JPS63248634A - Plastic vessel for fluid supplementation - Google Patents
Plastic vessel for fluid supplementationInfo
- Publication number
- JPS63248634A JPS63248634A JP62077329A JP7732987A JPS63248634A JP S63248634 A JPS63248634 A JP S63248634A JP 62077329 A JP62077329 A JP 62077329A JP 7732987 A JP7732987 A JP 7732987A JP S63248634 A JPS63248634 A JP S63248634A
- Authority
- JP
- Japan
- Prior art keywords
- ethylene
- random copolymer
- propylene random
- infusion
- plastic container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920003023 plastic Polymers 0.000 title claims description 18
- 239000004033 plastic Substances 0.000 title claims description 18
- 239000012530 fluid Substances 0.000 title 1
- 230000009469 supplementation Effects 0.000 title 1
- 229920005674 ethylene-propylene random copolymer Polymers 0.000 claims description 20
- 238000001802 infusion Methods 0.000 claims description 15
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 11
- 239000004707 linear low-density polyethylene Substances 0.000 claims description 11
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 10
- 239000005977 Ethylene Substances 0.000 claims description 10
- 239000003978 infusion fluid Substances 0.000 claims description 7
- 238000010253 intravenous injection Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 238000005452 bending Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000004711 α-olefin Substances 0.000 description 3
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 2
- RYPKRALMXUUNKS-UHFFFAOYSA-N 2-Hexene Natural products CCCC=CC RYPKRALMXUUNKS-UHFFFAOYSA-N 0.000 description 2
- 238000000071 blow moulding Methods 0.000 description 2
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 229920005604 random copolymer Polymers 0.000 description 2
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 1
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- Containers Having Bodies Formed In One Piece (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
産業上の利用分野
本発明は、内部に静脈注射用などの輸液を充填する輸液
用プラスチック容器に関するもので、さらに詳しくは蒸
気滅菌時の高温度により劣化することのない耐熱性を有
するとともに耐落下衝撃性を兼備する輸液用プラスチッ
ク容器に関するものである。DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a plastic container for infusion, which is filled with an infusion for intravenous injection. The present invention relates to a plastic container for infusions that has both heat resistance and drop impact resistance.
従来の技術
この種の輸液用プラスチック容器として従来より多用さ
れているのはガラス製容器である。このガラス製容器は
、滅菌時に、加えられる高温度に対して十分に耐えるこ
とができるとともにきわめて透明性が高いという特徴を
有し、さらに化学的に安定しているので異物が析出する
ことなくきわめて衛生的であるという特徴を有する。BACKGROUND OF THE INVENTION Glass containers have traditionally been widely used as plastic containers for this type of infusion. This glass container can withstand the high temperatures applied during sterilization, is extremely transparent, and is chemically stable, so it can be used without the precipitation of foreign substances. It has the characteristic of being hygienic.
また、近年落として割れないこと、軽量であることなど
の利点により急速にプラスチック化が進んでおり、特に
耐熱性・透明性及び柔軟性の点よりエチレン−プロピレ
ンランダム共重合体にて構成された輸液用プラスチック
容器が知られている（特開昭６０−６３０５９号）。In recent years, the use of plastics has been rapidly progressing due to their advantages such as not breaking when dropped and being lightweight.In particular, plastics made of ethylene-propylene random copolymer are being used for their heat resistance, transparency, and flexibility. A plastic container for infusion is known (Japanese Unexamined Patent Publication No. 60-63059).
発明が解決しようとする問題点
しかしながら、前掲前者のガラス製容器であれば落下す
ると割れるという欠点及び重いという欠点を有しており
、さらに前掲後者のエチレン−プロピレンランダム共重
合体容器であれは上記長所のほかに軽量であるという長
所を有するが、−力落下するとシール面から破袋すると
いう欠点を有しさらにエチレン−プロピレンランダム共
重合体から低分子物質が輸液内に析出して衛生性が損な
われるという欠点をも有している。Problems to be Solved by the Invention However, the former type of glass container has the disadvantage of breaking when dropped and is heavy, and the latter type of ethylene-propylene random copolymer container has the disadvantages of being heavy. In addition to its advantages, it has the advantage of being lightweight, but it also has the disadvantage of tearing the bag from the sealing surface if it is dropped by force, and furthermore, low-molecular substances from the ethylene-propylene random copolymer precipitate into the infusion solution, making it unhygienic. It also has the disadvantage of being damaged.
