JPS61502030A - In-body dialysis machine with wearable extracorporeal regeneration device - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] In-body dialysis device technology field with wearable extracorporeal regeneration device The present invention relates to kidney dialysis, and more particularly to a novel apparatus and method for performing artificial kidney dialysis. Regarding the law. More specifically, the present invention is useful for treating body fluids outside of veins and arteries, such as body fluids. fluid that circulates between and hydrates organs, especially the large and small intestines behind the peritoneum Contains continuous dialysis within the body of body fluids present in the area. Especially good In a suitable configuration, the present invention performs dialysis and draws blood without venous or arterial invasion. The rectum, which is rich in blood, is used as the dialysis site to perform dialysis within the body without expelling it. It's something. The device is wearable, continuous dialysis, and self-regenerating. allowing users to live more independently than was previously possible. Can be done.

background Blood is removed from the body when normal kidney function is lost or inadequate. and the purifying fluid contained in the artificial kidney (referred to herein as an “in vitro” device). Pass it in dialysis contact with the It is common practice to remove waste or contaminants from blood. hands like this Although tiers are common, they have many drawbacks, many of which are transparent. It is necessary to chemically condition the blood against undesirable clotting responses to analytical treatments. This means that Another difficulty is that a normal kidney undergoes dialysis only a few times a week. Excessive waste in response to the dialysis treatment schedule due to it being done only once A completely different cycle occurs between the loaded state and the ultra-clean state, so This means that regular chemical imbalances are created within the user's body.

The inventor's early patents are U.S. Pat. Nos. 3,388,803 and 388. No. 4808, the inventor proposed that when a user moves his or her limbs according to his or her daily routine, Blood circulates through the artificial kidney, dialysate is regenerated by a filtration device, and used for replenishment. Discloses an artificial kidney device that can be worn outside the body in which solids are continuously supplied to the dialysate did. Although these machines were superior to stationary “dialysis center” type dialysis machines, , the problems inherent in the technology for circulating blood outside the body remain unresolved. was left behind.

Disclosure of invention Therefore, an object of the present invention is to provide a new dialysis device for human use. While retaining the dialysis effect of the earlier devices, it is also possible to dialyze blood outside the body. It is an object of the present invention to provide a dialysis device that avoids these problems. Other purposes are to (referred to herein as “in vivo dialysis” or “internally operated dialysis”) ), and regenerating dialysate outside the body so that dialysate is circulated in and out of the body instead of blood. It is to be. Yet another purpose is to provide blood or uses body fluids other than blood, and transports waste products from such body fluids to unrestricted areas of the body. (e.g. near the intestines, inside the rectum, or inside the abdominal cavity) and removes the waste from the human body. The dialysate is transferred to a second dialysate (the composition of the first dialysate is adjusted). 5. Continuously process using filtration and, if necessary, replenishing solids to achieve the required composition. continuously regenerated) and pump means (advantageously integrated into this dialysis machine). waste products into a second dialysate under the pressure of can be carried by the human body as a waste-carrying belt. In certain embodiments , the dialysis zone or dialysis chamber is made of a semipermeable membrane, and this semipermeable membrane is made of Cuprafan ( Artificial semipermeable membranes such as Cupraphan θ), or e.g. vein or preferably a portion of the intestine (removed from the intestine and living tissue in common with the intestine) (recombined with the intestinal tract, but not in fluid communication with the waste products in the intestines) It is a natural semipermeable membrane that is part of your own tissue.

The above objects of the present invention and other objects which will become apparent hereinafter are directed to the storage of bodily fluids in the body. A wearable device consisting of a means for dialyzing dialysate and simultaneously regenerating the dialysate outside the body. dialysis machines that can be operated continuously within the body and regenerated outside the body. The above means are generally pump means for exchanging dialysate from outside the human body; dialysate an intracorporeal chamber placed inside the body to accommodate a patient and having a semipermeable wall suitable for dialysis; a body with semi-permeable walls suitable for dialysing used dialysate against a regenerating fluid; an external chamber; and conduit means for continuously communicating the dialysate containing portion with the dialysate outside the body; includes.

