JPS62230648A - Calcium phosphate based glass having water resistance and low viscosity - Google Patents
Calcium phosphate based glass having water resistance and low viscosityInfo
- Publication number
- JPS62230648A JPS62230648A JP7246586A JP7246586A JPS62230648A JP S62230648 A JPS62230648 A JP S62230648A JP 7246586 A JP7246586 A JP 7246586A JP 7246586 A JP7246586 A JP 7246586A JP S62230648 A JPS62230648 A JP S62230648A
- Authority
- JP
- Japan
- Prior art keywords
- calcium phosphate
- water resistance
- glass
- weight
- low viscosity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011521 glass Substances 0.000 title claims abstract description 19
- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 15
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract description 15
- 235000011010 calcium phosphates Nutrition 0.000 title claims abstract description 15
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 239000011575 calcium Substances 0.000 claims abstract description 9
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 4
- 229910052796 boron Inorganic materials 0.000 claims abstract description 4
- 229910052742 iron Inorganic materials 0.000 claims abstract description 3
- 229910052747 lanthanoid Inorganic materials 0.000 claims abstract description 3
- 150000002602 lanthanoids Chemical class 0.000 claims abstract description 3
- 229910052706 scandium Inorganic materials 0.000 claims abstract description 3
- 229910052733 gallium Inorganic materials 0.000 claims abstract 2
- 229910052727 yttrium Inorganic materials 0.000 claims abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
- 239000011574 phosphorus Substances 0.000 claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims description 3
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 abstract description 2
- 229910052738 indium Inorganic materials 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract 2
- FUJCRWPEOMXPAD-UHFFFAOYSA-N Li2O Inorganic materials [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 abstract 1
- XUCJHNOBJLKZNU-UHFFFAOYSA-M dilithium;hydroxide Chemical compound [Li+].[Li+].[OH-] XUCJHNOBJLKZNU-UHFFFAOYSA-M 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910000765 intermetallic Inorganic materials 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- NOTVAPJNGZMVSD-UHFFFAOYSA-N potassium monoxide Inorganic materials [K]O[K] NOTVAPJNGZMVSD-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000012237 artificial material Substances 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 239000006060 molten glass Substances 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000009750 centrifugal casting Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 150000002601 lanthanoid compounds Chemical class 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、低粘性でｕＪ耐水性を有するリン酸カルシウ
ム系ガラスに関するものである。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a calcium phosphate glass having low viscosity and uJ water resistance.
（従来の技術）
従来、リン酸カルシウム系ガラスは生体親和性に優れて
いると考えられる事から、骨置換材料、人工両材料とし
て検討されている。(Prior Art) Calcium phosphate glass has been considered as both a bone replacement material and an artificial material because it is thought to have excellent biocompatibility.
人工両材料としては１寸法精度の良い成形ができること
、長期間便用できる耐久性を具えていることが要求され
る。Artificial materials are required to be able to be molded with high dimensional accuracy and to be durable enough to be used for a long period of time.
リン酸カルシウムガラスは一般に低粘性であるため、鋳
造成形により非常に精度の良い成形が可能であるが、そ
の耐水性は十分でなかった。Since calcium phosphate glass generally has a low viscosity, it can be molded with very high precision by casting, but its water resistance has not been sufficient.
かかる１叶水性を向上せしめる目的で、Ｂや人工化合物
を添加する試みがなされている。In order to improve the water resistance, attempts have been made to add B or artificial compounds.
（発明の解決しようとする問題点）
しかしながら、これらの成分を耐水性が改番される迄添
加すると、溶融ガラスの粘度が鳩くなり、成形性が低下
する欠点を有している。(Problems to be Solved by the Invention) However, if these components are added until the water resistance is changed, the viscosity of the molten glass becomes cloudy, resulting in a decrease in moldability.
（問題点を解決するための手段）
本発明者は、かかる溶融ガラスの粘度を上昇せしめるこ
となく、高耐水性を付与したリンぼカルシウム系ガラス
を得る事を目的とし、種々研究、検討した結果、特定の
リン酸カルシウム系ガラスに対し、異なった２つの郡か
ら選ばれた物質を夫々特定量づつ添加することにより、
前記目的を達成し得ることを見出した。(Means for Solving the Problems) The present inventor has conducted various research and examinations with the aim of obtaining lime calcium-based glass that has high water resistance without increasing the viscosity of the molten glass. By adding specific amounts of substances selected from two different groups to a specific calcium phosphate glass,
It has been found that the above object can be achieved.
