JPS63143071A - Artificial bone cured and formed by mixing calcium triphosphate, acid, polysaccharide and water - Google Patents
Artificial bone cured and formed by mixing calcium triphosphate, acid, polysaccharide and waterInfo
- Publication number
- JPS63143071A JPS63143071A JP61288495A JP28849586A JPS63143071A JP S63143071 A JPS63143071 A JP S63143071A JP 61288495 A JP61288495 A JP 61288495A JP 28849586 A JP28849586 A JP 28849586A JP S63143071 A JPS63143071 A JP S63143071A
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- water
- artificial bone
- acid
- mixing calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 7
- 229920001282 polysaccharide Polymers 0.000 title claims description 5
- 239000005017 polysaccharide Substances 0.000 title claims description 5
- 239000002253 acid Substances 0.000 title claims description 4
- 150000004676 glycans Chemical class 0.000 title claims 3
- 229910000394 calcium triphosphate Inorganic materials 0.000 title 1
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 title 1
- 239000001506 calcium phosphate Substances 0.000 claims description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 12
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 10
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 10
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 3
- 239000012620 biological material Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 239000002639 bone cement Substances 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 239000000843 powder Substances 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 150000004804 polysaccharides Chemical class 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229920001284 acidic polysaccharide Polymers 0.000 description 1
- 150000004805 acidic polysaccharides Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- -1 polyTIN Mi Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- VQNBUJAEBQLLKU-UHFFFAOYSA-H tricalcium;diphosphate;hydrate Chemical class O.[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VQNBUJAEBQLLKU-UHFFFAOYSA-H 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
（イ）、産業上の利用分野
本発明のリン酸三カルシウムと酸と多糖類と水を混合す
る事により硬化生成した材料は、医療−Ｅ利用される。DETAILED DESCRIPTION OF THE INVENTION (A) Field of Industrial Application The material hardened by mixing tricalcium phosphate, acid, polysaccharide and water of the present invention is used for medical purposes.
すなわち、この材料を主に人工骨として生体に移植し、
骨の代用物あるいは骨セメン１−として利用する事を目
的とする。In other words, this material is mainly transplanted into living bodies as artificial bone,
The purpose is to use it as a bone substitute or bone cement.
（ロ）、従来の技術の欠点
従来の水酸アパタイト等の人工骨は焼成された物を田舎
して生体に適合させていたが、これは形態付与が困難で
ある。また、粉末状あるいは、粒状の水酸アパタイト等
を移植した場合生体内で散在してしまう欠点があった。(b) Disadvantages of the conventional techniques Conventional artificial bones made of hydroxyapatite and the like were fired and made to fit the living body, but it is difficult to give them a shape. Furthermore, when powdered or granular hydroxyapatite is implanted, there is a drawback that it becomes scattered in the living body.
また、従来の骨セメントは生体為害性を認めた。一方、
リン酸三カルシウムは従来より人工骨として利用されて
いるがこれは速やかに生体に吸収されてしまう欠点があ
った。また、特にα型のリン酸三カルシウム粉末は酸性
水７Ｗｉとの混合でリン酸へカルシウムあるいは水酸ア
パタイトへ転化し凝結硬化する事が知られているがこの
リン酸三カルシウムの水和凝結のみの生成物は脆弱で人
工骨として利用するには不適当であった。In addition, conventional bone cement was found to be harmful to living organisms. on the other hand,
Tricalcium phosphate has been used as an artificial bone for some time, but it has the disadvantage that it is quickly absorbed by the living body. In addition, it is known that α-type tricalcium phosphate powder, in particular, converts into calcium phosphate or hydroxyapatite and coagulates and hardens when mixed with acidic water 7Wi, but only tricalcium phosphate hydrates and coagulates. The product was brittle and unsuitable for use as artificial bone.
（ハ）、本発明の使用方法と利点
本発明の人工骨の原材料はリン酸三カルシウム粉末と酸
と多ＴＩＮ Ｍｉと水、あるいはリン酸三カルシウム粉
末と酸性の多糖類と水である。これらの至適な混合によ
り、特にα型のリン酸三カルシウムは３７℃前後で水和
凝結するが、この場合多Ｎ類の存在により人工骨あるい
は骨セメントとじて十分な強度分もったＮＦｉに硬化す
る。硬化するまでに数秒から数分を要するが、その硬化
の過程でｆ１意の形態に形成する事が可能である９本発
明による人工骨は形態付与が容易で手術中に形成でき手
術の簡素化と時間短縮が可能となる。また、硬化した材
料はＭ＆ｌ親和性に優れ、人工骨として臨床応用するに
十分なものと考えられる。(c) Usage method and advantages of the present invention The raw materials for the artificial bone of the present invention are tricalcium phosphate powder, acid, polyTIN Mi, and water, or tricalcium phosphate powder, acidic polysaccharide, and water. By optimally mixing these, α-type tricalcium phosphate in particular hydrates and coagulates at around 37°C, but in this case, the presence of polyNs makes it possible to form NFi with sufficient strength as an artificial bone or bone cement. harden. Although it takes several seconds to several minutes to harden, it is possible to form it into the desired shape during the hardening process.9 The artificial bone according to the present invention is easy to shape and can be formed during surgery, simplifying the surgery. This makes it possible to save time. Furthermore, the hardened material has excellent M&I affinity and is considered to be sufficient for clinical application as an artificial bone.