According to the present invention, in one embodiment, the contained dialysate is transferred to the body. A device consisting of means for dialyzing a fluid inside the body and at the same time exogenously generating the dialysate outside the body. A dialysis device that can be continuously operated in the body and regenerated outside the body is provided. The above means are generally pump means for exchanging dialysate from inside and outside the human body; dialysate a chamber in the body that is placed inside the body and has semipermeable walls that is suitable for dialysis; a body with semi-permeable walls suitable for dialysing used dialysate against a regenerating fluid; an external chamber; and conduit means for continuously communicating the dialysate containing portion with the dialysate outside the body; including.

In the above and similar embodiments, the invention provides that the intracorporeal means is housed in the intracorporeal chamber. a device comprising a semi-permeable wall suitable for dialyzing body fluids against a dialysate; The intracorporeal body has no internal fluid communication with the intestine but is composed of living tissue that shares common features with the intestine. Consists of part of the intestine, which also contains blood vessels related to body fluid dialysis within the septa that define the internal chambers. It may also include a semi-permeable wall structure.

The invention further provides for passing a first dialysate through the body in a body fluid dialysis relationship, the first dialysate comprising: Dialyzing a second dialysate whose composition is different from that of the first dialysate in a first dialysate regeneration relationship. and a method for continuous dialysis of body fluids in the body. This method also internal bands within the user's body that do not have internal communication with the pulse and arteries; defining external zones outside the body and exchanging the first dialysate between these zones; The external zone has a semi-permeable membrane, and the internal zone is in dialysis contact with body fluids within the body. The external zone is connected to the second dialysate outside the body; to define an internal zone in dialysis communication with body fluids; select a part of the user's intestine and It is a living tissue common to the intestine, but it is joined to the intestine without internal fluid communication and is permeable to body fluids. Determine the internal zone in the analysis state; alternatively, select a portion of the rectum separated from the user's intestines. selecting an internal zone, introducing a first dialysate therein, and introducing the first dialysate into the anus. Removal by mouth 1, in which case the first dialysate passes through the rectal wall and permeate between its introduction and removal. and a semipermeable wall is interposed between the first dialysate and the IH intestinal wall. , whereby the semi-permeable wall encompasses dialysis of body fluid within the rectal wall against a first dialysate. Contains.

In another embodiment, the dialysate contained in the body is dialyzed against body fluids while the dialysate is simultaneously dialyzed against body fluids. A continuous dialysis method is provided that includes regenerating the dialysate. This type of implementation In the present invention, the dialysate inside the body is renewed by exchanging the dialysate outside the body with the dialysate inside the body. Transparent; uses part of the user's body tissue to contain dialysate; semi-permeable Contains dialysate inside the body using a membrane 2; Recycles used dialysate from the body outside the body dialysate against fluid; replace the dialysate compartment with dialysate outside the body; replace conventional dialysate with stored in the body for liquid dialysis, and regenerates the conventional dialysate as a second dialysate outside the body; The body fluid is then dialyzed within the body by exchanging the regenerated dialysate with the stored dialysate. At the same time, the dialysate is regenerated outside the body; the conventional dialysate is housed in a hand-permeable membrane; and the semi-permeable membrane and dialyzing the dialysate contained therein against the user's rectal wall.

drawing The invention will be further described with respect to exemplary embodiments with reference to the accompanying drawings. Dew.

