JPS63158449A - Apparatus for measuring component in liquid - Google Patents

Abstract

PURPOSE:To simply know injection timing, by calculating the estimated value of the time required before electric output becomes stable from the point of time when the power source of a sensor is turned on and displaying an injection stand-by pattern stepwise displaying such a state that the time before the electric output becomes stable progresses. CONSTITUTION:When a measurement start/stop switch 32 is turned on, a rotary body 37 rotates to stir a pH buffer solution and a calibration liquid/liquid-to-be- measured injection stand-by pattern is displayed on a display part 39. The calibration liquid/liquid-to-be-measured stand-by pattern in constituted so that the horizontal bar at the center of each character part of a character display part 39a is allowed to light, and at every definite time, that is, for every part obtained by calculating the estimated value of the time before a stable current is outputted and quartering the result, from the first character part toward the fourth character part, those character parts thus determined are successively turned on and off. Therefore, the present position of the injection stand-by state, that is, how many seconds are required before injection can be easily judged.

Description

DETAILED DESCRIPTION OF THE INVENTION [Technical Field] The present invention relates to a liquid component measuring device used for measuring the concentration of a substance to be measured in a liquid, particularly glucose, uric acid, etc. in a body fluid.

[Background technology]

BACKGROUND ART Fluid component measuring devices that measure components in body fluids, such as glucose and uric acid, usually include a sensor that detects a substance to be measured in a sample fluid.

The sensor is immersed in the sample liquid and outputs an amount of electricity according to the concentration of the substance to be measured, and transmits the amount of electricity to the arithmetic control section. The arithmetic control section calculates the amount of electricity and displays it on the display section as a concentration measurement value.

When performing measurements using this in-liquid component measuring device,
Prior to measurement, work must be performed to calibrate the sensor by injecting a calibration solution into the buffer solution, and to inject the sample. Some large liquid component measuring devices used in frequently used locations such as hospitals and testing centers automate these tasks. However, large ones are expensive and are not suitable for home use. In other words, for example, many diabetic patients are instructed to measure their blood sugar levels not only in hospitals but also at home. is desired, and expensive ones are not suitable. For this reason, conventional home-use devices have been equipped with automatic sample injection means, such as the large-scale in-liquid component measuring device described above, or have been operated manually.

Generally, when a measurement voltage (usually 0.6 V) is applied to a sensor while immersed in a buffer solution, it immediately outputs a current, but it takes more than 5 minutes for this current to stabilize. Therefore, a method has been adopted in which a voltage higher than the measurement voltage (for example, 0.7 V) is first applied, and then the voltage is switched to the measurement voltage to shorten the time until the output current becomes stable. However, in this method, the time required to reach stability varies from 30 to 120 seconds. For this reason, the injection timing of the calibration solution and sample solution cannot be determined. For example, if the liquid to be measured is blood that has not been treated with pepperin, coagulation may occur if the time from blood collection is too long.

For this reason, as described above, if the timing of injection is not known, blood may be collected too early and coagulate before injection, making accurate measurement impossible. For this reason, conventional manual devices have been extremely difficult to use.

[Purpose of the invention]

In view of these circumstances, it is an object of the present invention to provide a small-sized liquid component measuring device that is inexpensive, compact, and allows anyone to easily determine the injection timing and perform accurate measurements. There is.

[Disclosure of the invention]

In order to achieve such an objective, the inventors thought that it would be appropriate to display the waiting time until the output current of the sensor becomes stable in stages. In other words, for example, if the waiting time is divided into four stages and the blood is drawn when the fourth stage is displayed, the sample liquid can be prepared efficiently and the measurement can be performed accurately. It was. However, as mentioned above, the time it takes to reach stability varies from 30 to 120 seconds, so for example,
It was found that if each stage was set to 10 seconds, the fourth stage would be 0 to 90 seconds, which would be meaningless and create a sense of distrust among the users. This invention has been completed over the years. Therefore, this invention detects the substance to be measured in the sample liquid stored in the reaction tank and outputs an amount of electricity corresponding to the amount of the substance to be measured. An in-liquid component measuring device comprising: a sensor that calculates the amount of the substance to be measured based on the electrical quantity; A predicted value of the time from when the power is turned on to the sensor until its electrical output stabilizes is calculated and equally distributed, and the injection step represents a state in which the time until the stabilization changes in stages based on the result. The gist of this invention is an in-liquid component measuring device characterized in that a waiting pattern is displayed on a display section.

