JPS62250413A - Detergent for contact lens - Google Patents

Abstract

PURPOSE:To obtain the titled detergent capable of removing protein effectively in a short period by incorporating papain and one or more kinds of surface active agents. CONSTITUTION:The detergent contains the papain and one or more kinds of the surface active agents shown by the formula. The anionic surface active agent is usually the agent shown by the formula wherein M is Na or NH(CH2 CH2OH)3, and is for example, one or two or more than two kinds of sodium lauryl sulfate, etc. The used amount of the anionic surface active agent is 0.02-0.15w/v% an effective concentration of the surface active agent, thereby improving the effect of adding the papain. To remove a floating material, 0.05-1.5w/v% of the non-ionic surface active agent is preferably incorporated to the titled detergent.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a cleaning agent for contact lenses, and more particularly to a novel cleaning agent for contact lenses useful for removing proteins attached or fixed to contact lenses.

[Prior art]

Contact lenses currently on the market can be roughly divided into non-hydroscopic types and hydrous types, but regardless of the type of contact lens, it is difficult to remove dirt that adheres to the lens surface during handling. This is an important issue, and if the stains such as lipids and proteins in the lachrymal fluid that adhere to contact lenses when worn are not sufficiently removed, the optical properties of the lenses will be affected and the wearing comfort will be worsened. It can also be a cause of serious damage to ocular tissues.

Most lipid stains on contact lenses can be removed with contact lens cleaning agents containing surfactants as a main ingredient, but proteins cannot be removed with these cleaning agents. In particular, water-containing contact lenses are required to be sterilized by boiling, and as a result, the attached proteins undergo denaturation and coagulation and strongly adhere to the water-containing contact lenses, causing the various problems mentioned above. Cleaning agents containing proteolytic enzymes and hydrosulfohydryl compounds are known as cleaning agents for contact lenses contaminated with 6 proteins that shorten the useful life of the lenses. had the problem that cleaning contact lenses took a very long time.

[Problem that the invention seeks to solve]

An object of the present invention is to eliminate the drawbacks of conventional contact lens cleaning agents and to provide a cleaning agent that can effectively remove proteins in a short period of time.

[Means to solve problems]

That is, the present invention provides papain and the following formula (I)c, Ht,
The present invention relates to a contact lens cleaning agent containing one or more surfactants represented by to(CHzCHzO) and SOzM (1).

[Structure and operation of the invention]

The amount of protein that contaminates contact lenses varies depending on the wearer's eyes, but it is impossible to completely remove the proteins on the lenses by regular treatment, such as once a week or once a month. , the protease activity in the solution is 300
u/Ill~1000"/cod is sufficient. If the protease activity is less than this range, it may not be possible to completely remove the protein on the lens with each treatment. On the other hand, if the protease activity is less than this range, If it is large, it will take time to remove the proteolytic enzyme from the lens surface.
It is not preferable to increase the amount of proteolytic enzymes unnecessarily. Note that protease activity is measured as follows.

Proteolytic enzyme activity measurement method: The sample is treated with 0.6% casein, and the proteolytic products are measured as absorption at 275 nm. Under the same conditions, 1 u is the enzyme activity that produces a non-protein substance that exhibits 275 nm absorption equivalent to tyrosine 1γ in 1 minute.

The anionic surfactant used in the present invention is represented by formula (1)
Anything is acceptable as long as it is expressed by
OH) s are commercially available and are preferred. Specifically, examples include sodium lauryl sulfate, sodium tetradecyl sulfate, sodium octadecyl sulfate, triethanolamine lauryl sulfate, sodium lauryl polyethylene glycol ether sulfate, and one or more of these. is used. These anionic surfactants are widely commercially available, for example, Nissan Persof) SF manufactured by NOF Corporation (hereinafter referred to as "NOF") (the active ingredient is M=Na, m=
Q, a mixture of n=12 and M=Nas m=0, n=14), Nira Samper Soft SL (the active ingredient is a mixture of M=N a, m=o, n=12 and M =Na, m=o, mixture of n=18), Nira Samper Soft SK (the active ingredient is M=Na in formula
s m-O, mixture of n=8 to 18), Nissan Persof) SFT (The active ingredient is M=HN(CH
, CHzOH)z , m=0% n=12 and M
=)IN(CHzCHzOH):+, m=o, n=1
Mixture of 4), Nila Sambar Soft EP (active ingredient is formula I, M=Na, m is 3 on average and distribution is 1-6)
, n-12), Nira Samper Soft EF (active ingredient is formula
, n=12 and M=Na, m has an average of 3 and a distribution of 1 to
6, mixture of n=14), Nino Sampersof 1-
EL (The active ingredient is M=Na in formula I, m is 3 on average
and the distribution is 1 to 6, n=12 to 18), etc. are preferably used.