FIG. 1 is a pictorial diagram showing the device of the invention worn by a user): FIG. 2 is a configuration diagram showing the functional relationship between the intracorporeal chamber and the extracorporeal chamber of the dialysis machine; Figure 3 is a cross-sectional view of the extracorporeal portion of the dialysis machine, which is attached to a support belt. Show me where; FIG. 4 is a cutaway view of another embodiment; FIG. 5 is a dialysis device inside the user's body. side view partially cut away to show internal body chambers; Figure 6 depicts the large intestine as a common tissue and the interior of the body joined for external regeneration. Q; Figure 7 shows a body chamber located within the rectum and defined by a closed semi-permeable wall. FIG. 8 is a schematic diagram of a dialysis machine; FIG. 8 is a view taken along line 8-8 of FIG. ; Figure 9 is a drawing taken along line 9-9 of Figure 7; Figure 10 is a view along line 9-9 of Figure 7; 10-10; and Figure 11 shows a rectum placed within the rectum and closed and defined by the rectal wall rather than a semi-permeable wall. FIG. 7 is a fragmentary view similar to FIG.

Dan33Jf-ball The inventor's early patents are U.S. Pat. Nos. 3,388,803 and 388. The content of No. 4808 is incorporated herein by reference, and the content of the dialysate described herein is incorporated herein by reference. Includes general composition.

In FIG. 1, the dialysis device of the present invention is indicated at 10 and is generally used to remove waste from body fluids. It removes waste products, but in some cases, it may also be necessary to remove substances of a selected composition to add, for example, drugs to the human body. 1 comprises means 12 for continuously circulating dialysate in and out of the human body. This specification honor smell "Continuously operated" means a continuation of processes similar to those in the human body that are performed by a non-device. refers to the method of performing dialysis and the capabilities of this device in accordance with the standard, whereby dialysis is essentially Continuous, but with occasional pauses to accommodate the body's needs and natural As close as possible to steady-state behavior to best mimic renal function, but not necessarily They do not need to operate at the same speed. Addition of drugs or removal of waste products is carried out by osmotic diffusion through a semipermeable membrane.

The general use of the first dialysate is to remove body fluid components such as uric acid. Body fluid components circulate in the bloodstream and enter veins, arteries, and other parts of the body, such as the intestines and rectum. into body fluids at the external surface of organs (including the intestines) and from which body fluids according to the present invention. removed.

The circulation means 12 includes a first pump 8, which returns the regenerated first dialysate to the body for the next dialysis. The inlet 14 from the external dialysate chamber 16 (see Figures 2 and 3) into the body; and an outlet 18 from the body to the external dialysate chamber. To regenerate the first dialysate, Two dialysates are prepared and kept completely outside the body, and for that second dialysate The first dialysate is dialyzed. This second dialysate generally has a similar composition to the first dialysate. However, there are some Substances are modified to be added to or removed from the first dialysate.

The specific composition of the first or second dialysate is well known and commercially available; , the composition of these dialysis fluids is not part of the invention; In the case of liquids, the only requirement is that the body fluid can be dialyzed to mimic normal kidney function (this The dialysate for this method is well known), and the second dialysate where the residual fluid is outside the body. If this is the case, this first dialysis fluid is It is only required to be able to dialyze the fluid. the second dialysate and indirectly the first dialysate. To regenerate, the device connects a second pump 34 to pump the second dialysate. and solid content for filtration (here including surface adsorption) in the filtration tank 36 adjustment zone 40 (all located within housing 20); located within belt 22; and the elongated dialysis channel supported by the -ζ silt 2 and the second dialysate. including a drain tap 42, all of which are located at the waist of the wearer as shown. This housing 20 functions as a belt buckle.

The dialysis machine shuts off water from the dialysate through tap 42 under pressure response as desired. This avoids excessive accumulation of water within the device, which was previously Artificial kidneys free users from ingesting water and large amounts of liquids, which was once prohibited. Providing users with new standards of convenience and comfort, as well as an increased sense of well-being and independence. It should be noted that this foreshadows

FIG. 2 depicts the functional relationships of the parts of the device. Chamber 16 containing the first dialysate is generally an elongated tube of semi-permeable membrane material containing the user's body tissues (described below). It is a thing. The dialysate chamber 16 is located inside the body divided by the skin line 28 for convenience of reference. It consists of a chamber 24 and an extracorporeal chamber 26, which are connected through the skin as shown. (e.g. a suitable fitting such as a Feistel not shown but ensuring a hygienic connection) communicate with each other (through various accessories). In the embodiment of FIGS. 7-11, the body chamber The anus is used to pass a fluid inlet tube and/or a fluid outlet tube between the body and the extracorporeal chamber. This will be explained later.