Hereinafter, embodiments of the present invention will be explained in detail with reference to the accompanying drawings.

Figures 1 (al) and (b) show the in-liquid component measuring device according to the present invention viewed diagonally from above.As seen in the figures, this in-liquid component measuring device includes a sensor BS, a reaction tank, 3
4 and a display section 39. The display section 39 is
As will be described in detail later, a calibration liquid/measurement liquid injection waiting pattern is displayed that notifies the injection waiting time of the calibration liquid or measurement liquid in stages. In this embodiment, reaction vessel 34 comprises a disposable container as shown in FIG. This disposable container should be
) (A predetermined amount of buffer solution (hereinafter simply referred to as "buffer solution") is put in and sealed with a sealing material 34a such as aluminum foil. When in use, after peeling off this sealing material 34a, As shown in a), the reaction tank installation part 41
It is designed to be installed in the hole. The reaction tank 34 is covered with a lid-like member 38 immediately above its opening during measurement. The sensor BS is incorporated into the sensor unit 35 and attached to the lid-like member 38. The lid-like member 38 has a rotating body 37
A thermistor 36 can also be attached. The sensor BS, the rotating body 37 and the thermistor 36 are
When the lid-like member 38 is closed, the reaction tank 34
It is designed to be immersed in a predetermined position in the liquid. The lid-shaped member 38 is formed with an injection port 40 for a calibration liquid and a sample liquid, so that these can be injected into the reaction tank 34 using a dropper or the like in the closed state.

Measured values such as the concentration of the substance to be measured are displayed as digital values on the display unit 39 by calculating the amount of electricity output from the sensor BS as described later. As shown in FIG. 2(a), the display section 39 displays the first to fourth four
It is composed of a character display part 39a having two character parts and units, and an illustration display part 39b that displays schematic diagrams of reaction vessels, sensors, batteries, etc., and displays measured values in the character display part 39a. By changing the display patterns of the character display section 39a and the illustration display section 39b, it is possible to display not only the above-mentioned calibration liquid/test liquid injection waiting pattern (but also the desired measurement-related information such as abnormal operating conditions and operation timing). It is also possible to announce various information. Figure 1 (a), (bl
Inside, 31 is a power switch, and 32 is a measurement start/stop switch. When the measurement start/stop switch 32 is turned on, the rotating body 37 is rotated to stir the buffer solution in the reaction tank 34, and measurement is started. The rotating body 37 is the reaction tank 3
A magnet (not shown) is built into the stirring part that is immersed in the slow induction liquid in step 4. Therefore, when the drive magnet placed at the bottom of the reaction tank 34 is rotated by the motor, the rotating body 3
This in-liquid component measuring device in which 7 is rotated has a built-in circuit as shown in FIG. That is, this circuit uses batteries 1. Constant voltage circuit 2. Voltage control circuit 3. Self-sustaining BS, I/V conversion circuit 4. A/D conversion circuit 5, temperature detection circuit 8. Arithmetic control section 6 and display circuit 7
It is equipped with

The constant voltage circuit 2 uses the battery 1 as a power source and outputs a constant voltage based on the output from the battery 1.

The voltage control circuit 3 includes an operational amplifier OP1. Resistance R1~R6
, and switches SWI and SW2. The switches SWI and SW2 are controlled from outside the circuit using relays or the like. The voltage control circuit 3 applies negative feedback to the single power supply operational amplifier OPI.
switch swi.

The configuration is such that the degree of negative feedback is switched by inserting a resistor R6 or providing direct feedback by closing or opening SW2. In other words, three types of constant voltage (in this example, +〇,
7V, +0.6V and 0V) (7).

