JPS6332766B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to electrolyte drinks useful for replenishing key components lost from body fluids through metabolic processes. Although the beverage according to the present invention is primarily intended for use by humans, and this specification is described to suit that purpose, the beverage may be used for animals such as horses and dogs as well. It is something. There are currently a number of electrolyte drinks on the market, all of which claim to replenish essential electrolytes and water lost from the body during physical exertion. However, these products taste bad and, in fact, often do not fully meet the body's needs by replenishing all of the missing essential components. Therefore, it is an object of the present invention to overcome the above-mentioned drawbacks and to
Furthermore, it is an object of the present invention to provide a beverage that quickly recovers the body after strenuous activity. As an example of an actual experiment conducted to achieve this objective, the results of an experiment conducted using racing greyhounds are shown below. Experimental Animals We selected racing greyhounds as the subjects for the experiment for the following reasons. (i) The large number of racing greyhounds in Australia makes it easy to select suitable experimental subjects. (ii) Greyhounds bred solely for racing must reach their adult racing age (approximately 2 to 2.5
They are under constant physical stress during their lifetime. Persistent physical stress often causes dehydration, which is an ideal condition for testing the efficacy of electrolytic formulations. (iii) Racing greyhounds maintain a nearly constant weight. The fluctuations range from 30 to 33 Kg, which allows the assumption that the experimental animals are essentially constant. (iv) Racing greyhounds chase mechanical rabbits. This chasing behavior is a greyhound's animal instinct, and greyhounds do this to the fullest of their competitive abilities. Other than the greyhound's physical ability and health, there are no significant natural or environmental factors on the racetrack that influence its behavior. Therefore, since all greyhounds have similar physical characteristics, their behavior is directly related to their health. (v) Racing greyhounds are subject to extremely strict dietary restrictions during their racing lives.
Over a period of time, intake of vitamins, minerals, carbohydrates, proteins and fats is carefully regulated. Therefore, any meaningful changes in the behavior of laboratory animals are due solely to the electrolytes provided to them. (vi) Racing greyhounds undergo an intense training schedule during their racing life. The predetermined amount of exercise is the same for all animals, so the stress on the experimental subjects is constant. (vii) The presence of dehydration in racing greyhounds can be easily detected by the skin pinch test. While the skin of a healthy animal quickly recovers to its normal position, dehydrated, dynamic skin may recover slowly or, if severely dehydrated, may even remain creased. The experimental specimens were selected from a large number of racing greyhounds in the Melbourne metropolitan area. The selected animals were free of injuries that could affect their competitive behavior. During the study period, the greyhounds were placed on a severely restricted diet. Test Method Each test was conducted with a group of 20 animals. Half of the animals served as controls, and the other half of the animals each received two doses of electrolytes per day for 14 days. The groups were given the same amount of exercise and their health was monitored daily. While the experimental groups showed varying results depending on the electrolyte formulation, the control group was observed to develop dehydration and related problems. Efficacy of each formulation was evaluated based on clinical findings (skin pinch test and urine PH), race track behavior and hematological assays. The group mean value was used as the reference value for assigning a score to each formulation. There are no known methods or devices capable of measuring intracellular fluid exchange during stress. Therefore, we devised a method to indirectly measure this alternation. Four types of tests were used to determine the efficacy of each formulation. The first two tests, the skin pinch test and the urine PH, are indicator tests. Comparative behavior of each dog on the race track, post-run findings and condition, and hematological assays of the blood provide an indirect measure of the efficacy of the electrolyte preparation. (i) Skin Pinch Test The skin of the Greyhound's lumbar spine was pinched and lifted approximately 1.5 inches. A healthy greyhound's skin quickly returns to its normal position. A dehydrated greyhound's skin will slowly return to its normal position, and if the greyhound is severely dehydrated, the skin folds may remain folded for some time. (ii) Urine Test Metabolic alkalosis is directly related to the lack of electrolyte uptake (both in quantity and quality) to meet the demands of metabolic processes. Metabolic alkalosis stress causes greyhounds to excrete acidic urine. This condition can be monitored using a PH meter. (iii) record greyhound behavior during races and compare with pre-race behavior; Any imbalance in electrolytes will affect the ability of the muscles to perform exercise, which will affect the greyhound's behavior. (iv) Hematological Assays Hematological assays provide a measure of dehydration in greyhounds. Evaluation was made using the average values listed below.

