JPS62258671A - Blood storage tank - Google Patents
Blood storage tankInfo
- Publication number
- JPS62258671A JPS62258671A JP61101723A JP10172386A JPS62258671A JP S62258671 A JPS62258671 A JP S62258671A JP 61101723 A JP61101723 A JP 61101723A JP 10172386 A JP10172386 A JP 10172386A JP S62258671 A JPS62258671 A JP S62258671A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- foam
- storage tank
- defoaming
- mesh number
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims description 191
- 239000008280 blood Substances 0.000 title claims description 191
- 239000006260 foam Substances 0.000 claims description 53
- 230000017531 blood circulation Effects 0.000 claims description 14
- 230000003254 anti-foaming effect Effects 0.000 claims description 8
- 239000002518 antifoaming agent Substances 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 6
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 4
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229920005830 Polyurethane Foam Polymers 0.000 description 16
- 239000011496 polyurethane foam Substances 0.000 description 16
- 210000004072 lung Anatomy 0.000 description 15
- 239000012528 membrane Substances 0.000 description 14
- 239000012510 hollow fiber Substances 0.000 description 11
- 239000007789 gas Substances 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 238000005192 partition Methods 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
■ 発明の背景
（１）技術分野
本発明は、人工肺などに用いられる体外血液循環回路中
において血液を一時的に貯溜するための硬質部材にて形
成された貯血槽に関するものである。Detailed Description of the Invention ■ Background of the Invention (1) Technical Field The present invention relates to a blood storage tank formed of a hard member for temporarily storing blood in an extracorporeal blood circulation circuit used in an artificial lung or the like. It is related to.
具体的には、貯血槽の血液流入部に消泡部材を設けた貯
血槽に関する。Specifically, the present invention relates to a blood storage tank in which a defoaming member is provided at the blood inflow portion of the blood storage tank.
（２）先行技術およびその問題点
従来より、人工肺を体外循環回路中に用いるとき、貯血
槽を用いて、体外循環中の血液を備蓄し、気泡が流入し
た場合に除去したり、万一回路チューブ折れなどにより
循環血液量が誠少した時のために、血液を貯溜する。(2) Prior art and its problems Conventionally, when an artificial lung is used in an extracorporeal circulation circuit, a blood reservoir is used to store blood during extracorporeal circulation, and to remove air bubbles in case of an inflow, Blood is stored in case the amount of circulating blood decreases due to a broken circuit tube, etc.
一般的には、この貯血槽には軟質部材からなるクローズ
ドタイプ貯血槽と硬質部材からなるオープンタイプ貯血
槽とがあり、オープンタイプ貯血槽はブライミングおよ
び血液の貯血量の確認が容易であること、さらに、超音
波の発信および受信装置、また発光素子および受光素子
を用いた貯血爪検知が容易であることから多く用いられ
ている。また、人工肺との一体化も容易であり一体にす
ることにより回路構成が簡単になり、回路のセットアツ
プおよびプライミングそこで、貯血槽を一体に設けた人
工肺が提案されている（特開昭５９−５７６６１号）。In general, there are two types of blood reservoirs: a closed type blood reservoir made of a soft member and an open type blood reservoir made of a hard member.The open type blood reservoir is easy to brim and check the amount of blood stored. Furthermore, it is widely used because it is easy to detect blood-accumulated nails using an ultrasonic transmitting and receiving device and a light-emitting element and a light-receiving element. In addition, it is easy to integrate with an oxygenator, which simplifies the circuit configuration and allows for easy circuit setup and priming.Therefore, an oxygenator with an integrated blood reservoir has been proposed (Japanese Patent Application Laid-Open No. No. 59-57661).
そして、貯血槽に流入する血液中に含まれている気泡を
十分除去することが出来ないことより、消泡部材を設け
ることが考えられていた。Since air bubbles contained in the blood flowing into the blood reservoir cannot be sufficiently removed, it has been considered to provide a defoaming member.
しかし、その消泡部材には制約があり、十分な消泡効果
を有するものを用いると圧力損失が高くなり必要な血液
流量を得ることができなくなり、さらに血球に損傷を与
えるおそれもあり、逆に圧力損失を起こさない程度のも
のでは、十分な消泡効果、とくに細かい気泡の除去が行
えなかった。However, there are restrictions on antifoaming materials, and if one with sufficient antifoaming effect is used, the pressure loss will be high, making it impossible to obtain the necessary blood flow rate, and there is also the risk of damaging blood cells. However, if it does not cause a pressure loss, a sufficient defoaming effect, especially the removal of fine bubbles, cannot be achieved.
■ 発明の目的
本発明は、上記先行技術の問題点を解決した十分な消泡
能を有し、かつ圧力損失の少ない消泡部材を有する貯血
槽を提供することにある。(2) Purpose of the Invention The object of the present invention is to provide a blood storage tank having a defoaming member having sufficient defoaming ability and a low pressure loss, which solves the problems of the prior art described above.
