JPS63229068A - Electric stimulation wound treatment apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an electrical stimulation wound treatment device for treating wounds and disorders of the skin and its appendages such as hair.

[Conventional technology]

BACKGROUND ART Conventionally, the main treatments for wounds on the skin or disorders of the skin and its appendages have been drug therapy using topical skin drugs, oral drugs, injection drugs, etc., or surgical treatments.

Among these, topical skin drugs used as topical treatment agents for skin wounds vary depending on the cause, severity, and other factors, but are usually disinfectants, antibacterial agents, antibiotics, anti-inflammatory agents, proteolytic enzymes, coagulants, etc. It consists of a mixture of agents, exudate absorbents, vitamins, hormones, etc. depending on the purpose.

On the other hand, severe burns that affect deep tissues over a wide area,
Skin injuries such as bedsores and trauma cause strong inflammatory reactions, local circulation disorders, infections, etc., and these drugs alone often do not respond to treatment. In this case, surgical suturing or skin grafting is usually the best treatment. In recent years, sugar has also begun to be used as a therapeutic agent for severe bedsores, as it has a remarkable granulation-forming effect.

On the other hand, drugs for skin disorders such as skin keratosis, various dermatitis, acquired pigment abnormalities, eczema, rough skin, shark skin, age spots, acne, cracks, chapping, diaper rash, chilblains, etc.
Keratolytic agents (such as salicylic acid), vitamins, anti-inflammatory agents, hormones, and various base agents are blended depending on the purpose.

Additionally, vasodilators, vitamins, hormones, and the like have been conventionally used for hair growth and hair growth for hair diseases such as gray hair and alopecia.

[Problem that the invention seeks to solve]

As mentioned above, drug and surgical therapy are the main treatments for skin wounds and disorders of the skin and its appendages, and electrical stimulation has a significant therapeutic effect on skin wounds and disorders of the skin and its appendages. That is not known. Moreover, as an external skin drug, it is not known that a drug containing sugar, potassium, and other therapeutic agents for branch diseases mentioned above has a significant therapeutic effect on branch wounds and disorders of the skin and its appendages.

Therefore, the inventor of the present application conducted various studies on the effect of electrical stimulation on the skin and topical skin drugs containing sugar and potassium for treating wounds and disorders of the skin and its appendages, and compared conventional drug therapy. Research has been conducted to find therapeutic agents, methods, and therapeutic devices that have therapeutic effects that are comparable to or exceed those of surgical and surgical treatments.

The present invention is based on the results of the above research, and it is possible to obtain high therapeutic effects by using electrical stimulation, and by using a mixture of sugar and potassium in conjunction with electrical stimulation. An object of the present invention is to provide an electrical stimulation wound treatment device.

[Means for solving problems]

For this purpose, the electrical stimulation wound treatment device of the present invention includes a stimulation electrode used for the treatment affected area, an indifferent electrode placed opposite to the stimulation electrode, and a stimulation signal generating means for applying electrical stimulation between the stimulation electrode and the indifferent electrode. It is characterized by consisting of.

[Effect]

In the electrical stimulation wound treatment device of the present invention, a high therapeutic effect can be obtained by applying electrical stimulation to the treated area through the stimulation electrode and the indifferent electrode using the signal from the stimulation signal generating means. Moreover, by applying electrical stimulation in combination with a wound treatment agent, the therapeutic effect can be synergistically enhanced. At least sugar and potassium, especially as wound treatment agents, as well as disinfectants, antibacterial agents, antibiotics, anti-inflammatory agents, vitamins, proteolytic enzymes, exudate absorbers, hormonal agents, keratolytic agents, vasodilators, and proteolytic inhibitors. The therapeutic effect can be further enhanced by selectively mixing agents, coagulants, and bases, and by adding electrolytes such as sodium chloride.

〔Example〕

Examples will be described below with reference to the drawings.

