JPS63212356A - Hyperthermia phantom - Google Patents
Hyperthermia phantomInfo
- Publication number
- JPS63212356A JPS63212356A JP4601787A JP4601787A JPS63212356A JP S63212356 A JPS63212356 A JP S63212356A JP 4601787 A JP4601787 A JP 4601787A JP 4601787 A JP4601787 A JP 4601787A JP S63212356 A JPS63212356 A JP S63212356A
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- phantom
- liquid crystal
- hyperthermia
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010020843 Hyperthermia Diseases 0.000 title claims description 13
- 230000036031 hyperthermia Effects 0.000 title claims description 13
- 239000004973 liquid crystal related substance Substances 0.000 claims description 19
- 238000000926 separation method Methods 0.000 claims description 2
- 238000009826 distribution Methods 0.000 description 20
- 238000010438 heat treatment Methods 0.000 description 16
- 210000003205 muscle Anatomy 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 101100389815 Caenorhabditis elegans eva-1 gene Proteins 0.000 description 1
- 239000004986 Cholesteric liquid crystals (ChLC) Substances 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
この発明は、ハイパーサーミア装置を評価するために用
いるファントムに関する。The present invention relates to a phantom used for evaluating hyperthermia devices.
ハイパーサーミア装置は、ファントムを用いた加温実験
によって評価される。すなわち、ハイパーサーミア装置
によってファントムを加温してみて温度分布（加温パタ
ーン）などの加温情報を得る。
従来のファントムは、生体等個物質の単なる塊からなり
、加温情報を得るため、サーミスタ等の多数の測温プロ
ーブをこの塊に刺し入れて多数点で温度計測するのが普
通である。
他に、分割型のファントムを用い、加温した後分離して
分離面における温度分布を観測することも行われている
。すなわち、熱放射を利用した赤外線温度計（いわゆる
サーモビューア−装置）で温度分布を測定するのである
（Ｇ、 Ｋａｎｔｏｒ：”Ｅｖａ １ ｕａ−ｔｉｏｎ
ａｎｄ ５ｕｒｖｅｙ ｏｆ Ｍｉｃｒｏｗａｖｅ
ａｎｄ Ｒａｄｉｏｆｒｅｑｕ−ｅｎｃｙ Ａｐｐｌｉ
ｃａｔｏｒｓ”、Ｊｏｕｒｎａｌ ｏｆ Ｍｉｃｒｏｗ
ａｖｅ Ｐｏｗｅｒ１６（２）、１９８１）。The hyperthermia device is evaluated by heating experiments using a phantom. That is, a phantom is heated using a hyperthermia device to obtain heating information such as temperature distribution (heating pattern). A conventional phantom consists of a simple mass of a substance similar to that of a living body, and in order to obtain heating information, a number of temperature measurement probes such as thermistors are inserted into the mass to measure the temperature at multiple points. Another method is to use a split phantom, heat it, separate it, and observe the temperature distribution on the separated surface. In other words, temperature distribution is measured with an infrared thermometer (so-called thermoviewer device) that uses thermal radiation (G. Kantor: "Eva 1 ua-tion").
and 5urvey of Microwave
and Radio frequency Appli
"Cators", Journal of Microw
ave Power 16(2), 1981).
しかしながら、多数の測温プローブを使用する場合には
、作業が非常に煩雑であるし、しかも高価なものとなる
。
また、赤外線温度計は非常に高価なもので、入手するの
は容易でないし、たとえ入手できたとしても保守・管理
に十分な注意が必要であるとともに使い方も簡便なもの
でないことから、実際上の使用が妨げられている。
この発明は、容易な作業で筒便に使用でき、しかも安価
に温度分布を計測することを可能とするハイパーサーミ
アファントムを提供することを目的とする。However, when a large number of temperature measuring probes are used, the work is very complicated and also expensive. In addition, infrared thermometers are very expensive and difficult to obtain, and even if they are available, they require careful maintenance and management, and are not easy to use. is prevented from being used. An object of the present invention is to provide a hyperthermia phantom that can be used as a tube with easy operation and that can measure temperature distribution at low cost.
