JPS62500661A - cosmetic composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] cosmetic composition 1 extra embryo 1.4 Falsehood: The present invention relates to cosmetic compositions, particularly compositions of this type containing a bactericidal preservative.

Preservatives are necessary additives in cosmetics to prevent bacterial growth. relatively high concentration There are several substances that act as preservatives or disinfectants in the body, but they do not irritate the skin. It is not added to cosmetics because it may cause irritation or other dermatological reactions. The concentration of preservatives used must not exceed the specified concentration; examples of such preservatives include Froic acid, its salts and esters (0,5%), propionic acid and its salts (2%-acid) , polyhexamethylene biguanide hydrochloride (0.3%), etc.

2. Ryo Atsushi Kai 4: Polyhexamethylene biguanide (also called CPHMB) is a preservation product for cosmetics. It has already been disclosed as an agent. Cosmetics published in March 1981 Published in and Toiletries issue 96, page 29 onwards. See the paper “Cosmetic [’reservatives – 1981”] Please note that this article is included in the list of cosmetic preservatives on page 30 of the product "Cosmo". According to this table, this is polyhexamethylene. - It is a 20% solution of biguanide hydrochloride, and the concentration used is 0.2-1.0% of the 20% solution. It is 0%. This is 0.04-0.2% or 400-2000ppm PI ( Corresponds to M8. The maximum fipH of "Cosmocil CQ" is 4.0-8.0 Although it has been disclosed that there is a Both street agents and ingredient combinations have been suggested.

roasting of invention The present invention covers various aqueous solutions, aqueous suspensions, powders, gels, creams, cakes, aqueous ointments, By including a buffer in the composition of cosmetics made from pastes, etc., the concentration can be reduced to unexpectedly low concentrations. I' [Based on the discovery that IMB can be used for preservation. In a preferred composition, PHM By adding a component that exhibits a remarkable synergistic effect with B, the concentration of PHMB can be kept at a constant level. The preservative-treated cosmetic composition of the present invention can reduce the amount of skin around the eyes. It is particularly suitable for use in The compositions of the present invention have broad-spectrum bactericidal or bacteriostatic action. In addition to having a However, the yT composition of the present invention is non-toxic and non-irritating to the skin.

The present invention is based on an O/W or W10 emulsion, an amount of biocides capable of exhibiting a bactericidal effect. It is made by combining guanide or its water-soluble salt with 11'ff system, and is effective against bacterial growth. providing a non-toxic, non-irritating cosmetic composition protected by the formula: where 11 is 1 to 500.

Description of feminine aspects The biguanides used in the present invention include hexamethylene biguanide, its polymers and and water-soluble salts of these basic compounds and polymers. In general, polymer molecules The upper limit of amount is about too, oo.

It is contained in an amount of about 100 parts by weight based on 100 parts of the cosmetic composition. here The bactericidal action of the biguanide-containing composition described in It can also be reinforced. The overall bactericidal action of such a combination composition is Therefore, sterilization in solution is larger than when using each disinfectant individually. The overall concentration of the agent can be reduced, thereby eliminating possible harmful toxic reactions. It can be reduced significantly.

The composition of the present invention includes 1. [1. Four mountains cover a wide range of areas such as L Effective against bacteria at low concentrations. The composition contains formula (I) as the primary fungicide. biguanide, which is a low molecular weight oligomer with n on average between 4 and 7. oligomer, a high molecular weight long chain polymer with an upper molecular weight of about 100,000, and ] is 1. Biguanides are free base water Soluble salts, such as hydrochlorides, borates, acetates, gluconates, sulfonates, tartaric acids It can also take the form of salt, citrate, etc. However, the preferred form is n A water-soluble salt of the above biguanide having an average value of 2 to 12, especially 3 to 8, such as the hydrochloride, is used. use. That is, the preferred group of water-soluble biguanides described herein is that the molecule Groups whose quantity is at least 1,000, especially i, ooo to so, ooo It is a pool.

Polymers in the high molecular weight range have lower toxicity levels than their counterparts in the lower molecular weight range. Polymers indicated as being usable in the solutions of the present invention as they are commonly found in and the wide molecular weight range of monomeric biguanides is surprising. However, monomers, e.g. For example, hexamethylene biguanide hydrochloride has an average value of n of 4 to 4 at low concentrations. It shows excellent bactericidal activity equivalent to polyhexamethylene biguanide hydrochloride, which is No. 7. vinegar.