The amount of anionic surfactant added is preferably 0.02% to 0.15% as the effective concentration of the surfactant. If the concentration is too low, the effect of papain cannot be enhanced, and if the concentration is too high, not only will it not be effective, but it will also cause some eye irritation, so from a safety perspective, it is important not to increase the concentration too high. is not desirable.

Although the cleaning solution of the present invention has sufficient effects with this alone, a phenomenon in which suspended matter is generated in the cleaning solution and cloudiness is generally observed. As a result, floating substances adhere to contact lenses during cleaning, but when used as a cleaning solution for non-hydroscopic contact lenses, there is no problem as the soot can be easily removed with soaking solution or purified water. .

However, when used as a cleaning solution for water-containing contact lenses, there is a possibility that the above-mentioned floating substances may enter and stick to the water-containing contact lenses, so it is preferable to dissolve the floating substances and make the cleaning solution transparent. .

For this purpose, it is particularly preferable to add a nonionic surfactant that does not reduce the cleaning effect and has a large transparency effect.

Examples of the nonionic surfactant include polyoxyethylene octylphenol ether, polyoxyethylene polypropylene glycol ether, etc., but there are no particular limitations, and generally commercially available nonionic surfactants are sufficient. Specifically, for example, Nisosannonion H3-240 (polyoxyethylene octylphenol ether, polyoxyethylene moiety is 40 moles on average) manufactured by NOF Corporation, Nisosannonion H3-2
20 (polyoxyethylene octyl phenol ether, polyoxyethylene moiety has an average molecular weight of 20 moles), Nisosanpronone 208 (polyoxyethylene polypropylene glycol ether, average molecular weight 10,000, and polypropylene glycol moiety has an average molecular weight of 2000).

In order to remove suspended matter, it is preferable to add 0.05 to 1.5% of the above-mentioned nonionic surfactant. If the amount is too small, the cloudiness will not disappear, and if the detergent of the present invention is made into a solid form such as tablets, granules, or powder, if a large amount of the nonionic surfactant is contained, it will be difficult to control the drying conditions. This is not desirable because it becomes complicated.

By adding a hydrosulfohydryl compound of
The effect of papain can be further ensured.

The amount added is preferably 0.01 to 6'y/%, and more preferably 0.01 to 6'y/%.
．． 05-0.5%% is most preferred.

Furthermore, it is also possible to add appropriate buffers and stabilizers. Specific examples include tartaric acid, citric acid, malic acid,
Edetic acid and its sodium salts, potassium salts, sodium bicarbonate, sodium carbonate, various phosphates, and the like. The usage amount is o, o o s~2%%
is preferable, and most preferably 0.01 to 1 wC%.

In addition, it is preferable to make the tonicity isotonic using sodium chloride, potassium chloride, or the like.

The cleaning agent of the present invention may be in any form such as powder, granules, tablets, etc., in addition to the liquid form described here.

When preparing a solid preparation, all the components may be made into a solid preparation, or only the components that easily become a solid preparation may be made into a solid preparation, the other components may be made into a liquid, and both may be mixed together at the time of use.

In the case of solid preparations, lubricants, binders, excipients, etc. may be added as necessary, examples of which include glycerin, sorbitol, propylene glycol, polyethylene glycol, dextran, methylcellulose, hydroxyethylcellulose, and carboxymethylcellulose. water-soluble salts, gelatin, alginate, tragacanth, pectin,
Examples include gum arabic and soluble starch.