It is transported into the body at the mouth 14 through the skin line 28. Generally closed volume tubular or spherical (see part 24 of FIG. 5 and part 124 of FIG. 7). The body chamber 24 is suitably located within the body for extensive dialysis contact with body fluids; The vein does not yet have direct internal communication with the arterial blood, i.e. the body chamber 24 is static. The invasion of pulses and arteries or communication with them is completely cut off, and this fruit Embodiments generally include a body in close proximity to an internal body organ, particularly the large intestine (see, for example, FIG. 5). cavity 30a, but such a body chamber does not interfere with normal bodily functions. (comfortable for the user) and free from crushed or bent pieces that may block fluid passages. It can exist anywhere within the system as long as it is not

Please also refer to FIG. In one embodiment, the abdominal cavity is This is currently predicted to be the ideal intracorporeal location, but better dialysis Exchanges also take place in other areas of the body, which will be discussed below.

The body chamber 24 carries the first dialysate through the body cavity 30a in which it is placed and the second dialysate. Based on well-known dialysis principles, the surrounding body fluids (venous and artery walls and moisturizing body fluids) water and salts contained in the water (including body fluids would accumulate in the absence of effective renal function), as well as the previously mentioned book. Excess water and salts at the same rate as hemodialysis covered in the inventor's earlier patents. The human body is fecalized by removing it.

The dialysate containing the accumulated diffused matter (that has passed through the semi-permeable wall) is pumped into the first battery-operated pump. It is carried from the inside of the body 30 to the outside of the body via the outlet 18 under the pressure of the pump 8 and becomes the second dialysate. It is regenerated by dialysis against. As shown, the first dialysate circulates inside and outside the body. In contrast, the second dialysate, which is always outside the body, contains impurities due to carbon adsorption. solids for removal and replenishment in tanks 36,38 of each zone 40 (e.g. It is repeatedly regenerated by the addition of salt and butosucrose) and then subjected to the first dialysis. is returned to its own dialysis action on the fluid. For this purpose, the envelope 53 is provided, which is defined by the belt 22 and which forms the extracorporeal chamber 26. The arrangement is such that the second dialysate and the first dialysate are brought into contact with each other over a wide range through the permeable membrane.

Envelope 53 is connected to collection vessel 44 controlled by tap 42 and valve 46. The water is drained regularly.

Referring now to FIG. 3, an exemplary physical diagram including a belt 22 having a buckle 20 The arrangement is depicted in the buckle 20 with an outlet 18 of the extracorporeal chamber 26 at the intake end. A first pump 8 is arranged in communication with the upstream part of the extracorporeal chamber, as shown in the belt 22. The dialysate is inverted multiple times so as to be , whereby the upstream chamber fluid is freed of unnecessary components and also meets the user's requirements and the first fluid. Depending on the composition of the second dialysate relative to the precipitate, drugs or analogs are added.

As shown, in the embodiment of FIG. 3, the housing 1 in the form of a buckle 20 2 defines the ends of the extracorporeal chamber 26 at 48 and has bells at both its open ends 50,52. The envelope 53 is defined by blocking the opening 22, and this envelope 53 is the second dialysate. a second dialysate 54 to regenerate the first dialysate in the extracorporeal chamber 26 disposed within the second dialysate 54; to accommodate.