The biguanides and their preparation are described in the literature. For example, U.S. Pat. No. 428,576 is from diamines and their salts, and diamine salts of ginimide. discloses the preparation of this biguanide. This patent applies, for example, to Praue State 19 897, Wilmington, ICIA+nericas, Inc. to Cosmo Polyhexamethylene biguanide hydrochloride commercially available under the trade name cil CQ discloses a manufacturing method. For convenience, the biguanides used to preservative cosmetic compositions are listed below. ゛yen below! 88'''.

Cosmetic compositions of the present invention may contain buffering agents, preferably borate buffering agents, such as boric acid, sodium borate, etc. Contains thorium, potassium tetraborate, potassium metaborate, or adulterants thereof. Ru. Surprisingly, borate buffers can be used without added buffers or with the addition of other buffers. r'+ at a concentration lower than the concentration that exhibits bactericidal properties in the field! M [3 as a cosmetic composition It shows a very remarkable effect that allows it to be used for

Applicants have obtained increased amounts of PHM B within the concentration range of the present invention, increased amounts of sequestering metal ions, for use with surfactants, amphoteric surfactants, nonionic surfactants or cationic surfactants. It has also been found that conventional buffering agents can be used in the present invention only if they are suitable. this kind of Known buffers include sodium or potassium citrate, citric acid, and sodium bicarbonate. , and the combination of NazllPO, Na1lzPO- and K112r'Q. Various mixed phosphate buffers. Generally, the buffering agent is about 0.05 to about 2.5 %, preferably about 0.1 to about 1.5% (W/W). Borate The MN agent is about 0.1 to about 2.5% by weight in the case of boric acid, and about 0.1 to about 2.5% by weight in the case of sulfur and lithium borate. They show excellent results at P II M B concentrations of about 0.10 to about 1.5% by weight.

Suitable sequestering agents include diaminetetraacetic acid (EDT), gluconate Acids include citric acid, tartaric acid and their salts, such as the sodium salt. 11 When used as a 2% agent enhancer, the above surface active 7FIJ content is 0.0001 % to 5.0% (W/W).

Zwitterionic surfactant molecules are relatively complex organic molecules that carry a purely positive or negative charge. consists of parts. This charge is in equilibrium with a positive or negative counterion: a covalent bond It is not bonded to the molecule via a molecule, but is separated by the attractive force between parts that are charged with opposite polarities. (e.g., Na'', Ci'-). In amphoteric molecules, the upper The complex organic moiety contains (at least one of each) positive and negative charges. single polarity As in the case of molecules that are charged with Both negative and positive counterions are required in the same molecule. The uncharged part of an amphoteric molecule is a hydrophobic group (charged The charged moieties usually act as part of the hydrophilic group) and are uncharged (i.e., non-ionized). onic) can contain parent wood groups.

Preferred amphoteric surfactant molecules of the present invention are chemically expressed as follows: Forgotten: C■■2 Since it exists in an aqueous medium, this structure is represented in ionized form. This structure smells and R is a C6C1m fatty acid group, for example, coconut oil (which is lauric acid, myriste It is a mixture of alic acid, oleic acid, stearic acid, valmitic acid, etc.); Uric acid; Capric acid; Caprylic acid and ethylcaproic acid; Oleic acid; Linol acid and stearic acid; R2 is M and M is a cationic salt-forming group such as water. As an elemental or alkali metal, X is OI-1, or an anionic surfactant, e.g. f, sodium lauryl sulfate , or an acidic group of sodium lauryl sulfonate, and R2 is 1-1 or However, if R5 is a hydrogen atom, M is not present, and n is an integer from 1 to 40. child Types of surfactants are available from Mirano, Toyon, New Jersey 08810. It is commercially available under the trade name 'Mirano' from Chemical Co. . (Commercially available under the product names Miranol 2MC^ and CAM) A typical example of an ionized amphoteric salt is represented by the following formula: C,,R2,OSO,- H- Broadly speaking, these compounds are monocarboxylate, dicarboxylate, or sulfonate. It is a phosphate salt. The counterions in the first example are Na'' and CI!+ 2H250SO 3-, and in the second example Na+ and OH-.

