JPS62132831A - Gelan gum for coating circumference of tablet or the like - Google Patents

Abstract

PURPOSE:To coat circumferential surface of tablet, tabletted granule, powder, etc., of food, drug, drug assistant, etc., with a coating layer resistance to heat, alkali and acid, by using a gelan gum which is a kind of polysaccharides as a component of the coating layer. CONSTITUTION:A fluid system consisting of a sol of an aqueous suspension containing <=2wt% gelan gum based on water or an incompletely gelled (solidified) suspension is applied at 35-85 deg.C to the circumferential surface of tablet, tabletted granule, etc., of a drug, etc., to be coated in a manner to form a layer of uniform thickness by an arbitrary method such as immersion, spraying, etc., to obtain a tablet, etc., resistant to deterioration of quality. The gelan gum coating layer has excellent heat-resistance, alkali-resistance and acid- resistance and is tasteless, odorless and colorless. Accordingly, it gives no adverse effect to the drug, etc. It has extremely low moisture-permeability.

Description

[Detailed Description of the Invention] This invention relates to foods, medicines, or pharmaceutical aids, and the peripheral surfaces of these tablets, fist tablets, powders, etc. are heat-resistant, alkali-resistant, and acid-resistant. The purpose of the present invention is to form a transparent coating layer industrially advantageously.

(Prior art and its disadvantages) It is impossible to cover the peripheral surface of tablet-shaped, granular-shaped or coarsely powdered medicines, auxiliary agents, or foods with a colloid or glue layer of uniform thickness. , widely known. This is to prevent the contents from deteriorating, to make it easier to eat and drink, and to prevent loss of weight.

Agar, carrageenan, gum arabic, CMC, and others are known as the 11g substance or paste used in these materials, but these known substances have the disadvantage of being poor in acid resistance, alkali resistance, and heat resistance.

OBJECT OF THE INVENTION It is a task for the person skilled in the art to adopt a coating material that does not have these drawbacks, and the present invention is an answer to this task.

This invention will be explained in detail below.

(Structure of the Invention) This invention uses a type of polysaccharide as a coating material. Adopt gellan gum.

To explain the mode of its use, first, an aqueous suspension system of gellan gum is made. The amount used is approximately 2% (weight,
(The same applies hereinafter) The following amount is sufficient. This aqueous system of gellan gum exhibits high viscosity at room temperature and gradually decreases in viscosity as the temperature increases. When the temperature reaches about 85°C, the gum undergoes molecular dispersion and becomes a sol.

This sol starts to gel at a temperature of about 35°C when its temperature is lowered. This sol thread or gel thread before completion of gelation, which is fluid thread before completion of solidification, is used to form a layer of uniform thickness on the surrounding surface of the drug, other tablets, granules, etc. to be coated. Apply as shown. The method of application may be dipping, spraying, or any other arbitrary method.

By drying and manipulating the coated tablets, etc., the desired pharmaceuticals, foods, etc. can be obtained.

Here, this invention achieves its purpose.

(Functions and Effects) The gellan gum coating layer of this invention has ■acid resistance, alkali resistance,
#Excellent heat resistance.

Furthermore, ■This product is tasteless, odorless, and colorless, so it does not have any adverse effects on tablets or other medicines. ■
Moisture permeability is extremely low. These points will be proven by the following experimental examples.

(Effect of the invention) Next, the present invention will be explained in detail based on experimental examples.

(Experimental Example 1) Dissolve 0.4 parts of the following gelled material sample in 99.6 parts of water (weight, same below), use this as a test solution, put it in a petri dish and harden at -20°C. The petri dish was stored in an open state without being sealed at the same temperature, and the moisture evaporation rate was determined after 3 days and 1 week.

(Results) (Experiment Example 2) Proof of effective viscosity of gellan gum Sample 0
．． 4 parts were stirred and dissolved in 99.6 parts of hot water at 95°C for 10 minutes, and the viscosity at 10°C was measured, and the results were as follows.

(Experiment Example 3) (Heat resistance) Add 0.05 parts of CaCl2 and 99.55 parts of water to 1 part of each sample below, bring both to a boil, and stir and dissolve for 5 minutes. The mixture was then cooled in a 7°C water bath for 2 hours to form a gel. Cut the gel into cubes of 2 cm on each side, place them in a heat-resistant container, and add 10 cm of water to this.
0 Put the yptf in, cover and heat at 95°C for 160 minutes and 1
The state of the gel was observed after heating for 115 minutes at 21'C.

(Experiment Example 4) (Acid resistance, alkali resistance) Each sample 1 below
After stirring and dispersing each part in 99 parts of water, each part was heated at 95°.
C. Dissolved with stirring for 5 minutes.

These sols were adjusted to pH 8, 7, or 11 with citric acid or aqueous sodium hydroxide solution, heated at 90'C for 20 minutes, placed in a standard jelly cup, and placed in a 7°C water bath for 2 hours to gel. Strength Hitsugiio Electric DI Model
301) was measured using a card meter.

The results were as follows.

Explanation: Calculate the gel strength (? / 1*) of peach at pH 7 as 100.

Example 1 Add 3 parts of β-carotene, 1 part of vitamin E, 45 parts of lactose, and 2 parts of gellan gum to 50 g of white sugar, and add 100 g of water.
A mixture of 50 parts of lactose and 50 parts of L-ascorbic acid was dispersed and mixed in 100 parts, and then tablet-coated using a coating pan and dried. This product was replaced by a tablet with a glossy surface and less deterioration in quality of ascorbic acid.

Example 2 50 parts of lactose and 50 parts of L-ascorbic acid were mixed and tableted to make tablets with a diameter of 22 mm and a height of 4 mm, and gellan gum was added in advance to a mixture of 84.6 parts of water and 15 parts of ethanol. A solution of 0.4 parts was applied by spraying, dried and repelled (at 60°C), and then placed in a 60°C Franchi.
The quality stability of L-ascorbic acid was observed over time.

Claims (1)

[Claims] Gellan gum is characterized by being made by coating the peripheral surface of tablets and other things.