JPS6182761A - Solid preparation using fiberscope and administration kit thereof - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention consists of a thin tube with a needle at its tip and a plunger that can freely slide inside the tube, and is capable of measuring semi-solid preparations or solid preparations in the form of needles or rods using a fiberscope. This invention relates to an administration device that is capable of administering to deep parts of the body.

Conventionally, it has been known to treat patients by implanting solid drugs into the body, but this method was complicated and required surgery.

On the other hand, in treatment using a fiberscope, drugs in solution form are administered, but their effects do not last long enough and they cannot be administered frequently due to patient pain and hassle. It was not possible to achieve the desired effect.

The present inventors paid attention to these current situations, and as a result of intensive study, they completed the administration device of the present invention.

The application filed by the present inventors related to the present invention is the patent application filed in 1983.
-286994, Japanese Patent Application No. 58-2869.96, Japanese Patent Application No. 58-286996, etc., but the present invention holds a tube for protecting the preparation inside the administration device, and directly inserts this device into the fiberscope. It is characterized by being inserted. In other words, this administration kit has a needle at its tip, a tube containing the preparation inside the other end, a thin tube with a fixed grip that can be passed through a fiberscope, and a plan for pushing out the preparation. This combination is extremely useful clinically.

To explain in more detail, the solid and semi-solid preparations referred to in the present invention are those in which a medicinal component is supported on a carrier with good biocompatibility. There are no particular limitations on the medicinal ingredients, but substances with strong pharmacological activity, such as interferon, interleukin, MS death factor, mitomycin, adriamycin, 5-fluorouracil, pleomycin, prostaglandin, prostacyclin, tesbamine, and various other substances. It is particularly effective for biological hormones, various biological hormone releasing factors, etc. Examples of carriers with good biocompatibility include proteins such as collagen, gelatin, and albumin, and polymeric carbohydrates such as chitin.
Alternatively, biodegradable substances typified by synthetic polymers such as polyglycolic acid, polylactic acid, and polyglutamic acid, or silicone that has little reactivity with biological tissue, etc., may be used. Further, these may be mixed and used depending on the case.

There are no particular limitations on the manufacturing method of the solid preparation held in the preparation protection tube, and various methods commonly used for molding may be selected depending on the purpose. For example, after freeze-drying a mixed solution of a medicinal ingredient and a carrier, the required amount of powder obtained by pulverization is put into a tube, and the whole tube is inserted into a mold and compression molded, or the mixed solution is pre-molded into a mold. A solid injection can be obtained by containing a rod-shaped or needle-shaped solid preparation obtained by injection molding, etc. in a preparation protective tube, which is injected into a tube, dried, and finally compression-molded.

In the case of semi-solid preparations, there are no particular limitations on the manufacturing method; for example, after mixing a gel-like base and a medicinal ingredient, the powdered base and medicinal ingredient are poured into a protective tube and mixed with a small amount of water. If you knead it, you can make kola'fn, gelatin, etc.

The drug product protection tube has, for example, an inner diameter of 0.5 to 8 mm and a length of about 5 to 50 mm, and its material is not particularly limited as long as it does not interact with the drug, but may be made of plastic, for example. , polyethylene, silicone, polypropylene, Teflon, etc.

The present invention is completed by combining the thus obtained preparation in the protective tube with an administration device for holding it, but there are no particular limitations on the manufacturing method of the administration device. Instead, it is created by combining the parts described below. That is, as shown in FIG.
~3 lengths), and the distal end has a formulation 4 (for example, length 5~3 mm).
Protective tube 8 with a diameter of 0.5-3M)
(For example, length 5 = 50 m, inner diameter 0.5-8, approximately)
A flexible thin tube l (for example, length 500~100 mm) with an outer diameter that penetrates inside the fiberscope and a grip 6 (for example, length 10~100 mm, inner diameter 0.6~7M) for fixing the fiberscope.
1500mm, inner diameter 0.5-3mm), and a flexible plunger 5 that can freely slide inside these (for example, length 500mm-1500mm, inner diameter 0, 5-8mm).
degree).

Next, a procedure for administering the solid or semi-solid preparation in the preparation protection tube into the body will be explained.

First, a fiberscope is inserted into the body. Next, the tip of the administrator is inserted through the inside of the syringe to the desired depth. The drug is then administered by pushing it out with a plunger. Finally, by removing the entire device along with the fiberscope, solid or semi-solid preparations can be implanted deep within the body.

Next, the present invention will be explained in more detail using experimental examples, but these examples do not limit the present invention.

Experimental example 1 Powdered atelocollagen 1? was dissolved in 25 s+Jl of Tris-glycine buffer, further mixed with 4 ml of 5% methyl cellulose solution and 20 MIU of interferon, and each liter was injected into a formulation protection tube and freeze-dried. This was fitted into a mold and compression molded to obtain a rod-shaped solid preparation with a diameter of 1.5 mm and a length of 7 mm held in a protective tube.

The solid formulation held in the resulting formulation protection tube is
It was inserted into the distal end of the administration device of the present invention and administered into the esophageal wall of a domestic rabbit according to the procedure described above. With this method, the preparation could be administered simply and safely, without requiring difficult surgery, even deep inside the body, after visually confirming the administration site.

[Brief explanation of the drawing]

FIG. 1 is a diagram representing the administration kit of the present invention. In the figure, l indicates a tubule, 2 indicates a needle, 3 indicates a drug product protection tube, 4 indicates a drug product, 5 indicates a plunger, and 6 indicates a fixed grip.

Claims (1)

[Claims] (i) A solid or semi-solid preparation held in a preparation protection tube; (ii) having a needle at the tip to which it can be attached and capable of passing through a fiberscope; , a thin tube with a fixed grip, and (iii) a plunger that can freely slide inside the tube.