JPS6230783B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a drug solution container that can be used in an oversized artificial kidney device. To be more specific, it can be used in an oversized artificial kidney device that also has the functions of an equalizer and a drug solution container that can be used to supply a treatment solution with a medical solution equivalent to the amount of liquid discharged from the oversized device of the oversized artificial kidney device. Concerning liquid medicine containers.

Hypermorphic artificial kidney devices are still in the realm of research and development. Among the oversized artificial kidney devices that have been introduced so far, the liquid to be processed, such as blood, is separated into a processed liquid containing many blood cell components and a plasma liquid containing waste products using a sieving device, and the liquid is used as waste liquid. For those that replenish the chemical solution equivalent to the amount of waste solution, as shown in FIG. 1, two check valves 16 and 17 are installed in series in the waste solution means, and a Two check valves 20 and 21 are installed in series in the liquid replenishing means 11, which measures the waste liquid with a syringe 18 connected to the syringe 18, and supplies the chemical liquid 4 from the chemical liquid bottle 19 to the processing liquid return means 12. A syringe 22 of the same type as described above is connected between the valves 20 and 21, and is connected to a pump mechanism 23 of the syringe so that the two syringes 18 and 22 operate simultaneously, so that when one syringe sucks liquid, the other syringe The check valves in the same circuit alternately open and close according to the reciprocating movement of the syringe so that the syringe also aspirates the drug solution 4, and conversely, when one syringe discharges the solution, the other syringe also discharges the drug solution. It was something to do.

As a result, the liquid is intermittently suctioned and discharged, and the chemical solution is also intermittently suctioned and discharged, and is supplied to the processing liquid return means.

In this oversized artificial kidney device, a check valve,
It is difficult to remove air bubbles in the circuit with a syringe, etc., and air bubbles are easily mixed in with the syringe from the close contact between the gasket and the outer cylinder due to the reduced pressure during suction, and if air bubbles are mixed in, the measured liquid and drug solution are equivalent. Instead, this resulted in an accumulated error and a disadvantage in that there was a difference between an overdose and the amount of drug solution.

Further, since the syringe is operated in batches by reciprocating, even if there is no air bubbles mixed in, unless the two syringes and their movements are exactly the same, cumulative errors will occur.

Furthermore, since the chemical solution is discharged from the syringe and supplied to the processing liquid intermittently, the processing liquid diluted with the chemical liquid has the disadvantage that the blood cell concentration becomes uneven over time.

In addition, the introduction of air bubbles into the syringe poses a risk of contamination or air blockage within the circuit.

Furthermore, it requires a replenishing fluid bottle, a check valve, a syringe, and a power mechanism, resulting in a complicated structure and associated troubles.

An object of the present invention is to provide a drug solution container that can be used in an oversized artificial kidney device that solves these drawbacks, simplifies the device, and prevents troubles from occurring.

What achieves the above object is a drug solution container that can be used to supply a treatment solution with a drug solution equivalent to the excess amount discharged from the oversized artificial kidney device, the container being made of three soft plastic sheets. It is a hollow plastic body having an opening formed by laminating the above three layers, leaving one part and sealing the other, and whose internal volume does not change due to an increase in internal pressure.
A sheet located between the two sheets divides the hollow body into a first chamber in which the chemical liquid is stored and a second chamber into which the liquid is introduced, and forms a deformable diaphragm. The opening of the body forms the opening of each of the first chamber and the second chamber, and each opening of each chamber is provided with at least one mouth. It is.

Furthermore, to explain in detail what achieves the above purpose, it has an opening formed by laminating three soft plastic sheets, leaving one part open and sealing the other, and is able to withstand increases in internal pressure. It is a hollow body made of plastic whose internal volume does not change, and the sheet located between the three sheets divides the hollow body into a first chamber in which the medicinal solution is stored and a second chamber into which the liquid is introduced. partitioning and forming a deformable diaphragm; further, the opening of the hollow body forms an opening of each of the first and second chambers, and at least one A filtration vessel comprising a chemical liquid container provided with a mouth, a chemical liquid filled in a first chamber of the container, and a mouth of the first chamber connected to a means for introducing a liquid to be treated, a means for returning a treated liquid, and a means for discharging the liquid. a second liquid replenishing means connected to the processing liquid return means;
This is an oversized artificial kidney device in which the mouth of the chamber is connected to the waste liquid means of the overflow device, and when the liquid is introduced into the second chamber, a medicinal solution corresponding to the amount of introduced liquid is discharged.

