JPS62243561A - Leucocyte removing filter device - Google Patents
Leucocyte removing filter deviceInfo
- Publication number
- JPS62243561A JPS62243561A JP8518186A JP8518186A JPS62243561A JP S62243561 A JPS62243561 A JP S62243561A JP 8518186 A JP8518186 A JP 8518186A JP 8518186 A JP8518186 A JP 8518186A JP S62243561 A JPS62243561 A JP S62243561A
- Authority
- JP
- Japan
- Prior art keywords
- filter
- blood
- nonwoven fabric
- cylindrical
- leukocyte removal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004369 blood Anatomy 0.000 claims description 75
- 239000008280 blood Substances 0.000 claims description 75
- 210000000265 leukocyte Anatomy 0.000 claims description 57
- 239000004745 nonwoven fabric Substances 0.000 claims description 57
- 239000000835 fiber Substances 0.000 claims description 2
- 239000011162 core material Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000004804 winding Methods 0.000 description 4
- 230000037452 priming Effects 0.000 description 3
- 229920001410 Microfiber Polymers 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 229940021013 electrolyte solution Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、大量の血液中の白血球を効率よく除去するた
めの白血球除去フィルター装置に関する。詳しくは、免
疫系に異常をきたした患者の血液中から、効率的にリン
パ球を含む白血球を除去して治療するために主に用いら
れる、白血球除去フィルター装置に関する。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a leukocyte removal filter device for efficiently removing leukocytes from a large amount of blood. Specifically, the present invention relates to a leukocyte removal filter device that is mainly used to efficiently remove and treat white blood cells, including lymphocytes, from the blood of patients with immune system abnormalities.
（従来技術とその問題点）
血液中の白血球を除去する方法に関しては、古くから研
究されているが、実用化されているものは比較的少ない
（鶴田禎二、バイオマテリアルサイエンス第２集、ｐ、
１５５〜ｐ、１６９南光堂、１９８２）、本発明者らは
、血液中の白血球を効率よく除去でき、しかもその血液
処理速度が十分に大きい実用的な白血球除去手段として
、平均直径が０．３ルｍ以上、３．０用ｍ未満の繊維か
らなる不織布フィルターが有効であることを見出し先に
特許出願した（特開昭６Ｏ−１９３４６８）、さらに、
本発明者らはこの白血球除去フィルターを用いた血液処
理装置が、免疫系に異常をきたした患者の血液中より効
率的かつ選択的にリンパ球を含む白血球を除去１．て治
療する手段として有効に用いうることを見出し、特許出
願した（特願昭６０−１１５４７８）。(Prior art and its problems) Methods for removing white blood cells from blood have been studied for a long time, but relatively few have been put into practical use (Teiji Tsuruta, Biomaterial Science Vol. 2, p.
155-p., 169 Nankodo, 1982), the present inventors have developed a method for removing leukocytes that has an average diameter of 0.3 as a practical leukocyte removal means that can efficiently remove leukocytes from blood and has a sufficiently high blood processing speed. A patent application was filed (Japanese Patent Application Laid-Open No. 6O-193468) on the effectiveness of a non-woven fabric filter made of fibers with a diameter of 1.0 m or more and less than 3.0 m.
The present inventors have demonstrated that a blood processing device using this leukocyte removal filter more efficiently and selectively removes leukocytes, including lymphocytes, from the blood of patients with immune system abnormalities.1. It was discovered that the invention could be effectively used as a means of treating the disease, and a patent application was filed (Japanese Patent Application No. 115478-1983).
特開昭６０−１９３４６８においては、その白血球除去
フィルターの形状は特に規定されていないが、実施態様
として示されているのは、円板状の形状である。５００
ｍ１の血液の処理を目的とした場合、不織布部分の大き
さは、例えばその有効断面積３６ｃｍ″、厚み４ｍｍ程
度である。この様な平板なフィルターの形状は、５００
ｒｎｌ程度の量の血液処理を目的とした場合には、適
当な大きさですむので製作は容易であり、血液処理時の
操作性も良好である。しかしながら、免疫に異常をきた
した患者の血液中より白血球を除去しようとする時のよ
うに大量の血液（例えば２文から６ｆＬ）の処理を目的
とした場合には、圧力損失を小さく保つにはフィルター
の厚みをあまり大きくすることができないことから、必
然的にかなり大きな断面積のものとなってしまい、容器
の成形、不織布を組み込んだ組立てなどがやりにくくな
り、また血液処理時の操作性も悪くなってしまうという
問題がある。別法として、５００ｍ１用のフィルターを
回路で適当な数だけ並列に連結する方法も可能であるが
、回路が複雑になってしまい、操作性もあまり良いもの
ではない。以上の様な理由から、大量の血液を処理する
ためのコンパクトで操作性の良好な白血球除去フィルタ
ー装置の開発が望まれていた。In JP-A-60-193468, the shape of the leukocyte removal filter is not particularly defined, but a disc-like shape is shown as an embodiment. 500
When the purpose is to treat 1 m of blood, the size of the nonwoven fabric part is, for example, about 36 cm in effective cross-sectional area and 4 mm in thickness.The shape of such a flat filter is 500 cm.
When the purpose is to treat an amount of blood on the order of rnl, an appropriate size is sufficient, so manufacture is easy and operability during blood treatment is also good. However, when the purpose is to process a large amount of blood (for example, 2 to 6 fL), such as when trying to remove white blood cells from the blood of a patient with an immune disorder, it is difficult to keep the pressure loss small. Since the filter cannot be made very thick, it inevitably has a fairly large cross-sectional area, making it difficult to form containers and assemble non-woven fabrics, and also to reduce operability during blood processing. The problem is that it gets worse. Alternatively, it is possible to connect an appropriate number of filters for 500 m1 in parallel in a circuit, but the circuit becomes complicated and the operability is not very good. For the above reasons, it has been desired to develop a leukocyte removal filter device that is compact and has good operability for processing large amounts of blood.
