JPS62234085A - Remedy for diabetic complication comprising thiazolidine derivative as active ingredient - Google Patents

Remedy for diabetic complication comprising thiazolidine derivative as active ingredient

Info

Publication number
JPS62234085A
JPS62234085A JP29794486A JP29794486A JPS62234085A JP S62234085 A JPS62234085 A JP S62234085A JP 29794486 A JP29794486 A JP 29794486A JP 29794486 A JP29794486 A JP 29794486A JP S62234085 A JPS62234085 A JP S62234085A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
alkyl
remedy
active ingredient
etc
1w4c
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP29794486A
Inventor
Hiroyoshi Horikoshi
Keiichi Matsuda
Shinji Yoshioka
Takao Yoshioka
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

PURPOSE: A remedy for diabetic complication having improved inhibitory action on aldose reductase, promoting action on prostaglandin I2 synthesis, inhibitory action on 5-lipoxygenase and low toxicity, comprising a thiazolidine derivative shown by a specific structural formula as an active ingredient.
CONSTITUTION: The aimed remedy comprising a thiazolidine derivative shown by formula [R1 is H or 1W8C alkyl; R2 is H or 1W5C alkyl; R3 is H, 1W4C aliphatic acyl, heteroatm-containing 5- or 6-membered heterocyclic acyl, etc.; R4 is 1W8C alkyl or 1W4C alkoxy; R5 is H, 1W5C alkyl, etc.,; W is methylene, carbonyl, group shown by formula II or formula III (R6 is H, 1W4C alkyl, aralkyl, etc.); U is methylene or U and R1 are optionally bonded to form double bond when W is carbonyl; U and W are optionally bonded to show double bond; n is 1W3] and a pharmaceutically acceptable salt thereof as an active ingredient.
COPYRIGHT: (C)1987,JPO&Japio
JP29794486A 1985-12-18 1986-12-15 Remedy for diabetic complication comprising thiazolidine derivative as active ingredient Pending JPS62234085A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP28531885 1985-12-18

Publications (1)

Publication Number Publication Date
JPS62234085A true true JPS62234085A (en) 1987-10-14

Family

ID=17689983

Family Applications (1)

Application Number Title Priority Date Filing Date
JP29794486A Pending JPS62234085A (en) 1985-12-18 1986-12-15 Remedy for diabetic complication comprising thiazolidine derivative as active ingredient

Country Status (1)

Country Link
JP (1) JPS62234085A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6438090A (en) * 1987-02-04 1989-02-08 Sankyo Co Thiazolidine compound
US5037842A (en) * 1990-06-05 1991-08-06 Pfizer Inc. Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
EP0469782A2 (en) * 1990-08-02 1992-02-05 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of cataract with prostacyclin compounds
WO1994019347A1 (en) * 1993-02-24 1994-09-01 Sankyo Company, Limited Arteriosclerosis remedy
WO1997027191A1 (en) * 1996-06-19 1997-07-31 Dr. Reddy's Research Foundation Novel polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation
WO1998010760A1 (en) * 1996-09-12 1998-03-19 Sankyo Company, Limited Glutathione reductase activity potentiator containing troglitazone
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives
WO2000007582A3 (en) * 1998-08-06 2000-06-22 John Hardwick Johnson Use of thiazolidinedione derivatives for the treatment or prevention of cataracts
WO2000030628A3 (en) * 1998-11-20 2001-10-11 Genentech Inc Method of inhibiting angiogenesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (en) * 1983-08-30 1985-03-22 Sankyo Co Ltd Thiazolidine derivative and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (en) * 1983-08-30 1985-03-22 Sankyo Co Ltd Thiazolidine derivative and its preparation

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6438090A (en) * 1987-02-04 1989-02-08 Sankyo Co Thiazolidine compound
US5037842A (en) * 1990-06-05 1991-08-06 Pfizer Inc. Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
EP0469782A2 (en) * 1990-08-02 1992-02-05 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of cataract with prostacyclin compounds
EP0469782B1 (en) * 1990-08-02 1997-01-02 R-Tech Ueno, Ltd. Treatment of cataract with prostacyclin compounds
WO1994019347A1 (en) * 1993-02-24 1994-09-01 Sankyo Company, Limited Arteriosclerosis remedy
WO1997027191A1 (en) * 1996-06-19 1997-07-31 Dr. Reddy's Research Foundation Novel polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation
WO1998010760A1 (en) * 1996-09-12 1998-03-19 Sankyo Company, Limited Glutathione reductase activity potentiator containing troglitazone
WO2000007582A3 (en) * 1998-08-06 2000-06-22 John Hardwick Johnson Use of thiazolidinedione derivatives for the treatment or prevention of cataracts
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives
WO2000030628A3 (en) * 1998-11-20 2001-10-11 Genentech Inc Method of inhibiting angiogenesis

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