JPS626534Y2 - - Google Patents
Info
- Publication number
- JPS626534Y2 JPS626534Y2 JP1979078002U JP7800279U JPS626534Y2 JP S626534 Y2 JPS626534 Y2 JP S626534Y2 JP 1979078002 U JP1979078002 U JP 1979078002U JP 7800279 U JP7800279 U JP 7800279U JP S626534 Y2 JPS626534 Y2 JP S626534Y2
- Authority
- JP
- Japan
- Prior art keywords
- sample
- water
- container
- evaporation
- cooling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001704 evaporation Methods 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 10
- 238000001073 sample cooling Methods 0.000 claims description 6
- 238000007664 blowing Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 description 20
- 229920006395 saturated elastomer Polymers 0.000 description 9
- 238000010586 diagram Methods 0.000 description 7
- 238000001962 electrophoresis Methods 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【考案の詳細な説明】
本考案は生化学分析装置にて用いられる試料の
冷却装置で特に試料中の水分の蒸発を防止するよ
うにした試料冷却装置に関するものである。[Detailed Description of the Invention] The present invention relates to a sample cooling device used in a biochemical analyzer, and particularly to a sample cooling device that prevents evaporation of water in the sample.
生化学分析装置において使用する試料の必要量
は近年著しく微量化して来ている。このように極
めて微量な試料の場合、保存中に水分が蒸発して
濃縮され分析結果に悪い影響を与える場合があ
る。そのために従来水分の蒸発防止策として試験
管状の試料容器では第1図のように試料2を入れ
た容器1の各々を薄いシート状の膜3で密封して
保存する方法が用いられていた。この方法では試
料容器から試料を吸引する際等にはシートを取除
かねばならず、この着脱作業が面倒であつた。ま
た電気泳動装置で使われる試料は数10μと更に
微量であるために、第2図に示すような底の浅い
凹部4aに試料5を入れるようにした試料容器4
が用いられる。この場合も水分蒸発が問題とな
り、特に試料が極めて微量であるので水分の蒸発
による試料の濃縮が測定データーに及ぼす悪影響
は極めて大きかつた。そのために第3図のような
水を含ませたガーゼ7等を入れた容器6に試料容
器4を入れて密封して保存しなければならず、試
料を塗布する際等には蓋8を取除く必要があり、
取扱いが不便であつた。 In recent years, the required amount of samples used in biochemical analyzers has become significantly smaller. In the case of such extremely small amounts of samples, water may evaporate and concentrate during storage, which may adversely affect analysis results. Therefore, as a conventional measure to prevent water evaporation, a method has been used for test tube-shaped sample containers, in which each container 1 containing a sample 2 is sealed with a thin sheet-like membrane 3 for storage, as shown in FIG. In this method, the sheet must be removed when sucking a sample from a sample container, and this attachment and detachment work is troublesome. In addition, since the sample used in the electrophoresis device is even smaller at several tens of micrometers, a sample container 4 is used in which the sample 5 is placed in a shallow recess 4a as shown in FIG.
is used. In this case as well, water evaporation was a problem, and especially since the sample was in an extremely small amount, the concentration of the sample due to water evaporation had a very large negative effect on the measurement data. For this purpose, the sample container 4 must be placed in a container 6 filled with water-soaked gauze 7, etc., as shown in Figure 3, and sealed and stored, and the lid 8 must be removed when applying the sample. It is necessary to exclude
It was inconvenient to handle.
本考案は以上の点に鑑みなされたもので試料容
器を収納するための容器を試料の吸引等を容易に
した構造とすると共に容器自身若しくは容器の近
くに冷却機構を設けた構造とすることによつて試
料の飽和蒸気圧を減少させて収納容器を密封する
ことなくしかも試料の蒸発が少ないようにした試
料冷却装置を提供するものである。 The present invention was devised in view of the above points, and the container for storing the sample container has a structure that facilitates the suction of the sample, and a cooling mechanism is provided on the container itself or near the container. Therefore, it is an object of the present invention to provide a sample cooling device that reduces the saturated vapor pressure of the sample, eliminates the need to seal the storage container, and reduces evaporation of the sample.