（発明の目的）
本発明の目的は、大量の血液を処理するためのコンパク
トで操作性の良好な白血球除去フィルター装置を提供す
ることにある。(Object of the Invention) An object of the present invention is to provide a leukocyte removal filter device that is compact and has good operability for processing a large amount of blood.
（発明の構成および作用）
本発明の白血球除去フィルター装置は、平均直径が０．
３弘ｍ以上、３．０μｍ未満のｌ！誰からなる不織布フ
ィルターと、これを収容する血液入口と血液出口を有す
る容器からなり、不織布フィルターが円筒形状に巻かれ
てその両端面がシールされており、円筒形状不織布フィ
ルターの外側面に前記容器の血液入口が、また円筒形状
不織布フィルターの内側面に容器の血液出口が、それぞ
れ通じており、さらに血液入口と血液出口は円筒形状に
巻かれた不織布フィルターによって隔てられていること
を特徴とする。(Structure and operation of the invention) The leukocyte removal filter device of the present invention has an average diameter of 0.
L of 3 hirom or more and less than 3.0 μm! It consists of a nonwoven fabric filter made of a nonwoven fabric filter and a container having a blood inlet and a blood outlet that accommodates the nonwoven fabric filter. The blood inlet of the container and the blood outlet of the container communicate with the inner surface of the cylindrical nonwoven fabric filter, respectively, and the blood inlet and the blood outlet are separated by a cylindrically wound nonwoven fabric filter. .
平均直径が０．３ルｍ以上、３．ＯｊＬｍ未満の極細繊
維からなる不織布フィルターが血液中の白血球を効率よ
く除去でき、しかも圧力損失が小さく血液の処理速度を
大きくできることに関しては、先に出願した特許に述べ
た通りである（特開昭６０−１９３４６８および、特願
昭６Ｏ−１１５４７８）。3. Average diameter is 0.3 lm or more. The fact that a nonwoven fabric filter made of ultrafine fibers with a diameter of less than OjLm can efficiently remove white blood cells from blood, reduce pressure loss, and increase the blood processing speed is as stated in the previously filed patent (JP-A-Sho). 60-193468 and Japanese Patent Application No. 60-115478).
本発明においては、上記の不織布フィルターが円筒形状
に巻かれることにより、平板状の不織布フィルターを用
いた場合に比べてフィルター装置全体をコンパクトにす
ることができ、大量の血液を処理するために相当量の不
織布を用いる場合でもフィルター装置の大きさはそれ程
大きくならず、血液処理時の操作性も良好に保つことが
できる。In the present invention, by winding the above-mentioned nonwoven fabric filter into a cylindrical shape, the entire filter device can be made more compact compared to the case where a flat nonwoven fabric filter is used, which is suitable for processing a large amount of blood. Even when a large amount of nonwoven fabric is used, the size of the filter device does not become so large, and operability during blood processing can be maintained favorably.
また、円筒形状に巻かれた不織布フィルターの両端面は
シールされており、その外側面に容器の血液入口が、ま
たその内側面に容器の血液出口が、それぞれ通じており
、これらの血液入口と血液出口は円筒形状に巻かれた不
織布フィルターによって隔てられた構造となっているの
で、血液は円筒形状に巻かれた不織布フィルターの外側
面から入って、円筒形状フィルターの半径方向を内側へ
向って流れた後に１円筒形状フィルターの内側面から出
て行く、これによって、同じ量の不織布を用いた平板状
のフィルターに比べて円筒形状のフィルターに、より高
い白血球除去性を持たせることを可能とする。すなわち
、血液中の白血球の大部分は、円筒形状フィルターの外
周部の大きな面積の不織布で迅速に除去され、除去され
ずに残ったわずかな白血球も、円筒形状フィルターの内
周部に到って、その小さな面積の不織布でも十分に除去
されるので、効率的な白血球除去が可能である。In addition, both end faces of the nonwoven fabric filter wound into a cylindrical shape are sealed, and the blood inlet of the container is connected to the outer face of the filter, and the blood outlet of the container is connected to the inner face of the filter. The blood outlet is separated by a cylindrically wound non-woven fabric filter, so blood enters from the outer surface of the cylindrical-shaped non-woven fabric filter and flows inward in the radial direction of the cylindrical filter. After flowing, it exits from the inner surface of the cylindrical filter, which allows the cylindrical filter to have higher leukocyte removal properties than a flat filter using the same amount of nonwoven fabric. do. In other words, most of the white blood cells in the blood are quickly removed by the large area of the nonwoven fabric on the outer periphery of the cylindrical filter, and the few remaining white blood cells reach the inner periphery of the cylindrical filter. Since leukocytes can be sufficiently removed even with a small area of the nonwoven fabric, efficient leukocyte removal is possible.
本発明の白血球除去フィルター装置において、円筒形状
に巻かれた不織布フィルターの平均外径と平均内径の比
は１．５から３０の間であることが好ましい、平均外径
と平均内径の比が１．５未満では外周部と内周部の間で
不織布面積の差が小さくなってしまい、平板状のフィル
ターに対する円筒形状フィルターの白血球除去能の優位
性がなくなってしまう、また、平均外径と平均内径の比
が３０を超えると、フィルターの厚みが厚すぎたり、或
は、円筒形状フィルターの内側面の面積が小さくなりす
ぎて、圧力損失の増大をもたらす。In the leukocyte removal filter device of the present invention, it is preferable that the ratio of the average outer diameter to the average inner diameter of the nonwoven fabric filter wound into a cylindrical shape is between 1.5 and 30, and the ratio of the average outer diameter to the average inner diameter is 1. If it is less than .5, the difference in the area of the nonwoven fabric between the outer periphery and the inner periphery becomes small, and the superiority of the leukocyte removal ability of the cylindrical filter over the flat filter is lost. When the ratio of the inner diameters exceeds 30, the thickness of the filter becomes too thick, or the area of the inner surface of the cylindrical filter becomes too small, resulting in an increase in pressure loss.