FIG. 1 is a diagram for explaining one embodiment of the electrical stimulation wound treatment device according to the present invention, and FIG. 2 is a diagram for explaining another embodiment of the electrical stimulation wound treatment device according to the present invention. . In the figure, 1 and 14 are indifferent electrodes, 2 and 13 are stimulation electrodes, 3 is a sheet battery, 4 is an electrical stimulation circuit, 11 is an electrical stimulation device,
12 and 15 are connectors, and 16 is a living body.

In FIG. 1, an electrical stimulation circuit 4 uses a sheet battery 3 as a power source to generate signals such as weak direct current stimulation, pulse stimulation, and alternating current stimulation between an indifferent electrode 1 and a stimulating electrode 2. Since it can be configured with a simple constant current circuit or pulse generation circuit, a small IC chip can be used. The stimulation electrode 2 has a layer of a wound treatment agent and applies electrical stimulation to the affected area by covering it with the wound treatment agent.The indifferent electrode 1 is made of, for example, conductive rubber and is an electrode on the non-stimulation side. It is attached to the skin surface as a mask.

If the indifferent electrode 1, the stimulation electrode 2, the sheet battery 3, and the electrical stimulation circuit 4 are made into one sheet as shown in the figure and configured to be attached to the affected area, it can be used as a disposable sheet.

FIG. 2 shows another embodiment of the present invention in which only the stimulation electrode portion is disposable. In Figure 2,
The stimulation electrode 13 and the indifferent electrode 14 are configured to be connected to the electrical stimulation device 11 through connectors 12.15, respectively. The stimulation electrode 13 is made by weaving thread-like electrodes into rectangular gauze so as to extend radially from the corners, and is configured so that it can be cut to any size and used.

The stimulation electrode is made of a material that is not toxic to the living body, such as stainless steel fiber (SUS 316L) or Hastelloy fiber with a diameter of about 8 μ to 15 μ, for example. By using these materials, it is of course possible to twist them into threads, coat the surface with Teflon, silicone, etc., and adopt various shapes.

Figure 3 is a diagram showing an example of treatment using a sheet-shaped stimulation electrode;
Figure 4 is a diagram showing an example of treatment using a filamentous stimulation electrode;
The figure shows an example of the shape of the electrode, and FIG. 6 shows an example of treatment of a surgically sutured part. In the figure, 21 and 31 are covered, 22 is a stimulating electrode, 23 and 33 are wound treatment agents, 32 is a thread electrode, 41 is a fiber exposed part, 42 is a covering, 43
51 is a connector portion, 51 is a suture portion, 52 is a suture thread, 53 is a lead wire, and 54 is an electrical stimulation device.

In the example shown in FIG. 3, a wound treatment agent 23 is applied to the wound area, a stimulation electrode 22 such as fiber-woven gauze is placed on top of the wound treatment agent 23, and a cover 21 is placed on top of the stimulation electrode 22. By passing a weak direct current, pulsed current, alternating current, etc. between the stimulation electrode 22 and the indifferent electrode, the wound treatment agent 23
Electrical stimulation therapy is performed in combination with

In the example shown in FIG. 4, a wound treatment agent 33 is applied to the wound area, a thread electrode 32 is placed therein to serve as a stimulation electrode, and a covering 31 such as gauze is placed on top of the wound treatment agent 33. FIG. 5 shows an example of the structure of such a thread-like electrode. That is, the thread-like electrode shown in FIG.
~ Peel off the coating by a few cm to make the fiber exposed part 41,
It is inserted into the wound and acts as a stimulation part. And the connector part 4
Until 3, apply a coating 42 of Teflon, silicone, etc.
Connector section 43 is connected to an electrical stimulation device as shown in FIG.

