JPS63122621A - Poultice - Google Patents

Abstract

PURPOSE:To obtain a poultice useful for shoulder discomfort, lumbago, bruise, sprain, etc., having excellent adhesivity and feeling to the skin, high releasability of the drug component and exhibiting improved remedying effect, by using a base cloth having uniform stretchability along all directions. CONSTITUTION:The objective poultice is produced by using an isotropic stretching base cloth having a 120% elongation load of 1-50g/cm, preferably 1-30g/cm and causing <=50%, preferably <=30% shrinkage along a direction perpendicular to the direction stretched at 150% elongation and applying a plaster to the base cloth using conventional method. The isotropic stretching base cloth is preferably a blend cloth composed of 50-90wt.% thermoplastic fiber and 10-50wt.% non-thermoplastic fiber. The plaster is those having an adhesivity of No.4 or higher by ball tack test and preferably contains a polyacrylic acid alkali metal salt, a copolymer of maleic anhydride and other monomer and polybutene.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a patch for the human body using a base fabric having equal stretchability in each direction (isotropic stretchability) in the base fabric part. This invention relates to a patch with excellent adhesive properties.

[Conventional technology]

Patch preparations are generally widely used as poultices for stiff shoulders, lower back pain, bruises, sprains, etc. Generally, the structure consists of a base part and a plaster part, and depending on the type of the plaster part, drugs such as methyl salicylate or menthol are mixed with gelatin, etc. It was kneaded with water-soluble polymers such as sodium acrylate and sodium alginate, mineral powders such as titanium oxide, and water. They are broadly classified into e-Tsuzo agents and Shirastar agents, which use various gums as adhesives instead of water-soluble polymers. And as the base fabric that holds these plasters, cloth, non-woven fabric, etc.?
A sheet of ligropyrene or the like is used, and the above-mentioned paste is applied to a base fabric to produce a product.

[Problem that the invention seeks to solve]

However, although the plaster itself used in conventional patches is generally stretchable, the base fabric holding it, such as cloth, nonwoven fabric, or torn propylene sheet, lacks stretchability. For this reason, when applied to a human body, the base fabric cannot fully synchronize with the movements of the human body, resulting in peeling of the patch.

This phenomenon is more noticeable in areas where the human body moves rapidly, such as joints.

Generally, such peeling is thought to be caused by insufficient adhesive strength of the plaster, and various studies have been made to increase the adhesive strength of the plaster. However, with this way of thinking, there is a limit to the improvement of the adhesive strength of the plaster, and if the adhesive is too strong, it will cause a poor feeling of use such as twitching and pain at the application site, so it is still not fully satisfactory. No patch was found.

On the other hand, as a means to prevent such peeling, it has been devised to use a flexible material for the base fabric (Japanese Patent Application Laid-Open No.
No. 7-42617, Japanese Unexamined Patent Publication No. 57-181010),
Since these are all base fabrics that stretch in only one direction, the directions in which the patch can be applied are limited, and they also tend to peel off in areas where joints and other areas move rapidly and expand and contract in both the vertical and horizontal directions. there were.

As described above, there has been a strong desire to develop a patch that is easy to peel off and has a good feel when applied to any part of the human body.

[Means for solving problems]

The inventors of the present invention have conducted repeated research to solve these problems, and have found that by using a base fabric with a specific isotropic stretch property as the base fabric, it is possible to solve the problem by using a base fabric that is said to have insufficient adhesive strength. The present invention was completed based on the discovery that even when a plaster is used, it has sufficient adhesion to the human body and improves the feeling of use.

That is, the present invention provides a patch having a base fabric part and a plaster part, in which the base fabric part has a load of 1 to 50 f/cIL when the base fabric is stretched to 120%, and the base fabric is stretched to 150% in one direction. The present invention provides a patch characterized by having an isotropically stretchable base fabric that shrinks by 50% or less in a direction that makes a 90 degree angle to the patch.

The requirements for the isotropically stretchable base fabric used in the patch of the present invention were discovered from the inventors' research on the stretchability of the skin of various parts of the human body, as shown in Reference Example 1 below.

In other words, among the various parts of the human body, the neck, shoulders, elbows, fingers, flanks, knees, ankles, etc. have high elasticity, and the elasticity of these parts is at its maximum (1. It is about 4 times as much. Therefore, in order to be able to follow the expansion and contraction of each part of the human body, the expansion rate of the base fabric does not need to be as high as 2 or 3 times, but it is required to be at least 1.5 times. It is desirable that the load (stress) required to stretch the length to the maximum length, which is 1.5 times the original length, be as small as possible; if the value is small, it may cause twitching or discomfort in the affected area. It doesn't cause any sensation, and it can follow the intense movement of the skin, making it less likely to peel off. On the other hand, when bending and stretching joints such as elbows and knees, the length is approximately 1
．． At the same time, the width is expanded by 1.1-1.3 times. However, the base fabric commonly used for patches,
Stretching in one direction causes contraction in the other direction. If this shrinkage rate is large, the patch that has been applied may peel off in the direction of shrinkage or cause a feeling of twitching.

