JPS62159B2 - - Google Patents
Info
- Publication number
- JPS62159B2 JPS62159B2 JP52028151A JP2815177A JPS62159B2 JP S62159 B2 JPS62159 B2 JP S62159B2 JP 52028151 A JP52028151 A JP 52028151A JP 2815177 A JP2815177 A JP 2815177A JP S62159 B2 JPS62159 B2 JP S62159B2
- Authority
- JP
- Japan
- Prior art keywords
- lys
- boc
- gly
- thr
- endorphin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 238000004810 partition chromatography Methods 0.000 description 1
- 238000012510 peptide mapping method Methods 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/675—Beta-endorphins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/667,747 US4038222A (en) | 1976-03-17 | 1976-03-17 | Untriakontapeptide with opiate activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS52113958A JPS52113958A (en) | 1977-09-24 |
| JPS62159B2 true JPS62159B2 (US20080094685A1-20080424-C00004.png) | 1987-01-06 |
Family
ID=24679466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2815177A Granted JPS52113958A (en) | 1976-03-17 | 1977-03-16 | Hetriaconpeptide |
Country Status (26)
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4123523A (en) * | 1976-06-21 | 1978-10-31 | Imperial Chemical Industries Limited | Analgesic and sedative polypeptides |
| US4320117A (en) * | 1976-06-21 | 1982-03-16 | Imperial Chemical Industries Limited | Polypeptide |
| US4371463A (en) * | 1977-02-17 | 1983-02-01 | The United States Of America As Represented By The Department Of Health And Human Services | Enzyme-resistant opiate pentapeptides |
| US4098781A (en) * | 1977-03-11 | 1978-07-04 | American Home Products Corporation | Polypeptides with morphine-like activity |
| US4317770A (en) * | 1977-03-11 | 1982-03-02 | Hoffmann-La Roche Inc. | D-amino acid analogs of beta-endorphin |
| US4081434A (en) * | 1977-03-11 | 1978-03-28 | Hoffmann-La Roche Inc. | Novel analogs of β-endorphin |
| US4127530A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel heneicosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said heneicosapeptides |
| US4127526A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tetradecapeptides, intermediates therefor, and compositions and methods employing said tetradecapeptides |
| US4127522A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel triacontapeptides, intermediates therefor and pharmaceutical compositions and methods employing said triacontapeptides |
| US4127534A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tripeptides, intermediates therefor and pharmaceutical compositions and methods employing said tripeptides |
| US4127540A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel derivatives of δ-endorphins, intermediates therefor, and compositions and methods employing said derivatives |
| US4139504A (en) * | 1977-06-16 | 1979-02-13 | Coy David Howard | Novel nonapeptides, intermediates therefor, and compositions and methods employing said nonapeptides |
| US4127528A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel derivatives of alpha-endorphin, intermediates therefor and compositions and methods employing said derivatives |
| US4127541A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel decapeptides, intermediates therefor, and compositions and methods employing said decapeptides |
| US4127523A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel undecapeptides, intermediates therefor, and compositions and methods employing said undecapeptides |
| US4127539A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel hexacosapeptides, intermediates therefore and pharmaceutical compositions and methods employing said hexacosapeptides |
| US4127524A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel dodecapeptides, intermediates therefor, and compositions and methods employing said dodecapeptides |
| ZA783287B (en) * | 1977-06-16 | 1980-01-30 | D Coy | Novel polypeptides |
| US4127535A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel dipeptides, intermediates therefor, and compositions and methods employing said dipeptides |
| US4127533A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel octapeptides, intermediates therefor, and compositions and methods employing said octapeptides |
| US4312857A (en) * | 1977-06-16 | 1982-01-26 | The United States Of America As Represented By The Veterans Administration | Novel derivatives of beta-endorphin, intermediates therefor and compositions and methods employing said derivatives |
| US4127521A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel octacosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said octacosapeptides |
| US4127536A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tricosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said tricosapeptides |
| US4127525A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tridecapeptides, intermediates therefor, and compositions and methods employing said tridecapeptides |
| US4127529A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel eicosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said eicosapeptides |