問題点を解決するための手段
そこで本発明は、３〜９重量ｇ／ｃｍ３のエチレンを含
有スルエチレン−プロピレンランダム共重合体にて構成
された内部に静脈注射用などの輸液を充填する飴液用プ
ラスチック容器においてこのエチレン−プロピレンラン
ダム共重合体の内側に密度が０．８９〜ｏ、９４ｇ／４
の線状低密度ポリエチレンを配したことを特徴とするも
のである。Means for Solving the Problems Therefore, the present invention provides a candy solution in which an infusion solution for intravenous injection or the like is filled into an interior made of a sulfethylene-propylene random copolymer containing 3 to 9 weight g/cm3 of ethylene. In a plastic container for use, the inside of this ethylene-propylene random copolymer has a density of 0.89~o, 94g/4
It is characterized by being made of linear low-density polyethylene.
なふ・、本発明のエチレン−プロピレンランダム共重合
体とは、エチレン含有量が３〜９重量％で曲げ弾性率（
ＪＩＳ Ｋ７２０３）が１０，０００に９／ｃＩ／Ｉ以
下のものをいう。エチレン含有量は、好適には４〜９重
量％であるが、このエチレン含有量が３重量％未満では
得られる共重合体の剛性が高く充分な柔軟性が得られず
、９重量％を越えるとエチレン−プロピレンランダム共
重合体を製造しようとしても製造時にファウリングを生
じ満足しうる状態で製造することが困難である。ｉだ曲
げ弾性率は、１０．０ＯＯＫＰ／ｃｒｌ以下であり、８
． ＯＯＯＫｙ／ｃｌ以下が望まれ、とりわけ５．００
０ Ｋｇ／ｃｄ以下が望ましい。この曲げ弾性率が１０
．０００ Ｋ９／ｃｒＡ を越えると剛性が高くなり輸
液用プラスチック容器として使用に難が生じる。The ethylene-propylene random copolymer of the present invention has an ethylene content of 3 to 9% by weight and a flexural modulus (
JIS K7203) is 10,000 to 9/cI/I or less. The ethylene content is preferably 4 to 9% by weight, but if the ethylene content is less than 3% by weight, the resulting copolymer will have high rigidity and sufficient flexibility will not be obtained, and if it exceeds 9% by weight. Even if an attempt is made to produce an ethylene-propylene random copolymer, fouling occurs during production, making it difficult to produce it in a satisfactory manner. The bending elastic modulus is 10.0OOKP/crl or less, and 8
．． OOOKy/cl or less is desirable, especially 5.00
0 Kg/cd or less is desirable. This bending modulus is 10
．． If it exceeds 000 K9/crA, the rigidity will increase and it will be difficult to use it as a plastic container for infusion.
また本発明の線状低密度ポリエチレンとは、中圧、低圧
又は場合によっては高圧法でも得られる密度が０．８９
〜０．９４ ｇ／Ｑｄのエチレンと他のα−オレフィン
との共重合体でその構造が線状の直鎖に短分岐をもった
ものを意味し、特にα−オレフィンとしてプロピレン、
ブテン、ペンテン、ヘキセン、ヘプテン、オクテン、４
−メチル−１−ペンテン等の炭素数０３〜ＣＩ□のα−
オレフィンを２０モル％以下、好ましくは１〜１０モル
％程度共重合したものをいう。線状低密度ポリエチレン
は、上記曲げ弾性率が５． ＯＯＯＫＰ／ｃｒｌ以下が
好ましいＯ
作 用
このように本発明は、３〜９重量ｇ／ｃｍ３のエチレン
を含有するエチレン−プロピレンランダム共重合体の内
側に密度が０．８９〜０．９４．＠／ｄの線状低密度ポ
リエチレンを配したので、エチレン−プロピレンランダ
ム共重合体自体の特長である耐熱性・透明性・柔軟性を
そのまま保持するとともにエチレン−プロピレンランダ
ム共重合体の欠点であるシール強度を飛躍的に向上させ
ることができ、さらに低分子物質が輸液内へ析出するの
を完全に防止できるのである。In addition, the linear low density polyethylene of the present invention has a density of 0.89 that can be obtained by medium pressure, low pressure, or in some cases high pressure method.
A copolymer of ~0.94 g/Qd ethylene and other α-olefins, whose structure is a linear straight chain with short branches, especially when α-olefins include propylene,
Butene, pentene, hexene, heptene, octene, 4
-α- having 03 to CI□ carbon atoms such as methyl-1-pentene
It refers to a product copolymerized with olefin in an amount of 20 mol% or less, preferably about 1 to 10 mol%. The linear low-density polyethylene has the above-mentioned bending modulus of 5. As described above, in the present invention, an ethylene-propylene random copolymer containing 3 to 9 weight g/cm3 of ethylene has a density of 0.89 to 0.94. Since @/d linear low-density polyethylene is used, it maintains the heat resistance, transparency, and flexibility that are the characteristics of the ethylene-propylene random copolymer itself, while also eliminating the disadvantages of the ethylene-propylene random copolymer. The seal strength can be dramatically improved, and furthermore, it is possible to completely prevent low-molecular substances from precipitating into the infusion solution.