In this embodiment, the sensor BS detects a glucose component in a liquid to be measured (blood), and has an enzyme such as glucose oxidase immobilized on an electrode such as platinum. When a voltage is applied to the sensor BS in the liquid to be measured,
A current is output according to the concentration of the substance to be measured, that is, the glucose component in the liquid to be measured.

The I/V conversion circuit 4 is configured to apply negative feedback to a single power supply operational amplifier OP2 using a resistor R7 and a capacitor C, and converts the current output from the sensor BS into a voltage and outputs the voltage. .

The temperature detection circuit 8 includes a temperature detection element R consisting of a thermistor 36.
The temperature detected at H is output as a voltage.

The A/D conversion circuit 5 A/D converts the output voltage of the I/V conversion circuit 4 and the output voltage of the temperature detection circuit 8, and outputs the result.

The arithmetic control unit 6 controls the closing and opening of the switches SWI and SW2 of the voltage control circuit 3 according to the measurement order, controls the measurement operation such as controlling the voltage applied to the sensor BS, and also controls the measurement operation according to the operation status. to display a predetermined display pattern on the display section 39. The digital values output from the A/D conversion circuit 5 in accordance with the output of the sensor BS and the output of the temperature detection circuit 8 are processed in the arithmetic control section 6 and output to the display circuit 7 to display the concentration of the substance to be measured, etc. is displayed on the display unit 39 as a measured value.

The normal measurement operation will be described. First, when the power is turned on, the arithmetic control section 6 switches the switch SW of the voltage control circuit 3.
Turn on only I. With this, the calculation control unit 6
The voltage applied to the sensor BS is set to 0■, the output from the sensor BS is eliminated, and the initial state of measurement is maintained. At the same time, the display section 39 displays an initial pattern as shown in FIG. After that, a reaction tank set request pattern is displayed.As shown in FIG. Wow, illustration display part 39b
It consists of a flashing illustration of the reaction tank inside. The reaction tank set request pattern is for prompting confirmation of whether or not the reaction tank 34 is normally set.

After confirming that the reaction tank 34 is set, the lid member 38 is closed. A sensor unit 35, a thermistor 36, and a rotating body 37 are attached to the lid member 38 in advance, and when the lid member 38 is closed, all of them face a predetermined position in the liquid of the reaction tank 34. As mentioned above, this is the case. The power switch 31 may be turned on after the lid-like member 38 is closed. Next, the measurement start/stop switch 32 is turned on. When the measurement start/stop switch 32 is turned on, the rotating body 37 rotates to stir the pH buffer solution, and the display section 39 displays a calibration solution/measurement solution injection waiting pattern. The calibration liquid/test liquid injection waiting pattern is the second one.
As shown in Figures tc) to (f), the horizontal bar at the center of each character part of the character display part 39a is lit up, and at regular intervals from the first character part to the fourth character part, that is, in a stable manner. It is constructed by calculating a predicted value of the time until the current is output, dividing it into four equal parts, and sequentially blinking each division based on the result. In this way, the blinking position of the horizontal bar moves at regular intervals, so it is easy to determine where the patient is currently waiting to be injected, or in other words, how many more seconds he or she needs to wait before injecting. can.

The method for calculating the predicted value is as follows. When the measurement start/stop switch 32 is turned on, the arithmetic control unit 6 opens the switch SWI so that the feedback path of the operational amplifier OPI in the voltage control circuit 3 passes only through the resistor R5. As a result, the voltage applied to the sensor BS becomes +7V.

When a voltage of +0.7■ is applied to the sensor BS, an inrush current flows once as shown in period T2 in Fig. 4 (al). I
The output voltage of the /V conversion circuit 4 immediately saturates to the negative side and continues until the inrush current becomes less than a predetermined value. T.A.
) is detected, and a predicted value is calculated from a function of the saturation voltage time and the time until stabilization stored in the arithmetic and control unit 6 as shown in FIG. In addition to this, the predicted value can also be calculated by the following method. That is, in the above embodiment, the 1/V conversion circuit 4 always becomes saturated when an inrush current flows, but the output voltage width of the I/V conversion circuit 4 is increased to prevent saturation. Then, as shown by the chain line in Fig. 4, the output voltage due to the rush current is monitored, and the slope (output voltage ΔV at a certain time Δt) immediately after this output voltage reaches its peak is detected. As shown in the figure,
This slope (Δ■/Δt) stored in the arithmetic control circuit 6
) and the time it takes for the output current of the sensor to stabilize. In this way, I/V
If the maximum output voltage width of the conversion circuit is wide (if the sensor BS
It becomes possible to measure liquids with high concentrations up to the full measurement capacity of the device.

