JPS62150318A - Detergent of non moisture containing contact lens - Google Patents

Abstract

PURPOSE:To obtain the titled detergent capable of removing a stain with safety, simply and in a short period by incorporating an oxidizing agent and a coloring agent which having a non coloring property against the non-moisture containing contact lens and a non decomposing decoloring property against the oxidant. CONSTITUTION:The titled detergent contains the oxidizing agent and the coloring agent which has non-decomposition decoloring property against the oxidizing agent and the coloring agent which has non-decomposition decoloring property against the oxidizing agent and the non-coloring property against the titled lens. As the oxidizing agent, one may use hydrogen peroxide, sodium perborate, sodium hypochlorite and sodium chlorite, etc., preferably sodium hypochlorite. The concn. of the oxidizing agent contd. in the detergent is preferably 0.5-3W/V%. As the coloring agent, one may use potassium permanganate, potassium perchromate, potassium chromate and titanium yellow, etc. The concn. of the coloring agent contd. in the detergent is preferably 0.005-0.05W/V%.

Description

Detailed Description of the Invention [Industrial Field of Application 1] The present invention relates to a cleaning agent for non-aqueous contact lenses, and more specifically, to a cleaning agent for cleaning non-aqueous contact lenses that is safer and more effective in removing stains from non-aqueous contact lenses. This invention relates to a non-hydrous contact lens cleaning agent that is colored for use.
・ [Prior art] Non-hydrous syntact lenses that have been used conventionally include ordinary hard contact lenses containing methyl methacrylate-1 as a main component, cellulose acetate-1-butyrate, siloxanyl methacrylate, There are oxygen-permeable hard contact lenses, which are mainly composed of fluoromethacrylate, and soft contact lenses, which are mainly composed of dimethylsiloxane, butyl acrylate, and the like. In recent years, non-water-containing contact lenses with particularly high oxygen permeability have come on the market. While these non-water-containing contact lenses have advantages that water-containing contact lenses do not have, they have the disadvantage that the higher the oxygen permeability, the more likely it is that dirt will adhere to them. Conventionally, this stain has been removed using a scrubbing method using a cleaning solution containing a surfactant, such as an enzyme wash containing proteins, degrading enzymes, etc. A method of decomposing dirt by soaking it in a p-agent, a method of decomposing and removing dirt by soaking it in an oxidizing agent such as hypomite, hypobromite, chlorite, etc. It has been known.

[Problem to be Solved by the Invention 1] However, although the method using a cleaning solution containing a surfactant is effective for cleaning lipids, dirt, etc., it is not effective against stubborn stains caused by proteins, etc. Enzyme cleaners are effective against stains caused by proteins, etc., but they have the disadvantage of long processing times due to the nature of enzyme action. In addition, when using oxidizing agents such as hypochlorite, hypobromine'PIi salt, and chlorite, the effect is excellent, but at high concentrations they cause damage to the anterior segment of the eye, so the moisture level used should be As a result of keeping it low, it has disadvantages such as a longer processing time and a more complicated method of use in order to achieve faster detoxification.

Furthermore, since the above-mentioned cleaning agent is colorless and transparent, it can be mistaken as a storage solution for contact lenses, and it is also one of the causes of eye problems caused by forgetting to perform the DJ-free treatment after cleaning and wearing it as is. I might get one.

Therefore, in order to comfortably wear non-hydrous contact lenses for a long period of time, it has been desired to develop a cleaning agent that can remove stains in a shorter time using a safer and simpler method.

[Means for Solving the Problems] In order to solve the problems of the prior art described above, the present inventors have conducted intensive research focusing on coloring an aqueous solution of an oxidizing agent. We have discovered a colorant that is non-degradable and bleaches color and does not stain water-containing contact lenses, and have completed a cleaning agent for non-water-containing contact lenses that contains the colorant and an oxidizing agent. Ta.

Therefore, the present invention provides a non-water-containing contact lens characterized by containing an oxidizing agent and a coloring agent that does not decompose and decolorize with respect to the oxidizing agent and does not color a non-hydrous contact lens. This is a cleaning agent for contact lenses.

The present invention will be explained in more detail below.

Examples of the oxidizing agent which is an essential component of the water-free contact lens cleaning agent of the present invention include hydrogen peroxide, sodium perborate, sodium hypochlorite, and sodium chlorite. Among these, 1-lium hypochlorite is particularly preferred. The concentration of the oxidizing agent contained in the cleaning agent is 0.1 to 5 W/V%, preferably 0.5 to 3 W
/V% range.

Note that W/V% represents the percentage CC of the solute volume W (q) in the solution volume IV (ml), for example, 1 W/V
% means that 100 ml of solution contains 1 g of solute.

As the coloring agent used in the present invention, an oxidizing agent may be used.
Any coloring agent can be used as long as it is not bleached and does not color the non-hydrous contact lens itself. Particularly preferred examples include potassium permanganate,
Examples include potassium dichromate, potassium chromate, and ditan yellow. The concentration of the colorant contained in the cleaning agent is 0005 to 0.5 W/V%, preferably 00
05 to 0.05 W/V%. In addition, this coloring agent is
Not only can it be used alone, but it can also be used in combination of two or more types.

