JPS6249256A - Biochemical measuring apparatus - Google Patents

Abstract

PURPOSE:To enable the checking for abnormality of a circuit or the like, by alternately displaying the dark zero value (the output value of a light receiving section when a light emitting section is not driven) of an intermediate value other than a quantitative value of material and the blank value (the output value of the light receiving section prior to the immersion into urine during the driving of the light emitting section). CONSTITUTION:When a switch 11 is turned ON, the check mode I for checking using a reaction test paper is set. When a switch 12 is turned ON, the check mode II for checking using a reference stick having standard colors before and after the reaction is set. Moreover, when the switches 11 and 12 are both OFF, the normal mode is set. A photoelectric detector section 21 is made up of a light emitting element 22 and a light receiving element 23 and light from the element 22 driven 27 by a command of a CPU27 is projected, reflected and received 23 by a test paper 25 of a stick 24 mounted 6 and converted 28 into a voltage signal and them, converted 29 into a digital signal to be taken into the CPU26. The quantitative value of urinary sugar obtained in the normal mode and the dark zero value, blank value, reaction value and ratio value in the check mode are displayed 3.

Description

Detailed Description of the Invention (a) Field of Industrial Application This invention is applicable to devices such as urine sugar measuring devices, which quantify biochemical substances in living organisms based on the degree of star color after immersing a test strip in a bovine body sample fluid. The present invention relates to a chemical measuring device, particularly a biochemical measuring device having a check function.

(B) Conventional technology Conventional urine sugar measuring devices measure the amount of reflected light obtained by shining light on a urine sugar test strip attached to the tip of a stick in an unreacted state, and the amount of reflected light obtained by immersing urine in the test strip. The ratio (l!(
Reflectance) is calculated, and from this ratio value, a corresponding urine sugar value is read out from the urine sugar value data recorded in advance in 1a corresponding to each ratio value, and urine sugar quantification is performed.

This type of urine sugar measuring device displays the measurement result obtained by shining light on the test strip before and after immersion in urine, that is, the urine sugar value, but it also displays the intermediate value, the amount of reflected light before immersion in urine, and the amount of light reflected after immersion in urine. The subsequent amount of reflected light, ratio value, etc. are not displayed.

(c) Problems to be solved by the invention Generally, when producing a urine sugar measuring device, blank values (
The gain of the amplifier on the output side of the light receiving section is adjusted so that the light receiving section (013 output value before urine immersion) becomes a constant value when the light emitting section is driven. However, in conventional devices, the blank value is not displayed on the display, so adjustments must be made each time using a separate display or meter.

In addition, if an abnormal result occurs during measurement with a urine sugar measuring device, by checking the dark zero value (the output value of the light receiving section when the light emitting section is not driven), you can determine whether the device circuit is good or not. It is also possible to check whether light has penetrated. Furthermore, by checking the blank value, it is possible to judge whether the test paper is good or bad. However, since conventional devices do not display dark zero values or blank values, it was not possible to check whether the test strip was defective or the circuit was abnormal.

In view of the above, an object of the present invention is to provide a biochemical measuring device that can easily check for test paper defects and circuit abnormalities.

(d) Means for solving the problems and (It 71) The biochemical measurement device of the present invention includes a test strip insertion section?-1 A light emitting section that projects light onto the test strip attached to the test strip insertion section. , a light-receiving part that receives light from the test paper, the ratio of the amount of light received by this light-receiving part from the test paper before being immersed in the biological sample liquid, the amount of light received before being immersed in the biological sample liquid, and the light-receiving part from the test paper; 1 step of ratio value calculation for calculating the ratio value and the substance value corresponding to each ratio value are stored α in advance, the substance value corresponding to the ratio (10) calculated by the ratio value calculation means is read out, and the substance value is quantified. a dark zero value, which is the output of the light receiving section when the light emitting section is not driven, and a dark zero value, which is the output of the light receiving section when the light emitting section is driven, and the output of the light receiving section due to light from the test paper before being immersed in the biological sample liquid when the light emitting section is driven. It is characteristically equipped with a storage means for holding and storing a certain blank value, and an offset display means for alternately displaying the blank value and the blank value when measuring the blank value.

In this chemical measuring device, the dark zero value and the blank value are alternately displayed on the display means during blank value measurement at the initial stage of measurement. Therefore, the measurer can know the dark zero value and the blank value at that time, and can check for circuit abnormalities and test paper defects based on these values.

(E) Examples The present invention will be explained in more detail with reference to Examples below.