The arithmetic control unit 6 sets the sensor BS to 0. The voltage of TV is applied, and the arithmetic control section 6 closes the switch SW2 so that the feedback path of the operational amplifier OPI passes through the resistors R5 and R6. As a result, the voltage applied to the sensor BS becomes +6 V of the measurement voltage.

In this way, the reason for applying a voltage higher than the measurement voltage and then applying the measurement voltage is to quickly stabilize the output current of the sensor BS. It is okay to apply +0.6cm of the measurement voltage.When the output current of the sensor BS becomes stable (point 21 in Fig. 4(a)), a calibration liquid injection request pattern is displayed on the display unit 39. be done. The calibration liquid injection request pattern consists of the illustration of the reaction tank in the illustration display section 39b lighting up and the illustration of the dropper on the left blinking as shown in Fig. 2 (as if seen in a phantom). This is a cracked jig for injecting the calibration fluid.

When the calibration liquid injection request pattern is displayed, the user injects a predetermined amount of calibration liquid into the reaction tank 3 through the opening 40 of the lid-like member 38.
Inject into 4. In this example, the calibration solution is a glucose solution with a predetermined concentration. When the calibration liquid is injected, this is detected by the arithmetic control section 6, and a pattern during calibration is displayed on the display section 39. The pattern during calibration is the second
As shown in the figure (hl), the second to
The fourth character part is used to draw the character rcALJ, which is made to blink, and is displayed until the output current of sensor BS stabilizes (point 22 in FIG. 4(a)). When the output current is stabilized, a test liquid injection request pattern is displayed on the display section 39. The sample liquid injection request pattern, as shown in FIG. 2+1), consists of the illustration of the reaction tank in the illustration display section 39b lighting up and the illustration of the dropper on the right flashing. When the liquid to be measured injection request pattern is displayed, the user injects a predetermined amount of the liquid to be measured into the reaction tank 34 through the opening 40 of the lid-like member 3. When the liquid to be measured is injected, it is detected by the sensor BS, and based on its output, the arithmetic control section 6 causes the display section 39 to display a pattern during measurement.

As shown in FIG. 2 (Jl), the measuring pattern consists of ro 00J flashing in the second to fourth character portions of the character display section 39a.The measuring pattern consists of the output of the sensor BS. The point at which the current stabilizes (2 in Figure 4 (a))
3 points) will continue to be displayed. When the output current becomes stable, stable points PL, P2 . A calculation is performed based on the output current of P3 to obtain a measured value, and the obtained result is displayed as a number by the second to fourth character parts in the character display section 39a, as shown in FIG. 2(k). be done. Note that the output current values of PL, R2, and R3 are stored in the calculation control section 6. After confirming that the measured value is displayed on the display section 39, the user presses the measurement start switch 3.
2 is turned off, the lid member 38 is opened, the reaction tank 34 is taken out, and the power switch 31 is turned off. Of course, every time - measurements are completed, the sensor unit 35. The thermistor 362 rotating body 37 must be cleaned. In addition, FIG. 4 (bl shows the change in the voltage output from the I/V conversion circuit 4 according to the output current of the sensor BS).

If measurements are to be taken continuously, each time the reaction tank 34 containing a new buffer solution is reset, and the measurement start switch 32 is turned on again. In this way, as in the first measurement, the display section 39 becomes the calibration liquid/test liquid injection waiting pattern.

In the case of continuous measurement, once the output current of sensor BS is stabilized,
The liquid to be measured injection request pattern is immediately displayed on the display unit 39. In other words, the calibration value is stored during the first measurement, and there is no need to perform calibration again when measurements are taken continuously. When the power switch 31 is turned off, this memory is erased, and when the power switch 31 is turned on again, the calibration liquid injection request pattern is displayed on the display 39, as in the case of the first measurement described above.
is now displayed. Therefore, the power switch 31 must be turned off after all measurements are completed.

