JPS62281952A - Protective material for skin damage surface - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a skin damage surface protecting material for protecting damaged skin surfaces such as wounds, burns, eczema, frostbite, and sunburn. The present invention relates to a skin injury surface protecting material that has excellent adhesion, safety, moisture permeability, and flexibility, and is capable of satisfactorily protecting a skin injury surface without causing a rash or the like.

[Conventional technology]

Conventionally, when protecting the skin from a wound or burn, +11: Apply gauze or absorbent cotton to the injured surface and secure with adhesive tape (2) Apply an emergency medical adhesive pad to the injured surface (3) Soak it in water. The method used is to apply a piece of cloth to the damaged surface. However, (in method 11, as the wound is being repaired, the gauze or absorbent cotton gets entangled in the wound and re-injures the wound, and the gauze or absorbent cotton is held down with adhesive tape, so the adhesive of the adhesive tape may cause a rash.) Method (2) has problems such as the adhesive tape for emergency medical adhesive pads being wider than the pad, so the affixed part may come off or the adhesive tape may come off. death,
The method (3) has problems such as not being able to wear clothes over it, and it has been desired to improve these problems.

[Problem that the invention seeks to solve]

The object of the present invention is to remove the conventionally used skin Jf fil.
(The goal is to solve the problems of the X-plane protective material and to obtain a safe product that has a high healing effect and causes less pain.

[Means for solving problems]

This object is achieved according to the invention by applying a gel composition containing a hydrophilic polymer and a polyhydric alcohol to the support.

The hydrophilic polymer is preferably one that forms a colloidal suspension in a polyhydric alcohol, such as alginic acid,
Gum talacant, gum arabic, gum karaya, gelatin, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid or a salt thereof, polyethylene oxide, carboxymethyl cellulose, and the like can be suitably used.

All commonly used polyhydric alcohols can be used, such as glycerin, sorbitol, propylene glycol, polyethylene glycol, di- or triethylene glycol, 1,3-propanediol, 1,4-butanediol, etc. One type or two or more types can be used.

The amount of the wood-loving polymer is 0.5 to 50% of the total gel composition.
% (weight %, the same applies hereinafter), particularly preferably 10 to 40%, and the amount of polyhydric alcohol blended is 0.5 to 40% of the entire gel composition.
It is preferable to set it as 809/6, and if it deviates from this range, the moisture retention property, adhesiveness, and softness|flexibility of a gel composition will deteriorate.

Although any support can be used, it is particularly preferable to use nonwoven fabric or gauze.

In the present invention, the damaged surface protecting material is obtained by mixing the above-mentioned hydrophilic polymer and polyhydric alcohol as they are, or by mixing them with water to prepare a gel composition, and applying this to a support. However, in this case, the amount of water can be 20 to 85% of the total gel composition, and by using the above-mentioned components, this gel composition has good shape retention even when a large amount of water is blended. It is something that has a nature. Also,
Gel compositions containing water may be heat-dried to remove moisture, or those with a reduced moisture content may also be suitably used as the protective agent of the present invention.

In addition, the above gel composition further includes benzethonium chloride,
Benzalkonium chloride, chlorhexidine gluconate,
Disinfectants such as cetylpyridinium chloride and Biosol, antihistamines such as chlorpheniramine maleate and diphenhydramine hydrochloride, local anesthetics such as dibucaine hydrochloride, lidocaine, pensicaine and virocaine hydrochloride, hemostatic agents such as ebilenamine hydrochloride, phenyleline hydrochloride and naphazoline hydrochloride; Active ingredients such as wound healing agents such as shikonin, ictamol, aloe, hinokitiol, glycyrrhizinic acid, and urea, excipients such as inorganic powders such as zinc oxide, hentonite, montmorillonite, and titanium oxide, etc. can be blended.

When the gel composition according to the present invention is spread and coated on a support, it is preferably spread and coated to a thickness of O91 to O511.

Depending on the wound, a large amount of 7ξ is produced,
If this exudate is trapped by the protective material and accumulated there, it may rot and fester.

In order to improve this point, a cut that does not reach the entire thickness of the support used in the present invention is made in advance, and by opening the cut as appropriate, a large amount of material that comes out from the wound surface can be used. It is also possible to prevent the exudate from accumulating by allowing the exudate to pass through and guide it to the outside of the protective material.

〔Example〕

Next, examples of the present invention will be described.

1 plate polyvinylpyrrolidone 3.0% glycerin 5.0% polyethylene glycol 400 5.0% zinc oxide
10.0% total
100.0% A gel composition having the above composition was uniformly spread and applied to a thickness of 1.0 mm on a non-woven fabric, and after air drying, it was sterilized with steam to obtain the skin I'f disintegration of the present invention. We were able to obtain the optimal face protection material, especially as a pain relief agent for skin harvest wounds caused by dermatome. We conducted an efficacy test for pain relief and obtained the following results.