〔Example〕

Next, the present invention will be explained in more detail with reference to Examples.
The invention is not limited only by the examples.

(Reference Example 1) Preparation of artificial tear fluid Lysozyme 0.12g, albumin 0.39g, globulin 0.16g, calcium chloride dihydrate O0025g
, trisodium citrate dihydrate, 0.1 g 1 potassium chloride 0.1 g, sodium chloride 0.89 g in distilled water 10
0all, and adjust the pH to 7.4 with 1/1 ON sodium hydroxide aqueous solution to prepare artificial lachrymal fluid.

(Reference Example 2) Adjustment of artificially cloudy water-containing lenses Water-containing contact lenses (manufactured by Toyo Contact Lens Co., Ltd., product name:
Menicon Soft A) was boiled for 15 minutes in 1.5 d of artificial tear fluid prepared in Reference Example 1 per lens, and then washed using a cleaning solution (manufactured by Toyo Contact Lens Co., Ltd., trade name: Meniclean). It was washed with a sponge (manufactured by Toyo Contact Lenses Co., Ltd., trade name: "Menicon Puff"). After repeating this operation three times, it is confirmed that the lens surface is completely cloudy, and the lens is treated as an artificially cloudy water-containing lens.

(Reference Example 3) Preparation of artificial lachrymal lenses: 1.5 d of the artificial tear fluid prepared in Reference Example 1 per oxygen permeable hard contact lens (manufactured by Toyo Contact Lenses Co., Ltd., trade name "Menicon α"). 15 inside
After boiling for a minute, it was rubbed with a finger using a cleaning solution (manufactured by Toyo Contact Lens Co., Ltd., product name "α Care"). After repeating this operation three times, it is confirmed that the lens surface is completely cloudy, and the lens is made into an artificial cloudy state.

(Example 1) A cleaning solution having a composition as shown in l1hO01 in Table 4 (this solution will be referred to as "Liquid A") was prepared.

A liquid having a composition as shown in column 027 in Table 6 (this liquid is referred to as "Liquid B") was used as a comparative liquid.

2 each of 5 artificial cloudy lenses prepared in Reference Example 3
One piece was immersed in 2.5 t of liquid A kept at 20°C, and the other piece was immersed in 2.5 t of liquid B kept at 20°C. After 5 minutes, it was taken out and the degree of white turbidity removed was measured using a dark-field stereoscopic microscope (manufactured by Olympus Optical Co., Ltd., product name:
Observation was made using an Olympus JM (Tr type).

The criteria for judgment are: ÷: A significantly exceeds B +: A exceeds B ±:　A,! :B is equivalent 1: A is less than B was used.

The results are shown in Table 1.

(Comparative Examples 1 to 4) The same procedure as in Example 1 was performed except that sodium lauryl sulfate was replaced with another surfactant. The results are shown in Table 1 together with Example 1. The surfactants used are as follows.

Comparative example 1: ncBHzsφ5O=Na Comparative example 2:
C++HzsCN(CHz)CzH4SOJa Comparative example 3: NOF type, product name "Nirasan Pronone 208" Comparative example 4: NOF type, product name "Nirasan Pronone H3"
-220J As is clear from Examples and Comparative Examples 1 to 4, the effects of the specific anionic surfactants of the present invention are very large.

(Examples 2 to 9) Cleaning liquids having compositions l1h002 to l1h009 in Table 4 were prepared.

The same operation as in Example 1 was performed using Solution B used in Example 1 as the comparative solution.

The results are shown in Table 2.

(Examples 10 to 19) Cleaning liquids having compositions of 1lho 10 to 020 in Table 5 were prepared.

When the light transmittance of distilled water at 457 nm is taken as 100, the light transmittance of each liquid at 457 nm (
(hereinafter referred to as "T%") was measured and defined as transparency. The results are shown in Table 3.

