JPS62260900A - Detergent composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to detergent compositions such as shampoos and kitchen detergents, and more particularly to hypoallergenic detergent compositions that stably contain enzymes and have enhanced detergency.

Background of the Invention Hypoallergenic detergent compositions have the property of suppressing rough hands, rough skin, dandruff, itching, etc., so they can be used as bases for kitchen detergents, liquid body cleansers, dandruff shampoos, baby shampoos, etc. It is suitable, but the drawback is that the cleaning power is weak.

For this reason, various attempts have been made to enhance the detergency by incorporating enzymes. Normally, the activity of enzymes is inhibited by the presence of anionic, cationic, or amphoteric surfactants, so they are processed into powders, capsules, granules, etc., or water-soluble polymers, buffer solutions, and specific nonionic surfactants. Although attempts have been made to enhance the cleaning power of hypoallergenic detergents by using them in combination with poorly water-soluble collagen agents, etc., to prevent inhibition of enzyme activity, they are expensive and do not provide sufficient cleaning power. However, the intended purpose has not been achieved.

The present inventor has conducted various studies to solve the above problems. As a result, it was discovered that a detergent containing a specific anionic surfactant and a specific enzyme provides a detergent composition that is hypoallergenic and has excellent detergency without deactivating the enzyme, and the present invention was completed. I ended up doing it.

DISCLOSURE OF THE INVENTION The present invention provides the following essential components: (a) Formula [I]: R' O503M CI+-0-(CH7Cl,0)n-C-CICII;
CO,M (1:1R.

[In the formula, R1 is an alkyl group having 7 to 18 carbon atoms or an alkenyl group having 7 to 18 carbon atoms; R, is hydrogen, and
0 alkyl group or alkenyl group having 1 to 10 carbon atoms;
However, the total number of carbon atoms of Ro and R3 is 7 to 28:n
is 0 to 20; M is an alkali metal, alkaline earth metal, N
114 or a cation derived from an alkanolamine] Anionic surfactant 1-10
% by weight and (b) one or more enzymes selected from the group consisting of lipase, pancreatin, and papain.

According to the detergent composition of the present invention, a hypoallergenic detergent composition that does not inhibit enzyme activity and has excellent detergency can be obtained.

Next, the results of evaluating the stability of lipase in samples prepared by blending lipase with various surfactants are shown.

The samples used were prepared according to conventional methods and published by Okta and Fujii, Journal of Biochemistry (J, Bi
Enzyme activity was measured by the method of J. Ochem), 61.313-319 (1967), and the inhibition rate was calculated based on the enzyme activity in a control without surfactant. The results are shown in Figure 1.

As is clear from FIG. 1, other surfactants inhibited the enzymatic activity of lipase, but the surfactant of formula (1) did not exhibit any inhibitory effect on the enzyme activity.

Next, the results of evaluating the stabilization of the enzymatic activity of lipase in samples prepared by blending lipase with the surfactant (2N) and combinations of various surfactants in various ratios are shown.

The samples used were prepared according to a conventional method, and the enzyme activity was measured using the same method as described above. The results are shown in Figure 2.

As is clear from FIG. 2, it was found that when the surfactant of formula CI) was added to various surfactants that suppress the enzymatic activity of lipase, the enzyme activity suppressing effect was reduced or eliminated. In particular, it has been found that the effect on polyoxychedylene alkyl ether sulfate is large.

Thus, the surfactant of formula [■] used in the cleaning composition of the present invention is blended in an amount of 1 to 10% by weight based on the total amount of the composition. One type of softanol may be used, or two or more types may be used in combination. If the blending amount is less than 10%, a sufficient enzyme stabilizing effect cannot be obtained;
If the amount is more than % by weight, there will be no effective change, but it will be expensive, which is not commercially preferable. Incidentally, the surfactant of the formula ([) used in the present invention is, for example, disclosed in JP-A-56-4
It is an anionic surfactant known from, for example, No. 3276. The cleaning composition of the present invention may further contain other anionic surfactants, and in that case, the total amount of surfactant using the surfactant of formula (1) is at least 10ff.
iff1% or more must be blended. The blending amount is 10
If the amount is less than % by weight, a sufficient enzyme stabilizing effect cannot be obtained.