上記目的を達成するものは、硬質部材により形成された
貯血槽であって、血液導入口と、該血液導入口と連通ず
る血液流入部と、該血液流入部と連通ずる貯血部と、該
貯血部の下部に設けられた血液排出口と、該貯血槽の上
方に設けられた該貯血槽内部と外部とを連通する連通口
２を有し、血液流入部には血液流入部の血液流路を横切
る消泡部材を設け、ざらに該消泡部材は、メツシュ数の
大きい発泡体とメツシュ数の小さい発泡体とで構成され
、かつ該２つの発泡体を前記メツシュ数の大きい発泡体
が前記血液導入口側となり前記メツシュ数の小さい発泡
体が前記貯血部側となるように並設させた貯血槽である
。What achieves the above object is a blood storage tank formed of a hard member, which includes a blood inlet, a blood inflow part communicating with the blood inlet, a blood storage part communicating with the blood inflow part, and the blood storage tank. It has a blood outlet provided at the lower part of the blood storage tank, and a communication port 2 provided above the blood storage tank that communicates the inside of the blood storage tank with the outside. A defoaming member is provided that crosses the foam defoaming member, and the defoaming member is roughly composed of a foam with a large mesh number and a foam with a small mesh number, and the foam with the large mesh number crosses the two foams. The blood storage tank is arranged in parallel so that the foam with the smaller mesh number is on the blood introduction port side and the foam is on the blood storage part side.
さらに、前記貯血槽が透明部材からなることが好ましい
。Furthermore, it is preferable that the blood reservoir is made of a transparent member.
また、前記消泡部材がウレタンフオームからなることが
好ましい。Further, it is preferable that the defoaming member is made of urethane foam.
さらに、前記消泡部材は、消泡剤がコーティングされて
いることが好ましい。Furthermore, it is preferable that the defoaming member is coated with a defoaming agent.
また、 前記消泡剤が、シリコーンであることが好まし
い。Moreover, it is preferable that the antifoaming agent is silicone.
■ 発明の詳細な説明
本発明の貯血槽を図面に示す人工肺、熱交換器を取り付
けた実施例を用いて詳細に説明する。(2) Detailed Description of the Invention The blood storage tank of the present invention will be described in detail using an embodiment shown in the drawings in which an oxygenator and a heat exchanger are attached.
本発明の貯血ｆｆＩ４は、硬質部材からなり、人工肺Ｉ
の血液流出口３と連通ずる血液流入部５と、血液流入部
５と連通する貯血部６と、貯血部６の下部に設けられた
血液排出口８と、上方に設けられた貯血槽４の内部と外
部とを連通ずる連通口２０とを有し、さらに血液流入部
５には血液流入１１８５の血液流路を横切るように消泡
部材７を設け、さらに消泡部材７は、メツシュ数の大き
い発泡体７ａとメツシュ数の小さい発泡体７ｂとで構成
され、かつそれら２つの発泡体をメツシュ数の大きい発
泡体７ａが人工肺Ｉの血液流出口３側となりメツシュ数
の小さい発泡体７ｂが貯血部６側となるように並設され
ている。The blood storage ffI4 of the present invention is made of a hard member, and the artificial lung I
A blood inflow port 5 that communicates with the blood outflow port 3 of It has a communication port 20 that communicates between the inside and the outside, and a defoaming member 7 is provided in the blood inflow section 5 so as to cross the blood flow path of the blood inflow 1185, and the defoaming member 7 has a mesh number. It is composed of a large foam 7a and a foam 7b with a small mesh number, and the foam 7a with a large mesh number is on the side of the blood outlet 3 of the oxygenator I, and the foam 7b with a small mesh number is They are arranged side by side on the blood storage section 6 side.
まず、人工肺について説明する。First, I will explain about the artificial lung.
人工肺は、血液中の二酸化炭素を除去し、酸素を添加す
るためのもの立食である。An artificial lung is used to remove carbon dioxide from the blood and add oxygen to it.
図面に示した人工肺は、ハウジングとハウジング内に軸
方向に収納された中空糸膜９の集合体と、中空糸膜９の
両端部をハウジングに液密に保持する隔壁と、隔壁の上
方に設けられ中空糸膜９の内部空間に連通ずるガス流入
ボートｌＯと、隔壁の下方に設けられ中空糸膜９の内部
空間に連通ずるガス流出ボート１１を有している。The oxygenator shown in the drawing includes a housing, an assembly of hollow fiber membranes 9 housed in the housing in the axial direction, a partition wall that holds both ends of the hollow fiber membranes 9 in a fluid-tight manner in the housing, and a partition wall above the partition wall. It has a gas inflow boat 1O provided and communicating with the internal space of the hollow fiber membrane 9, and a gas outflow boat 11 provided below the partition wall and communicating with the internal space of the hollow fiber membrane 9.
そして、隔壁とハウジング内壁と中空糸膜外壁と形成さ
れる血液室に連通する血液流入口２および血液流出口３
が設けられている。ガス流出ボー外１１は必ずしも設け
る必要はなく下部隔壁を解放にしておいてもよい。また
人工肺は、上記した中空糸膜の外側の血液を流すタイプ
のものに限らず通常の中空糸膜内に血液を流すタイプの
もの、さらに平膜型のものでもよい。好ましくは、上記
した中空糸膜の外側に血液を流すタイプのものであり、
この人工肺を用いれば、圧力損失が少ないため循環回路
中の人工肺の前に送血ポンプを設ける必要がなく、人体
からの落差のみによる脱血にて血液を人工肺にさらに貯
血槽に送ることができる。そして、人工肺ｌの血液室に
連通ずるカーディオドミ一連通ボー）１４が設けられて
いる。このカーディオドミ一連通ボー）１４は、図示し
ないカーディオドミー貯血槽と連通ずるためのものであ
る。A blood inlet 2 and a blood outlet 3 communicate with the blood chamber formed by the partition wall, the inner wall of the housing, and the outer wall of the hollow fiber membrane.
