JPS63164858A - Outer coat of soft capsule - Google Patents

Abstract

PURPOSE:To make it possible to process a hydrophilic material to be packed into soft capsules in a state of aqueous solution, by using a composition obtained by uniformly kneading a natural polysaccharide in a concentrated solution of a polyhydric alcohol, a sugaralcohol, etc. CONSTITUTION:A composition of natural polysaccharide and polyhydric alcohol obtained by uniformly kneading the following component B in a concentrated solution of the following component A in the presence or absence of an alkali is used as a raw material. The component A is at least one selected from a polyhydric alcohol, sugaralcohol, monosaccharide, disaccharide and oligosaccharide. The component B is at least one natural polysaccharide selected from carrageenan, alginic acid, alginic acid derivative, agar, locust bean gum, guar gum, tamarind seed gum polysaccharide, pectin, xanthan gum, glucomannan, chitin material, pullulan and cyclodextrin. The alkali may be ordinarily an inorganic or organic alkali substance.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a soft capsule shell that can be filled with substances other than oil-based substances.

[Conventional technology]

Soft capsules are gelatin-based sheets filled with oil-based chemicals, etc., and the content of the liquid inside is accurate, and the adhesive surface is completely sealed, so there is no leakage and the contents are exposed to the outside air. It has the advantages of being protected from oxidation, ensuring stable storage, and high productivity.

Traditionally, soft capsules have been made from gelatin as the main raw material. Gelatin is mixed with glycerin, sorbitol, etc., an aqueous solution is formed into a gel, and then the two sheets are heated and fed from a pair of left and right Glyrolls. 2
It is manufactured by continuously filling the spaces between the sheets with liquid, sealing them, and then drying them.

[Problem that the invention seeks to solve]

As mentioned above, soft capsules are very superior in terms of preservation of contents and high productivity, but because gelatin dissolves in water, they cannot be used if the contents are an aqueous solution, and the drugs to be filled cannot be used. It is limited to those that can be dissolved in oil-based solvents, which limits its range of use. Therefore, there was a need for an outer shell that could be filled into a soft capsule shape even in the form of an aqueous solution.

[Means of problem solving]

The present invention solves the above problems, and consists of a concentrated solution of at least one selected from polyhydric alcohols, sugar alcohols, monosaccharides, pentasaccharides, and oligosaccharides, as a raw material for soft capsule shells. Among them, carrageenan, alginic acid, alginic acid derivatives, agar, locust bean gum,
Guar gum, tamarind seeds I! At least one natural polysaccharide selected from the group consisting of pectin, xanthan gum, glucomannan, chitin, pullulan, and cyclodextrin, and optionally in the presence of an alkali and/or protein, obtained by uniformly kneading the polysaccharide. It is characterized by using a natural polysaccharide/polyhydric alcohol composition.

Examples of the polyhydric alcohol according to the present invention include polyhydric alcohols in a narrow sense such as propylene glycol and glycerin. Examples of the sugar alcohol include sorbitol, mannitol, maltitol, xylitol, reduced starch saccharide, and the like. Glucose, fructose, galactose, xylose, etc. are used as monosaccharides. Two tJ
! As I, saccharose, maltose, lactose, etc. are used. As oligosaccharides, sweet potato, potato,
The decomposition products of starch such as corn by enzymes and acids are used to produce pentasaccharides, tritJMs, tetraIlis, pentasaccharides,
Six Ij! Contains various types, etc.

Natural polysaccharides include carrageenan, alginic acid, alginic acid derivatives, agar, locust bean gum, guar gum, tamarind seed II, pectin, xanthan gum, glucomannan, chitin which is a type of mucopolymer, pullulan, cyclodextrin, etc. can also be widely used.

In some cases, it is preferable to use an alkali together.

The alkali may be any ordinary inorganic or organic alkaline substance, such as sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, barium hydroxide,
Sodium carbonate, potassium carbonate, calcium carbonate, ammonium carbonate, magnesium carbonate, sodium bicarbonate,
Examples include ammonium bicarbonate, basic amino acids, amines, and the like. Adding alkali generally improves the strength and heat resistance of the sheet.

Furthermore, the above natural child I! Proteins can also be used in combination. Proteins include soybean protein, wheat protein, milk protein,
Examples include egg white, collagen, collagen decomposition products, and microbial proteins. Proteolytic products include polypeptides, dipeptides, tripeptides, and amino acids. Generally, compositions obtained by using a protein in place of a part of the natural polysaccharide tend to have improved strength.

The present invention is characterized in that natural polysaccharides are reacted in a concentrated solution of at least one selected from these polyhydric alcohols, sugar alcohols, monosaccharides, 2Ns, and oligosaccharides. Concentrated solutions refer to liquid ones that can be used as they are or slightly diluted, and powdered ones that have a concentration of 30 to 90%.
% aqueous solution, preferably 50-80%, more preferably 6
At least one of the above-mentioned multi-ttptm is kneaded into this as a 0 to 80% aqueous solution.

The kneading temperature is 5 to 150°C, preferably 10 to 100°C.
℃, more preferably 20 to 80℃, and even if kneaded at a low temperature, if heated later during drying, the reaction will be sufficient. In general, higher temperatures result in compositions with denser structures;
If the temperature is low, a brittle composition with a coarse network structure is obtained.