本発明において、「円筒形状」とは円筒形に近い形状を
広く含むもので、四角形以上の多角形の断面を有するも
の、中心軸上の上方と下方で断面積が少々異なって円錐
形状となっているもの等も含むものである。その意味で
、明細書中では平均外径、平均内径という表現を用いて
いる。In the present invention, the term "cylindrical shape" broadly includes shapes close to a cylinder, such as those with a polygonal cross section of a square or larger shape, and those with a conical shape with slightly different cross-sectional areas above and below the central axis. This also includes things that are currently in use. In this sense, the expressions "average outer diameter" and "average inner diameter" are used in the specification.
本発明において、円筒形状に巻かれた不織布フィルター
の平均厚みは、５ｍｍから５０ｍｍの間であることが好
ましい、平均厚みが５ｍｍ未満では、白血球が除去しき
れずにもれてしまう可能性が高くなり、５０ｍｍを超え
ると圧力損失が高くなってしまう。In the present invention, the average thickness of the nonwoven fabric filter wound into a cylindrical shape is preferably between 5 mm and 50 mm. If the average thickness is less than 5 mm, there is a high possibility that white blood cells will not be completely removed and will leak. , if it exceeds 50 mm, the pressure loss will increase.
本発明において、円筒形状に巻かれた不織布フィルター
の中心軸方向の長さと平均外径の比は、０．５から２０
の間であることが好ましい。In the present invention, the ratio of the length in the central axis direction of the nonwoven fabric filter wound into a cylindrical shape to the average outer diameter is 0.5 to 20.
It is preferable that it is between.
この比が０．５未満の偏平なフィルターでは、結果的に
フィルターの厚みが厚くなってしまい圧力損失が大きく
なってしまうか、無理に肉薄のフィルターとするならば
フィルター全体が非常に大きくなってしまいコンパクト
性が失われてしまう。A flat filter with this ratio of less than 0.5 will result in a thicker filter, resulting in greater pressure loss, or if it is forced to be thinner, the entire filter will become extremely large. As a result, the compactness is lost.
また、この比が２０を超えると、フィルターが必然的に
非常に縦長になってしまい操作性が悪くなる。Furthermore, if this ratio exceeds 20, the filter will inevitably become very long, resulting in poor operability.
以下に、本発明の白血球除去フィルター装置を、その製
造方法と関連づけてより詳細に説明する。Below, the leukocyte removal filter device of the present invention will be explained in more detail in relation to its manufacturing method.
円筒形状に巻かれた不織布フィルターは、帯状の不織布
をそのまま巻いて円筒形状としたり、適当な芯材のまわ
りに巻きつけて、後で芯材を抜くといった方法でも製造
できる。不織布自体がある程度の機械的強度を持ってい
たり、不織布自体はそれ程の機械的強度がない場合でも
、巻いた後の円筒形状フィルターの肉厚が十分にある時
とか、内径が比較的小さい時などは、円筒形状とした段
階でフィルター全体として強度を持たせることができる
ので、こうした方法でも十分である。A nonwoven fabric filter wound into a cylindrical shape can be manufactured by simply winding a band-shaped nonwoven fabric into a cylindrical shape, or by wrapping it around a suitable core material and later removing the core material. The nonwoven fabric itself has a certain degree of mechanical strength, or even if the nonwoven fabric itself does not have that mechanical strength, the cylindrical filter after being rolled has sufficient wall thickness, or the inner diameter is relatively small. This method is also sufficient since the filter as a whole can be made strong at the stage of forming the filter into a cylindrical shape.
好ましい製造方法の１つとしては、適当な芯材のまわり
にまず荒いメツシュを１周以上巻いてから帯状の不織布
をその上に巻いていき、巻き終ってから芯材を抜く方法
がある。この場合は、内側面の荒いメツシュが形状の保
持の役をするので安定したフィルターとすることができ
る。径の大きな芯材を用いた場合は、芯材は抜き取らず
に残しておいた方が好ましい時もある。芯材は、機械的
強度を保つことと、フィルター装置のプライミングボリ
ュムを小さく押えることに効果がある。また、別の好ま
しい製造方法としては、多孔性で機械的強度のある円管
状の芯材のまわりに不織布を巻きつける方法もあげられ
る。One preferred manufacturing method is to first wrap a rough mesh around a suitable core material once or more, then wrap a strip of nonwoven fabric thereon, and then pull out the core material after the winding is complete. In this case, the rough mesh on the inner surface serves to maintain the shape, resulting in a stable filter. When using a core material with a large diameter, it is sometimes preferable to leave the core material without removing it. The core material is effective in maintaining mechanical strength and keeping the priming volume of the filter device small. Another preferred manufacturing method is a method in which a nonwoven fabric is wound around a circular tubular core material that is porous and has mechanical strength.
上述の各製法において１巻きつける帯状不織布は、１枚
の連続したものであってもよいし、複数枚のものであっ
て、それを同時に巻きつけるか、１枚づつ巻いて重ねて
いくこともできる０巻きつけ方は一般的には一様な力が
加わるようにしながら巻きつけていき、フィルター全体
としてムラがなく、血液が一様に流れるようになること
が好ましい。In each of the above-mentioned manufacturing methods, the band-shaped nonwoven fabric that is wrapped once may be one continuous piece, or it may be multiple pieces that can be wrapped at the same time or one piece at a time and stacked one on top of the other. In general, it is preferable to wind the filter so that a uniform force is applied so that the entire filter is even and the blood flows uniformly.