Table: The amount of plasma protein in the blood is a measure of hydration or dehydration in greyhounds. Judgment of test results The efficacy of various electrolyte preparations was evaluated by assigning points to the results of each test. The criteria for the scores given to each of the four exams are listed below. (i) Skin pinch test recovery speed score Number Normal 0 Moderately slow -1 Very slow -2 (ii) Urine test PH value score Number Normal (6.3) 0 6.2-6.0 -1/4 5.9-5.7 -1/ 2 5.6−5.4 −3/4 5.3−5.1 −1 5.0 or less −2 (iii) Behavior Number of time points passing through a certain area −3/10 seconds or more +4 ~−3/10 seconds +3 ~ −2/10 seconds +2 to -1/10 seconds +1 Average speed 0 to +1/10 seconds -1 to +2/10 seconds -2 to +3/10 seconds -3 +3/10 seconds or more -4 (iv) Blood assay Serum protein (g/L ) Scores 54-56 +2 57-59 +1 60-62 0 63-65 -1 66-69 -2 70-72 -3 73-75 -4 Results Each of the formulations listed below contains one dose of electrolyte. Contains. 2 doses of each formulation per day
It was given to test greyhounds for 14 days. The results obtained from each formulation are listed below. (i) Preparations based on human extracellular body fluid composition (b) Formulation

[Table] (B) Results Test Points Number Skin Pinch Test 0 Urine PH 0 Behavior 0 Blood Test +1 Total Score +1 This formulation did not provide any significant physiological benefit to the greyhound. (ii) Preparations based on human intracellular body fluid composition (a) Formulation

[Table] (B) Results Test Points Number Skin Pinch Test 0 Urine PH 0 Behavior +1 Blood Test 0 Total Score +1 This preparation caused a slight change in the behavior of greyhounds during races. This change was not significant. (iii) Preparations with varying ratios of sodium and potassium (magnesium content constant: 0.6 milliequivalents)

[Table] When the sodium:potassium ratio was 1.5:1, more meaningful scores were obtained than when using other ratios. The effect of this formulation was significant in greyhounds. (iv) Formulations with varying levels of magnesium (sodium and potassium concentrations remain constant) (a) Formulations

【table】 (b) Results

[Table] Fixed

Claims (1)

[Claims] 1. A composition suitable for preparing a beverage by reconstitution with water, which contains sodium ions, potassium ions derived from potassium chloride, magnesium ions, chloride ions, sulfate ions, phosphate ions, and citric acid. ion, sutucarose, dextrose, ascorbic acid and pyridoxine, and the relative ratio of sodium ion: potassium ion: magnesium ion: chloride ion: sulfate ion: phosphate ion is 5-7: 3-5: when calculated in milliequivalents. 1~
A composition having a ratio of 3:5 to 6:1 to 3:5 to 7. 2. The composition according to item 1, which contains a flavoring agent. 3. The composition according to item 1, which contains an artificial sweetener and/or coloring agent and/or preservative. 4. The composition according to any one of items 1 to 3, which has a pH buffered to 6.8 to 7.4 when reconstituted with water. 5. The composition according to any one of clauses 1 to 4, comprising sutucarose, dextrose, and citrate in amounts sufficient to provide 3.4 Kcal of energy per gram of the composition. 6. The composition according to item 5, comprising 0.48 g of sutucarose, 0.31 g of dextrose and 7.22 milliequivalents of citrate per gram of the composition. 7. The composition according to any one of items 1 to 6, which contains 10 mg of ascorbic acid and 2.5 mg of pyridoxine per gram of the composition. 8 Per 10g of composition, 6.1 milliequivalents of sodium ions, 3.85 milliequivalents of potassium ions, 2.47 milliequivalents of magnesium ions, 5.0 milliequivalents of chloride ions,
Sulfate ion 2.47 milliequivalent, phosphate ion 6.25 milliequivalent, citrate ion 7.22 milliequivalent, ascorbic acid 100 mg, pyridoxine 25 mg, sutucarose 4.8
8. The composition of claim 7, comprising: g, 3.1 g dextrose, and a suitable amount of lemon flavoring. 9 In the first term consisting of sodium chloride, potassium chloride, anhydrous magnesium sulfate, disodium hydrogen phosphate hydrate, sodium dihydrogen phosphate hydrate, dextrose, sutucarose, ascorbic acid, pyridoxine hydrochloride, sodium citrate and citric acid. Compositions as described. 10. The composition according to item 9, further comprising a lemon flavoring agent. 11. The composition according to item 10, wherein the amounts of each component are as follows. Sodium chloride 69.6mg Potassium chloride 288.0mg Magnesium sulfate 148.0mg Sodium citrate 120.0mg Disodium hydrogen phosphate hydrate 480.0mg Sodium dihydrogen phosphate hydrate 111.6mg Ascorbic acid 100.0mg Pyridoxine hydrochloride 25.0mg Citric acid 420.0mg Sutucarose 4.8 g Dextrose 3.18g Lemon flavoring 257.8mg