JPS63215631A - Wound remedy - Google Patents

Abstract

PURPOSE:To obtain a wound remedy containing sugar, potassium and germicide disinfectant or antibiotic or antimicrobial agent and further as necessary blended anti-inflammatory, etc. CONSTITUTION:25-85g sugar (monosaccharides such as grape sugar, oligosaccharides, etc., such as malt sugar) is blended with 100-400mg potassium, 5-10ml germicide disinfectant (e.g. isodine liquid, geben cream, etc.) or 0.5-3g antibiotic (e.g. erythromycin, tetracycline hydrochloride, etc.) or 1-3mg antimicrobial agent (e.g. ofloxacin, etc.) and further as necessary an anti- inflammatory agent, vitamin agent, proteolytic enzyme, proteolytic enzyme- inhibiting agent, exudate absorbent, corneum liquefacient, vasodilator and base to provide the wound remedy. The remedy is synergistically effected by blend use of the above-mentioned three ingredients and has wide healing action to impediment of skin, hair, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Use) The present invention relates to a therapeutic agent for wounds such as bedsores, and particularly to a wound therapeutic agent effective in electrical therapy.

(Prior Art and Problems to be Solved) Drugs used as topical treatments for skin wounds vary depending on the cause, severity, and other factors, but include disinfectants, anti-inflammatory agents, protease ointments, and exudate absorbents. , vitamin supplements,
It consists of a mixture of hormones and other drugs depending on the purpose.

However, severe inflammatory burns that reach deep tissue, such as burns, bedsores, skin ulcers, and trauma, can cause severe inflammatory reactions, local circulation disorders, infections, etc. In such injured areas, proteins, water, minerals, vitamins, etc. are lost due to the strong inflammatory response, and local circulation disorders make it difficult for these substances essential for tissue repair to be replenished, creating a vicious cycle. This repeated occurrence often results in the formation of ulcers that are extremely difficult to treat, and although surgical skin grafting is currently often the best treatment for such skin injuries, These treatments are only applicable after the infection and inflammatory response have been suppressed, so early drug treatment is extremely important.

On the other hand, sugar is known to have a granulation-forming effect on wounds and is used as a wound treatment agent; The law was not yet expected to have sufficient effects.

(Problems to be Solved by the Invention) The present inventors have proposed a method for suppressing inflammatory reactions, preventing and treating infections, improving circulation, and promoting tissue regeneration for severe burns, scalds, bedsores, etc. as described above. In addition to being essential for its treatment, it is also important to improve tissue regeneration disorders associated with local circulatory insufficiency.For this reason, the same environmental conditions as in tissue culture are achieved by directly applying ingredients equivalent to the culture medium in tissue culture to the injured area. As a result of various studies based on the idea that the purpose of the present invention is to produce It was finally completed.

(Means for Solving the Problems) That is, the present invention is a wound treatment agent comprising sugar, potassium, and a bactericidal disinfectant, an antibiotic, or an antibacterial agent, and further contains an anti-inflammatory agent, a vitamin agent, Proteolytic enzymes, protease inhibitors, exudate absorbers, keratolytic agents,
A wound treatment agent containing a vasodilator and a base. The sugars used in the present invention include glucose, fruit, monosaccharides such as mannose, and oligosaccharides such as maltose and sucrose, and the sugar and amount are selected depending on the purpose, but usually per 100 g of the therapeutic agent. The amount is about 25g to 85g, and the amount of potassium is 100g per 100g of the therapeutic agent. ~
The amount is about 400 square meters. Depending on the purpose of use, sterilizing agents, antibiotics, or antibacterial agents are added to make therapeutic agents. , have skin,
Shark skin, spots, acne, cracks, chapping, diaper rash,
For skin disorders such as chilblains, use keratolytic agents (such as salicylic acid), vitamins, anti-inflammatory agents, and hormones.
Hair nourishing agents such as vasodilators, vitamins, and hormones are added to treat hair diseases such as gray hair and alopecia.

The disinfectants used in the present invention include povidone-iodine solution, (trade name: Isodine solution), povidone-iodine gel (trade name: Isodine gel), and sulfadiazine silver cream (trade name: Goeben cream).
~10mQ, 10-30g for gel or cream
The antibacterial agent is ofloxacin (trade name Talibit) 1-3, and the antibiotic is erythromycin,
Tetracycline hydrochloride, fradiomycin sulfate, polymyxin B sulfate, and gentamicin sulfate, the amount of which is 0.
．． 5 to 3 g (1 million units for polymyxin B sulfate).

The method of applying the therapeutic agent of the present invention is not only by applying it directly to the affected area, but also by impregnating it into gauze in the form of a sabio or finger pouch. In particular, gauze impregnated with the wound treatment agent can be used. Electrical therapy can be very effective. That is, it is known that negative current stimulation promotes bone formation, heals fractures more quickly, and promotes the growth of nerve fibers. When used in combination, extremely early healing is possible, although the mechanism of action has not yet been elucidated. When used in electrical therapy, it is preferable to add sodium chloride to the therapeutic agent of the present invention in order to improve current conduction, and the amount is approximately 700 μg per 100 g of the therapeutic agent.
That's about it.

Furthermore, in the present invention, optional ingredients include vitamins, analgesics such as di-camphor, lidocaine, prohydroline hydrochloride, Glytail, and diphenhydramine, anti-inflammatory agents, and wound healing agents such as allantoin, as well as salicylic acid and urea. Add keratolytic agents, proteases such as trypsin, fibrinolysin, protease inhibitors such as tracinol, exudate absorbents such as polyethylene glycol, and vasodilators such as lecithin, pirocarbin hydrochloride, and carpronium chloride. I can do it.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 Glucose 1 was applied to a bedsore with a diameter of 10a1 on the heel of the foot.
50g of Isodine gel, 12ml of Isodine solution and KCL400■ are uniformly mixed to make approximately 200g of therapeutic agent.
I made it and applied it twice a day, and it completely healed in about a month.

In addition, when this glucose combination therapeutic agent was applied to small bedsores of the size of lai in the sacrum and iliac crest in two patients, the wounds completely healed in about one week. This seemed to result in healing about 1.5 to 2 times faster than when KCL was not added.

Example 2 For a large bedsore in which a hole with a diameter of 5 am was made in the skin of the left buttock and a cavity with a diameter of 15 g and a depth of 53 that reached the ischium was formed under the skin, 150 g of granulated sugar, 50 g of insin gel, 12+nl of isodine solution, and 400 KCL were treated. About 200 g of the therapeutic agent was made by uniformly mixing the above ingredients, and the mixture was placed in the bedsore cavity and a direct current of 10 μA was passed there. After about 2 months, the skin opening diameter was 7 cm, and the subcutaneous cavity diameter was about 7 cm. It was observed that the tumor size decreased to a depth of 2 am and 3 aa, and that the tumor tended to heal about twice as fast as the treatment using a therapeutic agent containing only sugar and disinfectant.

(Effects of the Invention) As described above, the present invention uses the combination of sugar, potassium, sterilizing agent, antibiotic, or antibacterial agent to act synergistically and cause problems such as skin and hair. It has a wide range of healing effects, and its effects are extremely large.

Claims (1)

[Scope of Claims] 1. Consisting of sugar, potassium, and a disinfectant, antibiotic, or antibacterial agent, and if necessary, an anti-inflammatory agent, a vitamin, a protease, a protease inhibitor, and an exudate absorbent. , a wound treatment agent 2 containing a keratolytic agent, a vasodilator, and a base, with a potassium concentration of 100 to 40 per 100 g of the treatment agent.
The wound treatment agent according to claim 1, which is 0 mg.