以上の様にして製作した円筒形状の不織布フィルターを
、血液の入口と血液の出口を有する容器（以後、たんに
「容器」と略称する）に収容するにあたっては、不織布
フィルターと容器の間に適当な支持枠を設けて、容器内
で不織布フィルターが安定して保持されるようにするこ
とが好ましい、好適な支持枠としては荒いメツシュまた
は孔径の大きな多孔性のシートがあげられる。これらを
円筒形状フィルターの周囲に０．５ｍｍ以上。When storing the cylindrical nonwoven fabric filter manufactured as described above in a container (hereinafter simply referred to as "container") having a blood inlet and a blood outlet, it is necessary to place an appropriate space between the nonwoven fabric filter and the container. It is preferable to provide a support frame to stably hold the nonwoven filter within the container. Suitable support frames include rough mesh or porous sheets with large pores. Place these around the cylindrical filter by 0.5 mm or more.
５ｍｍ以下の厚みで巻いて、これを容器内にすきまがほ
とんどない様に収容することによって、フィルターの容
器内での支持を簡便に行ない、かつフィルター装置全体
の充填容量（プライミングボリューム）を非常に小さく
することができる。By winding it to a thickness of 5 mm or less and storing it in the container with almost no gaps, the filter can be easily supported in the container, and the filling volume (priming volume) of the entire filter device can be greatly reduced. Can be made smaller.
メツシュまたはシートの厚みが０．５ｍｍ未満では、容
器の血液入口から入ってきた血液がメツシュ、またはシ
ートが形成する空間に沿って円筒形状不織布フィルター
の外側面全体に一様に拡がる時に、メツシュまたはシー
ト部での圧力損失が大きくなってしまったり、血液がフ
ィルター外側面全体に十分に拡がらなくなってしまった
りする。メツシュまたはシートの厚みが５ｍｍを超える
とフィルター装置の充填容量が大きくなってしまう。If the thickness of the mesh or sheet is less than 0.5 mm, when the blood entering from the blood inlet of the container spreads uniformly over the entire outer surface of the cylindrical nonwoven fabric filter along the space formed by the mesh or sheet, the mesh or sheet Pressure loss at the seat portion may become large, or blood may not spread sufficiently over the entire outer surface of the filter. If the thickness of the mesh or sheet exceeds 5 mm, the filling capacity of the filter device will become large.
以上の様に円筒形状に巻かれた不織布は、その両端面が
適当な方法によってシールされている必要がある。ここ
でいう両端面とは、円筒形状フィルターの上底面と下底
面をさす。シールすることによって、血液は円筒形状に
巻かれた不織布フィルターの通過にあたり、円筒形状の
外側面から内側面へ向って圧力損失が少ないよう主に半
径方向に流れ、血液は常に一定量（半径方向の厚み）以
上の不織布を通過することになり、安定した白血球除去
が行なえるようになる。端面がシールされていないと、
血液は端面からもれてしまい安定した白血球除去は行な
えない、端面のシールは、人工腎臓の製造に用いられて
いるポリウレタンの様な接着材を用いたり、不織布の端
面自体を加熱して熱融着させたり、適当な熱溶融性の材
料を加熱してから不織布の端面に押しつけて熱融着させ
たり、容器形状を工夫して不織布の端面を圧着したり、
などの手段によって行ないうる。Both ends of the nonwoven fabric wound into a cylindrical shape as described above must be sealed by an appropriate method. The term "both end surfaces" as used herein refers to the top and bottom surfaces of the cylindrical filter. By sealing, blood flows mainly in the radial direction from the outer surface to the inner surface of the cylinder to reduce pressure loss as it passes through the nonwoven filter wound in a cylindrical shape. This means that leukocytes can be stably removed by passing through a nonwoven fabric with a thickness greater than or equal to . If the end face is not sealed,
Blood leaks from the edge, making it impossible to remove white blood cells in a stable manner.To seal the edge, use an adhesive such as polyurethane, which is used in the manufacture of artificial kidneys, or heat-fuse the edge of the nonwoven fabric by heating it. by heating a suitable heat-melting material and then pressing it onto the end face of the non-woven fabric to heat-seal it, or by devising the shape of the container and crimping the end face of the non-woven fabric.
This can be done by means such as.
円筒形状に巻かれた不織布フィルターは１両端面をシー
ルしたのち血液入口と血液出口を有する容器に収容され
る。この容器の形状は全体的に円筒形状とし１円筒形状
の不織布フィルターを余分なすき間がないように包み込
むことが好ましい。A nonwoven fabric filter wound into a cylindrical shape is sealed at both end faces and then placed in a container having a blood inlet and a blood outlet. It is preferable that the container has an overall cylindrical shape and encloses a cylindrical nonwoven fabric filter without any unnecessary gaps.
この容器ははじめから一体化されたものでもよいし、い
くつかの部品にわかれており、不織布フィルターを収容
してから組み立てて一体化するものでもよい、また、円
筒形状の容器の内側面には、多数の突起または溝が形成
されていてもよい、この場合は、先に述べた不織布フィ
ルターと容器との間に設ける支持枠はなくてもよい。This container may be integrated from the beginning, or it may be divided into several parts and assembled into one after housing the nonwoven filter. , a large number of protrusions or grooves may be formed. In this case, the support frame provided between the nonwoven fabric filter and the container described above may not be provided.
上記の容器において血液の入口は、収容される円筒形状
不織布フィルターの外側面に通じうる位置であればどこ
に設けてもよく、また血液の出口は同じく内側面に通じ
うる位置ならばどこに設けてもよい、しかしながら、血
液の流れを一様とするには、円筒形状不織布フィルター
の中心軸上であって円筒形状の両端に対向するように、
血液の入口と血液の出口が設けられることが好ましい。In the above-mentioned container, the blood inlet may be provided at any position as long as it can communicate with the outer surface of the cylindrical nonwoven filter to be accommodated, and the blood outlet may be provided in any position that can communicate with the inner surface of the cylindrical nonwoven filter. However, in order to make the blood flow uniform, it should be placed on the central axis of the cylindrical nonwoven fabric filter and opposite both ends of the cylindrical shape.
