JPS6155979B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a mineral ion permeator that selectively and continuously adjusts the mineral ion concentration within a living body from outside the living body.

BACKGROUND ART Cell constituent substances are contained in predetermined concentrations in the living bodies of animals and plants, such as the human body, and when the balance is disrupted, maintenance of normal biological functions is inhibited. For example, the sodium and potassium ion concentration ratios [Na ⁺ ]/[K ⁺ ] are maintained at different constant values inside and outside of animal cells, and as the intracellular sodium ion concentration increases, blood pressure increases, and conversely, potassium ion concentration increases. It has the property of lowering blood pressure as the ion concentration increases. Furthermore, when the concentration of magnesium ions in plant cells decreases, the chlorophyll organism is inhibited, resulting in abnormal growth. Similarly, when the concentration of iron and copper ions in animal cells decreases, anemia occurs. On the other hand, some heavy metal ions that living organisms do not need, such as
Pb ²⁺ , Cr ²⁺ , Hg ²⁺ , Cd ²⁺ , etc. become factors that inhibit the normal functioning of biological functions when taken into the body, so they must be removed from outside the body without destroying the body. It would be convenient if you could. Conversely, it may be preferable for elements that are not normally contained in living bodies to be taken into living bodies. Examples include germanium, which self-activates antibody reactions when introduced and is said to be useful for producing macrophages and interferons, and radioactive isotopes that kill cancer cells. These elements are preferable for treatment of living organisms if they are selectively taken into the living body at appropriate concentrations.

The ingestion of necessary elemental ions as described above has conventionally been carried out by internal administration of foods and medicines, absorption of nutrients through the roots, or external application such as injection application. In addition, removal of unnecessary ions has been carried out naturally to some extent by biological defense reactions. However, there are limits to absorption and excretion through biological cell membranes and plasma membranes, as this occurs within the scope of biological mechanisms. Direct injection methods such as injections are also effective in the sense of delivering prescribed drugs into the skin of a living body, but absorption of the injected drugs into living cells depends on biological mechanisms. It may not always be sufficiently effective.

The present invention aims to continuously and selectively adjust the concentration of the various mineral ions described above from outside the body as necessary.

In order to achieve the above object, the present invention discloses a mineral ion permeator having the configuration generally shown in FIG. 1a or b. That is, conductive mineral A, which has a higher standard unipolar potential, and conductive mineral B, which has a lower standard unipolar potential, are electrically connected, and these are attached to a living body. The attachment may be carried out by directly pressing A and B against the skin surface 4 of the living body as shown in FIG. 1A, or by puncturing A and B into the skin of the living body as shown in FIG. 1B. Assume that A is made of elemental metal A and B is made of elemental metal B. In this case, the standard unipolar potential E ₀ has a relationship of E _OA >E _OB . Now, mineral ions exist in living organisms,
When a suitable polyvalent ionic mineral is C (C is 1
C ²⁺ →C ⁺ or C ⁺ →C ²⁺ (Standard unipolar potential E _OC ) A reaction can occur. By mounting as shown in FIG. 1a or b, the valence electrons of the elemental metal B move to the elemental metal A side due to the difference in the standard monopolar potentials of A and B. As a result, one of the following reactions occurs depending on the relationship between the standard unipolar potentials.

(1) When E _OC >E _OA >E _OB B→B ⁺ +e ^- , i.e., ionization of B and in-vivo penetration diffusion C ²⁺ +e ^- →C ⁺ , i.e., reduction of C ²⁺ (2) E When _OA > E _OC > E _OB When ion A ⁺ of elemental metal A is distributed in the living body, B → B ⁺ + e ^- , A ⁺ + e ^- → A, that is, A ⁺ is reduced and deposited on electrode A. (A ⁺ is excreted outside the body) When ion A ⁺ is not distributed in the body B→B ⁺ +e ^- , C ²⁺ +e ^- →C ⁺ (3) When E _OA > E _OB > E _OC Ion A When ⁺ is distributed in the body C ⁺ →C ²⁺ +e ^- , that is, oxidation of C ⁺ A ⁺ +e ^- →A When the ion A ⁺ is not distributed in the body C ⁺ →C ²⁺ +e ^- , D ²⁺ +e ^- →D ⁺ , that is, another ion in the living body
Reduction of D ²⁺ (however, E _OD > E _OC ) The arrangement as shown in Figure 1 b, that is, the connection of the bias power source and the puncture arrangement of A and B, promotes the above reaction expected in the arrangement as shown in Figure 1 a. It has a great effect. Also, as shown in Figure 1 c and d, A and B can be directly shorted without using conductors, or as shown in e.
It is also possible to sandwich the insulator 15 between AB and connect it with a conductor 16. For simplicity, A,
Although B and C are used as elemental metals, it is obvious that the invention can also be applied to alloys and compounds.