FIG. 2 is a perspective view of a urine Jy4 measuring device in which the present invention is implemented. This urine sugar measuring device I has a display 3, a power key switch 4, a measurement key switch 5 on the outer surface of a case 2, and is also provided with a buzzer 1o.

A stick holder 6 is provided at the tip of the case 2, and when the button 7 is pushed downward, the lid 8 opens and the test strip is inserted into the test strip insertion section 9 from the -L direction. is held vertically. Further, the case 2 houses a receiving/emitting section, an electronic circuit section, a battery, a check mode setting switch, and the like.

FIG. 1 is a circuit block diagram of the urine sugar measuring device 1. The second figure shows the same + jjl part even though the same number is attached.

In FIG. 1, 11 and 12 are switches for setting the check mode, and when the switch 11 is turned on, the check mode is set. Check mode (■) is a mode in which a check is performed using the usual measurement routine and a reaction test strip. When the switch 12 is turned on, the check mode (2) is set. The check 2 check mode is a mode in which a check is performed using a standard ink having standard colors before and after the reaction. Su Isochi 1
When both 1.1 and 12 are off, the mode is for normal measurement.

The photoelectric detection unit 21 is composed of a light emitting element 22 and a light receiving element 23. Light from the light emitting element 22 is projected onto the test paper 25 of the stick 24 attached to the stick holding part 6, and is reflected. It is designed to receive light at -23.

The light emitting element 22 is activated by the command from the CP U 26.

It is driven by an ED driver 27. Further, the light-receiving current flowing through the light-receiving element 23 is converted into a voltage signal by a current/voltage converter 28, converted into a digital signal by an A/D converter 29, and then taken into the CPU 26. .

The CPO2G has a built-in memory, and various data for urine sugar measurement are recorded in this memory.

CP L, J 26 is light emitting element 7-22 off and on,
A function to read the signal from the light-receiving element 23 of the test strip immersed in urine, a function to read the output of the light-receiving element 23, that is, a urine sugar reaction value, after a predetermined reaction time has elapsed after the test strip is immersed in urine, and a function to read the urine sugar reaction value before immersion in urine. A function to calculate the urine sugar reflectance (ratio value) from the reading value of the light receiving element 23 output and the urine sugar reaction value point, a function to quantify the urine sugar value from this reflectance, and a sound signal is output from the buzzer 10. It has various functions such as functions.

Further, the urine IJ3 constant value obtained in the normal mode, the dark zero value in the check mode, the blank value, the reaction value, and the ratio value are displayed on the display 3.

The display device 3 includes a display section 3a that displays numerical values such as urine sugar value, a display section 3b that displays semi-quantitative symbols -1±, g, +4, etc., and a stick (test strip) or candela. - A display section 3c is provided for displaying information and for instructing operations.

Next, the operation of the raw sugar measuring device 1 according to the embodiment L will be explained with reference to the flowcharts shown in FIGS. 3 and 4.

The power switch 4 is turned on, and processing such as clearing the memory of the CPO 26 is performed [Step ST (hereinafter referred to as ST)].
1] and the entire display section of the display unit 3.
Figure 51 (lit as shown in bl 5T2),
Buzzer 10 is turned on for 1 second (ST3). Note that before the power switch 4 is turned on, the display 3 shows the image shown in FIG. 5(a).
As shown, there is no indication. -1 The function of the display section is being checked by lighting all the display sections.

Next, it is determined whether the mode is check mode (ST4). When either switch 11 or switch 12 is turned on in the device and set to check mode, the check mode flag is set (ST5), but in normal measurement mode, the judgment in ST4 is No. Next, it is determined whether the battery is low (ST6). If the battery voltage is lower than the specified value, it is determined that the battery is low, a mark indicating battery low is displayed on the display section 3C (ST43), and after 30 seconds have passed (ST44),
Auto power off (ST45). When the voltage of the battery is equal to the regulation plate - 1, the judgment in ST6 is NO, and then S
Moving to T7, a request for a stick (test strip) set is displayed. This display is performed by blinking a stick mark on the display section 3c, as shown in FIG. is inserted into the test strip insertion section 9. Then, the measurement switch 5 is turned on.

The device continues to flash the stick mark until the measurement person turns on the measurement switch 5 (ST7.5T8).
, when the measurement switch 5 is turned on, as shown in FIG. Load via . The read value at this time is stored as a dark zero value (ST9). This dark zero value correction is used during check mode.

Next, the light emitting element 22 is turned on, the test paper 25 is exposed to light (STIO), and the output of the light receiving element 7-23 at this time is A/D.
Read via converter 29. This read value is recorded as a blank value 1a. This blank value corresponds to the amount of light reflected by the test paper 25 before the reaction.