かくして本発明は、カルシウムのリンに対する原子比Ｃ
ａ／Ｐが０．２〜０．７のリン酸カルシウムを７０重量
−以上含有し、かつＬｉ、Ｎａ、Ｋの化合物の１種ある
いは混合物をＬ１２０、Ｎａ２Ｏ，［２０に換算して０
．０２〜１５！ｔ％及びＢ、 Ａｌ、 Ｂａ％？ｅ、
Ｇａ、 Ｙ、Ｉｎ、ランタニド（痣称してＡと呼ぶ）の
化合物の１種あるいは混合物を酸化物Ａ２０３に換算し
て１〜２０重量％含有することを特徴とする低粘性で高
耐水性のり／酸カルシウム糸ガラスを提供するにある。Thus, the present invention provides that the atomic ratio of calcium to phosphorus C
Contains 70% by weight or more of calcium phosphate with a/P of 0.2 to 0.7, and contains one or a mixture of Li, Na, and K compounds as L120, Na2O, [0 in terms of 20.
．． 02-15! t% and B, Al, Ba%? e,
A low-viscosity, highly water-resistant glue characterized by containing 1 to 20% by weight of Ga, Y, In, and lanthanide (referred to as A) compounds by weight in terms of oxide A203. Calcium acid fiber glass is available.
本発明においてリン酸カルシウム系ガラスに含まれるリ
ン酸カルシウムは、カルシウムとリンの原子比Ｃａ／Ｐ
が０．２〜０．７の範囲が必要である。０．２未満では
リン酸分が多すぎて耐水性の高いガラスが得難くなり、
０．７を超えると均一なガラスが得難くなる。このリン
酸カルシウム質の含有量は７０重ｆチ以上が必要であり
、特に７８重１ｉｌチ以上が好ましい。７０１１Ｌ量チ
に満たない場合は、リン酸カルシウム質の生体親和性が
十分に発揮されないおそれがある。In the present invention, the calcium phosphate contained in the calcium phosphate glass has an atomic ratio of calcium and phosphorus of Ca/P.
is required to be in the range of 0.2 to 0.7. If it is less than 0.2, the phosphoric acid content is too high and it becomes difficult to obtain glass with high water resistance.
When it exceeds 0.7, it becomes difficult to obtain uniform glass. The content of this calcium phosphate substance must be at least 70w/ft, particularly preferably at least 78w/l. If the amount of 7011L is less than 1, the biocompatibility of calcium phosphate may not be fully exhibited.
一方、含有されるし１、Ｎａ、にの化合物は例えば単体
、酸化物、水酸化物、炭酸塩、硝噴塩、硫酸塩、ハロゲ
ン化物等として用いることができ、更にこれらを混合物
として用いることもできる。これらの化合物の添加量は
施加するガラスの組成にエリ厳密には決定されるが、一
般に０．０２〜１５重ｔ％添加するのが必要であり、荷
に０．１〜８］！童チが好ましい。０．０２ＴＬ重量チ
未満ではガラスの粘度を低下させる効果が与られず、１
５重量％を超えるとこれらの添加にエリガラスの耐水性
が低下してしまうおそれがある。On the other hand, the compounds contained in 1, Na, and Ni can be used as simple substances, oxides, hydroxides, carbonates, nitrates, sulfates, halides, etc., and they can also be used as mixtures. You can also do it. The amount of these compounds to be added is strictly determined by the composition of the glass to which they are added, but generally it is necessary to add 0.02 to 15% by weight, and 0.1 to 8% by weight to the load. Dochi is preferred. If the weight is less than 0.02 TL, the effect of lowering the viscosity of the glass will not be given, and 1
If the amount exceeds 5% by weight, there is a risk that the water resistance of Eriglass will deteriorate due to these additions.
また、これらと同時に含有されるＢ、Ａｌ、Ｓｃ、Ｆｅ
、Ｇａ、Ｙ、工ｎ、ランタニド化合物は、例えば単体、
酸化物、水酸化物、炭酸塩、硝酸塩、ハロゲン化物等と
して用いることができ、更にこｎらの混合物として用い
ることもできる。In addition, B, Al, Sc, Fe contained simultaneously with these
, Ga, Y, n, lanthanide compounds are, for example, simple substances,
It can be used as an oxide, hydroxide, carbonate, nitrate, halide, etc., and can also be used as a mixture of these.
これらの化合物の添加量は、添加するガラスの組成や添
加元素により厳密には決定されるが、一般に酸化物Ａ２
０３に換算して１〜２０重量％添加する必要がるり、特
に３〜１５重量％添加するのが好ましい。添加量が１重
量％に満たない場合は、耐水性向上の効果が十分でなく
、２０重量％を超える場合は均質なガラスが得られない
おそれがある。The amount of these compounds added is strictly determined by the composition of the glass to be added and the added elements, but in general, oxide A2
It is necessary to add 1 to 20% by weight calculated as 0.03, and it is particularly preferable to add 3 to 15% by weight. If the amount added is less than 1% by weight, the effect of improving water resistance will not be sufficient, and if it exceeds 20% by weight, a homogeneous glass may not be obtained.
