JPS6226709B2 - - Google Patents
Info
- Publication number
- JPS6226709B2 JPS6226709B2 JP55129149A JP12914980A JPS6226709B2 JP S6226709 B2 JPS6226709 B2 JP S6226709B2 JP 55129149 A JP55129149 A JP 55129149A JP 12914980 A JP12914980 A JP 12914980A JP S6226709 B2 JPS6226709 B2 JP S6226709B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- paper
- methionine
- concentration
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008280 blood Substances 0.000 claims description 45
- 210000004369 blood Anatomy 0.000 claims description 45
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 22
- 239000003963 antioxidant agent Substances 0.000 claims description 14
- 229930182817 methionine Natural products 0.000 claims description 10
- 230000003078 antioxidant effect Effects 0.000 claims description 8
- 125000001741 organic sulfur group Chemical group 0.000 claims description 5
- 229960004452 methionine Drugs 0.000 description 21
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 12
- 229930195722 L-methionine Natural products 0.000 description 12
- 244000063299 Bacillus subtilis Species 0.000 description 10
- 235000014469 Bacillus subtilis Nutrition 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- YODZTKMDCQEPHD-UHFFFAOYSA-N thiodiglycol Chemical compound OCCSCCO YODZTKMDCQEPHD-UHFFFAOYSA-N 0.000 description 7
- 238000005534 hematocrit Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 201000011252 Phenylketonuria Diseases 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 2
- 108700022128 Hypermethioninemia Proteins 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 208000022837 disorder of methionine catabolism Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000008245 hypermethioninemia Diseases 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 125000000101 thioether group Chemical group 0.000 description 2
- QRQVZZMTKYXEKC-UHFFFAOYSA-N 3-(3-hydroxypropylsulfanyl)propan-1-ol Chemical compound OCCCSCCCO QRQVZZMTKYXEKC-UHFFFAOYSA-N 0.000 description 1
- 208000029751 Amino acid metabolism disease Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 108700028608 Histidinemia Proteins 0.000 description 1
- 206010021602 Inborn errors of amino acid metabolism Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 208000022877 amino acid metabolic disease Diseases 0.000 description 1
- 230000037354 amino acid metabolism Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000006599 histidinemia Diseases 0.000 description 1
- 208000014468 inherited amino acid metabolic disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229950006389 thiodiglycol Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/839—Bacillus subtilis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55129149A JPS5754864A (en) | 1980-09-19 | 1980-09-19 | Standard blood filtering paper for measurement of methionine |
| US06/300,753 US4367286A (en) | 1980-09-19 | 1981-09-10 | Reference blood filter paper for measuring the concentration of methionine in the blood |
| FR8117488A FR2490827A1 (fr) | 1980-09-19 | 1981-09-16 | Papier filtre temoin destine a mesurer la concentration de methionine dans le sang |
| DE3137237A DE3137237C2 (de) | 1980-09-19 | 1981-09-18 | Testblut-Filterpapier zur Verwendung als Standard bei der Messung der Methioninkonzentration im Blut |
| GB08128345A GB2114735B (en) | 1980-09-19 | 1981-09-18 | Reference filter paper for use in diagnosis of homocystinuria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55129149A JPS5754864A (en) | 1980-09-19 | 1980-09-19 | Standard blood filtering paper for measurement of methionine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5754864A JPS5754864A (en) | 1982-04-01 |
| JPS6226709B2 true JPS6226709B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-06-10 |
Family
ID=15002343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55129149A Granted JPS5754864A (en) | 1980-09-19 | 1980-09-19 | Standard blood filtering paper for measurement of methionine |
Country Status (5)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5860257A (ja) * | 1981-10-07 | 1983-04-09 | Fujirebio Inc | ヒスチジン測定用標準血液濾紙 |
| GB2216258A (en) * | 1988-03-31 | 1989-10-04 | Cambridge Biomedical Limited | Reconstitutable forms of chemical reagents |
| US5416025A (en) * | 1993-11-29 | 1995-05-16 | Krepinsky; Jiri J. | Screening test for early detection of colorectal cancer |
| CA2253093A1 (en) | 1998-11-06 | 2000-05-06 | Jiri J. Krepinsky | Screening test for early detection of colorectal cancer |
| US7177246B2 (en) * | 2003-09-12 | 2007-02-13 | Hewlett-Packard Development Company, L.P. | Optical disk drive focusing apparatus using sum signal |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3245882A (en) * | 1962-04-16 | 1966-04-12 | Guthrie Robert | Bacteriologic testing method and means therefor |
| FR1531232A (fr) * | 1966-07-16 | 1968-06-28 | Merck Ag E | Procédé et agents pour le diagnostic précoce de la phénylcétonurie, de la maladie du sirop d'érable et de l'hypervalinémie |
| US4031023A (en) * | 1976-02-19 | 1977-06-21 | The Lubrizol Corporation | Lubricating compositions and methods utilizing hydroxy thioethers |
| JPS5315485A (en) * | 1976-07-23 | 1978-02-13 | Ajinomoto Co Inc | Convenient determination of amino acids by bioassay |
-
1980
- 1980-09-19 JP JP55129149A patent/JPS5754864A/ja active Granted
-
1981
- 1981-09-10 US US06/300,753 patent/US4367286A/en not_active Expired - Fee Related
- 1981-09-16 FR FR8117488A patent/FR2490827A1/fr active Granted
- 1981-09-18 DE DE3137237A patent/DE3137237C2/de not_active Expired
- 1981-09-18 GB GB08128345A patent/GB2114735B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2114735A (en) | 1983-08-24 |
| GB2114735B (en) | 1984-08-22 |
| US4367286A (en) | 1983-01-04 |
| FR2490827A1 (fr) | 1982-03-26 |
| FR2490827B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-03-15 |
| DE3137237A1 (de) | 1982-06-03 |
| DE3137237C2 (de) | 1984-01-12 |
| JPS5754864A (en) | 1982-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees | ||
| S199 | Written request for registration of transfer of right |
Free format text: JAPANESE INTERMEDIATE CODE: R313199 |
|
| R370 | Written measure of declining of transfer procedure |
Free format text: JAPANESE INTERMEDIATE CODE: R370 |