After reading the blank value, the light emitting element 22 is turned off (ST
1.2) Determine whether the check mode flag is turned on (ST13). Since this flag is not turned on in measurement mode, the judgment of 5T13 is NO.
Next, it is determined whether the measured value is normal, that is, whether the blank value minus the dark zero value is within a predetermined value (ST14).

If the measured value is not normal, an error message is displayed on the display section 3a (5T40) and the buzzer 10 sounds to issue an alarm (ST41). This caused the person taking the measurement to feel abnormally anxious (ζ1) and had to change the stick or press the measuring button 5 for re-measurement (Sr4.2).
), return to Sr6.

If the measured value is normal at 5T14, then the process moves to 5T15, where a request to prepare a urine cup is displayed.

This display is performed by blinking a cup mark on the display section 3C, as shown in FIG. 5te+. Seeing this flashing display, the person taking the measurement prepares a cup filled with urine. Then, the C1 measurement switch 5 is turned on.

On the other hand, in the case of check mode, since the check mode flag is turned on in Sr1, the determination of "check mode flag ON" in 5TI3 is YES, and 5T37
Then, as in 5T14, determine whether the measured value (blank value) is normal or not (2), and if it is normal, the buzzer 10 will sound an alarm. In some cases, 5T3 without going through S'r38
Move on to 9.

5T39 displays the results obtained so far, that is, the dark zero value and the blank value. If this is displayed, as shown in FIG. ,,': A display requesting the preparation of a urine cup is displayed. This display is also a flashing light of the Kanobu marker.

The device remains in cassopharmonic mode until the 4th river issona 5 is turned on.
point) The castle lighting continues εJ but (STi5.5T16.5
T39) When the measurement switch 5 is turned on, the buzzer 10 emits a sound for 0.1 seconds to receive a countdown, and the display 3 is turned on as shown in FIG. 5(f).
The number "5" indicating 5 seconds is displayed on the clock, and the NOAH button 7 on the display section 3c is lit continuously. And from then on, 5
The seconds count down (S"r17). Every second, the numbers on the display 3a change to 5-, 4-3-, 2-, etc.
...and it keeps changing.

This 5 second count involves dipping the test strip in the urine'f! i
I'm doing it for a.

At 5T15, the measurement switch 5 is turned on, and when 5 seconds have elapsed, the number on the display section 3a becomes O, and a stick mark and a cup mark appear on the display section 3C, as shown in FIG. Is displayed. These display marks just indicate that the stick should be placed in the cup and require that the test strip be dipped into the urine (ST18).

Then, a buzzer sound indicating the urine immersion timing is sounded for 0.2 seconds, and after 0.5 seconds, a buzzer sound indicating the timing to remove the test strip from the urine is output for 0.2 seconds (ST
i9). The tester listens to the previous buzzer sound and dips the test strip into the urine, and then pulls it out of the urine when the second buzzer sound is heard.

That is, the test strip is immersed in urine for 0.5 seconds between the two beeps.

Next, it is determined whether the check mode is ■ or not (ST2
0). When switch 12 is turned on, it is Chesoto mode ■, and in this case, the standard stick is used.
There is no need to soak the test strip in urine, so skip 5T21 and move on to 5T22. On the other hand, in measurement mode and check mode I, it is necessary to soak the test strip in urine.
A 30 second timer is started and a 30 second countdown begins (ST21). In this case, as shown in FIG. 5(h), the number "30" is displayed on the display section 3a (indicating 30 seconds) at the same time as the 2nd njT buzzer sounds.
The cassop mark is lit on the display section 3C. When one second has elapsed, the number on the display section 3a becomes 29, and the stick mark on the display section 3C becomes blinking, as shown in FIG. 5(1). From then on, until the 30 second tie J1 up, the numbers on the display 3a are 28.27.26.
,... is counted down and displayed.

During this time, the person taking the test applies the test strip pulled out of the urine to a Tissot Spaver or the like to absorb excess urine, and then inserts the stick into the test strip insertion section 9. It is desirable to perform this insertion before the display on the display section 3a becomes 10 or less.

Eventually, when the 30 second timer is fully engaged, the light emitting element 22 is turned on (ST22) and light is projected onto the test paper 25. The reflected light at this time is received by the light receiving element 23, and its output is read through the A/r) converter 29 (ST23). This read value is stored as a reaction value. This reaction value corresponds to the amount of reflected light after the test strip 25 reacts with urine. In CheckMot'■, instead of soaking Sti-7ri in urine and reacting it, 1. ! l! Since the 4t stick is used, the read value in this case is a pseudo reaction value.

