JPS6333666B2 - - Google Patents
Info
- Publication number
- JPS6333666B2 JPS6333666B2 JP2764481A JP2764481A JPS6333666B2 JP S6333666 B2 JPS6333666 B2 JP S6333666B2 JP 2764481 A JP2764481 A JP 2764481A JP 2764481 A JP2764481 A JP 2764481A JP S6333666 B2 JPS6333666 B2 JP S6333666B2
- Authority
- JP
- Japan
- Prior art keywords
- blood coagulation
- habu
- blood
- freeze
- fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000023555 blood coagulation Effects 0.000 claims description 26
- 241000015864 Protobothrops flavoviridis Species 0.000 claims description 12
- 210000002966 serum Anatomy 0.000 claims description 12
- 239000003053 toxin Substances 0.000 claims description 12
- 231100000765 toxin Toxicity 0.000 claims description 12
- 238000000926 separation method Methods 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000012360 testing method Methods 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000015271 coagulation Effects 0.000 description 6
- 238000005345 coagulation Methods 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 239000002504 physiological saline solution Substances 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002435 venom Substances 0.000 description 5
- 231100000611 venom Toxicity 0.000 description 5
- 210000001048 venom Anatomy 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 230000002949 hemolytic effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000002574 poison Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 3
- 241000015862 Protobothrops elegans Species 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 2
- 241000271508 Bothrops asper Species 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 241000271578 Ovophis okinavensis Species 0.000 description 2
- 102000015439 Phospholipases Human genes 0.000 description 2
- 108010064785 Phospholipases Proteins 0.000 description 2
- 240000004971 Pseudosasa japonica Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 241000271897 Viperidae Species 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000012154 double-distilled water Substances 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 240000009146 Blepharocalyx salicifolius Species 0.000 description 1
- 241000271506 Bothrops Species 0.000 description 1
- 241000907159 Bothrops alternatus Species 0.000 description 1
- 241000271530 Bothrops cotiara Species 0.000 description 1
- 241000271517 Bothrops jararaca Species 0.000 description 1
- 241000271513 Bothrops jararacussu Species 0.000 description 1
- 241000028954 Bothrops marajoensis Species 0.000 description 1
- 241000392415 Bothrops moojeni Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 description 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 description 1
- 235000009685 Crataegus X maligna Nutrition 0.000 description 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 description 1
- 235000009486 Crataegus bullatus Nutrition 0.000 description 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 description 1
- 235000009682 Crataegus limnophila Nutrition 0.000 description 1
- 235000004423 Crataegus monogyna Nutrition 0.000 description 1
- 240000000171 Crataegus monogyna Species 0.000 description 1
- 235000002313 Crataegus paludosa Nutrition 0.000 description 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241001487808 Protobothrops mucrosquamatus Species 0.000 description 1
- 241000879323 Protobothrops tokarensis Species 0.000 description 1
- 244000184734 Pyrus japonica Species 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 241000271577 Trimeresurus Species 0.000 description 1
- 241001532589 Trimeresurus stejnegeri Species 0.000 description 1
- 241000271939 Viperinae Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007982 barbital buffer Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 108010055222 clotting enzyme Proteins 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 229940026527 glycine 50 mg Drugs 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000007693 zone electrophoresis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2764481A JPS57142561A (en) | 1981-02-28 | 1981-02-28 | Blood coagulation promoting agent for serum separation and its manufacture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2764481A JPS57142561A (en) | 1981-02-28 | 1981-02-28 | Blood coagulation promoting agent for serum separation and its manufacture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57142561A JPS57142561A (en) | 1982-09-03 |
| JPS6333666B2 true JPS6333666B2 (fr) | 1988-07-06 |
Family
ID=12226632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2764481A Granted JPS57142561A (en) | 1981-02-28 | 1981-02-28 | Blood coagulation promoting agent for serum separation and its manufacture |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57142561A (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10385381B2 (en) * | 2010-09-20 | 2019-08-20 | Paul Masci | Serum preparation |
| JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | 凍結乾燥方法 |
| JP7471316B2 (ja) | 2019-03-14 | 2024-04-19 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | マルチパート凍結乾燥容器 |
-
1981
- 1981-02-28 JP JP2764481A patent/JPS57142561A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57142561A (en) | 1982-09-03 |
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