The arithmetic control unit 6 is designed to be able to store up to nine previous measurement values unless the power switch 31 is turned off, so that it is possible to forget to record a measurement value and perform the next measurement. Even if this happens, there is no need to re-measure. The stored measurement values are displayed on the display section 39 by pressing the memory switch 33. In other words, pressing the memory switch 33 once will display the previous measurement value, pressing it twice will display the second measurement value, and so on.
The measured values up to the previous time are displayed one after another in the second column in the character display area 39a.
~ It is displayed in the fourth character part.

At the 10th time, the first character in the 0 character display area 39a, where the previous measurement value is displayed again, is
It is now possible to display the previous measurement value.

At the same time, a (colon) was placed between the measured values,
As shown in Figure 2 (1), it lights up to indicate that the memory value is being displayed. The memory switch 33 cannot be operated until the measurement start/stop switch 32 is turned on and the measurement results are displayed. This is because there is a risk of confusion if memory display is performed during the measurement stage.

The output current of the sensor BS is unstable if the temperature of the liquid to be measured is lower or higher than a predetermined temperature range.

Therefore, in this liquid component measuring device, if the liquid temperature deviates from a predetermined temperature range between the time the measurement start/stop switch is turned on and the measurement result is displayed, the display section 39 The low temperature notification pattern or high temperature notification pattern is displayed and the measurement is stopped. As shown in FIG. 2(m), the high temperature notification pattern uses the first character part in the character display part 39a to
is turned on, and the illustration of the reaction tank in the illustration display section 39b is made to blink or turn on. As shown in FIG. 2(n), the low temperature notification pattern is made by lighting up L using the first character part of the character display section a9a and flashing or lighting up the illustration of the reaction tank on the illustration display section 39b. It is configured.

The reason why the illustration of the reaction tank is blinked or lit is to indicate that there is an abnormality in the reaction tank 34. The user is
When the low temperature notification pattern or the high temperature notification pattern is displayed, either replace the reaction vessel or wait until the temperature reaches a measurable temperature, and then turn on the measurement start/stop switch 32 to restart the measurement.

This in-liquid component measuring device is capable of: (1) when the measurement start/stop switch 32 is turned on with the lid member 38 open; (2) the sensor unit 35 is not completely set in the lid member; or (3) the reaction When there is no etfE solution in the tank 34, a sensor/buffer error notification pattern is displayed on the display section 39. Sensor/
As shown in FIG. 2(0), the buffer solution error notification pattern is such that the first character in the character display section 39a lights up E and the illustrations of the reaction tank and sensor in the illustration display section 39b alternate. It consists of lighting up. The reason why the illustrations of the reaction tank and the sensor are lit alternately is to indicate that there is an abnormality in either of them.

This in-liquid component measuring device detects, when the measurement start/stop switch is turned on, if a component other than the buffer solution is mixed in the reaction tank 34, that is, if the reaction tank has not been replaced with a new one, the display unit 39 The reaction tank replacement request pattern is now displayed. The reaction tank replacement request pattern is the second
As shown in Figure (p), the first character in the character display section 39a lights up E and the illustration of the reaction tank in the illustration display section 39b lights up or blinks. The reason why the illustration of the reaction tank is lit or blinking is to indicate that there is an abnormality in the reaction tank.

This in-liquid component measuring device can also display on the display section 39 information such as the time to replace the battery, the time to replace the sensor, and the fact that the concentration of the component to be measured is outside the measurable range. As shown in Figure 2 (Q), the timing for battery replacement is determined by the arithmetic control unit 6.
When the controller detects that the battery voltage has fallen below a predetermined value, the illustration of the battery in the illustration display section 39b is displayed by blinking or lighting up. The sensor replacement period is determined by the arithmetic control unit 6 as shown in Figure 2 (rl).
When the sensor detects that the calibration value is lower than a predetermined value, it is displayed by lighting or blinking an illustration of the sensor. As shown in Fig. 2 (3), by lighting the horizontal bar under the second to fourth character parts in the character display part 39a, it is indicated that the component to be measured is below the lower limit of the measurable range. As shown in FIG. 2 (1), by lighting the horizontal bars above the second to fourth character parts in the character display part 39a, it is possible to indicate that the component to be measured exceeds the upper limit of the measurable range. Display that.