実 施 例
本発明の実施例を図面に基づき説明する。図中１は、ブ
ロー成形により形成した輸液用プラスチック容器（以下
、単に容器という）であり、この容器ＩＶｉ、ゴム栓（
図示せず）を保持して内部の輸液を密封する゛口部２と
輸液を収容する胴部３と口部２の反対側にあって胴部３
に連設する吊具部４より構成されている。口部２の先端
にはプルトツブ２ａを備えており、プルトップ２ａを引
張り切除することによりゴム栓が露出するようになって
いる。Embodiment An embodiment of the present invention will be described based on the drawings. 1 in the figure is a plastic container for infusion (hereinafter simply referred to as a container) formed by blow molding, and this container IVi, a rubber stopper (
(not shown) to seal the internal infusion solution; a body section 3 that houses the infusion solution; and a body section 3 on the opposite side of the mouth section 2.
It is composed of a hanging tool part 4 that is connected to the. A pull top 2a is provided at the tip of the mouth portion 2, and a rubber stopper is exposed by pulling and cutting off the pull top 2a.
第２図は、胴部３の一部断面図であり、第２図中５は６
重量ｇ／ｃｍ３のエチレンを含有し曲げ弾性率が４、５
００ Ｋｆ／ｃｄのエチレン−プロピレンランダム共重
合体から成る外層上あり、６は密度が０．９２’４のエ
チレンと他のα−オレフィンとしてブテンを９モル％共
重合させた線状低密度ポリエチレンから・なる内層であ
る。このエチレン−プロピレンランダム共重合体の外層
５は、平均肉厚が０．２ ｍｍであり、線状低密度ポリ
エチレンの内層６は、平この容器１に５００ｃｃの生理
食塩水を入れて、１２１℃、３０分の水蒸気滅菌処理を
加えたところ、変形は認められなかった。これは、エチ
レン−プロピレンランダム共重合体の耐熱性に負うとこ
ろが大きく、しかも耐熱性の落ちる線状低密度ポリエチ
レンを内層に配して直接高温に露すことなくエチレン−
プロピレンランダム共重合体で保護しているためである
。またこの状態で２ｍの高さより容器１を落下させても
シール面から破袋することがなかった。FIG. 2 is a partial cross-sectional view of the trunk 3, and 5 in FIG. 2 is 6.
Contains ethylene weighing g/cm3 and has a flexural modulus of 4 to 5.
The outer layer is made of an ethylene-propylene random copolymer with a density of 0.00 Kf/cd, and 6 is a linear low-density polyethylene copolymerized with ethylene having a density of 0.92'4 and 9 mol% of butene as another α-olefin. It is the inner layer that consists of. The outer layer 5 of this ethylene-propylene random copolymer has an average thickness of 0.2 mm, and the inner layer 6 of linear low-density polyethylene is heated at 121° C. by placing 500 cc of physiological saline in a flat container 1. After applying steam sterilization treatment for 30 minutes, no deformation was observed. This is largely due to the heat resistance of the ethylene-propylene random copolymer, and by arranging linear low-density polyethylene, which has poor heat resistance, in the inner layer, ethylene-propylene random copolymer can be used without being directly exposed to high temperatures.
This is because it is protected by a propylene random copolymer. Further, even if the container 1 was dropped from a height of 2 m in this state, the bag did not break from the sealing surface.
なお上記実施例では、ブロー成形により成形した場合を
示したが、本発明の輸液用プラスチック容器は、これら
に限定されることなく成形できるもので、例えば上記構
成の２層のシートを予め形成してふ・き、２枚のシート
のまわりを高周波シールにより溶着して袋状の容器にし
てもよい。本発明の構成であれば、高周波シールによる
溶着にふ・いても充分なシール強度が得られるものであ
る。Although the above example shows a case in which the plastic container for infusions is molded by blow molding, the plastic container for infusions of the present invention can be molded without being limited thereto.For example, a two-layer sheet having the above structure may be formed in advance. Alternatively, the two sheets may be welded together using a high-frequency seal to form a bag-like container. With the configuration of the present invention, sufficient sealing strength can be obtained even when welding by high frequency sealing.
本発明の線状低密度ポリエチレンの肉厚は、上記のシー
ル強度を得るためには、全体の肉厚の３０％は必要であ
る。３０％未満の場合は、エチレン−プロピレンランダ
ム共重合体のシール強度を改良することは期待セきない
。逆に線状低冨度ポリエチレンの肉厚が全体の肉厚の８
０％を越えると透明性と耐熱性が低下してしまい充分な
水蒸気滅菌処理を行うことができない。The wall thickness of the linear low density polyethylene of the present invention needs to be 30% of the total wall thickness in order to obtain the above-mentioned sealing strength. If it is less than 30%, it cannot be expected to improve the seal strength of the ethylene-propylene random copolymer. Conversely, the wall thickness of linear low-rich polyethylene is 8% of the total wall thickness.
