JPS6289603A - Subliming fungistatic and insect-repellent composition - Google Patents

Abstract

PURPOSE:The titled composition that is composed of dimethyl fumarate and camphor, thus having high inhibition of mycotic growth and high antifeedant activity against insect pests to fiber products with high durability in addition to high safety to human bodies. CONSTITUTION:The objective compositions is composed of dimethyl fumarate and camphor at a weight ratio of 10/90-2/98. Since the composition is sublimable, it is used as a fungicide for food-packaging materials, medicine- packaging materials, after products, agricultural products, or used in closets, drawers, bath rooms, warehouses, or vinyl houses or as an insect repellent for clothes, carpets, silk and wool products. The composition can include a moisture-proofing agent such as silica gel or calcium chloride.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a sublimable fungicide/insect repellent composition. More specifically, the present invention provides an inexpensive practical sublimation preventive that is highly safe for the human body, has excellent growth inhibiting effects on filamentous fungi and antifeeding activity against textile pests, and has excellent long-lasting effects. This invention relates to a mold/insect repellent composition.

BACKGROUND OF THE INVENTION Molds exist everywhere in the natural world, and if environmental factors such as temperature, humidity, and nutrient sources are suitable, they can occur anywhere and cause various types of damage. For example, mold can grow not only in clothing and leather, but also in plastics such as vinyl chloride resin, using plasticizers as a nutrient source.In recent years, there has been an increase in the number of houses with moderate temperatures and high airtightness, such as ceilings, floors, toilets, etc. Mold can be found in the bathroom, kitchen, and sometimes even on the walls of living rooms.

The occurrence of such mold can impair the appearance, deteriorate the quality of the product, and even have an adverse effect on the human body.Mold must never be allowed to enter, especially in pharmaceutical and food factories. , thorough anti-fungal measures are being taken. Against this background, the need for fungicides has increased in recent years, and research and development to develop excellent fungicides has been actively conducted.

By the way, the fungicides so far include copper-based, organotin-based, chlorinated phenol-based, quaternary ammonium salt-based, thiazole and inthiazole-based.

Many drugs are known, including organic bromine-based drugs.

However, these drugs are usually applied by surface treatment or internal treatment such as spraying, coating, injection, or mixing, but it is difficult to treat the target object or location directly, and some substance.

For example, for food packaging materials, pharmaceutical packaging materials, textile products such as clothing, leather raw materials and their products, agricultural products, etc.
It has the disadvantage that it cannot be used because it involves pollution and toxicity.

Therefore, when contamination or toxicity is a concern, sublimation fungicides are usually used, and until now, p-dichlorobenzene and other fungicides, such as p-chloro-m
- mixtures with xylenol are most widely used (
(Special Publication No. 55-2403).

However, p-dichlorobenzene is a type of organic chlorine drug that can accumulate in living organisms and cause harm, and can also combine with the ocular mucosa and cause clouding of the lens (Industrial Poisoning Handbook). ), its use is likely to be regulated.

Therefore, in recent years, many compounds and combinations thereof have been proposed as sublimable fungicides to replace p-dichlorobenzene. For example, a sublimating fungicide containing adamantane, a sublimable hydrocarbon, and a sublimating or volatile fungicidal substance (%Kokai No. 4313/1983), t-
A butylphenol compound is used as an active ingredient, and at least one type selected from naphthalene, dichlorobenzene, sheet t-7'' methylbenzene, acetaldehyde trimer, propylaldehyde trimer, and isobutyraldehyde trimer is used as a synergist. A volatile fungicide containing a sublimable compound (Japanese Patent Publication No. 59-29161) has been proposed.

However, all of these fungicides are more expensive than p-dichlorobenzene and have inferior fungicidal effects, so they cannot be said to be practically satisfactory.

On the other hand, as insect repellents for clothing, so far known are camphor camphor, p-dichlorobenzene, and p-dichlorobenzene.
-Dichlorobenzene was the most widely used in large quantities.