The material of the plastic hollow body is polyethylene,
It is formed from thermoplastics such as polypropylene, polyvinyl chloride, and ethylene-vinyl acetate copolymer.

Depending on the characteristics and thickness of the plastic mentioned above, if the internal volume of the hollow body does not change in response to an increase in internal pressure, the hollow body will remain as it is, but if it is a flexible bag that expands in response to an increase in internal pressure, it will expand to the outside. It may also be provided with a shell whose internal volume does not change as the bag expands.

The material of the diaphragm is a deformable material, such as a flexible thermoplastic such as polyethylene, polypropylene, polyvinyl chloride, or ethylene-vinyl acetate copolymer, or a thin film-forming elastic material such as rubber or latex. The drug solution is, for example, a physiological saline solution, an electrolyte solution, an extracellular fluid replenisher such as an electrolyte-glucose solution, purified plasma, or the like.

The material of the mouth portion may be the same as the thermoplastic of the hollow body, and is preferably the same as at least the inner material of the hollow body in view of processability.

Hereinafter, one embodiment of the present invention will be described in detail with reference to the drawings.

The drug solution container 1 is made by laminating three sheets 2, 3, 2 made of polyvinyl chloride, which is a material with low elasticity, for example, and opening one end and high-frequency welding the other periphery to form a hollow body 2, 2 made of sheets on both sides. Diaphragm 3 of the intermediate sheet
The bag is made into a bag having two chambers, the first chamber is filled with a chemical solution 4, air is excluded from both chambers, and a cylindrical opening 5 made of polyvinyl chloride with an H-shaped cross section, for example, is easily connected to the means described below. 6 is held one by one at the open end of each chamber, and the bags 2, 3, 2 and the openings 5, 6 are welded together by high frequency.

The drug solution container 1 may be desirably sterilized together with the drug solution 4 using high-pressure heated steam.
The drug solution may be aseptically dispensed into containers sterilized with ethylene oxide gas.

The liquid to be treated introduction means 13 has a cannula at one end of a plastic tube, the other end of which is connected to the strainer 7, and a roller pump 14 for pumping the liquid to be treated is provided in the middle of the tube. The processing liquid return means 12 has a cannula at one end of a plastic tube, and the other end is connected to the strainer 7.

The liquid waste means 8 has one end of a plastic tube connected to the strainer 7, and the other end connected to the opening 6 of the chemical liquid container 1.
roller pump 9 in the middle of the tube.
has been established.

Further, the water removal means 10 has one end of a plastic tube connected to the liquid waste means 8, and a water removal roller pump 15 is provided in the middle of this tube.

The liquid replacement means 11 is made of a plastic tube, and one end is connected to the opening 5 of the chemical solution container 1, and the other end is connected to the processing liquid return means 12. This means 11 may include a drip tube installed in the middle of the tube to measure the amount of replacement fluid, if necessary.

The liquid to be treated, such as blood, is supplied from the cannula of the liquid to be treated introduction means 13 and sent to the overflow vessel 7 which is pressurized by a roller pump 14 .

The blood in the filtration device 7 is separated through a filter provided in the filtration device 7 into a treatment liquid containing many blood cell components and a plasma liquid containing waste products. The liquid is sent to waste liquid means 8.

The liquid in the waste liquid means 8 is pumped to the chemical liquid container 1 by a roller pump 9.

The liquid force-fed into the drug solution container 1 pushes and deforms the diaphragm 3, and the same amount of drug solution 4 as the amount of the liquid is transferred to the fluid replacement means 1.
1 to the processing liquid return means 12. The treatment liquid return means 12 mixes the treatment liquid containing many blood cell components and the medical solution, and discharges the mixed liquid from the cannula. In this case, the amount of the mixed liquid of the processing liquid and the chemical liquid discharged is the same as that of the liquid to be treated, and the blood cell concentration is also the same.

Further, when a necessary amount of water is removed from this system, the roller pump 15 of the water removal means 10 is driven.

When removing water and replacing fluid at the same time, the roller pump is divided into two parts: one for water removal and one for fluid replacement.

Therefore, when the water removal means 10 operates, the amount of the returned mixed liquid decreases by the amount of water removed from the amount of the liquid to be treated, and the blood cell concentration increases.