In all of the above examples, a wound treatment agent is applied to the wound area and a stimulation electrode is placed to cover the wound area, but the example shown in FIG. suture thread 52
is used as a stimulation electrode. In this case, a wound treatment agent is applied to the sutured portion 51, and each suture thread 52 is electrically connected to an electrical stimulation device 54 using a lead wire 53 as shown in the figure to apply electrical stimulation. In the illustrated example, each suture thread 52 is individually connected to the electrical stimulation device 54, but it goes without saying that each suture thread 52 and the electrical stimulation device 54 may be connected by a single lead wire.

As described above, the present invention uses electrodes of various shapes to provide electrical stimulation in combination with wound treatment agents, but as described above, this electrical stimulation uses a weak direct current (voltage) , alternating current (voltage), pulsed current (voltage), etc. can be used, and in the examples given so far by the inventor of the present application, the therapeutic effect is remarkable with any of them. The polarity of direct current stimulation is negative on the wound side, and the stimulation current value is approximately 2μ.
It is about A~500μ8. In addition, with pulse stimulation,
For example, by setting the pulse width to 0.1 to 1 msec and setting the frequency to 20 Hz, a negative square wave can be applied to the wound site, and for alternating current stimulation, a sine wave of 1 to 10 Hz can be used. .

FIG. 7 is a diagram showing an example of the configuration of an electrical stimulation generation circuit in the case of direct current stimulation, and FIG. 8 is a diagram showing an example of the configuration of the electrical stimulation generation circuit in the case of pulse stimulation.

In the case of direct current stimulation, as mentioned earlier, approximately 2 μA ~
The current value is weak to 500μ, and as shown in Figure 7, it is constructed with a simple circuit consisting of a field effect transistor FET and a resistor R, and the positive potential side is connected to the indifferent electrode, and the negative potential side is connected to the stimulation electrode. can be configured to connect to.

In the case of pulse stimulation, as shown in Figure 8, it consists of an oscillation circuit and a constant current circuit, and by supplying the output of the oscillation circuit to the stimulation electrode through the constant current circuit, the stimulation electrode A pulse train of a constant magnitude can be applied between the electrode and the indifferent electrode. The oscillation circuit consists of three IC chips 11, a capacitor C1 resistor R1, VH2, and a diode as shown in the figure, and a well-known circuit can be used in which the oscillation frequency can be set by the time constant of the capacitor C1 resistor VR, VH2. Can be done.

Wound treatment agents include sugar and potassium, as well as antiseptics, antibacterial agents, antibiotics, anti-inflammatory agents, vitamins, proteolytic enzymes, exudate absorbers, hormones, keratolytic agents, and vasodilators. A mixture of a proteolytic agent, a proteolytic inhibitor, a coagulant, and a base is used, and if necessary, an electrolyte such as sodium chloride is added.

Examples of sugar include monosaccharides such as glucose, fructose, and mannose, as well as oligosaccharides such as maltose and sucrose. Use types depending on the purpose.

Potassium is mixed in an amount of about 80 mg to 160 mg as potassium chloride per 100 g of the therapeutic agent. In addition, other ingredients to be mixed as necessary and their addition amount (100g of therapeutic agent)
(middle) is as follows, for example.

"Disinfectant and disinfectant" Povidone iodine solution 5-10ml (trade name: Isodine solution) Povidone-iodine gel 20-30g (trade name: Isodine gel) Sulfadiazine silver cream 10-25g (trade name: Goeben cream) "Antibacterial agent" Ofloxacin 1-3g (trade name: Taribisoto) ) "Antibiotics" Erythromycin 0.5-3g Tetracycline hydrochloride 3g Siladiomycin sulfate 0.5g Polymyxin B sulfate 1 million units Gentamicin sulfate 0.1 g (potency) Other "vitamin supplements" Vitamin Addition amount (therapeutic agent 100 g Middle) A
200,000 units B2 (as riboflavin phosphate) 274 mg B6 (as pyridoxine hydrochloride) IgE (as dl-alpha-tocopherol) 2 g "Analgesic and anti-inflammatory agent" di-camphor 1 g lidocaine 2.5-10% propyridine hydrochloride 2 g Glytail
0.5-5g diphenhydramine 1
g “Wound healing agent” Allantoin 200mg “Keratolytic agent” Salicylic acid 5-10g Urea
Log “Proteolytic enzyme agent” Trypsin 200,00011IJ,M
Fibrinolysin 100.0 “Proteolytic enzyme inhibitor” Trasylol 250,000 KIE “
Exudate absorbent” Polyethylene glycol Appropriate amount “Vasodilator” Lecithin 39g Pilocarpine hydrochloride 1g Carpronium chloride
5% Next, specific examples of treatments performed by the inventor of the present application will be explained. FIG. 9 is a diagram for explaining an example of the therapeutic effect on bedsores.