この発明によるハイパーサーミアのファントムは、少な
くとも２個に分離できる生体等価体と、これらの分離面
に挟まれる感温フィルムとからなる。The hyperthermia phantom according to the present invention consists of a bioequivalent body that can be separated into at least two parts, and a temperature-sensitive film sandwiched between these separation surfaces.
少なくとも２個に分離できる生体等価体の、その分離面
に感温液晶フィルムなどの感温フィルムを挟んでいるの
で、この感温フィルムは、ハイパーサーミア装置で加温
される生体等価体のその分離面の温度を反映する。した
がってこの感温フィルムを挟む生体等価体をハイパーサ
ーミア装置で加温した後、分離して感温フィルムを観察
すれば、その分離面での温度分布が色分布として測定で
きる。Since a temperature-sensitive film such as a temperature-sensitive liquid crystal film is sandwiched between the separated surfaces of the bioequivalent body that can be separated into at least two pieces, this temperature-sensitive film is a bioequivalent body that is heated by a hyperthermia device. reflects the temperature of Therefore, by heating the bioequivalent material sandwiching the thermosensitive film using a hyperthermia device, and then separating it and observing the thermosensitive film, the temperature distribution on the separated surface can be measured as a color distribution.
この発明の一実施例にがかるハイパーサーミアのファン
トムは、第１図に示すように感温液晶フィルム１を筋肉
等価体２．３で挟んで構成される。
感温液晶フィルム１は、コレステリック液晶が特定の波
長領域の光を選択的に反射し、その波長領域が温度に応
じて変化する性質を利用したもので、この液晶をフィル
ム面に塗布したものである。この液晶が温度に応じて黒
→赤→緑→青と色変化するので、フィルム面上の色分布
を観測することにより温度分布を測定することができる
。筋肉等価体２．３はＴＸ−１５０（米国Ｏｉｌ Ｃｅ
ｎｔｅｒ Ｒｅ５ｅｒｃｈ社の商品名）などを基材とし
たゲル状のものが取り扱いも楽で感温液晶フィルム１と
の密着性もよく、適している。筋肉等価体２は基台であ
り、その上に感温液晶フィルム１が載せられ、さらにそ
の上に厚さｔの筋肉等価体３が載せられ、この液晶感温
フィルム１が筋肉等価体２．３の間に隙間なくしっかり
と挟み込まれている。
そして、ハイパーサーミア装置の加温実験を行う場合、
このような構成のファントムの上にアプリケータ４が接
触して（あるいは非接触で）配置され、給電ケーブル５
より加温エネルギーが供給される。アプリケータ４から
電磁波などの加温エネルギーがファントム中に照射され
、筋肉等価体２．３が加温される。このとき、感温液晶
フィルム１自体は非常に薄いものなのでこの加温エネル
ギーの放射を妨げることがなく、アプリケータ４の面か
ら深さｔの面上での温度分布（加温パターン）に対応し
て感温液晶フィルム１の色分布が定まる。
第２図に示すように一方の筋肉等価体３として種々の厚
さの筋肉等価体を用意し、これらを取り替えてすべて同
じ条件（加温時間、加温エネルギーのパワー、初期温度
など）で加温実験を繰り返す、そして、その都度感温液
晶フィルム１の色分布を記録する。記録方法としてもっ
とも簡単なものはインスタントカメラによるカラー写真
記録である。こうして第３図のように多数のインスタン
ト写真６を得れば、その各々はある深さでの２次元的な
温度分布を示しているので、これらを深さ方向に並べる
ことにより３次元的な温度分布く加温パターン）を観察
できる。
この゛ように１枚の感温液晶フィルム１により種々の深
さでの２次元的な温度分布を知ることができ、非常に経
済的であるが、加温実験の再現性を懸念するなら感温液
晶フィルム１を複数枚用意し、第４図に示すように多数
の筋肉等価体２で挟むようにする。そしてアプリケータ
４から加温エネルギーを照射して行う加温実験を１回だ
け行う。すると、１回の加温実験により異なる深さでの
温度分布を同時に測定できる。
上記ではいずれもある一定の深さでの２次元的な温度分
布を求めたが、深さ方向に平行な面における２次元的な
温度分布を測定できることも勿論である。すなわち、た
とえば第５図のようにポリエチレン容器７内に基台とし
ての筋肉等価体２を入れた後厚さｔの筋肉等価体３を縦
に並べてそれらの間に感温液晶フィルム１を挟むように
すればよい。
また、感温液晶フィルム１の面上に、第６図のようにス
ケール８を設ければ、温度分布を観察するときの位置の
基準になり観察が容易になる。インスタント写真記録す
る場合も写真に色分布とともにスケール８も記録される
ので好都合である。
感温液晶の色変化は上記のように黒→赤→緑→青という
ものであるから、スケール８は白色系の塗料で形成すれ
ば見やすくなる。A hyperthermia phantom according to an embodiment of the present invention is constructed by sandwiching a temperature-sensitive liquid crystal film 1 between muscle equivalent bodies 2.3, as shown in FIG. The temperature-sensitive liquid crystal film 1 utilizes the property of cholesteric liquid crystal to selectively reflect light in a specific wavelength range, and the wavelength range changes depending on the temperature, and this liquid crystal is coated on the film surface. be. Since this liquid crystal changes color from black to red to green to blue depending on the temperature, temperature distribution can be measured by observing the color distribution on the film surface. Muscle equivalent 2.3 is TX-150 (US Oil Ce