In other words, the formula for the amount of liquid for each means is (Amount of liquid to be treated) = (Amount of liquid to be treated) + (Amount of liquid) (Amount of liquid) = (Amount of water removed) + (Amount of fluid for replacement fluid) (Amount of fluid for replacement fluid) = (Amount of chemical solution for replacement fluid) (Amount of returned mixed fluid) = (Amount of treated fluid) + (Amount of fluid for replacement fluid) Therefore, (Amount of returned mixed fluid) = (Amount of treated fluid) - (Amount of water removed) ) holds true.

In this manner, the amount of returned mixed liquid and its blood cell concentration can be freely controlled by operating the water removal circuit. next,
Another embodiment of the chemical liquid container 1 is shown in FIG.

When the container that comes into contact with the chemical solution in the drug solution container 1 is a stretchable plastic bag 2a whose internal volume is likely to change due to internal pressure, the outer volume of the bag is fixed by the hard plastic shell 2b. Changes in internal volume may be prevented.

As explained above, the drug solution container of the present invention is provided with a diaphragm so as to have two chambers in the hollow body whose internal volume does not change due to an increase in internal pressure, and if the first chamber is filled with a drug solution, the drug solution container and act as an equalizer.

In addition, since the drug solution container is sealed, unlike conventional syringes, air bubbles are not introduced into the circuit, and the fluid replacement means is not contaminated. No exchange errors occur when exchanging liquids and chemicals. In addition, the exchange of liquid and drug solution is not a batch operation using the reciprocating movement of a syringe as in the past, but the same amount of drug solution can be discharged based on the cumulative amount of liquid, so no cumulative error occurs. Fluid replacement is possible continuously, and the blood cell concentration in the returned mixed fluid is always uniform.

Furthermore, since the diaphragm deforms in a direction that balances the liquid pressure and chemical liquid pressure, there is no need to worry about damage.

Furthermore, in the present invention, the plastic hollow body is divided into two by a flat membrane-like diaphragm to form two chambers, and the liquid flows into one of the chambers (the second chamber), so that the liquid can flow in from the outside. can be easily confirmed. Furthermore, the diaphragm only deforms without needing to stretch, expanding the second chamber in proportion to the inflow of liquid, and causing the chemical liquid in the first chamber to flow out accordingly, so there is little risk of damage to the second chamber. Even if the chamber is damaged, the area most likely to be damaged is the periphery where the three sheets are fused together, so there is a risk that the liquid will leak outside and mix into the chemical solution in the first chamber. few. In addition, since the entire container is soft, air bubbles attached to the inside of the container after filling the first chamber with the chemical solution can be removed relatively easily by pressing or tapping from the outside of the container.

In addition, if the liquid does not flow into the container due to some reason (for example, blockage of the liquid inflow tube or leakage from the tube joint), the liquid can be easily delivered by pressing the container from the outside. .

In addition, since the drug solution container functions as a container and an equalizer, the oversized artificial kidney device can be made simpler and less likely to malfunction than in the past. Furthermore, the liquid accumulated in the container can be used as a material liquid for clinical tests, and can also be stored.

[Brief explanation of the drawing]

FIG. 1 is a circuit diagram showing a conventional example of an oversized artificial kidney device. FIG. 2 is a circuit diagram of an oversized artificial kidney device including a sectional view of a drug solution container that can be used in the oversized artificial kidney device of the present invention. FIG. 3 is a perspective view showing another embodiment of the drug solution container of the present invention. 1... Chemical solution container, 2... Plastic hollow body, 3... Diaphragm, 4... Chemical solution, 5, 6... Mouth part.

Claims (1)

[Scope of Claims] 1. A drug solution container that can be used to supply a treatment solution with a drug solution equivalent to the excess amount discharged from the oversized artificial kidney device, the container comprising three soft plastic sheets. It is a hollow body made of plastic that has an opening formed by stacking the sheets, leaving one part open and sealing the other, and whose internal volume does not change due to an increase in internal pressure. The sheet located in the hollow body divides the hollow body into a first chamber in which the medicinal solution is stored and a second chamber into which the liquid is introduced, and forms a deformable diaphragm, and furthermore, the opening of the hollow body is formed into a deformable membrane. 1. A drug solution container that can be used in an oversized artificial kidney device, characterized in that an opening is formed in each of a first chamber and a second chamber, and at least one opening is provided in each opening of each chamber.