Preferably, a blood inlet and a blood outlet are provided.
円筒形状に巻かれた不織布フィルターを血液入口と血液
出口を有する容器に収容して本発明の白血球除去フィル
ター装置とするにあたって重要なことは、先にも述べた
ように、血液の入口が両端面がシールされた円筒形状不
織布フィルターの外側面に通じ、血液の出口が同じく円
筒形状フィルターの内側面に通じ、これらの血液入口と
血液出口は上記のフィルターによって隔てられた構造と
することにある。このことにより血液は、血液の入口か
ら容器内に入って、適当な血液導入路を経て円筒形状フ
ィルターの外側面に拡がり、続いて円筒形状フィルター
を通過してその内側面に到り、適当な血液導出路を経て
血液の出口より容器の外へ出て行くことになる。上記の
血液導入路および血液導出路とは、容器内の円筒形状フ
ィルターによって隔てられた、血液の入口側の空間と血
液の出口側の空間を指す、なお１円筒形状フィルターの
両端面のシール部分は、容器の一部を形成して容器の外
部と接する形式にすることもできる。As mentioned earlier, it is important to accommodate the nonwoven fabric filter wound into a cylindrical shape in a container having a blood inlet and a blood outlet to form the leukocyte removal filter device of the present invention. is connected to the outer surface of the sealed cylindrical nonwoven fabric filter, and the blood outlet is also connected to the inner surface of the cylindrical filter, and these blood inlets and blood outlets are separated by the above-mentioned filter. As a result, blood enters the container from the blood inlet, spreads to the outside surface of the cylindrical filter through a suitable blood introduction path, and then passes through the cylindrical filter to reach the inside surface of the cylindrical filter. The blood exits the container from the blood outlet via the blood outlet path. The above-mentioned blood introduction channel and blood outlet channel refer to the space on the blood inlet side and the space on the blood outlet side that are separated by the cylindrical filter in the container, and the sealed portions on both end faces of the cylindrical filter can also form a part of the container and be in contact with the outside of the container.
本発明の白血球除去フィルター装置は、精製水または生
理的液体が充填されかつ滅菌されたものとすることがで
きる。このことは、白血球除去フィルター装置に精製水
または生理的液体を充填してから、高圧蒸気滅菌、ガン
マ線滅菌などで滅菌することによって実現でき、また、
エチレンオキサイドガス滅菌などであらかじめ白血球除
去フィルター装置を滅菌しておいてから無菌的に精製水
または生理的液体を充填することによっても実現できる
。生理的液体とは、生理食塩水、リン酸緩衝液、各種等
張電解質液などをさす。The leukocyte removal filter device of the present invention can be filled with purified water or physiological fluid and sterilized. This can be achieved by filling the leukocyte removal filter device with purified water or physiological fluid and then sterilizing it by autoclaving, gamma sterilization, etc.
This can also be achieved by sterilizing the leukocyte removal filter device in advance, such as by ethylene oxide gas sterilization, and then aseptically filling it with purified water or physiological fluid. Physiological fluids include physiological saline, phosphate buffer, various isotonic electrolyte solutions, and the like.
精製水または生理的液体が充填され、かつ、滅菌されて
いることにより、白血球除去フィルター装置は血液を通
過させる前に一般的に行なう生理食塩水でのプライミン
グ操作が全く不要または極めて容易になる。また、極細
繊維の不織布全体があらかじめ十分にぬれた状態となり
有効に白血球除去に用いることができるので、白血球除
去フィルター装置は、その白血球除去性能を最大限に安
定して発揮できる。By being filled with purified water or physiological fluid and being sterilized, the leukocyte removal filter device does not require or greatly facilitate priming with saline, which is typically done before passing blood. Further, since the entire nonwoven fabric of ultrafine fibers is sufficiently wetted in advance and can be effectively used for leukocyte removal, the leukocyte removal filter device can exhibit its leukocyte removal performance to the maximum extent and stably.
次に、添付図面により本発明の白血球除去フィルター装
置を説明する。Next, the leukocyte removal filter device of the present invention will be explained with reference to the accompanying drawings.
第１図と第２図は１本発明の白血球除去フィルター装置
の１具体例の縦方向の断面図（第１図）と横方向の断面
図（第２図）である、１はフィルター装置本体で、円筒
型の枠体２とキャップ３．３′とが嵌合されている。４
はメツシュ部であり、不織布フィルタ一層５の外周をと
り巻いている。６は５を内側から保持するメツシュ部で
ある。７．７′は接着材であり、２に４．５．６を接着
固定している。血液は入口８より入り、ｈ液導入口９か
ら４へ導入され、５の外周部に一様に拡がった後、５の
外側から内側へと流れてこの間に白血球が除去される。1 and 2 are a vertical sectional view (FIG. 1) and a horizontal sectional view (FIG. 2) of a specific example of a leukocyte removal filter device of the present invention, 1 is a main body of the filter device. The cylindrical frame 2 and the cap 3.3' are fitted together. 4
is a mesh portion, which surrounds the outer periphery of the nonwoven filter layer 5. 6 is a mesh portion that holds 5 from the inside. 7.7' is an adhesive, and 4.5.6 is adhesively fixed to 2. Blood enters from the inlet 8, is introduced into the h-liquid inlet 9 to 4, spreads uniformly around the outer periphery of 5, and then flows from the outside to the inside of 5, during which time white blood cells are removed.
白血球を除去された血液は６を通って血液導出通路１０
に入り、続いて血液出口１１よりフィルター装置の外部
へと流れていく。The blood from which white blood cells have been removed passes through 6 to a blood outlet passage 10.
The blood then flows to the outside of the filter device through the blood outlet 11.
次に、実施例によって本発明をより具体的に説明する。Next, the present invention will be explained in more detail with reference to Examples.