Based on the above facts, the base fabric used in the invention is
It must have isotropic stretchability, and the base fabric must have 120%
The load when stretched is 1 to 50t/equipment, preferably 1
~30P/cm, and when stretched to 150% in one direction, the shrinkage in a direction 90 degrees to that direction must be 50% or less, preferably 30% or less. If this contraction exceeds 50%, the base fabric cannot follow the movement of the skin, causing peeling. Furthermore, one direction of the base fabric is 150%
When stretched by 120% in a direction that is 90 degrees to that direction, the load in the latter ranges from 1 to 100 F/c! More preferably, it is 1L. In addition, the load when the above-mentioned base fabric is stretched can be measured by cutting the base fabric into 15×7z pieces, for example, and measuring the load when stretching 10 CII in the longitudinal direction to a predetermined length using a tensilon meter. 'The type of base fabric may be woven fabric, non-woven fabric, knitted fabric, etc., but non-woven fabric is particularly preferred.

The material for the base fabric is not particularly limited as long as it satisfies the above conditions, but it must be a blend of thermoplastic fibers and non-thermoplastic fibers, in particular 50 to 90% by weight of thermoplastic fibers and non-thermoplastic fibers. A blend of 10 to 50% by weight is preferred.

What about thermoplastic fibers? Riester IJI! I,? Liamide fiber? PVC fiber,? Examples include ribinyl alcohol fibers, polyethylene fibers, and zeripropylene fibers, and these can be used alone or in combination of two or more types. Non-thermoplastic fibers include rayon, hemp,
Examples include silk and Kyu f2.

There are no particular limitations on the method of manufacturing the base fabric using these fibers. Preferred is a method in which the fibers are entwined by needling to give them elasticity.

The plaster part of the patch of the present invention includes conventionally used plasters,
For example, a medicinal ingredient mixed with a water-soluble polymer, mineral powder, or water can be used, but it is preferable that the paste has the same degree of elasticity as the base fabric. However, in reality, it is difficult to make the elasticity of the plaster and the base fabric to be the same, and it is acceptable as long as the stretch rate of the plaster is higher than that of the base fabric. However, if the elasticity of the plaster and that of the base fabric are significantly different, if the adhesiveness between the plaster and the base fabric is insufficient, the base fabric and the plaster may peel, or when applied, the adhesive may stick to the skin. This is undesirable because only the plaster may remain on the surface.

Particularly preferred plasters that do not cause such drawbacks include:
? Examples include alkali metal salts of polyacrylic acid such as sodium lyacrylic acid salt, copolymers of maleic anhydride and other monomers, and plasters containing polybutene. As the other monomer copolymerized with maleic anhydride, vinyl monomers, particularly vinyl acetate, methoxyethylene, etc. are preferable. In addition, the alkali metal salt of acrylic acid in the paste is 1 to 10% by weight (hereinafter simply referred to as %), the copolymer of maleic anhydride and other monomers is 0.5 to 10%,
It is preferable to contain 0.5% to 10% of the content.

In addition, the plaster is generally required to have strong adhesive strength to prevent peeling, but in the present invention, a particularly strong adhesive strength is not required, and for example, adhesive strength of 4 or higher is sufficient when measured by the ball tack method. .

The adhesive patch of the present invention can be produced by applying a plaster to the base fabric described above according to a method known per se.

〔Effect of the invention〕

The adhesive patch of the present invention can follow the movements of the human body even if it is applied to a site where the body moves rapidly, and has good adhesive properties and a feeling of use. In addition, due to the increased adhesion, the release of medicinal ingredients from the plaster is improved and the therapeutic effect can be enhanced.

〔Example〕

Next, the present invention will be explained with reference to reference examples and examples.

Reference example We investigated the expansion and contraction of skin in various parts of the human body.

Neck, shoulder, elbow of 5 adult males (height 165-1753)
Wrist, index finger, back, flank, knee, calf, ankle 10
We measured the length that changed when each part was bent and stretched to the maximum in various directions. The results are shown in Table-1. In addition, the elongation rate in the table was determined according to the following formula. In the formula, the original length refers to the length of the natural state.