As an alternative to the arrangement of the extracorporeal chamber 26 in the second dialysate 54 shown in FIG. does not need to be filled with a second dialysate, but if a tube with a diameter larger than chamber 26 is locally The chamber 26 may be surrounded. In FIG. 4, chamber 26 is shown in belt envelope 53 (see Figure 3) (surrounded by an envelope tube 57 that can be arranged) , so that the second dialysate 54 is accommodated in the chamber 26 .

The second dialysate 54 surrounding the extracorporeal chamber 26 arranged within the belt envelope 53 is , a first double filter in which adsorbable impurities are removed, for example by carbon filtration. solids is circulated through the tank 36 to the replenishment tank 38, and this tank 38 required in the second dialysate to maintain the dialysis-suitable composition of the first dialysate. The additive is activated by the passage of the second dialysate through the tank 38. It is added by metering the solids solution in 8. The second dialysate is in the extracorporeal chamber 26. is returned to the envelope 53 for exchange with the first dialysate, after which the first dialysate The Kx pump 8 returns the body to the body chamber 24, at which point the dialysis cycle begins. is repeated from the beginning.

In this device, dialysis is performed continuously to avoid periodic imbalance. Users are free to carry out daily tasks at the central dialysis center without being restricted by machines. It is very advantageous in that it can be used in many ways.

Referring to FIG. 5, the body chamber 24 is located behind the skin line 28 and the peritoneum 60 in the large intestine. 62 and which removes the intraperitoneal organs surrounded by the peritoneum. Surrounded by moist body fluids.

In another aspect of the invention, the body chamber 24 is located in a leg vein or other suitable body part of the user's body. It consists of viable tissue obtained from a source, optimally from the intestine itself. can be done. The construction of this aspect of the invention is shown in FIG. large intestine 62 A portion 64 of the large intestine is removed by cutting. The large intestine portion 64 is the large intestine from which it was cut. 62 and between the opposite bends of the large intestine, as if by bypass. Although it is sewn in place, there is no fluid communication with the inside of the colon, which could contaminate the dialysate.

The outer wall of the large intestine 62 rather closes off both ends of its large intestine portion 64 . However, The inosu-like portion 64 forms a common living tissue with the large intestine 62 and grows together with it. This part, like all body tissues, is continuously self-renewing and aging. waste-free and using T-fittings 66 or otherwise in vitro regeneration systems as described above. Permanent dialysis when communicating with the dialysis machine to allow open communication with the extracorporeal chamber 26 of the dialysis machine. Ideal for performing functions.

Figures 7-10 (where parts similar to the embodiments of Figures 1-6 are added 100). (indicated by numbers), it depicts the rectal components of the intracorporeal dialysis chamber. There is.

In FIG. 7 and the accompanying FIGS. 8-10, the dialysis apparatus of the present invention is indicated at 110. , and are generally selected to remove waste products from body fluids, but in some cases A first dialysate fluid 102 having a composition selected for adding, for example, a drug to the fluid, is injected into the body. It includes means 112 for external circulation. Addition or extraction is done through the semipermeable membrane mentioned above. This is done by transmission diffusion. Common uses include circulating in the bloodstream and forming veins, arteries and extracting body fluid components, such as uric acid, from body fluids on the surface of other body parts and in particular in this embodiment the blood-rich lining of the rectum according to the present invention. Can be removed from the liquid.

In this embodiment, the body chamber 124 is mounted close to the inner wall 121 of the rectum 123. The bag of semi-permeable material 124a is then inserted, thus extending over the entire effective length of the rectum. Dialysis is performed through a semipermeable membrane. The lower end 125 of the intestine 127 as well as the rectum 123 However, communication is cut off by a surgically constructed wall 129, and the elderly The waste is directed to the bypass pipe 13], passes through the pulp 133 and exits the collector 135 to the final will be discarded. This configuration is similar to that obtained after colostomy, The rectum is released for use as an analysis site.

