JPS62402A - Fungicidal composition - Google Patents

Abstract

PURPOSE:To provide a fungicidal composition useful to prevent the microbial problems of industrial water system and products for general industry, by compounding tetrahalogenated isophthalonitrile with a dibromide or bronopol. CONSTITUTION:The objective composition can be produced by compounding (A) tetrahalogenated isophthalonitrile exhibiting remarkable effect against mold but having insufficient activity to bacteria with (B) dibromide (2,2-dibromo-2- cyanoacetamide) or bronopol (2-bromo-2-nitropropane-1,3-diol) exhibiting low activity against mold among microorganisms or using the above components in combination. The ratio of (A) to (B) is 1:4-4:1. The weak points of the components are diminished and a synergistic effect is attained by the combined use of both components.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a sterilizing composition used mainly for preventing microbial damage occurring in industrial water supply and for preventing microbial damage to general industrial products.

[Conventional technology]

In the white water system of the paper manufacturing process and the cooling water system of chemical plants, microorganisms grow using organic matter mixed in the water as a nutrient source, causing unpleasant odors, deterioration of product quality due to slime generation and peeling, and the need for continuous operation for cleaning. This causes troubles such as shutdowns and reduced cooling efficiency, resulting in significant damage. In addition, in general industrial products, microbial damage often occurs depending on the raw material composition and storage conditions of the product, and its control is important.

Conventionally, metallic compounds, mainly organic mercury agents, have been used as control measures for these diseases, but due to their strong toxicity to humans and animals and environmental pollution, in recent years non-metallic compounds have become more popular (known and used). There is.

For example, 2,2-dibromo-2-cyanoacetamide (hereinafter referred to as dipromide) is
Known as an antimicrobial agent in the specification of the publication, 2-bromo-
2-Nitropropane-1,3-diol (hereinafter referred to as Pronopol) is also known as an antimicrobial agent in Japanese Patent Publication No. 8917/1983. Furthermore, tetrahalogenated isophthalonitrile is also known to be effective as an exterminator for pests inhabiting the agricultural and horticultural fields (% Kosho 41-
11358 publication specification).

[Problems to be solved by the present invention]

However, both of these drugs pose problems when used alone. This is because chloromide and pronopol have low efficacy against filamentous fungi among microorganisms, and cannot be sufficiently effective in paper mills that use used paper raw materials that are prone to troubles mainly caused by filamentous fungi. Furthermore, unlike chloromide and pronopol, tetrahalogenated isophthalonitrile is highly effective against filamentous fungi among microorganisms, but is not sufficiently effective against bacteria.

As a result of intensive research aimed at compensating for the above-mentioned drawbacks of chloromide and pronopol and developing a more powerful and safe drug, the present invention has been developed by using tetrahalogenated f:/7 talonitrile in combination with chloromide or pronopol. We discovered a surprising effect that cannot be estimated from the use of single agents, that is, the characteristic properties of each agent are not simply additive, but the weak points of each agent are reinforced and act synergistically. .

[Means for Solving the Problems] The sterilizing composition of the present invention contains tetrahalogenated isophthalonitrile and chloromide or pronopol as active ingredients.

Examples of the tetrahalogenated isophthalonitrile used in the present invention include the following compounds.

Tetrachloroisophthalonitrile (hereinafter referred to as TPN)
.

5-chloro-2,4,6-drifluoroisofucronitrile (hereinafter referred to as CFPN).

In the germicidal composition of the present invention, an effective effect can be obtained when tetrahalogenated isophthalonitrile and chloromide are combined with pronopol. Forms of preparation include water-soluble liquid preparations with the addition of solvents, surfactants, solid fillers, and other adjuvants.
It is preferable to use it as an emulsifiable liquid, an aqueous phase agent, a granule, or a flowable formulation.

When preparing a water-soluble solution, the active ingredients tetrahalogenated isophthalonitrile, chloromide, and pronopol are sufficiently dissolved in a bath, and a solvent that is compatible with water is used.

As this solvent, amides such as N,N-dimethylformamide, ethylene glycol, diethylene glycol,
polyethylene glycol, polypropylene glycol,
Examples include polyhydric alcohols such as polyethylene glycol monomethyl ether and their derivatives, ketones such as acetone, isophorone, and cyclohexanone, and dimethyl sulfoxide, and each can be used alone or in combination. In addition, when adding a surfactant for the purpose of increasing dispersibility in water or in the product, anionic surfactants,
Nonionic surfactants and their combinations are selected and applied depending on the solvent used and the method of use.

When preparing as an emulsifiable liquid, benzene, xylene, hydrocarbons such as dissolved oil, 1+L1-)! Add a solvent such as a halogenated hydrocarbon such as J chloroethane, and a surfactant. Surfactants necessary for emulsification include anionic,
It is applied selectively depending on the solvent used, such as nonionic, anion-nonionic mixture, etc.

When preparing as wettable powders, granules, and flowable preparations, solid extenders such as clay, calcium carbonate, and white carbon, and surfactants are blended, then finely ground, and formulated into the respective dosage forms.