The in-liquid component measuring device according to the present invention is not limited to the above embodiments. For example, in the embodiment, information such as abnormal operating status or operation timing is announced by changing the display pattern of the text display area and the illustration display area, but instead of displaying text on the display area. I don't mind. Alternatively, the notification may be made by voice.

〔Effect of the invention〕

Since the in-liquid component measuring device of the present invention is configured as described above, anyone can easily determine the injection timing and perform accurate measurements even if the device is a small one for home use. Since it is small, it goes without saying that it is inexpensive and compact.

[Brief explanation of the drawing]

FIGS. 1(a) and 1(b) are perspective views of one embodiment of the in-liquid component measuring device according to the present invention, and FIGS.
) shows the closed state of the lid-like member, and the same figure (bl
The figure shows the state with the lid-like member open. Figures 2 (a) to (1) show each display pattern on the display section, where (a) is the initial pattern, (b) is the reaction tank set request pattern, and (C) to ( f) is the calibration liquid/test liquid injection waiting pattern, (g) is the calibration liquid injection request pattern, (h) is the calibration in progress pattern, and (1) is the measurement liquid injection request pattern. 0) is the pattern being measured, the same figure (kl is the measurement result, the same figure (1) is the memory display, the same figure ((2) is the high temperature notification pattern, the same figure (n) is the low temperature notification pattern, the same figure (0) is the sensor/kN iE liquid error notification pattern, (p) is the reaction tank replacement request pattern, (q) is the battery replacement timing notification pattern, <r+ is the sensor life notification pattern, and (S) is the sensor life notification pattern. The notification pattern for the lower limit of the measurable range (1) is the notification pattern for exceeding the upper limit of the measurable range. Figure 3 is a circuit diagram showing the internal circuit, and Figure 4 (8) is for the sensor BS. Figure 4 (b) is a graph showing changes in the output current, Figure 4 (b) is a graph showing changes in the voltage output from the I/V conversion circuit according to the output current, Figure 5 is a graph showing the changes in the voltage output from the I/V conversion circuit according to the output current, and Figure 5 is a graph showing the changes in the voltage output from the I/V conversion circuit according to the output current. Figure 6 is a graph showing the relationship between the saturation voltage time of the I/V conversion circuit and the time until the output level of the sensor stabilizes. It is a graph showing the relationship between the slope of the output voltage of the I/V conversion circuit and the time until the output level of the sensor becomes stable. 6... Arithmetic control section 34... Reaction tank 39... Display section 39a ...Character display section 39b...Illustration display section BS...Senna agent Patent attorney Takehiko Matsumoto (b) (cl) (e) (f) Figure 5 Figure 7 Figure 0 @ ki (mV/ m5ec
) Procedural Amendment (April 25, 1986 Address: 1048 Oaza Kadoma, Kadoma City, Osaka Name (583)) Matsushita Electric Works Co., Ltd. Representative I Fung Fuyaku Fujii Sadao 4, Agent!'' 1986 March 4th (shipment date 62.3.31)6
, Specification subject to amendment and Drawing 7, Contents of amendment (1) Specification, page 12, line 12 to page 15, line 1
In line 4, the statement "There is a hailstorm on the sensor BS." should be corrected as follows. - Memory [The output current of the sensor BS after the voltage is applied and the voltage output from the I/V conversion circuit according to this output current change as shown in Fig. 4. The upper side shows the change in the output current of the sensor BS, and the lower side shows the output voltage of the I/V conversion circuit. Sensor B
When a voltage of +7 V is applied to S, an inrush current flows once as shown in period T2 in FIG. 4, but this gradually decreases and stabilizes at a predetermined output current. After a predetermined period of time, the arithmetic control section 6 closes the switch SW2 so that the feedback path of the operational amplifier OPI passes through the resistors R5 and R6. As a result, the voltage applied to the sensor BS becomes +0.6 cm of the measured voltage. In this way, once
The reason for applying a voltage higher than the measurement voltage and then applying the measurement voltage is to quickly stabilize the output current of the sensor BS. The measurement voltage of +0.6v may be applied from the beginning without going through such a procedure. When the output current of sensor BS becomes stable (point 21 in Figure 4)