Another type of amphoteric surfactant is represented by the ionized form of chemical composition as shown below. I'm being ignored However, R is a hydrophobic group such as methyl octadecyl, methyl dodecyl, methyl octadecyl, tadecenyl, etc., M is an alkali metal such as Na, K, etc., and X is the negative part, for example CHIOSO,.

C211) OSO: l, Cf, Br, etc., and n is an integer from 1 to 40. child Surfactants of the species are located at ^rmst, Janesville, WI 53545. Commercially available from Rong Chemical Co., Inc. under the trade name 5anac. It is. This molecule has a nonionic functional group (CJ40) nH. As a specific example (2-(2-carboxyethyl)ethyl) [2-(2-hydroxyethyl) ) Ethylcomethyloctatosylammonium methyl sulfate, potassium Salt; (2-(2-carboxyethoxy)ethyl)(2-(2-hydroxyethoxy)ethyl C) Ethylcomethyloctadecenyl ammonium methyl sulfate I. and (2-(2-carboxyethoxy)ethyl)(2-(2-hydro xyethoxy)ethylcomethyldodecylammonium methyl sulfate, There are potassium salts.

Yet another group of amphoteric surfactants are represented by the ionized formal chemical structure below. There is something to be ignored.

However, RI is a fatty acid group or other hydrophobic group, and R2 is an alkyl or substituted alkyl group. kill group, Z is a sulfate or sulfone group, e.g. SO4, CI□CH□SOi ;M is an alkali metal such as Na or R, X is CtlJSOi, CzHs Quaternary compound formation (quaternizi) such as OSOs, C(1, Br, etc.) ng) is a negative group from the reactant.

Yet another group of amphoteric surfactants can be represented by the ionized formal chemical structure below. You can: CI+.

C coo However, R is alkylene having 12 to 13 atoms, and R-co- is coconut. It is an acid group like acid. This type of surfactant is available from North America, Illinois 60093. Product name Amphoso from Chemical Co. It is commercially available as lC8.

Suitable cationic surfactants include two-component quaternary ammonium compositions as described in U.S. Pat. No. 3,525,793 and No. 3,472,939; Chassis City, Chassis - 1 Onyx Chemical Compan It is commercially available from y under the trade name BTS 2125M.

When used, neutral or non-ionic surfactants have cleaning and conditioning properties. The upper limit of the content is usually 15% by weight. Surfactants are cosmetics Dissolves in the composition, is non-irritating to the eyes and other tissues, and contains parent trees and lipophilic bases. Lance (IILB) must be between 12.4 and 18.8. preferred non-ionic Examples of surfactants include polyethylene glycol esters of fatty acids, e.g. coconut, polysorbate, polyoxyethylene, or higher alkanes (C1 □-C1- polyoxypropylene ester is mentioned. Preferred nonionic Examples of surfactants include polysorbate 20 (Praue State 19897, USA). Wilmington, IC1, ^mericas Inc, product name Tween 2 commercially available as 0), polyoxyethylene (23) lauryl ether, trade name Br1H 35), polyoxyethylene (4o) stearate (trade name Myrj52), Lioxyethylene (25) Propylene Glycol Stearate (Product Name Δt las G 2612). Br1j35, Myrj52 and Δtlas G2 612 Ericas to ICI 8+, Wilmington, Praue State 19897 It is a trademark of Inc. and is a commercially available product from that company.

Ethylene diamine poly(oxypropylene) having a molecular weight of about 7,50 to about 27,000. pyrene)-poly(oxyethylene) adduct, at least four of said adducts A nonionic surfactant in which 0% by weight is poly(oxyethylene) is from about 0.01 to about It has been found to be particularly effective when used at a content of 15% by weight. CTFA C osmeticIngredient Dictionor+nry is of this type The name adopted for the surfactant is poloxamine. Such surfactants From BASF Wyandotte Carp, Wyandotte, Michigan It is commercially available under the registered trademark Goetronic"°. It is similar to the surfactant series BASF Wyand, New Jersey 07054, BASF Polyoxylic acid sold under the trademark "Pluronic" by Otte Corp. poloxamines consisting of polyethylene, polyoxypropylene block polymers ・There is a series.

Other amphoteric, cationic and nonionic surfactants suitable for use in the present invention include With the above explanation in mind, Glen Rock, New Chassis 07452, , MCP Publishing Co.

McCutc published by McCutcl+eon Division. heon’ 5Dcterrents and E+nulsifier, North America It can be easily found from the version.