Although it is convenient to use the active ingredients of the present invention as a mixed preparation, for convenience of use and stability, it is preferable to formulate them individually and at a component ratio of 1:4 to 4:1 at the time of use. If prepared in such a way, the same effect as a mixed preparation can be obtained.

〔Example〕

Next, the present invention will be described with reference to these examples.

Example 1 A water-soluble liquid preparation was obtained by mixing TPNS, 15 parts of chloramide, and 80 parts of polyethylene glycol 7-methyl ether.

Example 2 0 parts of CFPNl, 10 parts of chloramide, 23 parts of Tsurpol
An emulsifying agent was obtained by mixing 5 parts of 64 (surfactant manufactured by Toho Chemical Industry Co., Ltd.), 25 parts of polyethylene glycol Luna 200, and 50 parts of xylene.

Example 3 An emulsifying liquid preparation was obtained by mixing 5 parts of TPNl, 5 parts of dipromide, 5 parts of Tsurpol 800 (a surfactant manufactured by Toho Chemical Industry Co., Ltd.), 15 parts of polyethylene glycol monomethyl ether, and 60 parts of xylene.

Example 4 CFPNB part, Dipromide 12 parts, Demol N (manufactured by Kao Soapware) 2 parts, Carplexna 80 (Shionogi & Co., Ltd.)
A water phase agent was obtained by mixing and pulverizing 2 parts of Kunilite φ250 (manufactured by Kunimine Mineraka Kogyo) and 71 parts of clay.

Example 5 A water-soluble liquid preparation was obtained by mixing 0 parts of TPNl, 10 parts of Pronopol, and 80 parts of polyethylene glyco-77 monomethyl-te2.

Example 6 A water-soluble liquid preparation was obtained by mixing 4 parts of CFPN, 16 parts of Pronopol, 40 parts of polyethylene glycol monomethyl ether, and 40 parts of cyclohexanone.

Example 7 TPN 8 parts, Pronopol 12 parts, Tsurupol 800A
An emulsifying liquid preparation was obtained by mixing 5 parts of surfactant (manufactured by Toho Chemical Industry ■), 10 parts of cyclohexanone, and 65 parts of xylene.

Example 8 Part CFPNJ, 16 parts of Pronopol, 2 parts of Demol N (surfactant manufactured by Kao Soap ■), 2 parts of Carplex φ80 (white carbon manufactured by Shionogi & Co., Ltd.), Kunilite ÷ 2
50- (manufactured by Kunimine Mineraka Kogyo ■) and 71 parts of clay were mixed and ground to obtain an aqueous phase agent.

〔Effect of the invention〕

The sterilizing composition of the present invention has antibacterial activity over a wide range of industrially harmful microorganisms, regardless of whether they are filamentous fungi or bacteria, and its effective concentration is unexpectedly low.

The sterilizing composition of the present invention is mainly used as an agent for preventing microbial damage in systems that use a large amount of water, such as industrial water systems, such as paper manufacturing processes, industrial cooling water systems, and cooling water systems for air conditioning in buildings.
Furthermore, it can be used as an agent for preventing microbial damage in one-stage industrial products such as water-based paints for construction, paper coating paints in paper mills, metal processing oils, and thickeners such as starch and casein.

Next, the effects of the sterilizing composition of the present invention will be explained by giving test examples.

Test example 1 The degree of slime generation was measured using the following test method.

Test method: A temperature control device, a stirrer, and a thermometer were installed in a glass water tank measuring 20 mm in length (:! IL 1 and 30 mm in width and 20 holes in depth), and a slime amount measuring plate was placed in a glass tank measuring 20 mm in width, 20 mm in length, and 20 mm in thickness. L
5C! Two sheets of n lauan material were attached vertically. White water collected from the paper manufacturing process (pulp concentration 0.11%) is placed in this tank.
10 t of water was added thereto, and the test chemicals shown in Table 1 were added to the white water so that the amount of active ingredients was 1 ppm. 7
After 1 day, the weight of the slime attached to the slime attachment plate was measured and the effectiveness was determined. Table 1 shows the slime weight after 7 days, together with the composition of the disinfectant composition. The slime weight in the table is 2
This is the average value of the amount of slime attached to the measurement plates.

Table 1 Test Example 2 A vinyl acetate synthetic resin emulsion paint (vinyl acetate resin, concentration 45 cm) was prepared by adding 1 g of the same rotten emulsion paint as an inoculum, and this was divided into 4 categories. So ppm of each of the drugs shown in Table 2 was added as an active ingredient, and the mixture was stored sealed at 35°C.

After measuring the number of bacteria every week, 1 ml of spoiled emulsion was added and continued to be stored at 35°C. The results are shown in Table 2.

Table 2

Claims (1)

[Claims] A sterilizing composition comprising tetrahalogenated isophthalonitrile and 2,2-dibromo-2-cyanoacetamide or 2-bromo-2-nitropropane-1,3-diol as active ingredients.