（実施例１）
平均直径１．８ＪＬｍのポリエステル（ＰＥＴ ：密度
１．３８ｇ／Ｃｍ″）のａｍよりなる不織布（６５ｇ／
ｍ″目付）を幅１６２ｍｍに切断し、外径４ ｍ ｍの
ポリプロピレン製の円筒型のメツシュの周囲に巻いてい
き、長さ２４０ｃｍ分の不織布を巻いた所、外径３６ｍ
ｍの円筒状となった。この外周にポリプロピレン製のメ
ツシュを巻き、内径４０ｍｍ、長さ１８４ｍｍの円筒型
のポリカーボネート製の容器内に収め、接着材としてポ
リウレタン樹脂を両端からそれぞれ約１２ｍｍの所まで
注入し、樹脂が固まった後に血液の導入口と導出口を、
樹脂を切り取ることによって形成させ、最後に血液の入
口と出口を有するキャップを円筒型ポリカーボネートの
両端に超音波融着させることにより、第１図および第２
図に示すような円筒型のフィルター装置（以下「円筒型
フィルター」と略称する）を製作した。また、比較のた
めに同じ不織布を直径１６０ｍｍの円形に切断したもの
を２０枚重ねて用い、公知の平型フィルターを製作した
。その不織布フィルタ一部分の厚みは７ｍｍ、有効部分
の断面積は１６９ ｃｒｎ’であった。これら円筒型フ
ィルターおよび平型フィルターにおける不織布フィルタ
ーの有効部分の重さは約２１．９ｇでほぼ等しい、 上
記の２つのフィルターの各々に、ＡＣＤを添加した牛の
新鮮面６文（白血球濃度５５００コ／ＩＬｆＬ、血小板
濠度２１７０００コ／ｇＪＬ）を、３７℃の温度、５０
ｍＪＬ／ ｍ ｉ ｎの流速で流し、フィルター前後の
圧力損失、白血球除去率、血小板通過率を調べた。(Example 1) A nonwoven fabric (65 g/cm'') made of am of polyester (PET: density 1.38 g/Cm'') with an average diameter of 1.8 JLm.
m" fabric weight) to a width of 162 mm and wrapped around a polypropylene cylindrical mesh with an outer diameter of 4 mm. When wrapped with a 240 cm long nonwoven fabric, the outer diameter was 36 mm.
It became a cylindrical shape of m. A polypropylene mesh is wrapped around this outer circumference, and the container is placed in a cylindrical polycarbonate container with an inner diameter of 40 mm and a length of 184 mm. Polyurethane resin is injected as an adhesive up to about 12 mm from both ends, and after the resin hardens. blood inlet and outlet,
Figures 1 and 2 were formed by cutting out the resin and finally by ultrasonically welding caps with blood inlets and outlets to both ends of the cylindrical polycarbonate.
A cylindrical filter device (hereinafter abbreviated as "cylindrical filter") as shown in the figure was manufactured. For comparison, a known flat filter was manufactured by stacking 20 sheets of the same nonwoven fabric cut into a circular shape with a diameter of 160 mm. The thickness of a portion of the nonwoven fabric filter was 7 mm, and the cross-sectional area of the effective portion was 169 crn'. The weight of the effective part of the nonwoven filter in these cylindrical filters and flat filters is about 21.9g, which is almost the same.Each of the above two filters contains 6 grams of fresh cow beef supplemented with ACD (white blood cell concentration 5500 grams). /ILfL, platelet density 217,000/gJL) at a temperature of 37°C, 50
It was flowed at a flow rate of mJL/min, and the pressure loss before and after the filter, leukocyte removal rate, and platelet passage rate were examined.
結果は、圧力損失は円筒型フィルター、平型フィルター
ともに１５ｍｍＨｇ以下と低い値で安定していた。白血
球除去率は１円筒型フィルターで９２．７％、平型フィ
ルターで８３．９％であり、血小板通過率はそれぞれ８
７．９％、７９゜６％であった。円筒型フィルターの方
が、同じ量の不織布を用いた平型フィルターに比べて白
血球除去率が高いことがわかる。The results showed that the pressure loss was stable at a low value of 15 mmHg or less for both the cylindrical filter and the flat filter. The leukocyte removal rate was 92.7% with the cylindrical filter and 83.9% with the flat filter, and the platelet passage rate was 8.
It was 7.9%, 79°6%. It can be seen that the cylindrical filter has a higher leukocyte removal rate than the flat filter using the same amount of nonwoven fabric.
（実施例２）
実施例１の円筒型フィルターと同じものを４個製作した
。このうち２個に生理食塩水を十分に充填してから高圧
蒸気滅菌を行ない、また別のｌ （ＩＩは生理食塩水を
充填しない乾燥状態で高圧蒸気滅菌を行なった。(Example 2) Four cylindrical filters identical to those of Example 1 were manufactured. Two of these were sufficiently filled with physiological saline and then subjected to high-pressure steam sterilization, and another one (II) was subjected to high-pressure steam sterilization in a dry state without being filled with physiological saline.
生理食塩水を十分に充填してから高圧蒸気滅菌を行なっ
たフィルター１個と何もしていないフィルター１個に、
それぞれ、ＡＣＤを添加した牛の新鮮面６１（白血球濃
度６４００コ／ＩＬ！Ｌ、血小板濃度１３６０００コ／
終文）を実施例１と同じ様に流した。結果は、前者のフ
ィルターの白血球除去率９６．６％、血小板通過率８４
．７％に対して、後者の白血球除去率８６．３％、血小
板通過率７９．６％であった。One filter was fully filled with saline and then sterilized using high-pressure steam, and one filter was left empty.
Fresh beef side 61 supplemented with ACD (white blood cell concentration 6400/IL!L, platelet concentration 136000/IL)
(End) was run in the same manner as in Example 1. The results showed that the leukocyte removal rate of the former filter was 96.6%, and the platelet passage rate was 84%.