Then, the calibration liquid injection request pattern is displayed on the display unit 39. As shown in FIG. 2(g), the calibration liquid injection request pattern consists of the illustration of the reaction tank in the illustration display section 39b lighting up and the illustration of the dropper on the left blinking. The dropper is a jig for injecting the calibration fluid. When the calibration liquid injection request pattern is displayed, the user injects a predetermined amount of calibration liquid into the reaction tank 34 through the opening 40 of the lid-like member 38. In this example, the calibration solution is a glucose solution with a predetermined concentration. When the calibration liquid is injected, this is detected by the arithmetic control section 6, and a pattern during calibration is displayed on the display section 39. The calibration pattern is as shown in Figure 2 (h).
r using the second to fourth character parts in the character display part 39a.
It consists of drawing the letters CALJ and making it blink, indicating the point at which the output current of sensor BS becomes stable (
22 points in Figure 4) are displayed. When the output current is stabilized, the measurement target liquid injection pattern is displayed on the display section 39. The sample liquid injection request pattern, as shown in FIG. 2(1), consists of the illustration of the reaction tank in the illustration display section 39b lighting up and the illustration of the dropper on the right flashing. When the measurement target liquid injection request pattern is displayed, the user injects a predetermined amount of the measurement target liquid into the reaction tank 34 through the opening 40 of the lid-shaped member 38. When the liquid to be measured is injected, it is detected by the sensor BS, and based on the output thereof, the arithmetic control section 6 causes the display section 39 to display the pattern being measured. The pattern during measurement is shown in Figure 2 (
), it is constructed by flashing ro OOJ in the second to fourth character portions of the character display portion 39a. The measurement pattern continues to be displayed until the output current of sensor BS becomes stable (point 23 in FIG. 4). When the output current becomes stable, stable points PI, P2 . A calculation is performed based on the output current of P3 to obtain a measured value, and the obtained result is displayed as a number by the second to fourth character parts in the character display section 39a, as shown in FIG. 2(k). be done. In addition, Pl, P2. The output current value of P3 is stored in the calculation control section 6. After confirming that the measured value is displayed on the display section 39, the user turns off the measurement start switch 32, opens the lid-like member 38, takes out the reaction tank 34, and turns off the power switch 31. Of course, each time - measurements are completed, the sensor unit 35
The thermistor 361 and rotating body 37 must be cleaned. ” (2) On page 24 of the specification, lines 13 to 16, “4th
"Figure (a)...graph" should be corrected as follows. One memory: ``Figure 4 is a graph that vertically compares the change in the output current of the sensor BS and the change in the voltage output from the I/V conversion circuit in response to this output current.'' (3) In the attached drawing. , Figure 4 is corrected as shown in the attached sheet.

Claims (4)

[Claims] (1) A sensor that is immersed in a sample liquid stored in a reaction tank to detect a substance to be measured in the sample liquid and outputs an amount of electricity corresponding to the amount of the substance to be measured; A component measuring device in a liquid, comprising an arithmetic control unit that calculates the amount of The predicted value of the time until the output stabilizes is calculated and distributed evenly, and based on the results, an injection waiting pattern is displayed on the display that shows the state in which the time until the output stabilizes in stages. An in-liquid component measuring device characterized by: (2) The in-liquid component measuring device according to claim 1, wherein the time until stabilization is calculated based on the slope of the electrical output of the sensor immediately after the voltage is applied. (3) The in-liquid component measuring device according to claim 1, wherein the time until stabilization is calculated based on the time until the sensor outputs a predetermined amount of electricity immediately after voltage is applied. (4) The in-liquid component measuring device according to any one of claims 1 to 3, wherein the first stage pattern of the injection waiting pattern is displayed at the same time as voltage is applied to the sensor.