As the enzyme, one or more selected from the group consisting of lipase, pancreatin, and papain is used, and the amount is 0.001 to 5% by weight, preferably 0.01 to 1% by weight. If the amount is less than 0.001% by weight, sufficient cleaning power will not be obtained, and if it is more than 5% by weight, the stability of the enzyme activity may deteriorate, which is not preferable.

Furthermore, the cleaning composition of the present invention may contain appropriate nonionic surfactants, amphoteric surfactants, preservatives, drugs, pigments, fragrances, water, etc., as necessary, to enhance cleaning power without inhibiting enzyme activity. It can be added as long as it does not cause any damage.

The cleaning composition of the present invention can be manufactured according to a conventional method, and can be made into a conventional formulation such as a shampoo, a kitchen detergent, or a cleaning agent for pets.

The detergent composition of the present invention thus obtained is hypoallergenic and has excellent detergency without inhibiting enzyme activity.

jukage shin Next, the present invention will be explained in more detail with reference to Examples.

Example 1 A shampoo was prepared according to a conventional method using the following formulation.

Ingredients Weight %Polyoxene ethylene (POE nimole) Sodium monoalkyl sulfosuccinate (alkyl carbon number 20)
5 Polyoxyethylene (POE: 3 mol) Sodium lauryl ether sulfate 5 Coconut oil fatty acid diethanolamide 4 Lipase powder
0.5 dyes and preservatives
trace fragrance
0.5 purified water
Remaining Example 2 A shampoo was prepared according to a conventional method using the following formulation.

Ingredients Weight % Polyoxyethylene (POE・7'mol) Sodium monoalkyl sulfosuccinate (alkyl carbon number 20)
8 Sodium lauryl sulfate
5 Coconut oil fatty acid diethanolamide
4 Pancreatin powder 0.3 Pigments and preservatives Minor fragrance
0.5 purified water
Remaining Example 3 A shampoo was prepared according to a conventional method using the following formulation.

Ingredients Weight % Polyoxyethylene (POE nimole) monoalkyl sodium sulfosuccinate (alkyl carbon number 20)
5α-olefin sodium sulfate (olefin carbon number 12) 3
Papain powder 0.1 Color and preservative Minor fragrance
0.5 purified water
Remaining Example 4 A shampoo was prepared according to a conventional method using the following formulation.

Ingredients Weight % Polyoxyethylene (POE nimole) monoalkyl sodium sulfosuccinate (alkyl carbon number 20)
32-Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine (alkyl carbon number 12) 5 Coconut oil fatty acid diethanolamide 4 Lipase powder
0.3 Colors and preservatives
trace fragrance
0.5 purified water
Remaining Example 5 A shampoo was prepared according to a conventional method using the following formulation.

・Ingredients Weight% Polyoxyethylene (POE・7 mol) Sodium monoalkyl sulfosuccinate (alkyl carbon number 20)
4 lauroyl sarcosine sodium
4 Yano oil fatty acid diethanolamide 4
Papain powder 0.055
Colors and preservatives Minor fragrances
0.5 purified water
Remaining Example 6 A shampoo was prepared according to a conventional method using the following formulation.

Ingredients Weight % Polyoxyethylene (POE nimole) monoalkyl sodium sulfosuccinate (alkyl carbon number 20)
5 Lauroyl-glutamic acid triethanolamine 4 Coconut oil fatty acid diethanolamide 4 Pancreatin powder 0.5 Pigments and preservatives
trace fragrance
0.5 purified water
Remaining Example 7 A shampoo was prepared according to the recipe according to the conventional method.

Ingredients Weight % Polyoxyethylene (POE: 3 mol) Sodium lauryl ether sulfate 4 Sodium lauryl sulfosuccinate 5 Coconut oil fatty acid diethanolamide 4 Lipase powder
0.5 Pigments and preservatives Trace amount of perfume 0.5 Purified water Remainder Example 8 A kitchen detergent was prepared according to the conventional method using the following formulation.