is provided. The gas outflow bow outside 11 is not necessarily provided, and the lower partition wall may be left open. Furthermore, the artificial lung is not limited to the above-mentioned type that allows blood to flow outside the hollow fiber membrane, but may also be of a type that allows blood to flow inside a normal hollow fiber membrane, or even of a flat membrane type. Preferably, it is a type that allows blood to flow outside the hollow fiber membrane described above,
If this oxygenator is used, there is no need to install a blood pump in front of the oxygenator in the circulation circuit because there is little pressure loss, and blood is sent to the oxygenator and further to the blood storage tank by removing blood only by the drop from the human body. be able to. A cardiotome (14) communicating with the blood chamber of the artificial lung (1) is provided. This cardiodomy connection bow 14 is for communicating with a cardiodomy blood reservoir (not shown).
次に、本発明の貯血槽４について説明する。Next, the blood reservoir 4 of the present invention will be explained.
貯血槽４は、貯血部６および血液流入部５を形成するハ
ウジングとその上方に設けられた蓋体１３とからなり、
それらは硬質部材で形成され、ハウジング部分は透明で
あることが好ましい。The blood storage tank 4 includes a housing that forms a blood storage section 6 and a blood inflow section 5, and a lid 13 provided above the housing.
Preferably they are formed of a rigid member and the housing portion is transparent.
貯溜している血液を容易に確認できるからである。蓋体
１３には貯血槽４の内部と外部とを連通ずる連通口２０
が設けられている。貯血槽４に用いられる材料としては
、硬質塩化ビニル樹脂、スチレン樹脂、カーボネイト樹
脂などがある。This is because the accumulated blood can be easily confirmed. The lid body 13 has a communication port 20 that communicates the inside and outside of the blood storage tank 4.
is provided. Materials used for the blood storage tank 4 include hard vinyl chloride resin, styrene resin, and carbonate resin.
そして、貯血槽４は、人工肺ｌの血液流出口３と連通ず
る血液流入部５とこの血液流入部５と連通する貯血部６
を有しており、貯血部６の下方には血液排出口８が設け
られている。貯血部６は、血液を貯溜する部分である。The blood storage tank 4 includes a blood inflow section 5 that communicates with the blood outflow port 3 of the artificial lung 1, and a blood storage section 6 that communicates with the blood inflow section 5.
A blood discharge port 8 is provided below the blood storage section 6. The blood storage part 6 is a part that stores blood.
そして、人工肺ｌの血液流出口３と血液流入部５の一部
である血液導入口１２とが液密状に連通している。 こ
の血液流出口３と血液導入口Ｉ２は液密状に嵌合してい
るかまた液密状となるように超音波、高周波または接着
剤を用いて接着される。The blood outflow port 3 of the artificial lung 1 and the blood inlet port 12, which is a part of the blood inflow section 5, communicate in a fluid-tight manner. The blood outflow port 3 and the blood inlet port I2 are fitted in a liquid-tight manner, or are bonded to each other in a liquid-tight manner using ultrasonic waves, high frequency waves, or an adhesive.
血液流入部５は人工肺ｌの血液流出口３から流入した血
液が貯血部６に入るまでの血液流路を形成するものであ
り、貯血部６より高い位置にありかつ血液導入口１２と
ほとんど落差のない底面を有している。底面の形状は、
平坦状、半筒状などでもよいが、平坦状であれば、後述
する消泡部材７の設置が容易であり好ましい。The blood inlet 5 forms a blood flow path through which the blood flowing from the blood outlet 3 of the artificial lung 1 enters the blood storage part 6, and is located at a higher position than the blood storage part 6 and almost at a distance from the blood inlet 12. It has a bottom surface with no drop. The shape of the bottom is
It may be flat, semi-cylindrical, etc., but a flat shape is preferable because it facilitates the installation of the defoaming member 7, which will be described later.
そして、この血液流入部５には、その血液流路を横切る
ように消泡部材７が設けられている。A defoaming member 7 is provided in the blood inflow section 5 so as to cross the blood flow path.
消泡部材７は、気泡を含む血液が流れてきたとき消泡を
行い気泡のない血液を貯血槽４に送るためのものである
。この消泡部材７には、一般的に、発泡体が用いられ、
その疎水性を利用して気泡を成長させ、除去するもので
ある。発泡体とは、網目状をした三次元立法体をいう。The defoaming member 7 is for defoaming when blood containing air bubbles flows and sends the blood without air bubbles to the blood storage tank 4. Foam is generally used for this defoaming member 7,
It utilizes its hydrophobicity to grow and remove air bubbles. A foam is a three-dimensional cubic body with a mesh shape.
消泡部材７は流れてくる血液の総てが接触するように（
消泡部材に接触しない血液流路が形成されないように）
貯血槽４の血液流入部５の底面、側面に密着するように
配置されている。The defoaming member 7 is arranged so that all of the flowing blood comes into contact with it (
(so that no blood flow path is formed that does not come into contact with the antifoaming member)
It is arranged so as to be in close contact with the bottom and side surfaces of the blood inflow section 5 of the blood storage tank 4.
