
れていた周知のものを使用することができる。As the nonionic surfactant used in the present invention, conventionally known, well-known nonionic surfactants can be used.
たとえばエーテル型非イオン性界面活性剤としてはポリ
オキシエ準レンツルビクン脂肪酸エステル、グリセリン
・プロピレンゲリコール脂肪酸エステルの酸化エチレン
誘導体、ポリエチレングリコール脂肪酸エステル、ポリ
オキシエチレンアルキルエーテル、ポリオキシエチレン
ポリオキシプロビレンアルキルエーテル、ポリオキシエ
チレンアルキルフェニルエーテル、ポリオキシエチレン
ヒマシ油・硬化ヒマシ油誘導体、ポリオキシエチレンア
ルキルアミンおよび脂肪酸アミド等のＨＬＢ（ｉｌ［ｉ
１２〜１８のもの、ポリオキシエチレンノニルフェニル
ホルムアルデヒド縮合物、スチレン・マレイン酸共重合
物誘導体、ポリグリセリン脂肪酸スエテル等のＩ（Ｌ
Ｂが１２〜１８の高分子界面活性剤などである。For example, ether-type nonionic surfactants include polyoxyethylene semi-lenturubikune fatty acid esters, ethylene oxide derivatives of glycerin/propylene gellicol fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, HLB (il [i
I(L
Examples include polymeric surfactants in which B is 12 to 18.
非イオン性界面活性剤の配合量は０．０５〜３宙量％で
ある。The blending amount of the nonionic surfactant is 0.05 to 3% by weight.
本発明で用いられる可溶化補助剤としては、アルギニン
、ヒスチジン、リジン等の塩基性アミノ酸が挙げられる
。塩基性アミノ酸の中でもし一アルギニンが特に可溶化
力に優れている。Examples of the solubilization aid used in the present invention include basic amino acids such as arginine, histidine, and lysine. Among basic amino acids, arginine has particularly excellent solubilizing power.
塩基性アミノ酸の配合量は０．３％〜５重量％である。The basic amino acid content is 0.3% to 5% by weight.
本発明の可溶化組成物には、上記の必須成分に加えて必
要に応じて、保湿剤、染料、油分、香料、油溶性薬剤、
防腐剤、キレート形成剤等が配合される。もちろんこれ
らは本発明の目的を損なわない質的、量的条件下で使用
されなければならない。In addition to the above-mentioned essential ingredients, the solubilized composition of the present invention may optionally contain a humectant, a dye, an oil, a fragrance, an oil-soluble drug,
Preservatives, chelate forming agents, etc. are added. Of course, these must be used under qualitative and quantitative conditions that do not impair the purpose of the present invention.
本発明に係る可溶化組成物は、透明で安定な可溶化組成
物であり、経皮吸収力が強く、溶血性作用が強い非イオ
ン性界面活性剤の配合量を減少させることができる優れ
た可溶組成物である。The solubilized composition according to the present invention is a transparent and stable solubilized composition, has a strong transdermal absorption ability, and has an excellent ability to reduce the amount of nonionic surfactant that has a strong hemolytic effect. It is a soluble composition.
次に実施例によって本発明をさらに詳細に説明する。本
発明はこれにより限定されるものではない。配合量は重
量％である。Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.
〔し芝こにイクリｌ、２．３、上ヒ啼イ２Ｂ口１１．２
．３．４〕Ｘ※ エデト酸３Ｎａ ※ ポリオキ
シエチレン（製法）
■〜■をウォーターパーツとして秤量後攪拌混合する。[Shishibakoni Ikuri l, 2.3, upper Hi 2B mouth 11.2
．． [3.4]
次に■〜＠をアルコールパーツとして秤量ｆ＆ ｆｆｌ
ｆ！混合する。■〜■のパーツへ■〜＠のパーツを混
合しながら添加し、可溶化する。実施例１〜３に関して
は、０を可溶化後添加する。Next, weigh f & ffl using ■〜@ as alcohol parts.
f! Mix. Add parts ■~@ to parts ■~■ while mixing and solubilize. For Examples 1-3, 0 is added after solubilization.
（効果）
実施例１〜３、比較例１〜４の試料を高さ１０ｃｍの１
００ｍＲ容量の透明ガラス瓶に充填し、瓶の後方を黒い
紙でスクリーンにして照明下で透明度を比べたのが次の
表である。(Effect) The samples of Examples 1 to 3 and Comparative Examples 1 to 4 were placed at a height of 10 cm.
The following table shows the results of filling a transparent glass bottle with a capacity of 00 mR and comparing the transparency under illumination with a black paper screen at the back of the bottle.
（以下余白）
×；不透明
△； 曇った濁り
○； 透明
（以下余白）
〔カー１４．５．６．７、比較例５．６．７〕実施例１
〜３と同様にし、実施例４〜７および比較例５〜７の可
溶化組成物を得た。効果は上記の様に実施例４〜７は透
明効果に優れておりかつ被可溶化物質の歴に対する非イ
オン性界面活性剤口をＬ−アルギニンの添加により減少
できることがわかった。(Margin below) ×; Opaque △; Cloudy turbidity ○; Transparent (blank below) [Car 14.5.6.7, Comparative Example 5.6.7] Example 1
In the same manner as in -3, solubilized compositions of Examples 4-7 and Comparative Examples 5-7 were obtained. As for the effects, as mentioned above, Examples 4 to 7 had excellent transparency effects, and it was found that the amount of nonionic surfactant relative to the content of the substance to be solubilized could be reduced by adding L-arginine.
Claims (1)
量％とを配合することを特徴とする可溶化組成物。A solubilized composition comprising a nonionic surfactant and 0.3 to 5% by weight of a basic amino acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61179192A JPS6336826A (en) | 1986-07-30 | 1986-07-30 | Solubilized composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61179192A JPS6336826A (en) | 1986-07-30 | 1986-07-30 | Solubilized composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6336826A true JPS6336826A (en) | 1988-02-17 |
Family
ID=16061543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61179192A Pending JPS6336826A (en) | 1986-07-30 | 1986-07-30 | Solubilized composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6336826A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10511382A (en) * | 1994-12-23 | 1998-11-04 | メルク シヤープ エンド ドーム リミテツド | Prevention of hemolysis by surfactants and emulsions |
| AU782251B2 (en) * | 1999-12-21 | 2005-07-14 | 40 J's, Llc | Tissue sensitizing compounds for females with methods and apparatus for the delivery of these compounds |
| WO2015108057A1 (en) * | 2014-01-15 | 2015-07-23 | 株式会社明治 | Jelly-like food containing collagen peptides |
-
1986
- 1986-07-30 JP JP61179192A patent/JPS6336826A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10511382A (en) * | 1994-12-23 | 1998-11-04 | メルク シヤープ エンド ドーム リミテツド | Prevention of hemolysis by surfactants and emulsions |
| AU782251B2 (en) * | 1999-12-21 | 2005-07-14 | 40 J's, Llc | Tissue sensitizing compounds for females with methods and apparatus for the delivery of these compounds |
| WO2015108057A1 (en) * | 2014-01-15 | 2015-07-23 | 株式会社明治 | Jelly-like food containing collagen peptides |
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