以下本考案の詳細な内容を説明する。まず本考
案装置の具体的な構造の説明の前にその原理を説
明すると、従来のもののように試料容器自身を密
封したもの又は試料容器を収納する密封容器にお
ける試料よりの蒸発量と時間との関係を示すと第
4図の通りである。この図に示すように密封直後
は試料容器空間への蒸発があるが容器内の空間が
飽和すると蒸発は停止して試料の濃縮を防ぐこと
になる。又第5図に示すように試料上の蒸気圧は
試料よりの距離xによつて変化し、xが大になれ
ば蒸気圧は減少し、試料上の飽和蒸気圧pに対
し、xの点ではpxになる。この試料面上での飽
和蒸気圧pと点xでの蒸気圧pxとの差Δp=p
−pxにより蒸発が行なわれることになる。した
がつてこの圧力差Δpを零に近ずけてやれば、試
料よりの蒸発を防ぐことが出来る。一方飽和蒸気
圧と液体の温度との関係を示すと第6図に示す通
りであつて温度の上昇に伴ない飽和蒸気圧は上昇
し又逆に温度が減少すれば飽和蒸気圧も減少す
る。 The details of the present invention will be explained below. First, before explaining the specific structure of the device of the present invention, the principle will be explained. The relationship is shown in Figure 4. As shown in this figure, evaporation occurs into the space of the sample container immediately after sealing, but once the space inside the container is saturated, evaporation stops, preventing the sample from concentrating. Also, as shown in Figure 5, the vapor pressure above the sample changes depending on the distance x from the sample, and as x increases, the vapor pressure decreases, and the point x Then it becomes px. The difference between the saturated vapor pressure p on this sample surface and the vapor pressure px at point x Δp=p
-px will cause evaporation. Therefore, by bringing this pressure difference Δp close to zero, evaporation from the sample can be prevented. On the other hand, the relationship between the saturated vapor pressure and the temperature of the liquid is shown in FIG. 6. As the temperature rises, the saturated vapor pressure increases, and conversely, as the temperature decreases, the saturated vapor pressure also decreases.
本考案は以上の点に着目してなされたもので、
液体(試料)の温度を下げることによつて飽和蒸
気圧を下げ、これによつて飽和蒸気圧と試料面上
の空間(大気)の蒸気圧との差(前述の飽和蒸気
圧pとx点での蒸気圧pxとの差Δp)を小にす
ることによつて試料よりの蒸発を少なくしたもの
である。そしてこれによつて試料を覆うことなく
吸引等の操作を行ない易くしかも水分の蒸発を防
止したものである。 This invention was developed with the above points in mind.
By lowering the temperature of the liquid (sample), the saturated vapor pressure is lowered. Evaporation from the sample is reduced by reducing the difference Δp) from the vapor pressure px at . This makes it easy to carry out operations such as suction without covering the sample, and prevents moisture from evaporating.
次に第7図、第8図に示す一実施例にもとづき
本考案装置の具体的内容を説明する。10は容器
状をなす冷却容器本体、11は熱伝導の良い物質
(例えばアルミニウム、銅)よりなるテーブルで
その下面には多数の突出部11aを設けてある。
12はテーブル11の下面や突出部に貼りつけて
ある紙等の吸水性の良いシートでその下端部は
水13に浸されている。14は送風機でこれを用
いて本体10内へ送風し通風口10aより送り出
すようになつている。 Next, the specific contents of the device of the present invention will be explained based on an embodiment shown in FIGS. 7 and 8. 10 is a container-shaped cooling container body; 11 is a table made of a material with good thermal conductivity (for example, aluminum or copper), and a number of protrusions 11a are provided on the lower surface of the table.
Reference numeral 12 denotes a highly water-absorbent sheet such as paper that is pasted on the lower surface or protrusion of the table 11, and its lower end is immersed in water 13. Reference numeral 14 denotes a blower which blows air into the main body 10 and sends it out from the ventilation opening 10a.
このような構造の冷却容器本体10のテーブル
11上に図示するように第2図に示す構造の試料
容器4を載せ、又送風機14によりテーブル下面
の各突出部11a間へ風を送れば、紙12に含
まれている水分の蒸発が促進されて、この水分の
蒸発の際に蒸発熱を奪うためにテーブル11は冷
却され、その上に載せられている試料容器4も冷
却される。したがつて試料が冷却されて試料の飽
和蒸気圧が減少し、既に述べた理由により試料よ
りの水分の蒸発が抑制される。 As illustrated in FIG. 2, the sample container 4 having the structure shown in FIG. Evaporation of the water contained in the table 12 is promoted, and the table 11 is cooled to remove the heat of evaporation during the evaporation of the water, and the sample container 4 placed thereon is also cooled. Therefore, the sample is cooled, the saturated vapor pressure of the sample is reduced, and evaporation of water from the sample is suppressed for the reasons already mentioned.
第9図に示すものは例えば第8図に示すような
冷却機16を上方が開放されたケース15内に収
納したもので、その内部にラツク17に入れられ
た試験管1を覆いをすることなく設置したもので
ある。この実施例の場合ケース15内の大気が冷
却され第8図に示す実施例と同様に水分の蒸発が
抑制される。又冷却装置の上方は開放されまた試
験管も口が覆われていないので、そのままの状態
でノズルによる試料の吸引が可能である。 In the case shown in FIG. 9, for example, a cooler 16 as shown in FIG. 8 is housed in a case 15 that is open at the top, and a test tube 1 placed in a rack 17 is covered inside the case 15. It was installed without any problems. In this embodiment, the atmosphere inside the case 15 is cooled and evaporation of moisture is suppressed as in the embodiment shown in FIG. Furthermore, since the upper part of the cooling device is open and the mouth of the test tube is not covered, it is possible to aspirate the sample through the nozzle in that state.