Patient 5 was a man in his 40s who had quadriplegia due to an injury to the 7th cervical spinal cord, and his left buttock abrasion developed suppuration and was restarted. Despite receiving treatment using conventional methods, the condition did not improve.
Treatment was performed using the electrical stimulation treatment method of the present invention. As shown in Figure 9(a), the degree of reopening is as follows: a circular hole with a diameter of 3 cm is made in the skin, and an ulcer is formed that reaches the ischium (ischial tuberosity) 61 at a depth of 5 cm; It extended vertically as well, forming a complex sinus. A large amount of audible exudate was coming out from the bedsore, so much so that it soaked through his clothes and even the mattress of his wheelchair, and it also emitted a strong odor.

Therefore, first, after washing the bed sore with physiological saline, a stimulation electrode made of stainless steel fibers is inserted into the wound, and then a wound treatment agent containing Goeben (silver sulfadiazine), a disinfectant, is applied as an antibacterial agent. The indifferent electrode was attached to the flank. For electrical stimulation, a direct current of 10 μA was constantly applied, and the bedsore was treated four times a day.

From the day after the start of treatment, redness appeared in the wound, which had previously been blackish-purple, and the odor of the exudate weakened, and the amount of exudate decreased. The therapeutic effect became visible day by day, and after 4 days, the amount of exudate had decreased to about 1/3, the bad odor had completely disappeared, and the liquid had become completely clear. At this point, we conducted a bacterial test and tested for drug susceptibility, and as it showed the highest sensitivity to Krivit (an antibacterial agent), we changed the disinfectant to Krivit. Proliferation of granulation tissue and proliferation of blood vessels could also be clearly seen on the 5th day after the start of treatment.

Fifteen days after the start of treatment, the diameter of the skin opening has shrunk to 1.5 cm, half of the initial diameter, as shown in FIG. The ischium 61, which had previously been damaged, is now covered with granulation tissue. Furthermore, no bacteria were detected, and the amount of exudate had decreased to the extent that the gauze applied to the wound was wet. This treatment speed is the fastest that has not been achieved with previous treatments.

Note that the present invention is not limited to the above embodiments, and various modifications are possible. For example, in the above embodiment, electrical stimulation was applied in combination with a wound treatment agent, but a high healing effect can also be obtained by applying electrical stimulation alone to an affected area where a wound treatment agent cannot be used. Therefore, it may be configured to apply only electrical stimulation without using a wound treatment agent in combination. A wound treatment agent consisting mainly of sugar and potassium mixed with various drugs depending on the purpose was used, but the mixed drug may be a drug other than those listed in the above examples. It goes without saying that the ingredients of the wound treatment agent may be changed depending on the progress of the treatment or the symptoms as described in the above specific treatment examples. It goes without saying that other circuits known as constant current circuits or oscillation circuits may be used as the electric circuits shown in FIGS. 7 and 8.