消泡部材７の上端は必ずしも貯血槽４の蓋体１３に密着
する必要はないが、消泡部材７の移動を防止するため、
また消泡部材７の上端から血液が流出するのを防ぐため
には、密着していることが好ましい。さらに消泡部材７
の移動を防止するためにハウジングの内側面に係止ｆｆ
１２１が設けられている。係止部２１は、ハウジングの
内側面に形成されたリブで、計４つ設けられており、そ
れら係止部２１間で消泡部材７の端部を挟持している。Although the upper end of the defoaming member 7 does not necessarily need to be in close contact with the lid 13 of the blood reservoir 4, in order to prevent the defoaming member 7 from moving,
Further, in order to prevent blood from flowing out from the upper end of the defoaming member 7, it is preferable that they are in close contact with each other. Furthermore, the defoaming member 7
Locks on the inner surface of the housing to prevent movement of ff
121 is provided. The locking portions 21 are ribs formed on the inner surface of the housing, and a total of four locking portions 21 are provided, and the ends of the defoaming member 7 are held between the locking portions 21 .
係止部２１を形成するリプの形状としては、線状の連続
したものが好ましい。The lip forming the locking portion 21 preferably has a continuous linear shape.
また、血液導入口１２と面する部分にじゃま板３０が設
けられている。じゃま板３０は血液流入部５の全域を横
切ように設けられている。これは、じゃま板３０と血液
導入口１２間に血液の貯留空間を形成させるためのらの
である。この貯留空間を設けることにより、人工肺ｌ側
に貯血槽４側から空気が入ることを防止できるとともに
、人工肺１の血液室側が酸素室側（中空糸膜内面側）よ
り圧力がｉ、＜なり、中空糸膜を介して血液側に気泡が
流入することを防止することができる。Further, a baffle plate 30 is provided at a portion facing the blood introduction port 12. The baffle plate 30 is provided so as to traverse the entire area of the blood inflow section 5. This is to form a blood storage space between the baffle plate 30 and the blood introduction port 12. By providing this storage space, it is possible to prevent air from entering the oxygen chamber 1 side from the blood storage tank 4 side, and the pressure on the blood chamber side of the oxygen chamber 1 is lower than that on the oxygen chamber side (inner surface side of the hollow fiber membrane). This makes it possible to prevent air bubbles from flowing into the blood side via the hollow fiber membrane.
そして、消泡部材による消泡を効果的に行うためには、
消泡部材を構成する発泡体の目の細かさをある程度以上
にすることが必要である。目が気泡の大きさに対して大
きすぎると、発泡体のセルと気泡との接触が十分に行な
われないため、小さな気泡が流出してしまうことがある
。In order to effectively defoam using the defoaming member,
It is necessary that the foam constituting the defoaming member have a certain level of fineness. If the mesh is too large for the size of the bubbles, the cells of the foam will not come into sufficient contact with the bubbles, which may cause small bubbles to flow out.
しかしながら、また逆に、目が細かすぎると、発泡体で
の圧力損失が大きくなり、発泡体の血液の流入側に血液
が溜まってしまい、必要な流量が確保出来なくなるので
ある。さらに、このとき、発泡体を血液で濡らしておか
ないと、発泡体の血液の流出側において、通常血液の流
路となる以外の部分 °−゛
導中から血液が勢いよく噴出し、そのとき血液が泡立ち
気泡が混ざってしまうことがある。However, on the other hand, if the mesh is too fine, the pressure loss in the foam increases, and blood accumulates on the blood inflow side of the foam, making it impossible to secure the necessary flow rate. Furthermore, if the foam is not wetted with blood at this time, blood may gush out from the blood flow path on the blood outflow side of the foam, which is not normally used as the blood flow path. The blood may foam and contain air bubbles.
そこで、本発明では、消泡部材７は、発泡体でありかつ
メツシュ数の大きい発泡体７ａとメツシュ数の小さい発
泡体７ｂの２つの発泡体を密着させたもので構成されて
おり、かつ２つの発泡体をメツシュ数の大きい発泡体７
ａが血液導入口１２側となりメツシュ数の小さい発泡体
７ｂが貯血部６側となるように並設されている。このよ
うにメツシュ数の違う２つの発泡体を用い、さらにそれ
らを血液の流れ方向に対しメツシュ数が小さくなるよう
に並設したので、圧力損失を大きくすることなく、十分
な消泡能を有するのである。ここでいうメツシュ数とは
、２５．４ｉｚ（ｆｉｎ）間にある目の数をいい、本来
は、襟儒；目の大きさを示す尺度である。Therefore, in the present invention, the defoaming member 7 is composed of two foams, a foam 7a with a large mesh number and a foam 7b with a small mesh number, which are brought into close contact with each other. Foam with a large mesh number 7
They are arranged in parallel so that a is on the blood introduction port 12 side and foam 7b with a small mesh number is on the blood storage part 6 side. In this way, by using two foams with different mesh numbers and arranging them side by side in such a way that the mesh numbers are small in the blood flow direction, it has sufficient defoaming ability without increasing pressure loss. It is. The mesh number here refers to the number of eyes between 25.4 iz (fin), and is originally a measure of the size of the eyes.
