JPS6263597A - Prevention of sediment of aqueous ascorbic acid phosphate magnesium solution - Google Patents

Abstract

PURPOSE:To prevent the occurrence of the titled sediment so that the titled compound may be stably incorporated in an injection, etc., from low to high temperatures, by incorporating an aqueous solution of ascorbic acid phosphate magnesium with an organic carboxylic acid (salt), organic phosphoric acid (salt) or organic sulfate in a specific proportion. CONSTITUTION:An aqueous solution of ascorbic acid phosphate magnesium is incorporated with 0.03-5.0pts.wt., based on 1pts.wt. ascorbic acid phosphate magnesium, one or more selected from organic carboxylic acid (salt), e.g. sodium succinate, organic phosphoric acid (salt), e.g. phytic acid, and organic sulfate, e.g. chondroitin sulfate. The concentration of the ascorbic acid phosphate magnesium in the aqueous solution is preferably 1-5%.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a method for preventing oxidation in a magnesium ascorbic acid phosphate water bath solution, and more specifically, by incorporating special additives. This invention relates to a method for obtaining a transparent magnesium ascorbic acid phosphate aqueous solution that does not cause stains.

[Conventional technology]

Magnesium ascorbic acid phosphate is a stable derivative that has vitamin C action and is a compound that dissolves well in water. Since this compound is water-soluble, it can be used in transparent water-based lotions, injections, and various drinks.

Magnesium ascorbic acid phosphate can be obtained, for example, as follows. That is, vitamin C or 5.
6-inglobylidene-L~Ascorbic acid is phosphorylated by adding PO (J5) at 0°C under basic conditions (in the presence of KOH, pH 12).

After death with phosphoric acid, potassium is removed using a strongly acidic cation exchange resin, and then neutralized with magnesium oxide. After filtration, the solution is concentrated and reprecipitated with ethanol to obtain the desired product. [Problems to be solved by the invention] However, if the aqueous solution of magnesium ascorbic acid phosphate is left to stand, "Origin" will precipitate over time. It is difficult to commercialize this solution.Therefore, an effective method that can prevent the aqueous solution from collapsing is strongly desired.

[Means for solving problems]

In order to meet these demands, the present inventors investigated various methods for preventing the formation of aqueous solutions of magnesium ascorbic acid phosphate, and found that organic carboxylic acids or their salts, organic phosphoric acids or their salts, or organic sulfates were used. The present inventors have discovered that when appropriate amounts of one or more selected from among these are blended, evaporation can be prevented and a transparent aqueous solution can be obtained, and the present invention has been completed.

That is, the present invention adds 0.03 to 5.0 parts by weight of an organic carboxylic acid or a salt thereof, an organic phosphoric acid or a salt thereof, or The present invention provides a method for preventing staining of an aqueous magnesium ascorbic acid phosphate ester solution, which is characterized by blending one type selected from organic sulfates or two or more types of Fi.

Examples of organic carboxylic acids or salts thereof that can be used in the present invention include sodium succinate, sodium heptimalate, sodium citrate, sodium pyrrolidonecarboxylate, sodium edetate, clycyrrhizic acid, ammonium glycyrrhizinate, and dillium glycyrrhizinate. can give.

Examples of organic phosphoric acids and salts thereof include phytic acid and adenosine triphosphate. Examples of organic sulfates include chondroitin sulfate.

If the amount is less than 0.03 parts by weight per 1 part by weight of magnesium ascorbate ester, the effect of preventing acne will be insufficient, while if it is more than 5.0 parts by weight, it is unnecessary.

〔Effect of the invention〕

The method of preventing boils using an aqueous solution of magnesium ascorbic acid phosphate according to the present invention is very effective, and the sugar water in the aqueous solution can be used not only at room temperature but also at low temperatures below 0°C or at high temperatures above 30°C. Magnesium ascorbic acid phosphate can be stably incorporated into injections, injections, and various drinks.

The concentration of magnesium ascorbic acid phosphate in the aqueous solution is generally 0.1-10%, preferably 1-5%.

〔Example〕

A 5% aqueous solution of magnesium ascorbate ester was prepared, additives were added, and the mixture was uniformly dissolved.

This sample was left in a constant temperature bath with a cycle of -5° C. to 45° C. for 12 hours, and the precipitation of grains was examined by visual judgment. The time required for precipitation of #) was measured.

Dipotassium glycyrrhizinate 0.005
1 day or less 0.0 1 7 0.033 30 days 0.17 60 days or more Sodium chondroitin sulfate 0.017
Less than 1 day 0.033 25 days Sodium citrate 0.053 50 days 0.33
60 days or more

Claims (1)

[Claims] Ascorbic acid phosphate magnesium aqueous solution,
Contains 0.03 to 5.0 parts by weight of one or more selected from organic carboxylic acids or salts thereof, organic phosphoric acids or salts thereof, or organic sulfates per 1 part by weight of magnesium ascorbic acid phosphate. A method for preventing oozing of an aqueous solution of magnesium ascorbic acid phosphate.