Ingredients Weight% Polyoxyethylene (POE nimolar) sodium lauryl ether sulfate 8 Sodium laurylbenzene sulfate 5 Papain powder
0.5 dyes and preservatives
trace fragrance
Micro-purified water Remaining Examples 9 to 17 and Comparative Examples 1 to 7 Next, the cleaning power (artificial contamination Tables 1 and 2 show the results of the evaluation of skin and eye mucosal irritation. All numbers in the table below mean % by weight.

(Cleaning power) Using the artificially contaminated cloth method, a 0.5% aqueous solution of the detergent composition was used to directly clean a cloth that had a certain amount of dirt attached to it, and the results were summarized in the following table 4 [! : ○...Good △...Slightly poor ×...Poor

(Irritation) Using 6 Hartley white guinea pigs, 50% of the sample
A primary skin irritation test was conducted by applying an aqueous solution as a test substance to the skin of guinea pigs, and the results were summarized as follows.
/1: (=)...No irritation (+)...Slight irritation (++)...Evidence of irritation was evaluated.

In addition, an eye mucosal irritation test was conducted using three white rabbits by administering 0.111 (!) of the sample stock solution to the eyelids, and the results were summarized as follows: )...Slight irritation observed (++)...Evaluation was made based on obvious irritation observed.

Regarding enzyme activity stability, regarding lipase, see Okuda and Fujii, Journal of Biochemistry (Okuda, Hand Fujii).

S, J. Biochem, )6, 313-319
(1967) for pancreatin using the method of D. Nim Shotton, Methods in Enzymology (Shotton, D. M., Meth, E.
nzymol, ) 11.113-140 (1970)
For papain, after hydrolyzing the protein with trichloroacetic acid, the ultraviolet absorption of the supernatant was
By measuring at 0 nm, the following standard: O...
Good X...Evaluation was made as poor.

The results are shown in Tables 1 and 2.

As is clear from Table 1, based on the present invention in which a specific enzyme was blended with the surfactant of formula [1],
No. 12 stabilizes enzyme activity and exhibits good detergency, but
Comparative Examples 1 and 2, which lack specific enzymes, had poor detergency, and the formula [N
Comparative Example 3, in which a specific enzyme was blended with a surfactant other than the surfactant mentioned above, exhibited suppressed enzyme activity and did not exhibit good detergency.

As is clear from Table 2, based on the present invention in which a specific enzyme was blended with a surfactant of the formula (IE), <Example 13
Comparative Example 4 in which a specific enzyme was blended with a surfactant other than the surfactant of formula (1), although Comparative Example 4 - 17 is not irritating to the skin and eye mucous membranes and stabilizes enzyme activity. -7, Comparative Examples 4 and 6 are irritating to the skin and ocular mucosa and suppress enzyme activity, and Comparative Example 7 is irritating to the ocular mucosa and suppresses enzyme activity. Comparative Example 5 suppresses enzyme activity that is not irritating to the skin and eye mucous membranes.

[Brief explanation of drawings]

Figure 1 is a graph showing the inhibitory effect of surfactants on enzyme activity, and Figure 2 is a graph showing the inhibitory effect on enzyme activity when the surfactant of formula [I] is added to other surfactants. be.

Claims (1)

[Claims] (1) As an essential component, (a) Formula [I]: ▲There are mathematical formulas, chemical formulas, tables, etc.▼[I] [In the formula, R_1 is an alkyl group having 7 to 18 carbon atoms or an alkenyl group having 7 to 18 carbon atoms. Group; R_2 is hydrogen, carbon number 1
~10 alkyl group or alkenyl group having 1 to 10 carbon atoms; however, the total number of carbon atoms of R_1 and R_2 is 7 to
28; n is 0 to 20; M means a cation derived from an alkali metal, alkaline earth metal, NH_4 or alkanolamine]; A cleaning composition comprising one or more enzymes selected from the group consisting of pancreatin and papain.