As explained above, if the mineral ion permeator of the present invention is used, by selecting an appropriate combination, the injection of A ions necessary for the living body or the discharge of unnecessary A ions will be a physical phenomenon rather than a physiological phenomenon. It is ideal because it can be carried out continuously.

Hereinafter, the present invention will be described in detail based on examples.

(Example 1) Metallic iron 2 was vacuum-deposited to a thickness of about 1 μm on a cylindrical calcium calcium column 1 with a diameter of 2 mmφ and a height of 3 mm, except for the back surface, and the bottom surface of the calcium metal was polished in a hydrogen atmosphere. As shown in FIG. 2, the patch was applied to the ventral skin 4 of a mouse so that the bottom surface of the calcium 1 was brought into direct pressure contact. In this case, iron 2 is also added to the mouse skin surface 4 at the same time as calcium 1.
come into contact with. After about 100 hours, the calcium-iron composite block was removed, the mouse was dissected, and the subcutaneous tissue was examined. In comparison, it was observed that the calcium ion concentration increased and the iron ion concentration decreased. In the area up to about 3 mm directly below the skin surface, calcium ion concentration increases by about two orders of magnitude, and iron ion concentration increases by about 20%.
It was decreasing. This is because Fe ³⁺ ions in the mouse body were deposited on the Fe electrode by the reaction 2Fe ³⁺ +6e ^- →2Fe on the iron anode side of the calcium-iron composite block, or by the reaction 3Fe ²⁺ +6e ^- →3Fe. This is thought to be the result of Fe ²⁺ ions in the body depositing on the Fe electrode, and conversely, Ca ²⁺ ions penetrating into the mouse body through a reaction of 3Ca → 3Ca ²⁺ + 6e ^- on the calcium cathode side. The decrease in iron ions is smaller than the increase in calcium ions because
This is thought to be because the main reaction is the reduction of Fe ³⁺ ions to Fe ²⁺ ions.

(Example 2) When the eggplant seedlings grew to about 15 cm, 0.1% HgBr ₂ was added to the hydroponic culture solution, and the plants were taken out after about one week. When the stem of this sapling was cut and tissue examined, approximately 500 ppm of Hg was detected. At this stage, the hydroponic culture solution was removed and updated to contain no HgBr ₂ .
Then, metal connecting balls (Sn balls and Zn balls 13 each having a diameter of 2 mm are welded together) as shown in FIG. 3 were affixed to the stems 14 of two of the five eggplant seedlings by pressure-bonding using the adhesive tape 3. After approximately 150 hours, the metal head was removed, and the stem in the patched area was cut and histologically examined. At the crimped area, the stem surface was damaged, and sap within the stem was observed to seep out to the connecting spherical surface. A similar histological examination was performed on the remaining three eggplant stems to which metal connecting balls were not applied, and an average of 100 to 200 ppm of Hg ²⁺ was detected in the eggplant stems to which metal connecting balls were not applied. However, the Hg ²⁺ ion concentration decreased to about 10 ppm in the two eggplant stems to which the connecting bulbs were attached;
An approximately 50% increase in Zn ²⁺ ion concentration was observed. This suggests that a precipitation reaction of Hg ²⁺ +2e ^- →Hg occurred on the Sn anode side of the metal connection sphere, and a dissociation reaction of Zn→Zn ²⁺ +2e ^- occurred on the Zn cathode side.
The reduction reaction of Hg ²⁺ ions is greater than when the standard monopolar potential is Sn, so Hg is precipitated at the anode. Although Hg ²⁺ ions are harmful to living organisms,
It has been shown that the method of the present invention is removable.