After reading the reaction value, the light emitting element 22 is turned off (5T24
), then the reflectance (ratio i1η), that is, (reaction value - dark zero value)/(blank value - dark zero value) force ratio 1 is calculated (S'F25). Next, it is determined whether the check mode flag is on or not (ST26), but in the measurement mode, this determination is No, and then it is determined whether the reflectance is normal or not, that is, whether the reflectance is within a predetermined range. It will be judged. (ST
27).

If the reflectance is not normal, an error message should be displayed on the display section 3a (5T31) and a buzzer should be activated.
Make it louder and utter the arum (ST 32).

When the reflectance is normal at 5T27, that is, within a predetermined range, the corresponding urine sugar value is read out from the reflectance by referring to the detection V-ray table stored in the memory in the CPU 26, and the urine sugar value is determined. From 1±, 4, ++, etc.゛I
A fixed purchase price is calculated (ST28).

Then, the urine sugar level is displayed on the display section 3a as ``1'constant'' A.
(ll'f 4 display section 31) (sT29).

An example of the display is shown in FIG.

After displaying the measurement results, the buzzer 10 is turned on for 1 second to notify the end of the measurement (ST30).

After the completion, when the measurement switch 5 is turned on (ST36),
The process returns to ST6 and prepares for the next measurement.

In the case of check mode, 1) If either of the switches 11 or 12 is turned on, the judgment of ST26 becomes YES, and it is judged whether the reflectance is normal or not based on 3Jε (ST34), and the reflectance is Alarm occurs if the value falls within the specified range.
1. If the reflectance is within the predetermined range, that is, normal, the display unit 3 will be displayed as shown in Figure 7.
The reaction value and the inverse 1·j rate are alternately displayed in a (ST36).

In this example device, when measuring a blank value in the check mode, the dark zero value 1 and the blank value are displayed, and when measuring the reaction value, the reaction value and the reflectance are displayed on each letter. Test paper and circuit checks can be made.

However, in the above embodiment, the values are alternately displayed during both the blank value measurement and the reaction value measurement, and although this is desirable, it is also sufficiently practical to alternately display only the dark zero value and the blank value.

Further, in the above embodiment, the dark zero value and the blank value are alternately displayed in the check mode, but the present invention can also be applied to a device that does not have a check mode.

In addition, although the above embodiment described a urine sugar measuring device,
This invention is not limited to this, but can be broadly applied to biochemical measuring devices such as rrn sugar measuring devices that quantify substances in a biological sample by dipping a test strip in a biological sample and determining the degree of color reaction. Applicable.

(f) Effects of the Invention According to this invention, intermediate values other than quantitative values of substances such as dark upper 11 values and branch values are displayed alternately. The ti value is automatically displayed without providing a special key for displaying the ti value, and the ti value can be operated reliably by a very simple operation.

[Brief explanation of drawings]

FIG. 1 is a circuit block diagram of a urine sugar measuring device in which the present invention is implemented, FIG. 2 L1 is an external perspective view of the urinary sugar measuring device, and FIGS. 3 and 4 are diagrams of the same urine sugar measuring device. Figure 5 is a diagram showing the control flow, Figure 5 is a diagram showing a display example of the general operation process of the urine sugar measuring device, Figure 6 is a blank value measurement in check mode 1 of the intermittent 1j measuring device. Diagram No. 7171 is a diagram showing a display example for explaining the display operation of the time.
FIG. 3 is a diagram showing an example of a display for explaining the display ΦI and operation when measuring a reaction value of the urinary sugar measuring device. 3: Display, 9: Test strip insertion part, 22: Light emitting element, 23: Light receiving element, 25: Test paper, 26: CPU. Patent applicant Tateishi Electric Co., Ltd. Agent
Patent Attorney Shigeru Nakamura Shindai 5 ・Figure C G! a b3a 1゜ta''-fu Sepa E] I1 too. Day

Claims (1)

[Claims] (1) A test strip insertion section, a light emitting section that projects light onto the test paper attached to the test strip insertion section, a light receiving section that receives the light from the test paper, and the light receiving section before being immersed in the biological sample liquid. a ratio value calculation means for calculating a ratio value between the amount of light received from the test paper and the amount of light received from the reaction test paper after being immersed in the biological sample solution; In a biochemical measurement device including a substance quantification means for reading a substance value corresponding to a ratio value calculated by a ratio value calculation means and quantifying the substance value, a dark zero is the output of the light receiving unit when the light emitting unit is not driven. a storage means for holding and storing a blank value which is an output of a light receiving section due to light from a test paper before being immersed in a biological sample liquid when the light emitting section is driven; A biochemical measuring device comprising: a display means for displaying information.