消泡部材の厚さおよびメツシュ数は、流路の幅および最
大流量により相対的に決定されるものである。ここで、
流路の幅を１００〜２００１Ｎ、最大流量を６１２／ｓ
ｉｎと考えた場合、消泡部材７の厚さは、３〜６０ｍｍ
、好ましくは１０〜５０ｍｌ１１である。３ｍｍ以下で
は十分な消泡能を有さないことがあり、また６０ＩＩＩ
Ｉ１１以上では圧力損失が大きくなりすぎることがある
からである。メツシュ数の大きい発泡体としては、メツ
シュ数が８〜２０、好ましくは１０〜１５．２０メツシ
ュ以上では圧力損失が大きくなりすぎることがあり、８
メツシユ以下では十分な消泡能を有さないことがあるか
らである。より好ましくはＩ３メツシュである。厚さは
、３〜５０ ｍｍ、好ましくは５〜３０ＩＩＩＩｍであ
り、３ＩＩａ以下では十分な消泡能を有さないことがあ
り、また５０ａ＋ｍ以上では圧力損失が大きくなりすぎ
ることがあるからである。The thickness and mesh number of the foam-defoaming member are determined relative to the width of the channel and the maximum flow rate. here,
The width of the flow path is 100 to 2001N, and the maximum flow rate is 612/s.
When considered as in, the thickness of the defoaming member 7 is 3 to 60 mm.
, preferably 10 to 50 ml11. If it is less than 3 mm, it may not have sufficient defoaming ability, and
This is because if it is I11 or more, the pressure loss may become too large. For foams with a large mesh number, if the mesh number is 8 to 20, preferably 10 to 15.20 or more, the pressure loss may become too large;
This is because if it is less than mesh, it may not have sufficient defoaming ability. More preferred is I3 mesh. The thickness is from 3 to 50 mm, preferably from 5 to 30 m, because if it is less than 3 IIa, it may not have sufficient defoaming ability, and if it is more than 50 m, the pressure loss may become too large.
メツシュ数の小さい発泡体としては、メツシュ数が５〜
１２、好ましくは６〜ＩＯであり１２メツシュ以上では
通常の血液流路以外から血液が噴出し、泡立つことがあ
亨るからであり５メツシユ以下では十分な消泡能を有さ
ないことがあるからである。好ましくは、８メツシユで
ある。For foams with a small mesh number, the mesh number is 5 to 5.
12, preferably 6 to IO, because if it is more than 12 meshes, blood may gush out from other than the normal blood flow path and foaming may occur, and if it is less than 5 meshes, it may not have sufficient antifoaming ability. It is from. Preferably, it is 8 meshes.
厚さは３〜８０ｍｍ、好ましくは５〜５０ｍｎ＋である
。３ｆｆＩＩ１１以下では十分な消泡能を有さないこと
があり、また８０ｍｍ以上では圧力損失が大きくなりす
ぎることがあるからである。また、メツシュ数の大きい
発泡体とメツシュ数の小さい発泡体との厚さの比は、１
：１０−１０＋１．好ましくはｌ：４〜４：ｌである。The thickness is 3 to 80 mm, preferably 5 to 50 mm+. This is because if it is less than 3ffII11, it may not have sufficient defoaming ability, and if it is more than 80 mm, the pressure loss may become too large. In addition, the ratio of the thickness of the foam with a large mesh number and the foam with a small mesh number is 1
:10-10+1. Preferably it is 1:4 to 4:1.
また、メツシュ数の和は、１３〜３２、好ましくは１５
〜２５である。In addition, the sum of mesh numbers is 13 to 32, preferably 15
~25.
らの間に両者の中間のメツシュ数を有する発泡体を挿入
した３層状としてもよい。A three-layer structure may be used in which a foam having a mesh number intermediate between the two is inserted between the two.
消泡部材７に用いる発泡体としては、ウレタンフオーム
、セルロースフオーム、ナイロンフオームなどを用いる
ことができる。このましくは、ウレタンフオームである
。さらに、消泡部材７に消泡剤をコーチイブすることが
好ましい。消泡剤としては、一般にオイル類が使用でき
、シリコーンオイルがとくに好適に使用できる。As the foam used for the defoaming member 7, urethane foam, cellulose foam, nylon foam, etc. can be used. Preferably, it is urethane foam. Furthermore, it is preferable to coach the defoaming member 7 with a defoaming agent. As the antifoaming agent, oils can generally be used, and silicone oil can be particularly preferably used.
そして、人工肺の血液流入口２には熱交換器１５が取り
付けられている。熱交換″ｌ５１５は、内部に多数の熱
交換用管体を収納しており、血液人口１６より血液が流
入し熱交換用管体の外側を流れ、そのとき熱交換用管体
内部に温水または冷水を流して血液を加温したり冷却し
たりするものである。この熱交換器１５には、人工肺１
を通さずに血液を貯血槽４の血液排出口８付近に排出す
る排出ライン１９が設けられている。又、熱交換ｖＳ１
５および貯血槽４には、温Φ
度測定用プローブ挿入口１７．１８が設けらている。A heat exchanger 15 is attached to the blood inlet 2 of the oxygenator. The heat exchanger 1515 houses a large number of heat exchange tubes inside, blood flows in from the blood population 16 and flows outside of the heat exchange tubes, and at that time, hot water or This heat exchanger 15 heats or cools blood by flowing cold water.This heat exchanger 15 includes an artificial lung 1
A discharge line 19 is provided for discharging blood near the blood discharge port 8 of the blood storage tank 4 without passing the blood through it. Also, heat exchange vS1
5 and the blood reservoir 4 are provided with probe insertion ports 17 and 18 for temperature measurement.
次に、本発明の貯血槽の実施例および比較例について行
った実験について説明する。Next, experiments conducted on examples and comparative examples of the blood reservoir of the present invention will be described.