第10図は本考案装置を自動電気泳動装置に用
いた場合を示すもので、例えば第7図、第8図に
示すような本考案冷却容器本体10のテーブル1
1上に図示してない位置決め部材により所定位置
に複数の試料容器をセツトしたトレイ18が置か
れている。一方20は自動電気泳動装置にて用い
られる検体の塗布装置であつて、21は塗布具移
動装置、22は検体塗布具、23はセルロースア
セテート膜等の支持体である。 FIG. 10 shows a case where the device of the present invention is used in an automatic electrophoresis device. For example, the table 1 of the cooling container main body 10 of the present invention as shown in FIGS. 7 and 8
A tray 18 on which a plurality of sample containers are set is placed at a predetermined position by a positioning member (not shown) on the tray 1 . On the other hand, 20 is a sample coating device used in an automatic electrophoresis apparatus, 21 is an applicator moving device, 22 is a sample applicator, and 23 is a support such as a cellulose acetate membrane.
この第10図に示した構成において、塗布具2
2を図示するAの位置に移動させた後これを下降
すれば、その真下にある試料は塗布具22の先に
付着される。続いて塗布具22を上昇した後矢印
方向に移動させ鎖線で示すBの位置で下降させれ
ば塗布具22の先に付着した試料は支持体23上
に塗布され、塗布後は塗布具22を元のAの位置
に戻す。上述のように塗布具22の先端に試料を
付着せしめてから後の塗布具の移動中にトレイ1
8を適宜移動機構により試料容器の間隔tだけ第
10図で左側へ移動させれば、塗布具22がAの
位置に戻つた時には塗布具の下には第10図で左
から二番目の試料容器が来ている。したがつて塗
布装置による前述の動作の繰返しによつて順次各
試料容器に入れられた試料は供給され支持体上に
塗布されて行く。これらの動作は上が開放されて
いる冷却装置のテーブル上で行なわれるので何物
にも邪魔されることなしに行なわれる。又冷却装
置はそのテーブルが冷却されているので前述のよ
うに試料よりの水分の蒸発は抑制される。 In the configuration shown in FIG. 10, the applicator 2
2 is moved to position A shown in the figure and then lowered, the sample directly below is deposited on the tip of the applicator 22. Next, when the applicator 22 is raised, moved in the direction of the arrow, and lowered to the position B shown by the chain line, the sample adhering to the tip of the applicator 22 will be applied onto the support 23, and after coating, the applicator 22 will be moved. Return to original position A. As described above, after the sample is attached to the tip of the applicator 22, the tray 1 is moved while the applicator is being moved.
8 to the left side in FIG. 10 by the distance t between the sample containers using an appropriate moving mechanism, when the applicator 22 returns to position A, the second sample from the left in FIG. 10 is under the applicator. The container is coming. Therefore, by repeating the above-described operations by the coating device, the samples placed in each sample container are sequentially supplied and coated onto the support. These operations are performed on the table of the cooling device, which is open at the top, and are therefore performed without any interference. Further, since the table of the cooling device is cooled, evaporation of water from the sample is suppressed as described above.
以上説明したように本考案の試料冷却装置は試
料容器の収納および供給を行なう部分が少なくと
も開放された状態であるので試料の吸引等の供給
操作を容易に行ない得ると共に試料の冷却によつ
て試料よりの水分の蒸発を抑制し得るので、試料
の濃縮による測定データーへの影響がない。 As explained above, in the sample cooling device of the present invention, since at least the part for storing and supplying the sample container is open, it is possible to easily carry out supply operations such as sucking the sample, and also to cool the sample by cooling the sample. Since the evaporation of water can be suppressed, there is no effect on measurement data due to sample concentration.