〔Effect of the invention〕

As is clear from the above explanation, according to the present invention, sugar and potassium, which are essential for tissue regeneration such as skin and nerve tissues, are supplied to the injured area, and electrical stimulation is also applied, so compared to conventional treatment methods. A treatment method and treatment device with significant effects can be provided. As mentioned earlier, sugar has recently begun to be used as a treatment agent for severe fractures, as it has a remarkable granulation-forming effect, and electrical stimulation is also known to be effective in treating fractures. However, the electrical stimulation treatment method and treatment device according to the present invention can provide therapeutic effects that far exceed those of such conventional therapeutic agents and treatment methods.

[Brief explanation of drawings]

FIG. 1 is a diagram for explaining one embodiment of the electrical stimulation wound treatment device according to the present invention, FIG. 2 is a diagram for explaining another embodiment of the electrical stimulation wound treatment device according to the present invention, and FIG. Figure 3 is a diagram showing an example of treatment using a sheet-shaped stimulation electrode, Figure 4 is a diagram showing an example of treatment using a thread-shaped stimulation electrode, Figure 5 is a diagram showing an example of the shape of the electrode, and Figure 6 is a diagram showing a surgical example. 7 is a diagram showing an example of the configuration of an electrical stimulation generation circuit in the case of direct current stimulation, and FIG. 8 is a diagram showing an example of the configuration of the electrical stimulation generation circuit in the case of pulse stimulation. , FIG. 9 is a diagram for explaining an example of the therapeutic effect on restart. 1 and 14...indifferent electrodes, 2 and 13...stimulation electrodes,
3... Sheet battery, 4... Electric stimulation circuit, 11...
・Electrical stimulation device, 12 and 15...Connector, 16...
・Treatment area, 21 and 31... Cover, 22... Stimulation electrode, 23 and 33... Wound treatment agent, 32... Thread-like electrode, 41... Fiber exposed part, 42... Cover , 4
3... Connector part, 51... Suture part, 52... Suture thread, 53... Lead wire, 54... Electric stimulation device. Applicant: New Technology Development Corporation Agent, Patent Attorney: Ryukichi Abe! = ゑ −s.

Claims (10)

[Claims] (1) Electrical stimulation characterized by comprising a stimulation electrode used on the treated area, an indifferent electrode placed opposite to the stimulation electrode, and a stimulation signal generating means for applying electrical stimulation between the stimulation electrode and the indifferent electrode. Wound treatment equipment. (2) The electrical stimulation wound treatment device according to claim 1, characterized in that one or more filamentous electrodes are used as the stimulation electrodes. (3) The electrical stimulation wound treatment device according to claim 2, characterized in that a plurality of thread-like electrodes are arranged radially from the corners of the rectangular surface. (4) The electrical stimulation wound treatment device according to claim 1, characterized in that a suture thread is used as a stimulation electrode. (5) The electrical stimulation wound treatment device according to claim 1, wherein the stimulation signal generation means comprises a sheet battery and a signal generation circuit that generates stimulation signals using the sheet battery as a power source. (6) The electrical stimulation wound treatment device according to claim 1, wherein the stimulation signal generating means generates a weak direct current as the stimulation signal. (7) The stimulation signal generating means generates a weak pulse current as the stimulation signal, as claimed in claim 1.
The electrical stimulation wound treatment device described in Section 1. (8) The electrical stimulation wound treatment device according to claim 1, characterized in that the stimulation electrode, the indifferent electrode, and the stimulation signal generation means are integrated into one sheet and can be attached. (9) The electrical stimulation wound treatment device according to claim 1, characterized in that a wound treatment agent containing at least sugar and potassium is used together with the stimulation electrode. (10) Sugar and potassium as a wound treatment agent, and
Disinfectants, antibacterial agents, antibiotics, anti-inflammatory agents, vitamins, proteolytic enzymes, exudate absorbers, hormones, keratolytic agents,
The electrical stimulation according to claim 9, characterized in that a vasodilator, a proteolytic inhibitor, a coagulant, and a base are selectively mixed together, and an electrolyte such as sodium chloride is added. Wound treatment equipment.