貯血槽としては、容！１１４ｆｆ、ポリカーボネイトか
らなる透明体で形成し、形状は図面に示したものと同じ
である。血液流入部の長さは、４０ｍＩＩ＋とし底面は
平坦状とした。また、血液導入口との落差は、３０ＩＩ
Ｉ１１とした。また、血液流入部の幅は１５０ＩＩＩＩ
１１とした。As a blood storage tank, Yong! 114ff, is made of a transparent material made of polycarbonate, and its shape is the same as that shown in the drawing. The length of the blood inflow section was 40 mII+, and the bottom surface was flat. Also, the height difference between the blood inlet and the blood inlet is 30II.
It was set as I11. Also, the width of the blood inflow part is 150III
It was set to 11.
そして、消泡部材は全体の厚さを３０ｎｎ＋とじ、幅は
１５０ｆｆＩｌ１１とした。流した、血液量は、６ｆｆ
／ｍｉｎとした。The antifoaming member had a total thickness of 30 nn+ and a width of 150 ffIl11. The amount of blood shed was 6ff.
/min.
［実施例１］
消泡部材に１３メツシユのポリウレタンフォーム（厚さ
１５ｎ＋ｍ）と８メツシユのポリウレタンフォーム（厚
さ１５ｘｍ）とを密着させたものを用い、１３メツシユ
のポリウレタンフォームが血液の流入側、８メツシユの
ポリウレタンフォームが流出側となるようにした。[Example 1] A defoaming member in which 13 meshes of polyurethane foam (thickness 15n+m) and 8 meshes of polyurethane foam (thickness 15xm) were brought into close contact was used, and the 13 meshes of polyurethane foam were placed on the blood inflow side, 8 mesh polyurethane foam was placed on the outflow side.
一血液の噴出は起こらず、小さな気泡の流出も認められ
なかった。No gushing of blood occurred, and no small air bubbles were observed to flow out.
［実施例２］
実施例１における１３メツシユのポリウレタンフォーム
の厚さを５ ｍ＋＊、 ８メツシユのポリウレタンフォ
ームの厚さを２５ｎｎ＋とじた以外は実施例１と同じも
のとした。[Example 2] The same procedure as in Example 1 was used except that the thickness of the 13 mesh polyurethane foam in Example 1 was 5 m+*, and the thickness of the 8 mesh polyurethane foam was 25 nn+.
血液の噴出は起こらず、小さな気泡の流出も認められな
かった。No gushing of blood occurred and no small air bubbles were observed.
［実施例３コ
実施例！におけるＩ３メツシュのポリウレタンフォーム
の厚さをｌ０１ｍ、８メツシユのポリウレタンフォーム
の厚さを２０ｍ１１とした以外は実施例１と同じものと
した。[Example 3 Examples! The same procedure as in Example 1 was used except that the thickness of the polyurethane foam for I3 meshes was 101 m, and the thickness of the polyurethane foam for 8 meshes was 20 m11.
血液の噴出は起こらず、小さな気泡の流出し認められな
かった。No blood gushing occurred, and no small bubbles were observed.
［実施例４コ
実施例１における１３メツシユのポリウレタンフォーム
の厚さを２５ａ＋ｓ、８メツシユのポリウレタンフォー
ムの厚さを５ａ＋ｍとした以外は実施例１と同じものと
した。[Example 4] The same as Example 1 was used except that the thickness of the polyurethane foam of 13 meshes in Example 1 was 25a+s, and the thickness of the polyurethane foam of 8 meshes was 5a+m.
血液の噴出は起こらず、小さな気泡の流出も認められな
かった。No gushing of blood occurred and no small air bubbles were observed.
［比較例１］
消泡部材に８メツシユのポリウレタンフォーム（厚さ１
５ｘｍ）の単体を用いた。[Comparative Example 1] 8 mesh polyurethane foam (thickness 1
5xm) was used.
しかし、細かな気泡は除去しきれず、気泡が貯血槽の貯
血部側に流出するのが認められた。However, small air bubbles could not be removed completely, and it was observed that the air bubbles leaked to the blood storage part side of the blood storage tank.
［比較例２］
消泡部材に１３メツシユのポリウレタンフオ−ム（厚さ
１５１３１）の単体を用いた。[Comparative Example 2] A single piece of 13-mesh polyurethane foam (thickness: 15131 mm) was used as a defoaming member.
流し始めに、消泡部材の上方より血液が噴出したが、そ
の後は、気泡の流出は見られなかった。At the beginning of the flow, blood spouted out from above the defoaming member, but after that, no bubbles were observed to flow out.
しかし、血液の流入側で血液面の上昇が見られ、圧力損
失の点で限界であると思われた。However, an increase in the blood level was observed on the blood inflow side, which seemed to be the limit in terms of pressure loss.
［比較例３］
消泡部材に８メツシユのポリウレタンフォーム（厚さ１
５ｍｍ）と１３メツシユのポリウレタンフォーム（厚さ
１５ｚｍ）とを密着させたものを用い、８メツシユのポ
リウレタンフォームが血液の流入側、１３メツシユのポ
リウレタンフォームが流出側となるようにした。[Comparative Example 3] 8 mesh polyurethane foam (thickness 1
5 mm) and 13 mesh polyurethane foam (thickness 15 zm) were used, with 8 mesh polyurethane foam on the blood inflow side and 13 mesh polyurethane foam on the blood outflow side.