[Effect 1] The water-free contact lens cleaning agent of the present invention is used daily or periodically, for example, once a week, as follows. That is, after removing the contact lens from the eye, it is lightly washed with water and immersed in the cleaning agent of the present invention for 5 to 30 minutes. After immersion, the lens is washed again with water to completely remove the cleaning agent, and then stored in a storage solution. By using the non-water-containing contact lens cleaning agent of the present invention, not only can stains be removed more easily and effectively than before, but since the cleaning agent is made of stone, it is possible to remove stains even during cleaning. It is easy to understand, there is no risk of accidentally getting the cleaning agent into your eyes, and it is effective in terms of safety.

1 Example] Hereinafter, the present invention will be explained in detail with reference to Examples.

A cleaning agent of Example No. 1 was prepared by dissolving 10 ml of 10 W/V% sodium hypochlorite aqueous solution a and 0.01 g of potassium chromate in distilled water to make a total volume of 100 ml.

Similarly, as shown in Table 1, predetermined amounts of sodium hypochlorite, potassium chromate, potassium permanganate, and titanium yellow were dissolved in distilled water and the total amount was 100ml. Example No. 12 to No. 6
Each cleaning agent was prepared.

Oxygen-permeable contact lenses with artificial dirt attached (1" OYA HA RD /
The lenses were immersed in each of the cleaning agents shown in Table 1 for 1 to 5 minutes using a lens (manufactured by Hoya Corporation) to evaluate the stain removal effect and the presence or absence of coloring on the lenses. The results are shown in Table 1.

As is clear from Table 1, Example No. 1 to No.
Each of the 6 cleaning agents was effective in removing stains from artificially soiled lenses. It was also found that there was no coloring of the lenses.

Incidentally, the artificial staining was carried out by the following method.

Lysozyme 1.0 (1, 10 g of albumin and 0.9 g of chloride) was dissolved in distilled water and the total volume was 100 ml.
It was used as a stain solution. Immerse the lens in this stain solution for 80 minutes.
Heat treatment was performed at ℃ for 2 hours. This operation was repeated 5 times to adhere dirt to the lens.

Next, a hard contact lens (+-10Y Al-I A RD made by Hoya ■) and an oxygen-permeable hard contact lens (TOYOY) that became cloudy after being actually worn were used.
PA I-I A RD / Hoya ■ and Menicon 02 Toyo Contact Lenses Inc.) were immersed in the cleaning agents of Example No. The presence or absence was evaluated. The results are shown in Table 2.

Table 2 As is clear from Table 2, Examples N003 and Nα5
It was found that the cleaning agent had an excellent dirt removal effect on all types of lenses. Further, no coloring of the lenses occurred.

Next, the stability of the non-hydrous contact lens cleaning agent of the present invention was investigated.

The cleaning agent of Example No. 3 was prepared and filled into a polyethylene light-shielding container, which was sealed tightly and kept at a temperature of 40°C and a humidity of 70°C.
% for 4 months and measured the content of sodium hypochlorite and the absorbance at 400 nm, the decrease rate of sodium hypochlorite content was 9%, and the decrease rate of absorbance was It was 20%. As a result of immersing the artificially soiled lens in this cleaning agent for 5 minutes, the soil was completely removed and the lens returned to its original transparent state. Moreover, the coloring of this cleaning agent was sufficiently visible to the naked eye. Therefore, it was found that the cleaning agent of the present invention is also excellent in terms of stability.

Next, the influence of the non-hydrous contact lens cleaning agent of the present invention on lens shape was investigated.

Oxygen permeable hard contact lenses (HOY△HARD
10P (manufactured by Hoya ■), Example No. 1 to No.

4. After soaking in each cleaning agent for 48 hours and washing with running tap water, the parameters of each lens [base curve (
As a result of measuring the curvature of the back surface, the power (apex refractive power), the diameter, and the wall thickness, no change in the parameters was observed before and after immersion in the cleaning agent. Therefore, it was confirmed that the cleaning agent of the present invention does not affect the lens shape.

[Effects of the Invention] As detailed above, the water-free contact 1 according to the present invention
~The lens cleaning agent has a soaking time of 5~ to remove dirt.
It was confirmed that a sufficient effect was obtained in a short treatment time of 15 minutes, and that the lens was not affected at all even after being immersed for an extended period of time. Furthermore, lenses that have been processed are washed with running tap water, but even if you forget that the lenses are being processed, there is no risk of wearing them as they are because they are colored, making it safer and more reliable. stain removal treatment can be performed.

Claims (3)

[Claims] (1) A non-water-containing contact lens characterized by containing an oxidizing agent and a coloring agent that does not decompose and decolorize the oxidizing agent and does not color the non-hydro-containing contact lens. cleaning agent. (2) The non-hydrous contact lens cleaning agent according to claim 1, wherein the oxidizing agent is sodium hypochlorite, sodium chlorite, hydrogen peroxide, or sodium perborate. (3) The water-free contact according to claim 1, wherein the colorant is a colorant containing at least one selected from the group consisting of potassium permanganate, potassium dichromate, potassium chromate, and titanium yellow. Lens cleaning agent.