JPS6182756A - 皮膚貫通管 - Google Patents

Info

Publication number

JPS6182756A

JPS6182756A JP59205215A JP20521584A JPS6182756A JP S6182756 A JPS6182756 A JP S6182756A JP 59205215 A JP59205215 A JP 59205215A JP 20521584 A JP20521584 A JP 20521584A JP S6182756 A JPS6182756 A JP S6182756A

Authority

JP

Japan

Prior art keywords

skin

glutamate

amino acid

tube

cells

Prior art date

1984-09-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920001577 copolymer Polymers 0.000 claims description 16
• DHQUQYYPAWHGAR-UHFFFAOYSA-N dibenzyl 2-aminopentanedioate Chemical compound C=1C=CC=CC=1COC(=O)C(N)CCC(=O)OCC1=CC=CC=C1 DHQUQYYPAWHGAR-UHFFFAOYSA-N 0.000 claims description 13
• 235000001014 amino acid Nutrition 0.000 description 13
• 210000004027 cell Anatomy 0.000 description 10
• 238000000465 moulding Methods 0.000 description 5
• 230000021164 cell adhesion Effects 0.000 description 4
• 239000000463 material Substances 0.000 description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• 150000001413 amino acids Chemical class 0.000 description 3
• 239000011521 glass Substances 0.000 description 3
• 230000000149 penetrating effect Effects 0.000 description 3
• HFZKKJHBHCZXTQ-JTQLQIEISA-N (4s)-4-azaniumyl-5-oxo-5-phenylmethoxypentanoate Chemical compound OC(=O)CC[C@H](N)C(=O)OCC1=CC=CC=C1 HFZKKJHBHCZXTQ-JTQLQIEISA-N 0.000 description 2
• WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• SEWIYICDCVPBEW-BYPYZUCNSA-N L-glutamate methyl ester Chemical compound COC(=O)[C@@H](N)CCC(O)=O SEWIYICDCVPBEW-BYPYZUCNSA-N 0.000 description 2
• YEJSPQZHMWGIGP-UHFFFAOYSA-N dl-glutamic acid dimethyl ester Natural products COC(=O)CCC(N)C(=O)OC YEJSPQZHMWGIGP-UHFFFAOYSA-N 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• SEWIYICDCVPBEW-UHFFFAOYSA-N methyl glutamate Chemical compound COC(=O)C(N)CCC(O)=O SEWIYICDCVPBEW-UHFFFAOYSA-N 0.000 description 2
• 229920002379 silicone rubber Polymers 0.000 description 2
• 239000004945 silicone rubber Substances 0.000 description 2
• OJTJKAUNOLVMDX-LBPRGKRZSA-N (2s)-6-amino-2-(phenylmethoxycarbonylamino)hexanoic acid Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 OJTJKAUNOLVMDX-LBPRGKRZSA-N 0.000 description 1
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• 229930195714 L-glutamate Natural products 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 238000000944 Soxhlet extraction Methods 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 150000001509 aspartic acid derivatives Chemical class 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 229910002092 carbon dioxide Inorganic materials 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 238000000502 dialysis Methods 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 210000000959 ear middle Anatomy 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 230000005611 electricity Effects 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 150000002306 glutamic acid derivatives Chemical class 0.000 description 1
• 238000001631 haemodialysis Methods 0.000 description 1
• 230000000322 hemodialysis Effects 0.000 description 1
• 229920001519 homopolymer Polymers 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 150000002668 lysine derivatives Chemical class 0.000 description 1
• 229930182817 methionine Natural products 0.000 description 1
• 238000012758 nuclear staining Methods 0.000 description 1
• 239000008363 phosphate buffer Substances 0.000 description 1
• 239000002861 polymer material Substances 0.000 description 1
• 229920002635 polyurethane Polymers 0.000 description 1
• 239000004814 polyurethane Substances 0.000 description 1
• 229920000915 polyvinyl chloride Polymers 0.000 description 1
• 239000004800 polyvinyl chloride Substances 0.000 description 1
• 229920001059 synthetic polymer Polymers 0.000 description 1
• 239000004474 valine Substances 0.000 description 1