A gel-like material having a base material such as (trade name of Terre Re5erch) is suitable because it is easy to handle and has good adhesion to the temperature-sensitive liquid crystal film 1. The muscle equivalent body 2 is a base, on which the temperature-sensitive liquid crystal film 1 is placed, and on top of that the muscle equivalent body 3 having a thickness of t is placed, and this liquid crystal temperature-sensitive film 1 is used as the muscle equivalent body 2. It is firmly sandwiched between 3 without any gaps. When conducting a heating experiment with a hyperthermia device,
The applicator 4 is placed in contact with (or without contact with) the phantom having such a configuration, and the power supply cable 5 is connected to the phantom.
More heating energy is supplied. Heating energy such as electromagnetic waves is irradiated into the phantom from the applicator 4, and the muscle equivalent body 2.3 is heated. At this time, since the temperature-sensitive liquid crystal film 1 itself is very thin, it does not hinder the radiation of this heating energy, and corresponds to the temperature distribution (heating pattern) on the surface at a depth t from the surface of the applicator 4. As a result, the color distribution of the temperature-sensitive liquid crystal film 1 is determined. As shown in Figure 2, muscle equivalent bodies with various thicknesses are prepared as one muscle equivalent body 3, and they are all heated under the same conditions (heating time, power of heating energy, initial temperature, etc.) by replacing them. The temperature experiment is repeated, and the color distribution of the temperature-sensitive liquid crystal film 1 is recorded each time. The simplest recording method is color photographic recording using an instant camera. In this way, if a large number of instant photographs 6 are obtained as shown in Fig. 3, each of them shows a two-dimensional temperature distribution at a certain depth, so by arranging them in the depth direction, a three-dimensional Temperature distribution (warming pattern) can be observed. In this way, it is possible to know the two-dimensional temperature distribution at various depths with one temperature-sensitive liquid crystal film 1, and it is very economical. However, if you are concerned about the reproducibility of heating experiments, A plurality of hot liquid crystal films 1 are prepared and sandwiched between a number of muscle equivalent bodies 2 as shown in FIG. Then, a heating experiment performed by irradiating heating energy from the applicator 4 is performed only once. Then, temperature distributions at different depths can be measured simultaneously in a single heating experiment. In each case above, a two-dimensional temperature distribution at a certain depth was determined, but it is also possible to measure a two-dimensional temperature distribution in a plane parallel to the depth direction. That is, for example, as shown in FIG. 5, a muscle equivalent body 2 as a base is placed in a polyethylene container 7, then muscle equivalent bodies 3 having a thickness of t are arranged vertically, and a thermosensitive liquid crystal film 1 is sandwiched between them. Just do it. Furthermore, if a scale 8 is provided on the surface of the temperature-sensitive liquid crystal film 1 as shown in FIG. 6, it will serve as a positional reference when observing the temperature distribution, making observation easier. This is also advantageous when instant photographic recording is performed because the scale 8 is also recorded in the photograph along with the color distribution. Since the temperature-sensitive liquid crystal changes color from black to red to green to blue as described above, it will be easier to see if the scale 8 is formed with white paint.