As detailed in the above examples, by using the mineral ion permeator of the present invention, the selective intake of mineral ions necessary for living organisms or the selective removal of unnecessary mineral ions depends on physiological reactions. It can be done effectively without doing anything. This is a device that applies a type of biological battery reaction (physical phenomenon), and can be used continuously from outside the body for the purpose of promoting the growth of living organisms, exchanging metal ions, or for treatment.
This makes it possible to easily achieve the above objective.

Note that the above embodiments describe only a part of the present invention, and if the mineral ion permeator of the present invention is applied not only to a part of the skin surface of a living body but also to the entire skin surface, the ion exchange in the living body will be improved. It is obvious that this can be done effectively.

Although the content of the present invention is completed with the above detailed explanation, finally, the constituent elements of the mineral ion permeator of the present invention will be comprehensively described in connection with the "claims."

As is well known, the difference in ionization between different metals is the basic principle that causes redox reactions in chemical batteries, and the present invention actively utilizes this principle to selectively penetrate necessary mineral ions into living organisms. The present invention provides a device that selectively discharges unnecessary mineral ions from the living body. In order to achieve this objective, in addition to the two types of minerals used in the cathode and anode of the battery, a third mineral ion distributed in the living body is considered, and the redox ability between these three types of mineral ions, In other words, an appropriate selection must be made with attention to the difference in standard unipolar potential. In other words, mineral ion penetration into the living body occurs on the cathode side by ionization of cathode constituent elements, and mineral ion discharge outside the living body occurs on the anode side by precipitation (reduction) on the anode. These ionizations or precipitations are made possible only by charge compensation through reduction or oxidation of the third mineral ion within the bioelectrolyte, as described above. Therefore, when performing selective penetration of necessary elemental ions into the living body, for example, as described in the background of the invention, the necessary elemental ions are ions of cell constituent substances and the concentration of the element has decreased, so replenishment is performed. In some cases, as described in other parts of the background of the invention, when infiltrating ions of elements that are not normally contained in living organisms but whose inclusion is desirable from the viewpoint of activating or recovering biological functions, these The cathode is a mineral A (an element or a compound or alloy containing the element) that contains an element necessary for living organisms, and the anode is a mineral A with a higher standard unipolar potential. As a result, at the same time as the ionization (oxidation) of A, the reduction of the biodistributed ions in the area immediately below the instep occurs, and the objective is achieved.
On the other hand, as described in the other part of the background of the invention, the selection of A is more important in the case of ion excretion of element C, which is distributed in the living body but is unnecessary and should be eliminated from the living body. In other words, since C is reductively precipitated on the upper surface of the shell, heavy metal elements such as Hg, Pb, Cd, and Cr, i.e., standard unipolar elements with a lower concentration than C, are strongly generated when C ions have a reducing effect. A mineral with electrical potential is selected as the instep. Since the standard unipolar potential of the anode component B is naturally selected to be lower than A and C, the reduction and precipitation of C ions onto the anode compensates for the ionization of B or the oxidation reaction of ions in the body directly below B. It becomes possible only if

It goes without saying that the above-mentioned effect occurs only when an electrical closed circuit is formed by the pressure contact or puncture of A and B on the living body's skin surface and the electrical connection between A and B.

[Brief explanation of the drawing]

FIG. 1 is a diagram for explaining the principle of the present invention, and FIGS. 2 and 3 are diagrams for explaining different embodiments of the present invention. In the figure, 1 is
Ca, 2 is Fe, 3 is anti-inflammatory, 4 is skin surface,
12 is Sn, 13 is Zn, 14 is an eggplant stem, and 15 is an insulator.

Claims (1)

[Claims] 1. Consists of a conductor in which two types of conductive minerals having different standard unipolar potentials are electrically connected, and each of the two types of conductive minerals is pressed or pressed against the skin surface of a living body. (1) The mineral with the lower standard unipolar potential of the two types of conductive minerals (hereinafter referred to as B) is injected into the body at an appropriate concentration in the device placed so as to be punctured into the skin. (2) When an element (hereinafter referred to as C) that should be eliminated from the body is accumulated in the body, Of the two types of conductive minerals mentioned above, A and B have been selected so that the mineral with a higher standard unipolar potential (hereinafter referred to as A) is an element or compound with a lower standard unipolar potential than C. Characteristic mineral ion permeator.