JPS6247553A - Biochemical measuring instrument - Google Patents

Abstract

PURPOSE:To enable a measuring person to smoothly continue succeeding operations by making a symbol display corresponding to the stage of each prescribed state when the stage of said state is attained by the operation. CONSTITUTION:The symbols corresponding to requests are displayed 3 in the respective operation stages of, for example, the request for mounting test paper 25, the request for preparing a vital specimen liquid, the request for immersing the test paper 25 into the vital specimen liquid, etc. The measuring person, therefore, continues the measurement while understanding the contents of the succeeding operations by the symbol marks by viewing the display. The smooth operation is thus made possible without wavering in the operation. The light from a light emitting element 22 driven by an LED driver 27 according to the command from a CPU 26 is reflected by the paper 25 and is detected in a photodetector 23. The photodetection current of the element 23 is taken via a current/voltage converter 28 and an analog-to-digital converter 29 to the CPU 26. The value of the ratio between the quantities of the light detected from the test paper prior to the immersion into the vital specimen liquid and after the immersion is calculated and the material quantity such as urinal sugar value is quantitatively determined from the value of such ratio in the CPU 26.

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Industrial field of application This invention is applicable to biochemical applications such as urine sugar measuring devices, which quantify biochemical substances in a living body based on the degree of coloration after a test strip is immersed in a biological sample solution. Concerning a measuring device.

(B) Conventional technology A conventional urine sugar measuring device involves dipping a urine sugar test strip attached to the tip of a stick into urine, and shining light from a light-emitting part on the colored reaction. The amount of reflected light is received by the light receiving section, a signal corresponding to the amount of reflected light is extracted, and the urine sugar level is determined based on this signal. That is, in this type of urine sugar measuring device, first, an unreacted test strip that is not immersed in urine is irradiated with light, and the amount of reflected light obtained is measured for a predetermined period of time (e.g., 301 seconds) after the test strip is immersed in urine. Calculate the ratio of the amount of reflected light obtained by shining light on the object that has passed, and from this ratio value, read out the corresponding urine sugar value from among the urine sugar value data stored in advance corresponding to each ratio value. , urine sugar determination is performed.

(C) Problems to be Solved by the Invention In the urine sugar measuring device described above, from the operator's perspective, an unreacted test strip is prepared and attached to the test strip insertion section. Prepare a cup filled with urine for soaking.

Take out the test strip from the test strip insertion part and soak it in the urine in the cup. It requires quite a number of steps, such as taking out the test strip and reinserting it into the test strip insertion part within a predetermined time, and is not necessarily easy. Conventional urine sugar measuring devices use simple text displays to notify the operator of each operation step. .

In view of the above, an object of the present invention is to provide a biochemical measuring device that can be easily operated without errors.

(d) Means and Effects for Solving Problems The biochemical measurement device of the present invention includes a test strip insertion section, a light emitting section that projects light onto the test strip attached to the test strip insertion section, and a test strip inserted into the test strip insertion section. A ratio value calculation that calculates the ratio between the light receiving part that receives light from the paper, the amount of light received from the test paper before immersion in the biological sample liquid, and the amount of light received from the reaction test paper after being immersed in the biological sample liquid. means and
A substance value corresponding to each ratio value is stored in advance, and a substance value corresponding to the ratio value calculated by the ratio value calculation means is read out,
and a substance value quantification means for quantifying a substance value, a state of requesting that a test strip be attached to the test strip insertion section, a state of requesting preparation of the biological sample liquid, a state of requesting the preparation of the biological sample liquid, and a state of requesting the preparation of the biological sample liquid. It is comprised of a specifying means for specifying each of a plurality of operation steps such as a state requiring immersion, and a display means for displaying a symbol of the requested content of each state in correspondence with the plurality of specified states.

In this biochemical measuring device, when a state stage of each predetermined state is reached through operation, a symbol corresponding to that state stage is displayed on the display means, and the measuring person looks at the symbol display and performs the next operation. Understand what to do.