A second fungicide can be used as a solution preservative, which will It can also enhance or supplement the bactericidal action of M[l, or expand the range of bactericidal action. Ru. Such a second seedling agent is compatible with PIIM[3 and has r'! I MB does not precipitate in the presence of MB and has a concentration of about 0.00001 to about 0.5% by weight, preferably or about 0.0001 to about 0.1% by weight of the fungicide. . Suitable supplemental fungicides include thimerosal, sorbic acid, 1.5bentanedi ols, alkyl triethanolamines, phenyl mercuric salts, e.g. nitric acid Salts, borates (including acetates, chlorides, and mixtures thereof); other bactericidal Compounds and salts may also be used. Suitable salts have at least 0.5 wt. Soluble in water up to %. Such salts include gluconate, isothionate ( 2-hydroxyethanesulfonate), formate, acetate, glutamate, amber citrate, monodiglycolate, dimethane sulfonate, lactate, diisobutyrate , glucoheptonate, etc.

In addition, it has a wide range of bactericidal action and can be used as an augmentation or supplementary bactericidal agent that can be used in combination with pHMB. There are some quaternary ammonium 11 compounds that have a warming effect. like this Examples of quaternary ammonium compounds include n-alkyl dimethyl benzyl chloride. A typical example is a balanced mixture of Mmonillanow.

In cosmetics, the amount of preservatives added to PII MDtai is about 0.5pp+n to about 110 Products can be preserved by sufficiently inhibiting bacterial growth at a level of 0pp. can. The cosmetics of the present invention mainly include eye makeup remover, mascara, Such as eye shadow. PIIMD buffer/added preservative system is aqueous solution, aqueous suspension. Works in liquids, powders, gels, creams, cakes, aqueous ointments, pastes, etc. . As the M street agent, borates such as boric acid, sodium borate, potassium tetraborate , potassium metaborate, or mixtures thereof are preferred.

The concentration of PllMB in the composition of the present invention is the concentration of PllMB containing PIIMB. from about 0.5 ppm to about 1, lower than the concentration suggested by known examples for cosmetic compositions. 100 pp is sufficient, but the concentration in cosmetic compositions with high solids content may be higher. must be much higher than the lower limit of the stated range. Therefore, cosmetic cream , Base 1 ~, Cake, Powder, etc. are water-based eye makeup and rims, which will be described later. Solid products rather than aqueous solutions or gels, such as makeup removers or gel eye makeup removers. content is much higher. In this way, compositions with a high solid content and oily content are relatively For high compositions, the P11M13fi degree is about 10 to about 100 pp+n, preferably If r'l1MB is used in combination at about 40 to about 60 ppm, the composition can be effectively preservative. Moreover, the composition hardly irritates the skin.

The P II MD preservative may be added to the cosmetic composition according to known methods.

In many cases, the preparation process varies depending on the aqueous condition of the preservative. For example, It is desirable to produce a 0/W imulsion if the product is However, specific The manufacturing method is not important for wood invention.

The examples listed below are representative of the cosmetics of the present invention.

These examples are merely examples for explaining the cosmetic composition of the present invention, and The scope of the invention is not limited by these examples. The preparation procedure is a known method. Depends on order. All of these compositions are non-toxic and non-irritating. More important features As a sign, these compositions protect against bacterial growth.

Aqueous eye makeup remover with the following composition on the surface of Poloxamiso/10F Activator 1.00 lauroano\fuocarpoxyglycinate 5.00 EDTA O, 11 Propylene glycol 5.00 Glycerin 5,00 Polyhexamethylene biguanide l(:I21.1+) 111111 Boric acid 0 ．． 80 Sodium borate 0.10 Purified water up to ioo, oo Sufficient amount Example　■ %Eng uZ”υ− Polokizami 240 surfactant 22.00 Lauroa 1\focarboxyglycide )-4,00EDTA O,10 Polyhexamethylene biguanide HC (11, lppm boric acid 0.80 Sodium borate 0.15 Purified water up to ioo, oo Sufficient amount Prepare a cream eye makeup remover with the following composition: %work W, lυ− Ni aluminum magnesium silicate 1.5Vr ice making 45.0 Propylene glycol 4.0 8 parts Meloxapol 58 8.0 Meloxabol 314 4.0 Mineral oil 23.0 Trisolan LP' 2.5 Emulsified wax, N, F, 2.0 For q milk polyhexamethylene biguanide HCj2 75ρpa + boric acid 0.8 Sodium borate 0.1 Purified water up to 100.00 Sufficient amount 1. E+nery Indus, Linden, New Chassis 07036 tries.