Elongation rate (%) = Table-1 Example 1 (113D x 65 mm of ?Reester and 3DX5
1rnrn rayon at a ratio of 70:30 with a basis weight of 70t
/ m” random wave was created and heated to approximately 200℃.
An isotropically stretchable nonwoven fabric was obtained by heat treatment at a moving speed of 3 m/min. This nonwoven fabric has a thickness of 25 to 3.
5 mm, and when this nonwoven fabric is cut into a size of 15 mm lengthwise and 7011 mm wide, and the 1 m section is stretched to 120% with a Tensilon meter (manufactured by Toyo Goldwin ■), the load is 7 f. /cIIL.Similarly, when the 10fl'IIL portion in the vertical direction was stretched to 150%, the contraction in the horizontal direction was 15%, and at the same time, the contraction in the horizontal direction was 5C.
The load when the IK portion was expanded by 120% was 211/α.

A plaster of the following composition was applied to this nonwoven fabric at 1100 r/m! A stretchable Q-77 agent (product 1 of the present invention) was obtained.

Plasme composition: Menthol 2 (wt%
) Methyl salicylate 2 Glycol salicylate 1 Glycerin
20 aluminum hydroxide
0.3 breaking Trubate 80
1Calzexymethylcellulose
0.5 Sodium alginate
0.5 water
72 Lance (2) The paste obtained in (1) was coated on a non-stretchable non-woven fabric or knitted fabric to give a ratio of 1100f/α: to produce comparative products 1 and 2.
The present invention product 1 obtained in 1) was administered to the shoulders, elbows, backs, and
The tape was applied to the knees and ankles, and each part was bent and stretched, and the number of times until peeling occurred was measured. As a result, as shown in Table 2, the adhesive patch of the present invention had extremely excellent adhesive properties.

Margin Example 2 (1) 3D x 51mm? Riester, 3
DX51mm vinylon and 3D X 40mm
of Cugra in the ratio of 60:20:20 with a basis weight of 70f/f
An isotropically stretchable nonwoven fabric was obtained by creating f+2 random waves and heat-treating them at about 200°C and a moving speed of 3 m/mln. This nonwoven fabric has a thickness of 10 to 3.5
When the nonwoven fabric was stretched in mm and the load was measured in the same manner as in Example 1, the load when stretched by 120% in the longitudinal direction was g, 5 t/as. Also, the vertical direction is 150
%, the contraction in the transverse direction was 20%, and when the longitudinal direction was stretched to 150% and the transverse direction was also stretched to 120%, the latter load was 23 f/C1i.

A paste having the following composition was applied to this nonwoven fabric at a concentration of 110 Qr/ml to obtain a stretchable adhesive (invention product 2).

Glue composition: Menthol 1.5 (wt%) Methyl salicylate 2
Glycol salicylate 1 Glycerin 20 Aluminum hydroxide 0.3? Rin Rupet
1.5 carboxymethylcellulose 0.5 water
Balance (2) Stretchability was obtained in the same manner as in (1) except that the plaster composition of (1) except that polybutene was removed or the methoxyethylene-maleic anhydride copolymer was used as the paste. A No. 9 drug (invention product 3 or 4, respectively) was obtained. These /fi! As a result of the adhesion test conducted on the horn agent using the ball tack method (JIS), the product 2 of the present invention had a grade of 6, the product 3 of the present invention had a grade of 5,
Product 4 of the present invention was rated 6.

These e-Tsuzo agents were applied to the elbows of five healthy men, and their adhesion was examined in the same manner as in Example 1 by performing bending and stretching exercises. In addition, we examined not only the adhesiveness between the skin and the patch, but also the adhesiveness between the base fabric and the plaster. As a result, as shown in Table 3, all of the invention products 2 to 4 had excellent adhesive properties, but among them, the invention product 2 had the best properties as a patch.

that's all

Claims (1)

[Claims] 1. In a patch having a base fabric part and a plaster part, the base fabric part has a load of 1 to 50 g when the base fabric is stretched to 120%.
/cm, and when stretched to 150% in one direction, the patch is an isotropically stretchable base fabric that shrinks by 50% or less in a direction at 90 degrees to that direction. 2. The patch according to claim 1, wherein the isotropically stretchable base fabric is a blended base fabric of thermoplastic fibers and non-thermoplastic fibers. 3. The adhesive strength of the plaster using the ball tack method is No. 1. 4 or more, the patch according to claim 1 or 2. 4. The adhesive patch according to any one of claims 1 to 3, which contains an alkali metal salt of polyacrylic acid, a copolymer of maleic anhydride and other monomers, and polybutene in the paste. .