気泡の流出は認められないが、流し始めにおける血液の
噴出が起こった。Although no air bubbles were observed to flow out, blood gushing occurred at the beginning of the flow.
■ 発明の具体的作用
本発明の貯血槽は対外循環回路中に設けられ、例えば、
図面に示したように人工肺１の血液流出口２に液密に取
り付けられる。さらに、人工肺ｌには熱交換器＋５が取
り付けられる。熱交換器１５の血液入口１６から流入し
た血液は人工肺Ｉの血液流入口２に至る間に加温または
冷却される。そして、人工肺Ｉの血液流入口２から流入
した血液はハウジングとガス交換膜９との間により形成
された血液室を通る間に二酸化炭素が除去され、酸素が
添加される。このとき、ガス流入口ｌＯからは酸素を含
んだガスがガス交換膜である中空糸膜内に流される。酸
素を添加された血液は、人工肺ｌの血液流出口３から流
出し貯血槽４の血液導入口１２を経て血液導入部５に流
れる。そして、血液は消泡部材１７を通過しこのとき含
まれている気泡は消泡部材１７の発泡体のセルに接触し
、成長し貯血槽の上方に移動し除去される。■Specific effects of the invention The blood reservoir of the present invention is provided in the external circulation circuit, for example,
As shown in the drawings, it is fluid-tightly attached to the blood outlet 2 of the oxygenator 1. Furthermore, a heat exchanger +5 is attached to the oxygenator l. Blood flowing in from the blood inlet 16 of the heat exchanger 15 is heated or cooled while reaching the blood inlet 2 of the artificial lung I. Then, while the blood flowing in from the blood inlet 2 of the artificial lung I passes through the blood chamber formed between the housing and the gas exchange membrane 9, carbon dioxide is removed and oxygen is added. At this time, oxygen-containing gas flows from the gas inlet lO into the hollow fiber membrane that is the gas exchange membrane. The oxygenated blood flows out from the blood outlet 3 of the artificial lung 1, passes through the blood inlet 12 of the blood reservoir 4, and flows into the blood inlet 5. Then, the blood passes through the defoaming member 17, and the bubbles contained therein contact the cells of the foam of the defoaming member 17, grow, move above the blood reservoir, and are removed.
■ 発明の具体的効果
本発明の貯血槽は、硬質部材により形成された貯血槽で
あって、血液導入口と、該血液導入口と連通ずる血液流
入部と、該血液流入部と連通ずる貯血部と、該貯血部の
下部に設けられた血液排出口と、該貯血槽の上方に設け
られた該貯血槽内部と外部とを連通ずる連通口とを有し
、血液流入部には血液流入部の血液流路を横切る消泡部
材を設け、さらに該消泡部材は、メツシュ数の大きい発
泡体とメツシュ数の小さい発泡体とで構成され、かつ該
２つの発泡体を前記メッンユ数の大きい発泡体が前記血
液導入口側となて前記メツシュ数の小さい発泡体が前記
貯血部側となるように並設させたものであるので、消泡
部材での圧力損失が少なく、かつ流入した血液が含んで
いる気泡を確実に消泡することができる。■Specific Effects of the Invention The blood reservoir of the present invention is a blood reservoir formed of a hard member, and includes a blood inlet, a blood inlet communicating with the blood inlet, and a blood reservoir communicating with the blood inlet. a blood outlet provided at the lower part of the blood storage section, and a communication port provided above the blood storage tank that communicates the inside of the blood storage tank with the outside; A defoaming member is provided that crosses the blood flow path in the area, and the defoaming member is composed of a foam with a large mesh number and a foam with a small mesh number, and the two foams are connected to a foam with a large mesh number. Since the foam is arranged in parallel so that the foam is on the blood introduction port side and the foam with a small mesh number is on the blood storage part side, the pressure loss at the defoaming member is small and the inflow of blood is It is possible to reliably defoamer the air bubbles contained in it.
さらに、消泡部材に消泡剤がコーチイブされていれば、
より高い消泡を行うことができる。Furthermore, if the antifoaming member is coated with an antifoaming agent,
Higher defoaming can be achieved.
図面は、本発明の貯血槽に人工肺および熱交換器を取り
付けたものの部分破断側面（支）である。
ｌ・・人工肺 ２・・血液流入口３・・血液流
出口 ４・・貯血槽
５・・血液流入部 ６・・貯血部
７・・消泡部材 ８・・血液排出ロアａ・・メツ
シュ数の大きい発泡体
７ｂ・・メツシュ数の小さい発泡体
Ｉ３・・蓋体 １５・・熱交換冴２０・・連通
口 ２１・・係止部３０・・じゃま板The drawing is a partially cutaway side view (support) of a blood storage tank of the present invention with an oxygenator and a heat exchanger attached thereto. l.. Artificial lung 2.. Blood inflow port 3.. Blood outflow port 4.. Blood storage tank 5.. Blood inflow section 6.. Blood storage section 7.. Defoaming member 8.. Blood discharge lower a.. Number of meshes Foam 7b with a large mesh number... Foam I3 with a small mesh number... Lid body 15... Heat exchanger 20... Communication port 21... Locking part 30... Baffle board
Claims (5)
導入口と、該血液導入口と連通する血液流入部と、該血
液流入部と連通する貯血部と、該貯血部の下部に設けら
れた血液排出口と、該貯血槽の上方に設けられた該貯血
槽内部と外部とを連通する連通口とを有し、血液流入部
には血液流入部の血液流路を横切る消泡部材を設け、さ
らに該消泡部材は、メッシュ数の大きい発泡体とメッシ
ュ数の小さい発泡体とで構成され、かつ該２つの発泡体
を前記メッシュ数の大きい発泡体が前記血液導入口側と
なり前記メッシュ数の小さい発泡体が前記貯血部側とな
るように並設させたことを特徴とする貯血槽。(1) A blood storage tank formed of a hard member, which includes a blood inlet, a blood inflow part communicating with the blood inlet, a blood storage part communicating with the blood inflow part, and a blood storage tank provided below the blood storage part. The blood inlet has a blood outlet and a communication port provided above the blood reservoir for communicating between the inside and the outside of the blood reservoir, and the blood inlet has an antifoaming member that crosses the blood flow path of the blood inlet. Further, the defoaming member is composed of a foam with a large mesh number and a foam with a small mesh number, and the two foams are arranged such that the foam with the large mesh number is on the side of the blood inlet port. A blood storage tank characterized in that foams with a small mesh number are arranged side by side on the blood storage section side.