| US4127538A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel pentacosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said pentacosapeptides |
| US4127531A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel hexapeptides, intermediates therefor, and compositions and methods employing said hexapeptides |
| US4127520A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel nonadecapeptides, intermediates therefor, and compositions and methods employing said nonadecapeptides |
| US4127518A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel derivatives of gamma-endorphins, intermediates therefor, and compositions and methods employing said derivatives |
| US4127537A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tetracosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said tetracosapeptides |
| US4127517A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel docosapeptides, intermediates therefore and pharmaceutical compositions and methods employing said docosapeptides |
| US4127519A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Octadecapeptides, intermediates therefor, and compositions and methods employing said octadecapeptides |
| US4127527A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel pentadecapeptides, intermediates therefor, and compositions and methods employing said pentadecapeptides |
| US4127532A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel heptapeptides, intermediates therefor, and compositions and methods employing said heptapeptides |
| US4105652A (en) * | 1977-08-05 | 1978-08-08 | Hoffmann-La Roche Inc. | Synthesis of human β-endorphin |
| US4232008A (en) * | 1978-11-17 | 1980-11-04 | Ortho Pharmaceutical Corporation | Tetrapeptides and methods |
| US4116950A (en) * | 1978-01-16 | 1978-09-26 | Hoffmann-La Roche Inc. | Analogs of human β-endorphin |
| US4330465A (en) * | 1978-03-02 | 1982-05-18 | Hoffmann-La Roche Inc. | Novel β-endorphin analogs |
| US4219468A (en) * | 1978-11-13 | 1980-08-26 | Hoffmann-La Roche Inc. | Tritiated β-endorphin |
| US4396606A (en) | 1979-11-05 | 1983-08-02 | Addiction Research Foundation | Novel polypeptide analgesics |
| US4250087A (en) * | 1979-12-10 | 1981-02-10 | Hoffmann-La Roche Inc. | Carboxyl terminus analogs of β-endorphin |
| JPS56108750A (en) * | 1980-02-01 | 1981-08-28 | Takeda Chem Ind Ltd | Polypeptide and its preparation |
| US4438104A (en) | 1980-01-03 | 1984-03-20 | Endorphin, Inc. | Endorphins having placental or pancreatic origin |
| US4316895A (en) * | 1980-01-03 | 1982-02-23 | Kimball Charles D | Endorphins having placental or pancreatic origin |
| US4350764A (en) * | 1980-03-10 | 1982-09-21 | The Regents Of The University Of California | Microbiological synthesis of beta endorphin |
| US4313937A (en) * | 1980-08-12 | 1982-02-02 | Tsutomu Oyama | Method for producing long-lasting analgesic effects of β-endorphin |
| DE3152892T1 (de) * | 1981-06-16 | 1983-09-08 | John C. 98199 Seattle Wash. Houck | Aus placenta oder pancreas gewonnene endorphine |
| FR2857873B1 (fr) * | 2003-07-21 | 2006-02-24 | Courtage Et De Diffusion Codif | Procede et produit cosmetique destines a limiter la croissance des tissus adipeux |
-
1976
- 1976-03-17 US US05/667,747 patent/US4038222A/en not_active Expired - Lifetime
-
1977
- 1977-02-16 CH CH193477A patent/CH625785A5/de not_active IP Right Cessation
- 1977-03-06 AU AU23298/77A patent/AU514499B2/en not_active Expired
- 1977-03-09 MC MC771235A patent/MC1137A1/xx unknown
- 1977-03-15 FR FR7707621A patent/FR2348912A1/fr active Granted
- 1977-03-15 PH PH19558A patent/PH13864A/en unknown
- 1977-03-15 IL IL51660A patent/IL51660A/xx unknown
- 1977-03-15 NZ NZ183605A patent/NZ183605A/xx unknown
- 1977-03-15 CA CA274,024A patent/CA1092602A/en not_active Expired
- 1977-03-16 JP JP2815177A patent/JPS52113958A/ja active Granted
- 1977-03-16 IE IE571/77A patent/IE44226B1/en unknown
- 1977-03-16 PT PT66311A patent/PT66311B/pt unknown
- 1977-03-16 AR AR266874A patent/AR222778A1/es active
- 1977-03-16 DE DE2711487A patent/DE2711487C2/de not_active Expired
- 1977-03-16 BE BE175818A patent/BE852510A/xx not_active IP Right Cessation
- 1977-03-16 DK DK116177A patent/DK149203C/da not_active IP Right Cessation
- 1977-03-16 NO NO770941A patent/NO147105C/no unknown
- 1977-03-16 AT AT178877A patent/AT355238B/de not_active IP Right Cessation
- 1977-03-16 ZA ZA00771593A patent/ZA771593B/xx unknown
- 1977-03-16 NL NL7702849A patent/NL7702849A/xx not_active Application Discontinuation
- 1977-03-16 SE SE7703004A patent/SE436354B/xx not_active IP Right Cessation
- 1977-03-16 LU LU76963A patent/LU76963A1/xx unknown
- 1977-03-16 GB GB11109/77A patent/GB1563654A/en not_active Expired
- 1977-03-16 FI FI770835A patent/FI63391C/fi not_active IP Right Cessation
- 1977-03-16 ES ES456901A patent/ES456901A1/es not_active Expired
- 1977-03-17 GR GR53010A patent/GR63092B/el unknown
- 1977-08-08 US US05/822,772 patent/USRE29842E/en not_active Expired - Lifetime
- 1977-11-25 AR AR270126A patent/AR222007A1/es active
-
1978
- 1978-03-01 ES ES467453A patent/ES467453A1/es not_active Expired
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