If it exceeds 0%, transparency and heat resistance will decrease, making it impossible to perform sufficient steam sterilization.
発明の効果
以上のように本発明の輸液用プラスチック容器は、３〜
９重量ｇ／ｃｍ３のエチレンを含有するエチレン−プロ
ピレンランダム共重合体の内側に密度が０．８９〜０．
９４９／Ｃｒ／Ｉの線状低密度ポリエチレンを配したの
で、エチレン−プロピレンランダム共重合体自体の特長
である耐熱性・透明性・柔軟性をそのまま保持するとと
もにエチレン−プロピレンランダム共重合体の欠点であ
るシール強度を飛躍的に向上させることができさらに低
分子物質が輸液内に析出することがないので衛生的であ
る。Effects of the Invention As described above, the plastic container for infusion of the present invention has three to
The inside of the ethylene-propylene random copolymer containing 9 weight g/cm3 of ethylene has a density of 0.89-0.
949/Cr/I linear low-density polyethylene maintains the heat resistance, transparency, and flexibility that are the characteristics of the ethylene-propylene random copolymer itself, while also eliminating the drawbacks of the ethylene-propylene random copolymer. The seal strength can be dramatically improved, and furthermore, it is hygienic because low-molecular substances do not precipitate into the infusion solution.
第１図は本発明の一実施例である輸液用プラスチック容
器の斜視図、第２図は第１図の輸液用プラスチック容器
の胴部の一部拡大断面図である。
１・・・輸液用プラスチック容器、４・・・エチレン−
プロピレンランダム共重合体層、５・・・線状低密度ポ
リエチレン層FIG. 1 is a perspective view of a plastic container for infusion according to an embodiment of the present invention, and FIG. 2 is a partially enlarged sectional view of the body of the plastic container for infusion shown in FIG. 1...Plastic container for infusion, 4...Ethylene-
Propylene random copolymer layer, 5... linear low density polyethylene layer
Claims (1)
ンランダム共重合体にて構成された内部に静脈注射用な
どの輸液を充填する輸液用プラスチック容器において、
該エチレン−プロピレンランダム共重合体の内側に密度
が０．８９〜０．９４ｇ／ｃｍ＾３の線状低密度ポリエ
チレンを配したことを特徴とする輸液用プラスチック容
器。In a plastic container for infusion, which is made of an ethylene-propylene random copolymer containing 3 to 9% by weight of ethylene, and is filled with an infusion solution for intravenous injection, etc.
A plastic container for infusion, characterized in that a linear low-density polyethylene having a density of 0.89 to 0.94 g/cm^3 is arranged inside the ethylene-propylene random copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62077329A JPS63248634A (en) | 1987-03-30 | 1987-03-30 | Plastic vessel for fluid supplementation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62077329A JPS63248634A (en) | 1987-03-30 | 1987-03-30 | Plastic vessel for fluid supplementation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63248634A true JPS63248634A (en) | 1988-10-14 |
Family
ID=13630892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62077329A Pending JPS63248634A (en) | 1987-03-30 | 1987-03-30 | Plastic vessel for fluid supplementation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63248634A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5968239A (en) * | 1982-10-14 | 1984-04-18 | 東洋製罐株式会社 | Multilayer stretched plastic vessel |
| JPS6024946A (en) * | 1983-07-21 | 1985-02-07 | 昭和電工株式会社 | Polypropylene multilayer transparent vessel |
| JPS61100451A (en) * | 1984-10-22 | 1986-05-19 | オ−エンス−イリノイ・インコ−ポレ−テツド | Multilayer plastic structure and composition |
| JPS61249751A (en) * | 1985-04-29 | 1986-11-06 | ダブリュー・アール・グレイス・アンド・カンパニー―コネチカット | Flexible film and flexible vessel manufactured from said film |
-
1987
- 1987-03-30 JP JP62077329A patent/JPS63248634A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5968239A (en) * | 1982-10-14 | 1984-04-18 | 東洋製罐株式会社 | Multilayer stretched plastic vessel |
| JPS6024946A (en) * | 1983-07-21 | 1985-02-07 | 昭和電工株式会社 | Polypropylene multilayer transparent vessel |
| JPS61100451A (en) * | 1984-10-22 | 1986-05-19 | オ−エンス−イリノイ・インコ−ポレ−テツド | Multilayer plastic structure and composition |
| JPS61249751A (en) * | 1985-04-29 | 1986-11-06 | ダブリュー・アール・グレイス・アンド・カンパニー―コネチカット | Flexible film and flexible vessel manufactured from said film |
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