１項に記載の貯血槽。(2) The blood reservoir according to claim 1, wherein the blood reservoir is made of a transparent member.
求の範囲第１項または第２項に記載の貯血槽。(3) The blood reservoir according to claim 1 or 2, wherein the defoaming member is made of urethane foam.
るものである特許請求の範囲第１項ないし第３項のいず
れかに記載の貯血槽。(4) The blood reservoir according to any one of claims 1 to 3, wherein the antifoaming member is coated with an antifoaming agent.
第４項記載の貯血槽。(5) The blood reservoir according to claim 4, wherein the antifoaming agent is silicone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61101723A JPS62258671A (en) | 1986-05-01 | 1986-05-01 | Blood storage tank |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61101723A JPS62258671A (en) | 1986-05-01 | 1986-05-01 | Blood storage tank |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62258671A true JPS62258671A (en) | 1987-11-11 |
| JPH037391B2 JPH037391B2 (en) | 1991-02-01 |
Family
ID=14308217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61101723A Granted JPS62258671A (en) | 1986-05-01 | 1986-05-01 | Blood storage tank |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62258671A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989000056A1 (en) * | 1987-07-07 | 1989-01-12 | Terumo Kabushiki Kaisha | Blood storage tank |
| JPH0260657A (en) * | 1988-08-26 | 1990-03-01 | Terumo Corp | Blood storage tank |
| US5160332A (en) * | 1987-07-07 | 1992-11-03 | Terumo Kabushiki Kaisha | Blood reservoir |
| JP2013017806A (en) * | 2011-07-12 | 2013-01-31 | Sorin Group Italia Srl | Dual chamber blood reservoir |
| US10458833B2 (en) | 2014-05-16 | 2019-10-29 | Sorin Group Italia S.R.L. | Blood reservoir with fluid volume measurement based on pressure sensor |
| US11229729B2 (en) | 2009-05-29 | 2022-01-25 | Livanova Deutschland Gmbh | Device for establishing the venous inflow to a blood reservoir of an extracorporeal blood circulation system |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62258673A (en) * | 1986-04-22 | 1987-11-11 | 株式会社 日本メデイカル・サプライ | Blood storage tank |
-
1986
- 1986-05-01 JP JP61101723A patent/JPS62258671A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62258673A (en) * | 1986-04-22 | 1987-11-11 | 株式会社 日本メデイカル・サプライ | Blood storage tank |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989000056A1 (en) * | 1987-07-07 | 1989-01-12 | Terumo Kabushiki Kaisha | Blood storage tank |
| US5112480A (en) * | 1987-07-07 | 1992-05-12 | Terumo Kabushiki Kaisha | Blood reservoir |
| US5160332A (en) * | 1987-07-07 | 1992-11-03 | Terumo Kabushiki Kaisha | Blood reservoir |
| JPH0260657A (en) * | 1988-08-26 | 1990-03-01 | Terumo Corp | Blood storage tank |
| US5000764A (en) * | 1988-08-26 | 1991-03-19 | Terumo Kabushiki Kaisha | Blood storage container |
| JPH0657252B2 (en) * | 1988-08-26 | 1994-08-03 | テルモ株式会社 | Blood reservoir |
| US11229729B2 (en) | 2009-05-29 | 2022-01-25 | Livanova Deutschland Gmbh | Device for establishing the venous inflow to a blood reservoir of an extracorporeal blood circulation system |
| US11844892B2 (en) | 2009-05-29 | 2023-12-19 | Livanova Deutschland Gmbh | Device for establishing the venous inflow to a blood reservoir of an extracorporeal blood circulation system |
| JP2013017806A (en) * | 2011-07-12 | 2013-01-31 | Sorin Group Italia Srl | Dual chamber blood reservoir |
| US10213541B2 (en) | 2011-07-12 | 2019-02-26 | Sorin Group Italia S.R.L. | Dual chamber blood reservoir |
| US11389580B2 (en) | 2011-07-12 | 2022-07-19 | Sorin Group Italia S.R.L. | Dual chamber blood reservoir |
| US10458833B2 (en) | 2014-05-16 | 2019-10-29 | Sorin Group Italia S.R.L. | Blood reservoir with fluid volume measurement based on pressure sensor |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH037391B2 (en) | 1991-02-01 |
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| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |