JPS6211863B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an ultraviolet dose measuring device that is applied to measure the ultraviolet dose obtained by ultrafiltration during treatment using an artificial kidney.

In treatment using an artificial kidney, it is important to accurately know the extreme excess dose in order to provide the correct treatment. However, as the amount of dialysate is 300 to 700 ml per minute, the ultra-overflow is very small at 1.5 to 25 ml per minute, so accurate measurement is impossible with current flow measurement technology, and in reality, Currently, the ultraviolet dose is measured by measuring the patient's weight before and after the treatment.

This invention eliminates the above-mentioned inconveniences, and uses an artificial kidney to accurately and accurately control the extreme excess dose during treatment.
Moreover, it is an object of the present invention to provide an ultraviolet dose measuring device that can measure the amount without interfering with treatment.

An embodiment of the present invention will be described below with reference to the drawings. In FIG. 1, reference numeral P ₁ indicates a supply pump for pumping dialysate supplied from a supply mechanism (not shown) into line 1 or line 2 via valve V ₉ . The system line 1 has two valves V ₁ and V ₂ , and the valves V ₁ and V ₂ are configured to supply dialysate to one or both of a reserve tank 3 and a measurement tank 4 having a predetermined capacity. Operate. Note that the reference numeral 5 indicates a level meter for detecting the level of the dialysate in the measurement tank 4. Furthermore, level detectors 3a and 4a are provided to detect levels L _up2 and L _up1 in the reserve tank 3 and measurement tank 4, respectively, and to detect that a predetermined amount of dialysate has been contained.

The accuracy with which the level detectors 3a and 4a measure the levels L _up2 and L _up1 in the preliminary tank 3 and the measurement tank 4, respectively, is not high, and the level detectors 3a and 4a do not measure the levels L _up2 and L _up1 of the dialysate, respectively. This is to roughly detect when the respective values have been reached. Further, since the level meter 5 can detect the level in the measuring tank 4 with high accuracy, it is suitable for measuring the ultra-limit amount. Therefore,
Level that can be measured by level meter 5 as described below
_L12 is at a slightly lower level than the level _Lup1 , and the ultra-limit excess amount is measured using this level _L12 as a reference as will be described later.

Further, the route 6 for taking out the reserve tank 3 or the measurement tank 4 has valves V ₃ and V ₄ for selecting the reserve tank 3 or the measurement tank 4, and the dialysate taken out from this route 6 and the above-mentioned route Either one of the dialysates taken out from 2 is selected by valve V ₁₀ and sent to route 7 or 8 via supply pump P ₂ , flow control valve V ₁₁ , flow meter FM and valve V ₇ . Path 8 is for supplying dialysate to a dialyzer 9 having a general structure, and path 7
constitutes a bypass path for route 8. The dialysate taken from path 7 or 8 then passes through valve V ₈ and is then sent to ultra-excess detection tank 10 via the same path 14 passing through negative pressure pump P ₃ and valve V ₅ . Note that reference numeral 11 indicates a negative pressure gauge for detecting the negative pressure acting on the dialysate side of the dialyzer 9.

The ultra-excess detection tank 10 is cylindrical and has a discharge path 12 with a valve V ₆ at the bottom.
A detecting section 10a having an elongated cylindrical shape is provided at the top of the detecting section 10a so as to extend vertically.
A level meter 13 for detecting the liquid level inside 0a is inserted. Also,
A level detector 10b for detecting the level L ₁₂ is provided in the portion of the ultra-excess detection tank 10 below the detection unit 10a.
is provided. A central processing unit (hereinafter referred to as "CPU") 2 that receives the detected values of the level meters 5 and 13 as input and generates signals to control valves, etc. according to a predetermined program.
0 is provided, and the measurement of the limit excess amount is performed using this
This is automatically performed according to a command from the CPU 20. In addition, the CPU 20 is connected to level detectors 3a, 4a, and 10b to input level detection signals, and also connects to pumps _P1 to _P3 and valves.
It is also connected to V ₁ to _{V 11} to control these operations.

The flowchart in FIG. 2 shows the order of measurement and the control state of each element by the CPU 20 at each stage of preparation before measurement, V calibration, ΔV measurement preparation, ΔV measurement, and post-measurement processing.

Next, CPU2 in actual ultra-overmeasurement
The operation of 0 will now be described, and the calibration operation that is performed prior to the ultra-limit excess measurement will be described. The principle of this invention is based on the liquid level when a predetermined amount V of dialysate is stored in the detection tank 10, and the same amount of dialysate passed through the dialyzer 9 and stored in the detection tank 10. The purpose is to detect the ultraviolet excess amount ΔV introduced into the dialysate while passing through the dialyzer 9 from the difference between the liquid level and the liquid level when the dialyzer 9 passes through the dialyzer 9. Therefore, prior to actual measurement, a certain amount V
It is necessary to calibrate the liquid level when V+ΔV is accommodated and the liquid level when V+ΔV is accommodated. If this calibration is performed correctly, changes in the volume of the detection tank 10 over time, changes in the outputs of the level meters 5 and 13 over time, etc. will be canceled out, and accurate measured values will always be obtained.

(Calibration of V) First, as a preparation before measurement, if the level detector 10b has already detected that the dialysate exceeds the level _L21 in the detection tank 10, first open the valve _V6. , the liquid in the detection tank 10 is discharged, and when the liquid level reaches a predetermined level _L21 and is detected by the level detector 10b, the valve _V6 is closed. In addition, adjustment of the level L ₂₁ as a preparation before other measurements is performed when the dialysate does not exceed the level L ₂₁ in the detection tank 10 and when there is not enough dialysate in the reserve tank 3, the level is detected. When the level detector 3a detects that the dialysate has been supplied to the reserve tank 3 up to the level L _up2 , the level detector 3a opens the valve _V3 while keeping the valve _V6 closed, and detects the dialysate. The dialysate is supplied to the tank 10, and when the level of the dialysate in the detection tank 10 reaches the level _L21 and is detected by the level detector 10b, the valve _V5 is switched to the drain side.

Next, move on to the calibration of V, valves V ₉ , V ₁ , V ₂ , V ₄
is operated to introduce the dialysate into the measuring tank 4 until the liquid level reaches the level L _up1 and is detected by the level detector 4a, and then the valve _V2 is closed. Next, valves V ₄ , V ₁₀ , V ₇ , and V ₈ are operated to cause the dialysate in measurement tank 4 to flow through paths 6, 7, and 9 to the position of valve V ₅ . This valve V ₅ is switched to the drain side until the liquid level in the measurement tank 4 reaches the level L ₁₂ and is detected by the level meter 5, so that the dialysate does not flow into the detection tank 10. . However, when the liquid level in the measurement tank 4 reaches the level _L12 and is detected by the level meter 5, the valve _V5 is switched to the detection tank 10 side, and the dialysate is caused to flow into the detection tank 10 through the valve _V5 . In other words, the dialysate in the measurement tank 4 is
The liquid moves into the detection tank 10 without any quantitative change during the process, and in this process, the liquid level in the measurement tank 4 falls and the liquid level in the detection tank 10 rises.
When the liquid level in the measurement tank 4 drops to _L11 and is detected by the level meter 5, a detection signal is input from the level meter 5. When the liquid level in the measurement tank 4 falls from level _L12 to _L11 , a certain amount of dialysate has been transferred to the detection tank 10,
At this time, the liquid level in the detection tank 10 reaches level _L22 . This level L ₂₂ is set to be located below the detection part 10a by selecting the volume of the detection tank 10 to an appropriate value, and the level meter 13 indicates that this level L ₂₂ has been reached. detected,
The CPU 20 inputs the detection signal from the level meter 13 and stores it.

In this example, levels L ₁₁ , L ₁₂ , and L ₂₁ are fixed, but level L ₂₂ is variable, an arbitrary position is selected according to conditions, and the position is stored in the CPU 20.

In the above explanation, the level L ₁₁ in the measurement tank 4 is
and L ₁₂ are fixed and the upper limit level L ₂₂ in the detection tank 10 is variable. However, it is also possible to fix the level L ₂₂ and make the level L ₁₁ variable instead. In this case, an advantage is obtained that the level L ₂₂ can be maintained at a predetermined position even if various conditions change. Further, in order to detect the level _L11 sensitively, it is desirable to make the lower end of the measuring tank 4 thin.

(Calibration of ΔV) In the above-mentioned calibration of V, when the liquid level in the detection tank 10 reaches the level _L22 , a certain amount of V of dialysate is introduced into the detection tank 10. When more dialysate is introduced into the detection tank 10 in this state, the liquid level rises in accordance with the newly introduced amount. Therefore, if known quantities ΔV ₁ , ΔV _{2 .} . . are introduced and the levels at this time are stored in the CPU 20, when an unknown quantity is introduced, the introduced amount can be calculated from the level at that time. . Note that these amounts stored in the CPU 20 may be set and stored using a digital switch or the like.

To measure the ultraviolet dose during actual treatment, after performing the above-mentioned V and ΔV calibration,
This is performed with _V7 and _V8 switched and dialysate flowing through the dialyzer 9. When calibrating V, all the dialysate transferred from the measurement tank 4 to the detection tank 10 passes through the bypass path 7, so no change occurs in the amount of dialysate. However, since the dialysate passes through the dialyzer 9 during measurement, ultraviolet components are mixed in due to the ultraviolet effect from the blood, and the amount thereof increases by ΔV. In other words, when a certain amount of dialysate fluid flows out from the measurement tank 4, the amount of fluid V+ΔV flows into the detection tank, and the liquid level in the detection unit 10a is at the level
It is higher than L ₂₂ by a value corresponding to ΔV. Therefore, by detecting the liquid level at this time using the level meter 13, it is possible to determine the extreme excess amount within the time required for the liquid level in the measurement tank 4 to fall from level _L12 to _L11 . The value of ΔV, that is, the flow rate of the ultraviolet component can be known. Further, by repeating the same measurement operation at a constant cycle over the entire period of treatment and integrating the ultraviolet amount obtained each time, it is possible to know the total amount of ultraviolet amount during treatment.

To explain in more detail the above-mentioned measurement of the ultraviolet amount, first, the dialysate is raised to a level L _up in the measuring tank 4.
The dialysate level in the detection tank ₁₀ is adjusted to level _L21 . Here, the valve V ₅ is operated to the drain side, and the valves V ₇ and V ₈ are operated to the dialyzer 9 side. Open valve V ₃ ,
Since the valve _V4 is closed, the dialysate in the reserve tank 3 passes through the dialyzer 9, the valve _V5, etc., and is drained. Next, after the above conditions are met, the valve
V ₃ is closed, valve V ₄ is opened, and by operating pumps P ₂ and P ₃ , the dialysate in measurement tank 4 passes through dialyzer 9, valve 5, etc., and is drained. When the dialysate level in the measurement tank 4 changes from level L _up1 to level L ₁₂ , this level L ₁₂ is detected by the level meter 5, and this detection signal causes the valve V ₅ to be switched to the detection tank 1.
Switch to 0 side. At this point, time measurement begins. The dialysate in the measurement tank 4 passes through the dialyzer 9, is supplied to the detection tank 10, and is accumulated therein. Eventually, the level of the dialysate in the measuring tank 4 reaches L ₁₁ , and the level meter 5
This level _L11 is detected, and upon this detection, the above-mentioned time measurement is ended, and if this measured time is ΔT, this ΔT is stored. Also, switch valve _V5 to the drain side, and then
Open V ₃ and close valve V ₄ . Further, as described above, the ultra-limit excess amount ΔV is calculated and stored based on the result of the level of the liquid in the detection tank 10 detected by the level meter 13. In addition, the above-mentioned time ΔT
At the same time, the flow rate ΔV/ΔT of the ultraviolet component is calculated and stored. Note that during the measurement period of the ultraviolet amount using the measurement tank 4, the level of the dialysate in the preliminary tank 3 is adjusted to the level L _up2 . Therefore,
When valve _V3 is opened, the dialysate in reserve tank 3 is sufficiently filled to level L _up2 . The dialysate in the reserve tank 3 is operated as pumps P ₂ and P ₃ to pass through the dialyzer 9, valve V ₅ , etc., and is treated as waste fluid. During this time, the valve _V2 is opened until the dialysate in the measuring tank 4 reaches the level L _up1 , and the measuring tank 4 is replenished with dialysate by operating the pump _P1 . After this replenishment is completed, the dialysate in the detection tank 10 is drained by opening the valve _V6 until it reaches the level _L21 . As described above, the dialysate in the measurement tank 4 is made to reach the level L _up1 , and the dialysate in the detection tank 10 is adjusted to the level _L21 .