A mixture of isopropyl ralt and lanolin commercially available from Inc. Product name.

24 E+nery rndust, Linden, New Chassis 07036 rues.

Trade name of acetylated lanolin commercially available from Inc.

3, Vanderbi, R.T., Norwalk, CT 06855 N-cocoyl sarcosine commercially available from LCo, Inc. product name.

The product of Example ■ can be prepared by mixing the ingredients of parts A, B and C separately. I can do it. The mixture of parts A and B is then emulsified together. This emulsified mixture The final product is obtained by adding part C to the mixture.

Example　■ Prepare cake-like mascara with the following composition: KD 4) Beeswax 30.0 Petroleum benzine 356 52.0 Iron oxide 5,0 Oat flour 2.0 Polyhexamethylene biguanide IIcβ 50ppm Sodium borate 0.6 Purified water up to 100.00 Sufficient amount Zinc nistearate to prepare pressed powder eye shadow with the following composition 8 ．． 0 Kaolin 10.0 Oat flour 20. 〇 Titanium dioxide 10.0 Ultra pearl colorant 10.0 Dark blue colorant 10.0 Polyhexamethylene biguanide llCf 50ppm boric acid 0.80 Sodium borate 0.10 Purified water up to 100.00 Sufficient amount Takumi--l Sip the liquid eyeshadow with the following +■ composition.

Five Deaf”] 3516 Ultramarine Blue 5.10 Titanium Dioxide 4.50 Pearl colorant 9. OO Polymer JR30M* 0.60 Propylene glycol 10.00 Oat flour 2.00 Polyhexamethylene biguanide l1fJ 50ppm boric acid 0.80 1! Sodium llate 0.10 Purified water up to ioo, oo Sufficient amount Commercially available from Union Carbide Co., Danbury, Conn. Product name of cationic cellulose resin.

In other preferred cosmetic compositions of the present invention, a mixture of several ingredients It increases the bacteriostatic power of existing agents and protects cosmetic compositions from a wider range of bacteria. Ru. This preferred composition contains, in addition to I'ltMB and selected cosmetic ingredients, Secondary bacterial agents such as azolidinyl urea, borate buffers (sodium borate and boric acid ) and amphoteric or nonionic surfactants. Preferred amphoteric surfactants are camidopropyl betaine, and the preferred nonionic surfactant is Tetron. icl107''' is a poloxamine known as a surfactant.

Preferred concentration ranges for each component of this synergistic composition are as follows: P HM B 0.5-50ppm Borate (total of sodium borate and boric acid) 0.1-1.5% by weight Surfactant 0 ．． 1-2,0% by weight Diazolidinyl urea 0.05 to 0.5% by weight or more, according to the present invention in connection with specific examples Although described above, this specific example is merely an example for explanation. A person skilled in the art would understand the following: Many changes, improvements can be made in the light of the above description, and therefore these Changes and improvements are also included within the scope of the appended claims.

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Claims (1)

[Claims] 1. A bactericidal or fungicidal effective amount of a biguanide or a water-soluble salt thereof together with a buffer. A non-toxic and non-irritating cosmetic composition containing and protected against bacterial or fungal growth. in which the biguanide has the formula (wherein n is 1 to 500), and the biguanide has the composition non-toxic and non-irritating, present in a proportion of 0.5 to 100 parts by weight per 100 parts of cosmetic composition. 2. Claim No. 1, wherein the biguanide is a water-soluble salt of polyhexamethylene biguanide. Composition according to item 1. 3. 2. A composition according to claim 1, wherein n of the biguanide is on average from 4 to 7. 4. The content of biguanide is 10 to 100 parts by weight based on 100 parts of the composition. The composition according to claim 2. 5. The content of biguanide is 40 to 60 parts by weight based on 100 parts of the composition. The composition according to claim 4. 6. Claims where the composition is a cosmetic cream, paste, powder or cake The composition according to item 5. 7. 3. The composition of claim 2, wherein the buffer is a borate buffer. 8. The buffering agent is about 0.1% to about 2.5% by weight of boric acid and about 0.10% to about 2.5% by weight of sodium borate. A composition according to claim 7 comprising 1.5% by weight.