第1図は試験管状の試料容器における試料より
の水分の蒸発を防止するための従来の手段を示す
図、第2図は電気泳動等で用いる試料容器の斜視
図、第3図は第2図に示す試料容器における試料
よりの水分の蒸発を防止するための従来の手段を
示す図、第4図は前記各従来例における試料より
の水分の蒸発状況を示す図、第5図は試料よりの
距離とその点における蒸気圧との関係を示す図、
第6図は温度と飽和蒸気圧との関係を示す図、第
7図は本考案の第1の実施例の斜視図、第8図は
第7図における−線断面図、第9図は本考案
の第2の実施例の断面図、第10図は本考案装置
を自動電気泳動装置の試料塗布装置に用いた場合
の例を示す図である。
1,4……試料容器、10……冷却容器本体、
11……テーブル、14……送風機。
Fig. 1 is a diagram showing a conventional means for preventing evaporation of water from a sample in a test tube-shaped sample container, Fig. 2 is a perspective view of a sample container used in electrophoresis, etc., and Fig. 3 is a diagram showing a conventional means for preventing evaporation of water from a sample in a test tube-shaped sample container. 4 is a diagram showing the state of evaporation of water from the sample in each of the conventional examples, and FIG. A diagram showing the relationship between distance and vapor pressure at that point,
Fig. 6 is a diagram showing the relationship between temperature and saturated vapor pressure, Fig. 7 is a perspective view of the first embodiment of the present invention, Fig. 8 is a cross-sectional view taken along the - line in Fig. 7, and Fig. 9 is a diagram showing the main FIG. 10, which is a sectional view of the second embodiment of the invention, is a diagram showing an example in which the apparatus of the invention is used in a sample application device of an automatic electrophoresis apparatus. 1, 4...sample container, 10...cooling container body,
11...Table, 14...Blower.
Claims (1)
装置において、下方に複数の突出部を有し且つ上
方に試料容器を載置するテーブルと前記複数の突
出部を覆いその一部が浸水している吸水性シート
とから成る冷却器本体と、前記冷却器本体内に外
気を導入する送風器とを備え、送風により前記吸
水性シートに含まれている水分を蒸発させ前記テ
ーブルを冷却することにより試料を冷却するよう
にしたことを特徴とする試料冷却装置。 A sample cooling device for cooling a sample contained in a sample container, which has a plurality of protrusions below and a table on which the sample container is placed above, and a table that covers the plurality of protrusions and is partially submerged in water. A cooler body made of a water-absorbing sheet and a blower for introducing outside air into the cooler body are provided, and the sample is cooled by evaporating water contained in the water-absorbing sheet and cooling the table by blowing air. A sample cooling device characterized in that it is configured to cool.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1979078002U JPS626534Y2 (en) | 1979-06-08 | 1979-06-08 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1979078002U JPS626534Y2 (en) | 1979-06-08 | 1979-06-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55177654U JPS55177654U (en) | 1980-12-19 |
JPS626534Y2 true JPS626534Y2 (en) | 1987-02-14 |
Family
ID=29311459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1979078002U Expired JPS626534Y2 (en) | 1979-06-08 | 1979-06-08 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS626534Y2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000075581A1 (en) * | 1999-06-07 | 2000-12-14 | Seft Development Laboratory Co., Ltd. | Cooling machine |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5821566A (en) * | 1981-07-31 | 1983-02-08 | Fuji Photo Film Co Ltd | Incubator |
JPS5892669U (en) * | 1981-12-17 | 1983-06-23 | オリンパス光学工業株式会社 | Reagent storage device |
JPS58127361U (en) * | 1982-02-22 | 1983-08-29 | オリンパス光学工業株式会社 | Turret type reagent selection device for automatic biochemical analyzer |
JPS58127360U (en) * | 1982-02-24 | 1983-08-29 | オリンパス光学工業株式会社 | Constant temperature device |
JP2006030144A (en) * | 2004-07-21 | 2006-02-02 | Kajikkusu Trading:Kk | Sample tube heat-insulating tray and heat insulating box for multi-well plate |
ATE457831T1 (en) * | 2006-07-04 | 2010-03-15 | Eppendorf Ag | MODULAR STORAGE SYSTEM FOR LABORATORY LIQUIDS |
JP4371157B2 (en) | 2007-07-11 | 2009-11-25 | 株式会社デンソー | Liquid volume measuring device and liquid volume measuring method |
JP2009042226A (en) * | 2007-07-18 | 2009-02-26 | Hitachi High-Technologies Corp | Capillary electrophoretic apparatus and sample tray |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4924461U (en) * | 1972-06-03 | 1974-03-01 | ||
JPS559382U (en) * | 1978-07-04 | 1980-01-22 | ||
JPS55103464A (en) * | 1979-02-02 | 1980-08-07 | Hitachi Ltd | Sampler for chemical analyzing device |
-
1979
- 1979-06-08 JP JP1979078002U patent/JPS626534Y2/ja not_active Expired
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4924461U (en) * | 1972-06-03 | 1974-03-01 | ||
JPS559382U (en) * | 1978-07-04 | 1980-01-22 | ||
JPS55103464A (en) * | 1979-02-02 | 1980-08-07 | Hitachi Ltd | Sampler for chemical analyzing device |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000075581A1 (en) * | 1999-06-07 | 2000-12-14 | Seft Development Laboratory Co., Ltd. | Cooling machine |
Also Published As
Publication number | Publication date |
---|---|
JPS55177654U (en) | 1980-12-19 |
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