．． 7%, the latter had a leukocyte removal rate of 86.3% and a platelet passage rate of 79.6%.
また、生理食塩水を十分に充填してから高圧蒸気滅菌を
行なったもう１個のフィルターと生理食塩水を充填しな
いで高圧蒸気滅菌を行なったフィルター１個に、それぞ
れ、、ＡＣＤを添加した牛の新鮮面６文（白血球濃度５
６１０コ／ＩＬｆＬ、血小板濃度２３２０００コ／ ｐ
−、Ｑ、 ）を実施例１と同様に流した。結果は、前者
のフィルターの白血球除去率９６．５％、血小板通過率
９１．８％に対して、後者の白血球除去率７０．８％、
血小板通過率８６．９％であ−クた。In addition, ACD was added to another filter that was sufficiently filled with physiological saline and then autoclaved, and one filter that was autoclaved without saline. Fresh side 6 sentences (white blood cell concentration 5
610/ILfL, platelet concentration 232,000/p
-, Q, ) were run in the same manner as in Example 1. The results show that the former filter has a leukocyte removal rate of 96.5% and a platelet passage rate of 91.8%, while the latter has a leukocyte removal rate of 70.8% and a platelet passage rate of 91.8%.
The platelet passage rate was 86.9%.
上記の実験において、生理的−＠！堵木有−充填１．た
状態で滅菌されたフィルターの、血液を流す前Ｖ゛行な
う生理食塩水のプシイミング（洗浄およびフィルター内
の空気を追い出すこと）は、何もしていないフィルター
または乾燥状態１′滅菌されたフィルターに比べて極め
て容易であ：８ｔやｉた結果からもわかるように、前者
のフィルターの方が後者のフィルターに比べて白血球除
去性も優れていた。In the above experiment, physiological −@! Toki Aru - Filling 1. The saline pushiming (washing and expulsion of air in the filter) of a filter that has been sterilized in a dry state before blood flow is significantly lower than that of a filter that has been sterilized in a dry state or a dry state. As can be seen from the results, the former filter was also superior in leukocyte removal compared to the latter filter.
（発明の効果）
本発明は、大量の血液を処理するためのコンパクトで操
作性の良好な白血球除去フィルター装置を提供するもの
である０本発明の白血球除去フィルター装置により、免
疫系に異常をきたした患者の血液中から白血球を除去し
て治療する手法がより簡便に、かつ効果的に行なえるこ
とが期待される。(Effects of the Invention) The present invention provides a leukocyte removal filter device that is compact and has good operability for processing a large amount of blood. It is expected that treatment by removing leukocytes from the blood of patients with cancer will become easier and more effective.
第１図は本発明の白血球除去フィルター装置の１具体例
の縦方向の断面図、第２図はその横方向の断面図である
。
１、フィルター装置本体 ７．７’、接着材２６円筒型
枠体 ８．血液入口３．３’、キャップ
９．血液導入口４、外周メツシュ部 １０．血液導
出通路５、不織布フィルタ一層 １１．血液出口６、内
周メツシュ部FIG. 1 is a vertical cross-sectional view of a specific example of the leukocyte removal filter device of the present invention, and FIG. 2 is a horizontal cross-sectional view thereof. 1. Filter device main body 7.7', Adhesive material 26 Cylindrical frame body 8. Blood inlet 3.3', cap
9. Blood inlet 4, outer mesh part 10. Blood outlet passage 5, one layer of nonwoven fabric filter 11. Blood outlet 6, inner mesh part
Claims (4)
維からなる不織布フィルターと、これを収容する血液入
口と血液出口を有する容器からなるフィルター装置にお
いて、前記不織布フィルターが円筒形状に巻かれてその
両端面がシールされており、円筒形状不織布フィルター
の外側面に前記容器の血液入口が、また円筒形状不織布
フィルターの内側面に容器の血液出口が、それぞれ通じ
ており、さらに血液入口と血液出口は円筒形状に巻かれ
た不織布フィルターによって隔てられていることを特徴
とする白血球除去フィルター装置。(1) A filter device comprising a nonwoven fabric filter made of fibers with an average diameter of 0.3 μm or more and less than 3.0 μm, and a container containing the nonwoven fabric filter having a blood inlet and a blood outlet, in which the nonwoven fabric filter is wound into a cylindrical shape. The blood inlet of the container is connected to the outer surface of the cylindrical non-woven filter, and the blood outlet of the container is connected to the inner surface of the cylindrical non-woven filter. A leukocyte removal filter device characterized in that an outlet is separated by a nonwoven fabric filter wound into a cylindrical shape.
径と平均内径の比が１．５から３０の間である特許請求
の範囲（１）記載の白血球除去フィルター装置。(2) The leukocyte removal filter device according to claim (1), wherein the ratio of the average outer diameter to the average inner diameter of the nonwoven fabric filter wound into a cylindrical shape is between 1.5 and 30.
が５ｍｍから５０ｍｍの間である特許請求の範囲（１）
、または（２）に記載の白血球除去フィルター装置。(3) Claim (1) in which the average thickness of the nonwoven fabric filter wound into a cylindrical shape is between 5 mm and 50 mm.
, or the leukocyte removal filter device according to (2).