また、これらの成分の他に例えばＲｕ、Ｎｉ、Ｇｏ等の
贋色成分等の他成分を本発明の目的を阻害しない限り添
加することもできる。Further, in addition to these components, other components such as for example, Ru, Ni, Go, etc., may be added as long as they do not impede the object of the present invention.
（！ｉ！施例）
艮１の組成のガラスを白金るつぼ中で１２００°Ｏで溶
融しておき、Ｋｅｒｒ社製遠心鋳造機を用いて８Ｘ８×
４■の直方体の形状の空洞と、８ｘ８Ｘ０．５■の板状
の空洞をもった６００’Ｏに保たれた鋳型中に鋳造した
。直方本状空洞に鋳込んだガラスは脱型後、８０°０５
０１！ｌの蒸留水中に２０時間浸漬した後の重量減少を
測足し、表面積当りの重量減少を求めた。−男根状空洞
に鋳込んだガラスは、板全体にガラスが流れ込んで成形
できているかどうかを確認し、その成形の可否を見た。(!i!Example) Glass having the composition of A1 was melted at 1200°O in a platinum crucible, and 8x8x was melted using a Kerr centrifugal casting machine.
It was cast in a mold maintained at 600'O having a 4-inch rectangular parallelepiped-shaped cavity and an 8x8x0.5-inch plate-shaped cavity. The glass cast into the rectangular main cavity has a temperature of 80°05 after demolding.
01! The weight loss after 20 hours of immersion in 1 of distilled water was measured, and the weight loss per surface area was determined. -The glass cast into the phallic cavity was checked to see if it could be formed by flowing into the entire plate to see if it could be formed.
その結果を戎１に示した。The results are shown in Table 1.
Claims (1)
〜０．７のリン酸カルシウム質を７０重量％以上含有し
、かつＬｉ、Ｎａ、Ｋの化合物の１種あるいは混合物を
Ｌｉ＿２Ｏ、Ｎａ＿２Ｏ、Ｋ＿２Ｏに換算して０．０２
〜１５重量％及びＢ、Ａｌ、Ｓｃ、Ｆｅ、Ｇａ、Ｙ、Ｉ
ｎ、ランタニド（総称してＡと呼ぶ）の化合物の１種あ
るいは混合物を酸化物Ａ＿２Ｏ＿３に換算して１〜２０
重量％含有することを特徴とする低粘性で高耐水性のリ
ン酸カルシウム系ガラス。1. The atomic ratio of calcium to phosphorus Ca/P is 0.2
Contains 70% by weight or more of calcium phosphate of ~0.7, and 0.02% by weight of one or a mixture of Li, Na, and K compounds converted into Li_2O, Na_2O, and K_2O
~15% by weight and B, Al, Sc, Fe, Ga, Y, I
n, one type or mixture of lanthanide (generally referred to as A) compounds converted to oxide A_2O_3 from 1 to 20
Calcium phosphate glass with low viscosity and high water resistance, characterized by containing % by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7246586A JPS62230648A (en) | 1986-04-01 | 1986-04-01 | Calcium phosphate based glass having water resistance and low viscosity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7246586A JPS62230648A (en) | 1986-04-01 | 1986-04-01 | Calcium phosphate based glass having water resistance and low viscosity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62230648A true JPS62230648A (en) | 1987-10-09 |
Family
ID=13490081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7246586A Pending JPS62230648A (en) | 1986-04-01 | 1986-04-01 | Calcium phosphate based glass having water resistance and low viscosity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62230648A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0463126A1 (en) * | 1990-01-12 | 1992-01-02 | New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Methods of enhancing wound healing and tissue repair |
| US5556645A (en) * | 1990-01-12 | 1996-09-17 | Bockman; Richard | Methods of enhancing wound healing and tissue repair |
| US5686116A (en) * | 1990-01-12 | 1997-11-11 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Methods of enhancing repair, healing and augmentation of bone implants |
-
1986
- 1986-04-01 JP JP7246586A patent/JPS62230648A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0463126A1 (en) * | 1990-01-12 | 1992-01-02 | New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Methods of enhancing wound healing and tissue repair |
| US5556645A (en) * | 1990-01-12 | 1996-09-17 | Bockman; Richard | Methods of enhancing wound healing and tissue repair |
| US5686116A (en) * | 1990-01-12 | 1997-11-11 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Methods of enhancing repair, healing and augmentation of bone implants |
| US6165514A (en) * | 1990-01-12 | 2000-12-26 | The Hospital For Special Surgery | Methods of enhancing repair, healing and augmentation of tissues and organs |
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