However, p-dichlorobenzene has hygienic problems as mentioned above, and in recent years, research has been widely conducted to develop insect repellents that are harmless to the human body in place of p-dichlorobenzene, and many new compounds and combination drugs have been developed. is proposed. For example, insect repellents for wool containing as active ingredients triisopropyl-8-trioxane or tritert-butyl-5-1rioxanthantolinalool, anethole, menthol, cinnamaldehyde, thymol, eugenol, or a combination of these derivatives ( (Japanese Patent Application Laid-Open No. 50-24436)
, an insect repellent containing a cyclic compound having 10 carbon atoms and an ether bond as an active ingredient (Japanese Unexamined Patent Application Publication No. 110823/1982), which contains adamantane, a sublimable hydrocarbon, and a sublimable or volatile polar compound. (Japanese Unexamined Patent Publication No. 53-121936), an insect repellent containing a combination of naphthalene and thymol as active ingredients (Japanese Unexamined Patent Publication No. 53-121936)
No. 109938), an insect repellent for clothing containing a combination of naphthalene and 2-isopropyl-5-methylphenol as an active ingredient (Japanese Patent Application Laid-open No. 1983-32620), an insect repellent for clothing containing acetoxime as the main ingredient ( JP-A-54-1
01425), an insect repellent containing as an active ingredient an aromatic compound having a substituent such as a carbon chain having a branch at the α-position (Japanese Unexamined Patent Publication No. 110321/1983), l
- Aromatic insect repellent containing carvone as an active ingredient (Unexamined Japanese Patent Publication No. 55
19229) and the like have been proposed.

However, all of these insect repellents are more expensive than p-dichlorobenzene and have problems with their insect repellent effects and their sustainability, and cannot be said to be fully satisfactory in practice.

Problems to be Solved by the Invention Under these circumstances, the purpose of the present invention is to provide a method that is extremely safe for the human body, has excellent fungicidal and insect repellent effects, and has good sustainability of its effects. The objective is to provide an inexpensive and practical sublimation fungicide/insect repellent.

Means for Solving the Problems As a result of intensive research, the present inventor has found that the vapor of a mixture of dimethyl fumarate and gunfer has an excellent effect of inhibiting the growth of filamentous fungi and an antifeeding activity against textile pests, and is harmful to the human body. The inventors have discovered that they have a high safety profile, are chemically stable, have a high melting point, and have a melting point, and have completed the present invention based on this knowledge.

That is, the present invention provides a sublimable fungicide/insect repellent composition comprising dimethyl fumarate and gunfer.

Dimethyl fumarate used in the present invention is a colorless crystalline solid with a melting point of 102°C and a boiling point of 88.5°C and 7121111 Hg.
Acute oral toxicity LD50 value for rats is 2240■/
9. The skin toxicity LD5Q value for rabbits is 1250■
/phrase, and is a highly safe and stable compound.

Ganfer, which is used in combination with dimethyl fumarate, is a compound that is widely used as a sublimation insect repellent for clothing, but when combined with dimethyl fumarate, its effectiveness is significantly improved and it also exhibits a fungicidal effect. be done.

The mixing ratio of dimethyl fumarate and gunfer in the composition of the present invention is selected in a weight ratio of 10:90 to 2.98. Again, if the amount of dimethyl fumarate is small, the insect and fungal effects will be insufficient. Furthermore, even if the amount of dimethyl fumarate is increased, there is no particular disadvantage in terms of effectiveness, but it is disadvantageous because it increases the cost.

In addition to these essential components, the composition of the present invention can also contain a moisture-proofing agent such as silica gel or calcium chloride.

The sublimation mold/insect repellent composition of the present invention contains a combination of dimethyl fumarate and gunfer as active ingredients, and is not only highly safe for the human body but also has excellent fungicidal and insect repellent effects. It is an inexpensive and practical drug with excellent long-lasting effects.