(1) Method A dermatome skin harvest wound was selected as the target for use, and the same conditions were used for both the 15 layers of pharmacopoeial gauze for effect comparison and this protective material regarding the depth, width, location of the wound, age of the patient, etc. I chose it to be close to.

(11) As a result of comparing the degree of pain every 3.7 days after applying the results,
The results shown in FIG. 1 were obtained. (a) is when the protective material according to the present invention is used, and (b) is when 15 layers of pharmacopoeial gauze are used. As a result of dividing into two cases, it can be seen that the use of the protective material according to the present invention significantly reduces pain within one day.

Disaster Gai 1 Karaya Gum 5.0% Glycerin 10.0% Ethylene Glycol 3.0% Zinc Oxide
10.0% gelatin
3.0% total
t o o, o% The gel composition having the above composition is uniformly spread and applied on a nonwoven fabric to a thickness of 2.01 cm, heated and dried, and then sterilized with steam to obtain a Jf damaged surface protection material of the present invention. In particular, it was possible to obtain a material that was effective as a healing promoting material on the open side where red granulation was formed and exudate was reduced.

We conducted an efficacy test for its healing promoting function and obtained the following results.

(i) Method The hair of the rat was clipped with scissors, the skin surface was washed with soap and water, the skin was anesthetized, and a thickness of 25 mm was cut on both sides of the back using a dermatome.
/1000 inch, 10 rectangular scratches each measuring 7 x 10 squares were made. One of the wounds was covered with the protective material of the present invention, and the local wound was covered with five layers of localized local gauze, and the epithelialized area was measured every day to determine the epithelialization rate (healing rate).

(ii) Results The results shown in FIG. 2 were obtained as the epithelialization rate versus the number of days elapsed. a is when the protective material according to the present invention is used, b
1 shows the case of stacking 5 gauze layers, and it can be seen that the method of the present invention achieves a higher epithelialization rate in fewer days.

In addition, similar tests were conducted on the skin-damaged surface protective material of Example 1.2 above, which was heat-dried to remove moisture, or immersed in physiological saline for 1 to 2 minutes immediately before use. It was found to be effective.

Figure 3a shows an example of the pattern of cuts formed on the support, in which cuts discontinuously formed on a straight line are arranged parallel to each other, and the positions of the cuts are alternately shifted to form rows A and B. It is formed from. FIG. 4 is a cross section taken through the support at right angles to the longitudinal direction of the cut, and it can be seen that the cut 2 is formed with a depth t smaller than the total thickness d of the support 1. In Figure 3a, for example, if you pull along the position of the notch in the row A at right angles to the longitudinal direction of the notch and to both sides in the direction of arrow P, the notch at that position will tear, and the depth t in Figure 4 will be The total thickness d is reached and the third
r! ! The hole will be drilled as shown in Jb. Therefore, by selecting the pulling position, the aperture position and the number of apertures can be changed. Therefore, by changing the opening state of the incision depending on the amount of exudate on the wound surface, the exudate can be sufficiently permeated and the accumulation of exudate (which can cause suppuration) can be prevented. Can be done.

In Fig. 5, the size of the incision is as follows: 1 crane ≦ a (a') ≦ 10 crane 0.5 dragon ≦ b (b') ≦ 5 dragon 11 days ≦ c (c') ≦ 10 crane OB ≦ X Sa crane It is preferable that Note that the cut pattern is not limited to the one shown in FIG. 3a, and various combinations of straight lines or curved lines can be used.

〔Effect of the invention〕

According to the present invention, when applied to a damaged skin surface, the gel composition containing a hydrophilic polymer and a polyhydric alcohol has adhesive properties, so it blends well into the affected area, and is lightly covered with a bandage or the like. Because it only needs to be fixed as an auxiliary fixer, there is no rash caused by adhesive tape, etc., and since it uses highly safe ingredients, there will be no rash on the damaged surface or other areas. In addition, it has high moisture permeability, so it does not cause swelling of the affected area or swelling caused by swelling.It also has various advantages such as relieving pain without external or mechanical stimulation due to its flexibility. It is extremely effective in protecting damaged skin.

[Brief explanation of drawings]

Figures 1a and b are diagrams showing the test results of the pain relief effect of the protective material according to the present invention and the conventional one, and Figure 2 is a diagram showing the test results of the healing effect of the protective material according to the present invention and the conventional one. Figures 3a and 3b are explanatory diagrams of an example of the pattern formed on the support used in the present invention before and after opening, respectively, and Figure 4 is an example of the support used in the present invention. FIG. 5 is an explanatory diagram of the size of the pattern formed on the support. 1... Support body, 2... Notch. ＾118) Agent Patent Attorney Tomimura Tame Figure 1 (α) (b) Otsu Piece 7 Despicable Suggestion Loco with Pain Power Figure 2 Figure 4 Figure 5 (b) Δ

Claims (1)

[Claims] 1) A protective material for damaged skin, which is made by coating a support with a gel composition containing a hydrophilic polymer and a polyhydric alcohol.