In this way, the above-mentioned measurement operation is repeated and performed continuously over the entire treatment period, and dialysate is constantly sent to the dialyzer 9 during the entire treatment period.

As explained above, by integrating the ultraviolet excess ΔV obtained each time, the total amount of ultraviolet excess during treatment can be determined. For example, let T ₁ be the above-mentioned time ΔT, let T ₂ be the time during which dialysate is supplied from the reserve tank 3, etc., and let T ₁ =T ₂ . In this case, the actual ultraviolet excess value is twice the total amount of ultraviolet excess values. For example, here we simply write T ₁ = T ₂
= 1 minute, and dialysis took 3 hours, and the time
If the limit excess amount is ΔV=V ₁ (cc) per T ₁ , then
The ultraviolet amount of V ₁ (cc) is measured for 1 minute every 2 minutes, so 30 measurements are taken in 1 hour and 30 times in 3 hours.
90 ultra-excess measurements were carried out, thus:
V ₁ ×90 × 2 (cc) is the total amount of ultraviolet dose during treatment. Note that if the time T ₁ and the time T ₂ are not equal, correction is performed according to this time, and the total amount of ultraviolet excess can be obtained. Further, when determining this total amount, the above-described flow rate ΔV/ΔT of the ultraviolet component is used, for example.

As explained above, according to the present invention, it is possible to accurately and automatically measure the amount of ultraviolet excess mixed into a certain amount of dialysate while it flows through a dialyzer. Additionally, operations such as cleaning, inspection, and calibration are easy, and dialysis operations are not affected during measurement or in the event of a failure.

[Brief explanation of the drawing]

FIG. 1 is a system diagram showing the configuration of an ultraviolet excess measuring device used in an embodiment of the present invention, and FIG. 2 is a flowchart showing the order of operation of each part of the device. 1, 2...route, 3...preparation tank, 4...measuring tank, 5...
Level meter, 6, 7, 8...route, 9...dialyzer, 10
...Detection tank, 10a...Detection section, 12...Route, 13...
Level meter, 14...route, 20...CPU, V ₃ , V ₄ ,
V ₆ , V ₇ ... valve, P ₂ ... pump.

Claims (1)

[Scope of Claims] 1. A measurement tank containing dialysate, and a measurement level meter that detects the level of dialysate in the measurement tank to detect that a certain amount of dialysate has been delivered from the measurement tank. and a delivery means for sending out the dialysate in the measurement tank through a delivery path communicating with the measurement tank, a bypass path for bypassing the dialysate that has passed through the delivery path, and a bypass path parallel to the bypass path. a first valve for selectively connecting the delivery route to the bypass route or the dialyzer; a second valve for drainage on the bottom side for receiving and accommodating dialysate flowing through the bypass path or dialyzer and for setting the level of dialysate to a reference level each time before receiving dialysate; a detection tank having a detection tank, a detection level meter that performs detection when setting the reference level and detects the level of the dialysate contained in the detection tank from the reference level, and A detection signal is input to control the opening and closing of the first and second valves and the delivery of dialysate by the delivery means, and the amount of dialysate is adjusted according to the increase in the level of dialysate detected by the detection level meter. The central processing unit is provided with a central processing unit that stores data on increment amounts in advance and calculates and outputs the ultraviolet excess amount, and this central processing unit transfers each fixed amount V of dialysate in the measuring tank to the dialyzer and the bypass path. selectively passing through the dialyzer to introduce it into the detection tank preset to the reference level, and measuring the time when a certain amount of V of the dialyzer is delivered from the measurement tank to the dialyzer,
Calculate the deviation of the detection signal from the detection level meter when the dialysate passes through the dialyzer and when it passes through the bypass path, and use this deviation, the data, and the measured time to obtain the signal obtained by the dialyzer. What is claimed is: 1. An ultraviolet amount measuring device that calculates and outputs the ultraviolet amount per unit time. 2. A reserve tank that accommodates dialysate and communicates with the delivery path is provided, and the delivery means sends dialysate from the reserve tank when dialysate is not delivered from the measuring tank. The ultraviolet amount measuring device according to item 1.