When using this product as a fungicide, it has sublimation properties, so it can be applied to objects or places where direct treatment with chemicals such as surface treatment or internal treatment is not suitable, such as food packaging materials, pharmaceutical packaging materials, clothing, etc. Textile products, leather raw materials and their products, agricultural products, etc., or in the house, such as cupboards, drawers, etc.
It is useful for preventing mold in closets, bathrooms, inside furniture, clothing cases, and outdoors in warehouses and greenhouses such as vinyl houses.

- When used as an insect repellent, it is useful for insect repelling textile products such as silk and wool, such as clothing and carpets, because it has excellent feeding inhibiting activity against textile pests.

Example Next, the present invention will be explained in more detail by way of examples.

Example 1 100 μ of a mixture of 1 part by weight of dimethyl fumarate and 9 parts by weight of camphor was placed at the bottom of a 1 ton wide-mouth bottle, and above it was placed a burr (Tinea pellionella L, ).
A cage containing 10 larvae and a wool standard test cloth was fixed.

Next, the bottle was sealed and left in a constant temperature and humidity chamber at a temperature of 30°C and a humidity of 65°C for 7 days, after which the insects were removed and the number of dead insects was counted.

For comparison, Ganfer alone and dimethyl fumarate alone were also tested in the same way. Three tests were conducted, and the average values are shown in Table 1.

Table 1 From this table, it can be seen that a synergistic effect is produced when dimethyl 7malate and Ganfer t- are used together.

Example 2 A heated and liquefied potato dextrose agar medium was poured into a glass Petri dish with a diameter of 5 cn1, and allowed to cool to form a flat medium. Next, Aspergillus can be found only in one point in the center.
Aspergil'lus nigerATC
C6275). Place this petri dish in a 1 ton glass bottle, place a mixture of gunfer and dimethyl fumarate next to it, seal it tightly, and keep it at a temperature of 25°C.
The mold was cultured for a certain period of time in an incubator with a humidity of 65%, and the state of mold growth was observed. In addition, for comparison, experiments were conducted simultaneously with no drug, with only gunfer, and with only dimethyl fumarate.

The mold-preventing effect was evaluated by dividing the mold growth into five stages as shown below, and the results are shown in Table 2.

Judgment criteria - No mold growth + Slightly found +1 - Moderately found - H-1 - Mostly seen Chiu Procedural amendment fully accepted (voluntary) February 1988] 7th Commissioner of the Japan Patent Office Kuro 1) Yu Akira, Patent Application No. 124291, filed in 1986, 2, Name of the invention: Sublimated fungicide/insect repellent composition 3, Axis) Relationship with the person who makes the right decision Patent applicant's address: Tokyo 1-3-1 Kasumigaseki, Chiyoda-ku Name
(114) Director of the Agency of Industrial Science and Technology Kozo Iizuka 4, Designated Agent Voluntary 6, Number of inventions increased by amendment 08, Contents of amendment (1) The following sentence is added after Table 1 on page 10 of the specification. .

Example 2 400 mg of a mixture of 1 part by weight of dimethyl fumarate and 9 parts by weight of camphor was placed at the bottom of a 1Q wide-mouth bottle, and above it were 10 larvae of Attagenus piceus (Attagenus piceus 01iv) with an average weight of 9II1 g per head. The basket containing the wool standard test cloth was fixed.Next, the bottle was sealed and left in a constant temperature and humidity chamber at 25℃ and 65% humidity for 20 days.The number of dead insects was counted, and the number of dead insects was counted. The amount of feeding damage was measured.

For comparison, dimethyl fumarate alone and gunfer alone were also tested at the same time. The test was conducted three times and the average value is shown in Table 2.

"Table 2" (2) Line 111 from the bottom of page 10 of the specification, "From this table" is corrected to "From Tables 1 and 2."

(3) On the 9th line from the bottom of page 10 of the specification, [Example 2] will be corrected to "Example 3."

(4) ``Table 2'' in the 6th line from the bottom of page 10 of the specification is changed to ``Table 3''.
Corrected Table J.

(5) "Table 2" on page 12 of the specification will be corrected to "Table 3."

Claims (1)

[Claims] 1. A sublimable fungicide/insect repellent composition comprising dimethyl fumarate and gunfer.