この発明のハイパーサーミアファントムによれば、感温
フィルムを分割型生体等価体に挟み加温した後分離して
取り出せばよいだけなので、極めて簡単な構造であり、
作業も容易であって、しかも感温フィルムは非常に安価
であるから、経済的に非常に有利である。According to the hyperthermia phantom of the present invention, it is an extremely simple structure because all that is required is to sandwich the temperature-sensitive film between split-type bioequivalent bodies, heat it, and then separate and take it out.
It is easy to work with, and the temperature-sensitive film is very inexpensive, so it is very economically advantageous.
第１図はこの発明の一実施例の斜視図、第２図は各種の
筋肉等価体を示す斜視図、第３図は得られた３次元的な
温度分布の模式図、第４図及び第５図はそれぞれ他の実
施例の断面図、第６図は感温液晶フィルム面を示す図で
ある。
１・・・感温液晶フィルム、２．３・・・筋肉等価体、
４・・・アプリケータ、５・・・給電ケーブル、６・・
・インスタント写真、７・・・ポリエチレン容器、８・
・・スケール。FIG. 1 is a perspective view of an embodiment of the present invention, FIG. 2 is a perspective view showing various muscle equivalents, FIG. 3 is a schematic diagram of the obtained three-dimensional temperature distribution, and FIGS. FIG. 5 is a sectional view of each of the other embodiments, and FIG. 6 is a diagram showing the temperature-sensitive liquid crystal film surface. 1... Temperature-sensitive liquid crystal film, 2.3... Muscle equivalent,
4... Applicator, 5... Power supply cable, 6...
・Instant photo, 7...Polyethylene container, 8.
··scale.
Claims (2)
らの分離面に挟まれる感温フィルムとからなるハイパー
サーミアファントム。(1) A hyperthermia phantom consisting of a bioequivalent body that can be separated into at least two pieces and a temperature-sensitive film sandwiched between these separation surfaces.
ることを特徴とする特許請求の範囲第１項記載のハイパ
ーサーミアファントム。(2) The hyperthermia phantom according to claim 1, wherein the temperature-sensitive film is a temperature-sensitive liquid crystal film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4601787A JPH0720480B2 (en) | 1987-02-28 | 1987-02-28 | Hyperthermia phantom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4601787A JPH0720480B2 (en) | 1987-02-28 | 1987-02-28 | Hyperthermia phantom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63212356A true JPS63212356A (en) | 1988-09-05 |
| JPH0720480B2 JPH0720480B2 (en) | 1995-03-08 |
Family
ID=12735281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4601787A Expired - Lifetime JPH0720480B2 (en) | 1987-02-28 | 1987-02-28 | Hyperthermia phantom |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0720480B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2021065800A1 (en) * | 2019-10-04 | 2021-04-08 |
-
1987
- 1987-02-28 JP JP4601787A patent/JPH0720480B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2021065800A1 (en) * | 2019-10-04 | 2021-04-08 | ||
| WO2021065800A1 (en) * | 2019-10-04 | 2021-04-08 | 国立研究開発法人 産業技術総合研究所 | Temperature-sensitive phantom, and ultrasonic evaluation device in which same is used |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0720480B2 (en) | 1995-03-08 |
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