方向の長さと平均外径の比が０．５から２０の間である
特許請求の範囲（１）〜（３）のいずれか１つに記載の
白血球除去フィルター装置。(4) Any one of claims (1) to (3), wherein the ratio of the length in the central axis direction to the average outer diameter of the nonwoven fabric filter wound into a cylindrical shape is between 0.5 and 20. The leukocyte removal filter device described in .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8518186A JPS62243561A (en) | 1986-04-15 | 1986-04-15 | Leucocyte removing filter device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8518186A JPS62243561A (en) | 1986-04-15 | 1986-04-15 | Leucocyte removing filter device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62243561A true JPS62243561A (en) | 1987-10-24 |
Family
ID=13851486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8518186A Pending JPS62243561A (en) | 1986-04-15 | 1986-04-15 | Leucocyte removing filter device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62243561A (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03188872A (en) * | 1989-12-20 | 1991-08-16 | Taiichiro Iwakura | Method for deactivating aids virus |
| WO1992004906A1 (en) * | 1990-09-25 | 1992-04-02 | Asahi Medical Co., Ltd. | Leukocyte removal method and leukocyte removal filter system |
| US5863436A (en) * | 1990-05-24 | 1999-01-26 | Pall Corporation | Venting system |
| US5902490A (en) * | 1994-03-10 | 1999-05-11 | Hemasure, Inc. | Filtration method and device useable for removal of leukocytes and other blood components |
| WO1999058172A1 (en) | 1998-05-13 | 1999-11-18 | Asahi Medical Co., Ltd. | Filter device and method for processing blood |
| US6010633A (en) * | 1997-03-06 | 2000-01-04 | Hemasure Inc. | Method of preventing air from becoming entrapped within a filtration device |
| US6251292B1 (en) | 1994-03-10 | 2001-06-26 | Hemasure, Inc. | Method of preventing air from becoming entrapped within a filtration device |
| JP2002172163A (en) * | 2000-07-26 | 2002-06-18 | Toray Ind Inc | Cell adsorbent material and column for extracorporeal circulation and method for manufacturing them |
| WO2006126497A1 (en) * | 2005-05-23 | 2006-11-30 | Asahi Kasei Medical Co., Ltd. | Body fluid treating filter device |
| JP2007190372A (en) * | 2005-12-20 | 2007-08-02 | Asahi Kasei Medical Co Ltd | Blood processing filter apparatus |
| JP2007330290A (en) * | 2006-06-12 | 2007-12-27 | Toray Ind Inc | Carrier module |
| WO2009128564A1 (en) | 2008-04-18 | 2009-10-22 | 日機装株式会社 | Adsorbent for the removal of blood cells |
| WO2012133609A1 (en) * | 2011-03-30 | 2012-10-04 | 東レ株式会社 | Blood-purifying column |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5631737A (en) * | 1979-08-22 | 1981-03-31 | Baxter Travenol Lab | Blood filter for white corpuscle |
| JPS60203267A (en) * | 1984-03-27 | 1985-10-14 | 旭メデイカル株式会社 | Filter apparatus for removing leucocyte |
-
1986
- 1986-04-15 JP JP8518186A patent/JPS62243561A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5631737A (en) * | 1979-08-22 | 1981-03-31 | Baxter Travenol Lab | Blood filter for white corpuscle |
| JPS60203267A (en) * | 1984-03-27 | 1985-10-14 | 旭メデイカル株式会社 | Filter apparatus for removing leucocyte |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03188872A (en) * | 1989-12-20 | 1991-08-16 | Taiichiro Iwakura | Method for deactivating aids virus |
| US5863436A (en) * | 1990-05-24 | 1999-01-26 | Pall Corporation | Venting system |
| WO1992004906A1 (en) * | 1990-09-25 | 1992-04-02 | Asahi Medical Co., Ltd. | Leukocyte removal method and leukocyte removal filter system |
| US6015500A (en) * | 1994-03-10 | 2000-01-18 | Hemasure Inc. | Filtration device useable for removal of leukocytes and other blood components |
| US6251292B1 (en) | 1994-03-10 | 2001-06-26 | Hemasure, Inc. | Method of preventing air from becoming entrapped within a filtration device |
| US5902490A (en) * | 1994-03-10 | 1999-05-11 | Hemasure, Inc. | Filtration method and device useable for removal of leukocytes and other blood components |
| US6010633A (en) * | 1997-03-06 | 2000-01-04 | Hemasure Inc. | Method of preventing air from becoming entrapped within a filtration device |
| WO1999058172A1 (en) | 1998-05-13 | 1999-11-18 | Asahi Medical Co., Ltd. | Filter device and method for processing blood |
| JP2009022762A (en) * | 1998-05-13 | 2009-02-05 | Asahi Kasei Kuraray Medical Co Ltd | Filter device and method for treatment of blood |
| JP2002172163A (en) * | 2000-07-26 | 2002-06-18 | Toray Ind Inc | Cell adsorbent material and column for extracorporeal circulation and method for manufacturing them |
| US7597806B2 (en) | 2005-05-23 | 2009-10-06 | Asahi Kasei Kuraray Medical Co., Ltd. | Body fluid treating filter device |
| WO2006126497A1 (en) * | 2005-05-23 | 2006-11-30 | Asahi Kasei Medical Co., Ltd. | Body fluid treating filter device |
| JP5189360B2 (en) * | 2005-05-23 | 2013-04-24 | 旭化成メディカル株式会社 | Body fluid treatment filter device |
| JP2007190372A (en) * | 2005-12-20 | 2007-08-02 | Asahi Kasei Medical Co Ltd | Blood processing filter apparatus |
| JP2007330290A (en) * | 2006-06-12 | 2007-12-27 | Toray Ind Inc | Carrier module |
| WO2009128564A1 (en) | 2008-04-18 | 2009-10-22 | 日機装株式会社 | Adsorbent for the removal of blood cells |
| US8541538B2 (en) | 2008-04-18 | 2013-09-24 | Nikkiso Co., Ltd. | Adsorbent for the removal of blood cells |
| US8748560B2 (en) | 2008-04-18 | 2014-06-10 | Nikkiso Company, Ltd. | Adsorbent for the removal of blood cells |
| WO2012133609A1 (en) * | 2011-03-30 | 2012-10-04 | 東レ株式会社 | Blood-purifying column |
| JP5870920B2 (en) * | 2011-03-30 | 2016-03-01 | 東レ株式会社 | Blood purification column |
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