Natural child wMs, polyhydric alcohols, sugar alcohols, monosaccharides, 2I! The compounding ratio of at least one compound selected from the group consisting of polysaccharides and oligosaccharides is 0.05 to 15 parts by weight, preferably 0.1 to 15 parts by weight, per 1 part by weight of natural polysaccharides.
It is 10 parts by weight.

The composition obtained by kneading the above raw materials is generally a somewhat moist powder. When this is dissolved in water, the solid content is 2~
It becomes a 10% viscous solution or paste, and can be irreversibly solidified by standing at room temperature, freezing, refrigeration, or heating. In addition, the obtained coagulated material is preferable as the outer shell of soft capsules because any physical properties, particularly strength, heat resistance, and dissolution temperature in water, can be adjusted by combining the raw materials used.

Embodiments of the soft capsule shell according to the present invention include (A) a sheet formed by forming an aqueous solution of the composition according to the present invention into a sheet having a size of 5 to 500 μm, preferably 10 to 50 μm, in place of the gelatin sheet; (B) A gelatin sheet and a sheet of the composition according to the present invention are laminated, and the sheet according to the present invention is the inner layer. (C) A gelatin solution for soft capsules and a composition solution according to the present invention are mixed. Examples include those made of a sheet that has been washed and dried.

Vitamins B+, Bz, Bs, B6, which have traditionally been difficult to use as oil-based solutions as filling materials for soft capsules.
Examples include water-soluble vitamins such as B10, niacin, folic acid, and vitamin C; nutrients such as carbohydrates, proteins, and minerals; encapsulated seasonings and spices; and cosmetics packaged in single-use portions.

[Effect]

Since natural polysaccharides have complex structures with various reactive groups and side chains, it is thought that a large number of hydroxyl groups react in a highly concentrated solution to form a complex matrix. By adding water, a complex three-dimensional structure further develops, irreversibly forming a water-resistant and heat-resistant coagulated material, resulting in the formation of a unique gel-like material.

Since such a gel-like material is water resistant, it can be preferably used as a soft capsule shell for enclosing and preserving filled materials such as drugs, foods, and cosmetics in the form of aqueous solutions.

[Example 1] 75 parts of 100 parts of gelatin, 30 parts of glycerin, and 60 parts of water
The mixture was stirred and dissolved at ℃, and defoamed using a vacuum pump.

Thickness 4 with rotary set continuous soft capsule automatic filling machine
It was made into a 50 μm gelatin film.

Separately, 5 parts by weight of glucomannan, 2 parts by weight of carrageenan,
1 part by weight of xanthan gum dissolved in 80% sucrose? f
An aqueous solution of 3 parts by weight of the composition obtained by kneading 7.1.5 parts by weight at 80° C. for 10 minutes in 97 parts by weight of water was formed into a film by wet casting to obtain a film with a thickness of 25 μm. This film was laminated with the above-mentioned gelatin film to create two sets of double films, and the two sets of left and right films were passed between a pair of die rolls and bonded under heat while the content liquid was 500+g/L-ascorbic acid aqueous solution (8 degrees 30%). A capsule was formed by press-fitting the capsules using a filling pump. The obtained capsules were dried to obtain soft capsules.

[Example 2] 3 parts of a composition obtained by kneading 5 parts of glucomannan, 0.5 parts of carrageenan, 0.12 parts of calcium carbonate, and 1 part of glycerin at 70°C for 30 minutes was dissolved in 97 parts of water. The obtained viscous aqueous solution was formed into a film by a wet casting method to obtain a film having a thickness of 1511 mm. Using this film, a soft capsule shell having a double structure with a gelatin film was obtained in the same manner as in Example 1. Soft capsules were obtained which were filled with 2 g/capsule of a seasoning liquid for instant chicken soup as the content liquid. When 150 ml of boiling water at 90° C. was added to one soft capsule and thoroughly stirred, the soft capsule collapsed and chicken soup was obtained.

[Example 3] 75 parts of gelatin, 30 parts of glycerin, and 10 parts of water
The solution was stirred and dissolved at ℃ and degassed using a vacuum pump. Separately, 5 parts glucomannan, 3 parts carrageenan.
B was an aqueous solution obtained by dissolving 3 parts of the composition of the present invention obtained by kneading 5 parts of glycerin and 1.5 parts of glycerin at 70°C in 97 parts of water. 60 parts of A and 840 pieces were thoroughly kneaded and filled with 290a+g/pcs of Astrinzen Lotion using a rotary continuous soft capsule automatic filling machine using a known rotary die method to obtain NO65 oval soft capsules. When in use, I was able to pierce the soft capsule with a needle and take out one dose of lotion.

〔effect〕

According to the present invention, it has become possible to soft capsule a hydrophilic filling material in the state of an aqueous solution, and the applications of soft capsules have further expanded.

Claims (1)

[Claims] In a concentrated solution of at least one selected from polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides,
At least one natural polysaccharide selected from carrageenan, alginic acid, alginic acid derivatives, agar, locust bean gum, guar gum, tamarind seed polysaccharide, pectin, xanthan gum, glucomannan, chitin, pullulan, and cyclodextrin in the presence of an alkali. A soft capsule shell made from a natural polysaccharide/polyhydric alcohol composition obtained by uniformly kneading it in the presence or absence of the substance.