(E) Examples The present invention will be explained in more detail with reference to Examples below.

FIG. 2 is a perspective view of a urine sugar measuring device in which the present invention is implemented. This urine sugar measuring device 1 has a display 3, a power key switch 4, a measurement key switch 5 on the outer surface of a case 2, and is also provided with a buzzer 10.

In addition, a stick holder 6 is provided at the tip of the case 2, and when the button 7 is pushed downward, the lid 8 opens and the stick with the test strip affixed to the tip is vertically inserted into the test strip insertion section 9 from above. It is designed to be held in Also, case 2
Inside, the receiving/emitting part, electronic circuit part, battery, etc. are housed.

FIG. 1 is a circuit block diagram of the urine sugar measuring device 1. Components with the same numbers as in FIG. 2 indicate the same components.

The photoelectric detection unit 21 is composed of a light emitting element 22 and a light receiving element 23. Light from the light emitting element 22 is projected onto a test paper 25 on a stick 24 attached to the stick holding part 6, and is reflected. The light is received at 23.

The light emitting element 22 is driven by the LED driver 27 according to a command from the CPU 26 . Further, the light-receiving current flowing through the light-receiving element 23 is converted into a voltage signal by a current/voltage converter 28, converted into a digital signal by an A/D converter 29, and then taken into the CPU 26.

The CPU 26 has a built-in memory, and this memory stores various data for measuring urine sugar.

The CPU 26 controls the light receiving element 23 before dipping the test strip in urine.
A function to read the output of the light-receiving element 23, that is, a urine sugar reaction value, after a predetermined reaction time has passed after immersion in urine, and a function to read the output of the light-receiving element 23 before immersion in urine and the urine sugar reaction value. It has various functions, such as a function to calculate the urine sugar reflectance (ratio value) from this reflectance, a function to quantify the urine sugar value from this reflectance, and a function to output a sound signal from the buzzer 10.

In addition, in this urine sugar measuring device 1, when the power switch 4 is turned on, when the measurement switch 5 is turned on, the timing of dipping the test strip into urine and the timing of taking it out, and the timing of ending the measurement,
It is designed to be sounded by buzzer 10.

Further, the quantitative urine sugar value obtained by the CPU 26 is displayed on the display 3.

The display unit 3 includes a display section 331 that displays the urine sugar value numerically, a display section 3b that displays semi-quantitative symbols -1±, +, ++, . . . , and a display section 3b that displays stains (test strips) and cup marks. It also includes a display section 3C for instructing operations.

Next, the operation of the urine sugar measuring device 1 according to the above embodiment will be explained with reference to the flowcharts shown in FIGS. 3 and 4.

The power switch 4 is turned on, and processing such as clearing the memory of the CPU 26 is first performed.
) 1], all the display parts of the display 3 are
As shown in FIG. 5(b), it lights up (5T2) and the buzzer 10 turns on for 1 second (Sr3). Note that, before the power switch 4 is turned on, nothing is displayed on the display 3, as shown in FIG. 5(a). By lighting up all of the above display units, a function check of the display units is being performed.

Next, it is determined whether the mode is check mode (Sr4). When the check mode is set to 0 in the device, the check mode flag is set (Sr5), but in the normal measurement mode, the determination of Sr4 is NO, and then it is determined whether the battery is low (Sr1 ). If the voltage of the battery is lower than the specified value, it is determined that the battery is in a low state, and a mark indicating a low state is displayed on the display section 3C (Sr
43), after 30 seconds (Sr44), auto power off (Sr45). When the voltage of the battery is above the specified value, the judgment of Sr1 is NO, and then the process moves to Sr7.
A request for a stick (test strip) set is displayed. This display is performed by blinking a stick mark on the display section 3C as shown in FIG. Insert the test strip into the test strip insertion section 9.

Then, the measurement switch 5 is turned on.