また、本発明の材料を、人工生体材料と骨との結合を目
的として骨セメントとして利用した場合従来のものに比
して組ｍ親和性に優れた材料となり、十分な接着性が得
られる。Furthermore, when the material of the present invention is used as a bone cement for the purpose of bonding an artificial biomaterial to a bone, it becomes a material with superior affinity for mating compared to conventional materials, and sufficient adhesion can be obtained.
４、図のＦＪ ＊ ｆｃ説明
第１図は本発明により生成した人工骨断面の予想模式拡
大図である。4. Explanation of FJ*fc in Figures Figure 1 is a schematic enlarged view of a cross section of an artificial bone produced according to the present invention.
１は未反応のリン酸三カルシウム。1 is unreacted tricalcium phosphate.
２はリン酸三カルシウムが水和凝結してリン酸へカルシ
ウム、あるいは水酸アパタイトに転化したものと多糖類
の結合物。2 is a combination of tricalcium phosphate hydrated and condensed and converted to calcium phosphate or hydroxyapatite and a polysaccharide.
Claims (1)
三カルシウムと多糖類と水を混合する事により、混合物
が凝結硬化する、この方法により硬化生成した材料の人
工骨およびその他の生体材料としての利用By mixing tricalcium phosphate, acid, polysaccharide, and water, or tricalcium phosphate, polysaccharide, and water, the mixture solidifies and hardens, and the material hardened by this method can be used as artificial bones and other biomaterials. use of
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61288495A JPS63143071A (en) | 1986-12-03 | 1986-12-03 | Artificial bone cured and formed by mixing calcium triphosphate, acid, polysaccharide and water |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61288495A JPS63143071A (en) | 1986-12-03 | 1986-12-03 | Artificial bone cured and formed by mixing calcium triphosphate, acid, polysaccharide and water |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63143071A true JPS63143071A (en) | 1988-06-15 |
Family
ID=17730953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61288495A Pending JPS63143071A (en) | 1986-12-03 | 1986-12-03 | Artificial bone cured and formed by mixing calcium triphosphate, acid, polysaccharide and water |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63143071A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0298501A2 (en) * | 1987-07-10 | 1989-01-11 | Asahi Kogaku Kogyo Kabushiki Kaisha | Composition for forming calcium phosphate type hardening material and process for producing such hardening material |
| JPH02232057A (en) * | 1989-03-07 | 1990-09-14 | Yasusuke Ono | Adhesive agent for bone packing material and bone packing material using this agent |
| EP0416398A1 (en) * | 1989-08-24 | 1991-03-13 | Asahi Kogaku Kogyo Kabushiki Kaisha | Paste for bonding granular bone prosthesis and bone prosthesis using same |
| JPH03128061A (en) * | 1989-10-16 | 1991-05-31 | Natl Inst For Res In Inorg Mater | Water-curable type calcium phosphate cement composition |
| US5180426A (en) * | 1987-12-28 | 1993-01-19 | Asahi Kogaku Kogyo K.K. | Composition for forming calcium phosphate type setting material and process for producing setting material |
-
1986
- 1986-12-03 JP JP61288495A patent/JPS63143071A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0298501A2 (en) * | 1987-07-10 | 1989-01-11 | Asahi Kogaku Kogyo Kabushiki Kaisha | Composition for forming calcium phosphate type hardening material and process for producing such hardening material |
| US5180426A (en) * | 1987-12-28 | 1993-01-19 | Asahi Kogaku Kogyo K.K. | Composition for forming calcium phosphate type setting material and process for producing setting material |
| US5281404A (en) * | 1987-12-28 | 1994-01-25 | Asahi Kogaku Kogyo K.K. | Composition for forming calcium phosphate type setting material and process for producing setting material |
| JPH02232057A (en) * | 1989-03-07 | 1990-09-14 | Yasusuke Ono | Adhesive agent for bone packing material and bone packing material using this agent |
| EP0416398A1 (en) * | 1989-08-24 | 1991-03-13 | Asahi Kogaku Kogyo Kabushiki Kaisha | Paste for bonding granular bone prosthesis and bone prosthesis using same |
| JPH03128061A (en) * | 1989-10-16 | 1991-05-31 | Natl Inst For Res In Inorg Mater | Water-curable type calcium phosphate cement composition |
| JPH0528627B2 (en) * | 1989-10-16 | 1993-04-26 | Kagaku Gijutsucho Mukizaishitsu Kenkyushocho |
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