It can be seen that the addition of the nonionic surfactant eliminated the cloudiness of the cleaning solution.

(Examples 21 to 23, Comparative Example 5) A cleaning liquid having a composition of 0.21 to 0.23 in Table 6 and a liquid having a composition of 11kLO24 in Table 6 were prepared as a comparative liquid.

The artificial cloudy water-containing lens prepared in Reference Example 2 was divided into four parts, and the following operations were performed.

One piece of cod was immersed for a certain period of time in each of the 2°5 cod of the cleaning solution and the comparative solution kept at 0.020°C.

■Take out the lens piece, wash it with a cleaning sponge (manufactured by Toyo Contact Lenses Co., Ltd., product name ``Menicon Puff''), boil it with distilled water and dry it, and measure the degree of white turbidity removed using a dark-field stereoscopic microscope (Olympus Optical). Observation was made using an Olympus JM, Tr type (trade name, manufactured by Co., Ltd.).

Next, it was boiled in distilled water to make it hydrated, and then returned to the original solution (however, it was replaced with a new solution).

■■~■ were repeated.

The criteria for evaluation were as follows.

+: The cloudiness was completely removed. ±: Some of the cloudiness has been removed. m: No change in cloudiness The results were as follows.

(“Actual” indicates an example, “ratio” indicates a comparative example) (Examples 24 to 26, Comparative Example 6) Operated in exactly the same manner as Examples 21 to 23 and Comparative Example 5 to confirm reproducibility. did. The results were as follows.

(“Actual” indicates an example, “ratio” indicates a comparative example) (Examples 27 to 29, Comparative Example 7) Operated in exactly the same manner as Examples 21 to 23 and Comparative Example 5 to confirm reproducibility. did. The results were as follows.

(“Actual” indicates an example, “ratio” indicates a comparative example) Even if a nonionic surfactant is added, the effectiveness of the cleaning liquid of the present invention does not decrease.

(Example 30, Comparative Example 8) A liquid with the composition of N1025 in Table 6 and a liquid with the composition of r1kL026 in Table 6 as a comparative example were prepared.

- Prepare three hydrated lenses (manufactured by Toyo Contact Lenses Co., Ltd., trade name: Menicon Soft AJ) that have been worn on the human eye for a long time and are cloudy due to fixed stains, and divide each lens into two to use as test pieces. One piece of each was immersed in 5 tll each of the cleaning solution and the comparison solution kept at 20°C for 45 minutes and the degree of removal of stuck dirt was examined.The test pieces treated with the washing solution had all the stuck dirt completely removed. On the other hand, there was almost no change in the fixed stains of the test pieces treated with the comparative solution.

(Example 31) The above ingredients were mixed and pressed to prepare tablets.

When one L tablet was dissolved in 10 tll of distilled water, it dissolved while foaming, and the solution after dissolution was cloudy.

(Example 32) When one L tablet prepared in Example 31 was dissolved in 10 all of M solution having the above composition, it was dissolved while foaming, and the solution after dissolution was colorless and transparent. 5ml of this solution
Oxygen-permeable hard lenses (manufactured by Toyo Contact Lens Co., Ltd.) that have been worn on the human eye for a long time and have become cloudy due to fixed dirt.
When the product (trade name: "Menicon e") was immersed at 20°C for 4 hours, the fixed stains were completely removed.

〔Effect of the invention〕

According to the present invention, the protein removal effect of papain is significantly enhanced, and contact lenses can be effectively cleaned in a short period of time.

Furthermore, if necessary, the solution can be made transparent and can be used for all contact lenses, whether water-containing or non-water-containing.

Chapter 1 Table (Margin below) Table 2 (Margin below) Table 3 (Margin below)

Claims (1)

[Claims] (1) Papain and the following formula (I) C_nH_2_n_+_1O(CH_2CH_2O)_
mSO_3M(I) (wherein M is a group selected from the group consisting of Na, K, and NH(CH_2CH_2OH)_3, n is an integer of 8 to 18, m is an integer of 0 to 6) A contact lens cleaning agent characterized by containing one or more of the surfactants shown below.