The device continues to flash the stick mark until the measurement person turns on the measurement switch 5 (Sr7.5T8).
, when the measurement switch 5 is turned on, as shown in FIG. 5(d), the stick mark is lit continuously and the output of the light receiving element 23 with the light emitting element 22 not lit is transmitted to the A/D converter. 29. The read value at this time is stored as a dark zero value (Sr9). This dark zero value is used in check mode.

Subsequently, the light emitting element 22 is turned on, the test paper 25 is irradiated with light (STIO), and the output of the light receiving element 23 at this time is read through the A/D converter 29. This read value is stored as a blank value. This blank value corresponds to the amount of light reflected by the test paper 25 before the reaction.

After reading the blank value, the light emitting element 22 is turned off (ST
12) Determine whether the check mode flag is turned on (ST13). Since this flag is not turned on in the measurement mode, the determination in 5T13 is No, and then it is determined whether the measured value is normal, that is, whether the blank value - dark zero value is within a predetermined value (ST14). .

If the measured value is not normal, an error message is displayed on the display section 3a (5T40) and the buzzer 10 sounds to issue an alarm (Sr41). The measurer notices the abnormality, replaces the stain, etc., and presses the measurement switch 5 for re-measurement (Sr42).
Return to r1.

If the measured value is normal at 5T14, then the process moves to 5T15, where a request to prepare a urine cup is displayed.

This display is performed by blinking a cup mark on the display section 3C, as shown in FIG. 5(e). Seeing this flashing cup mark, the person taking the measurement prepares a cup filled with urine. Then, the measurement switch 5 is turned on.

The device continues to flash the cup mark until the measurement switch 5 is turned on (ST15.5T16), but when the measurement switch 5 is turned on, the buzzer 10 makes a sound for 0.1 seconds in order to receive a countdown. At the same time, as shown in FIG. 5(f), a clock mark and a 5.
The number "5" indicating the second is displayed, and the cup on the display section 3C is lit continuously.

After that, a 5 second countdown is performed (ST17
). Every second, the numbers on the display 3a change to 5-4-3.
It changes as -2-... This 5 second currant is
This is done in preparation for dipping the test strip in urine.

At 5T15, the measurement switch 5 is turned on, and when 5 seconds have passed, the number on the display 3a changes to 0, as shown in FIG. 5(g).
At the same time, a stick mark and a cup mark are displayed on the display section 3C. These display marks just indicate that the stick should be placed in the cup and require that the test strip be dipped into the urine (ST18). Then, a buzzer sound indicating the urine immersion timing is sounded for 0.2 seconds, and after 0°5 seconds, a buzzer sound indicating the timing to take out the test strip from the urine is output for 0.2 seconds (SrI2
). The tester listens to the previous buzzer sound and dips the test strip into the urine, and then pulls it out of the urine when the second buzzer sound is heard.

That is, the test strip is immersed in urine for 0.5 seconds between the two beeps.

Next, it is determined whether the check mode ■ is in effect (ST20
), but this judgment is N in measurement mode.

Then, a 30 second timer is started and a 30 second countdown begins (ST21). In this case, as shown in FIG. 5(h), at the same time as the second buzzer sounds, the number "30" is displayed on the display section 3a (indicating 30 seconds), and a cup mark is displayed on the display section 3c. is lit in dimmer mode. Subsequently, after one second has elapsed, the number on the display section 3a becomes 29, and the stick mark on the display section 3c lights up in decreasing numbers, as shown in FIG. 5(1). From then on, the numbers on the display 3a will be 28.27.26 until the 30 second time amplification.
... is counted down and displayed.

During this time, the person taking the test applies the test strip pulled out of the urine to tissue paper or the like to absorb excess urine, and then inserts the stick into the test strip insertion section 9. It is desirable to perform this insertion before the display on the display section 3a becomes 10 or less.

When the 30 second timer eventually counts up, the light emitting element 22 is turned on (ST22) and light is projected onto the test paper 25. The reflected light at this time is received by the light receiving element 23, and its output is read through the A/D converter 29 (ST23). This read value is stored as a reaction value. This reaction value corresponds to the amount of reflected light after the test strip 25 reacts with urine.

After reading the reaction value, the light emitting element 22 is turned off (ST24).
), followed by the reflectance, i.e. (reaction value - dark zero value)/
(Blank value - Dark zero value) is calculated (ST25
). Next, it is determined whether the check mode flag is on or not (ST26), but in the measurement mode, this determination is No, and then it is determined whether the reflectance is normal or not, that is, whether the reflectance is within a predetermined range. It will be judged. (ST27).

If the reflectance is not normal, an error message is displayed on the display section 3a (5T31), and the buzzer 10 sounds to issue an alarm (ST32).

When the reflectance is normal at 5T27, that is, within a predetermined range, the corresponding urine sugar value is read out from the reflectance by referring to the calibration curve table stored in the memory in the CPU 26, and one value is calculated from that urine sugar value. Semi-quantitative values such as 1±, +, ÷+, etc. are calculated (ST28).

Then, the urine sugar value is displayed on the display section 3a, and the semi-quantitative value is displayed on the display section 3b (ST29). An example of the display is shown in Figure 5 U)
It is shown in

After displaying the measurement results, the buzzer 10 is turned on for 1 second to notify the end of the measurement (ST30).

After the completion, when the measurement switch 5 is turned on (ST36),
The process returns to Sr1 and prepares for the next measurement.

In addition, in the case of check mode, 5T13 or 5T2
6 is YES, and the process moves to the check process, but since it is not important to this invention, it is only described in the flowchart and the explanation will be omitted.

In addition, in the above embodiment, the test strip is dipped in urine and the buzzer sounds twice to notify the timing to take it out, but when the time comes to dip the test strip, the buzzer sounds and the buzzer continues to operate. , the buzzer may be turned off at the timing when the test strip is removed from the urine.

In addition, although the above embodiment described a urine sugar measuring device,
This invention is not limited to this, but can be widely applied to biochemical measurement devices such as blood sugar measuring devices that quantify substances in a biological sample by dipping a test strip into a biological sample and determining the degree of color reaction. can.

(F) Effects of the Invention According to the present invention, requests such as a request to attach a test strip, a request to prepare a biological sample solution, a request to immerse a test strip in a biological sample solution, etc. can be handled at each operation stage. Since the symbol to be used is displayed on the display means, the measurer can continue the measurement by looking at this display at each step and understanding the next operation using the symbol mark, without getting confused about the operation. , you can continue operating smoothly.

[Brief explanation of drawings]

FIG. 1 is a circuit block diagram of a urine sugar measuring device in which the present invention is implemented, FIG. 2 is an external perspective view of the urine sugar measuring device, and FIGS. 3 and 4 are FIG. 5, which is a diagram showing the control flow, is a diagram showing an example of display during the operation process of the urine sugar measuring device. 32 Display, 9: Test strip insertion section, 22: Light emitting element, 23: Light receiving element, 25: Test strip, 26: CPU Figure 4 Figure 5 Procedure amendment 1 ((voluntary) November 29, 1985 Day

Claims (1)

[Claims] (1) A test strip insertion section, a light emitting section that projects light onto the test paper attached to the test strip insertion section, a light receiving section that receives the light from the test paper, and the light receiving section before being immersed in the biological sample liquid. a ratio value calculation means for calculating a ratio value between the amount of light received from the test paper and the amount of light received from the reaction test paper after being immersed in the biological sample solution; In a biochemical measurement device including a substance quantification means for reading a substance value corresponding to a ratio value calculated by a ratio value calculation means and quantifying the substance value, a state in which a test strip is requested to be attached to the test strip insertion part; identification means for specifying each of a plurality of operation steps, such as a state of requesting preparation of the biological sample solution, a state of requesting immersion of the test strip in the biological sample solution, and a specifying means corresponding to the plurality of specified states; , and display means for symbolically displaying the required contents of each state.