It is held in the instep of the body chamber 124 by the spider 139 on the tubular stem 141. An inverted dome deflector 137 is provided, whereby the The first dialysate 102 that has passed through the stem is stored in the body chamber 124 housed in the rectum. The orientation is turned downward and the first dialysate is preferably placed at a suitable depth. is accumulated until it hydraulically fills chamber 24.

The first dialysate 102 with a waste load flows out from the rectum 123 at the anus 143 and is In this case an outlet 118 is provided at 145 in the chamber 124 .

Circulation means 112 for the dialysate 102 includes a first pump 108 and an inlet 114 of the dialysate chamber. including. The circulating dialysate 102 is passed through the inlet 114 by Bon-71OS into the body chamber 1. 24, and the tubular stem portion 141 of the population 114 is first inserted into the rectum. placed in the diversion and recovery basin as described in . Used dialysate 3.02 It is passed through outlet 118 to the regeneration stage. In this embodiment, the regeneration step A similar belt configuration is used as in the embodiment, but with some differences. Exit] 18 is again The dialysate 102 to be produced is placed below the belt 122 filled with distilled water. into a tube 126 located in section 122a where distilled water 101 is dialysed. Uric acid and other salt wastes disappear from the liquid 102, and the distilled water is finally It is extracted as mentioned above.

The tube 126 is then filled with a second dialysate 154 - above the silt 122. It leads to minute 122b. Circulating dialysate 102 can be used for a limited number of times as needed. Rather, it can circulate around belt 1220 multiple times.

The dialysate 102 contains sintered metal and It is sent to a metal filter cartridge 149 made of charcoal. As a circulating medium The advantage of using dialysate rather than blood, as taught here, is that its permeability This is indicated by the ability to filter metal contaminants from the precipitating solution. This process is called ``artificial blood''. ” can be used when blood is the medium instead of circulating dialysate 102. I can't.

After regeneration and filtration, dialysate 102 is pumped by pump 108 to inlet 114. and from there to the rectum 123 as described above.

As in the previous embodiment, the second dialysate 154 is of similar composition to the first dialysate. is necessary for effective renal function to be present or withdrawn from the first dialysate. Substances can be added to change its composition. The regeneration of the second dialysate 154 is Although performed as in the embodiment and not further described herein, the pump 134 The filter element 136,1 of FIG. Note that 38 and 140 are present. Distilled water 101 as needed Can be easily replaced.

See Figure 11 (here similar parts to Figures 7-1o are designated by the same numbers) Then, the rectum 123 itself has no intervening semipermeable wall like the wall 124a in FIG. used as a body chamber. For this purpose, the rectum 123 is cut from the large intestine 127. and a waste bypass 131 is provided. Rectum 123 is entrance 11 4a thereon for receiving the first dialysate fluid entering the body tissue at 115. Open your mouth at both ends, and if there is enough, open your anal sphincter, and It has a plug configuration that allows dialysate to be retained in the rectum for dialysis. Closed at the lower end. Exit 118 leads from the anus to the regeneration stage described in connection with Figure 7. I understand. The embodiment of FIG. 11 shows a blood-rich dialysis surface with minimal Provides an optimal combination of foreign material insertion and the benefits of natural cavity use.

Therefore, it is clear that the artificial kidney function is wearable and can be manipulated within the body. Ru. The belt attachment during the regeneration stage and the internal placement of the dialysis function for simultaneous operation are It brings unparalleled convenience and comfort to users. A single batch operation that takes place in the body However, due to the uniformity of the process and the absence of users of any tier, stomach. This is because the process is continuous, and some of the normal dialysate is used against body fluids. When being dialyzed without the necessary invasion of arteries or veins, other than that normal dialysate This is because a portion is played back. In addition, the regenerating fluid itself is the dialysate being regenerated. automatically regenerates when you use the device, and all done by a wearable device).

The present invention combines non-drug processing, wearability, and dialysis processing of blood in a single integrated device. continuity and uniformity, non-invasive methods, maximizing dialysis rates consistent with in-vivo implementation There has been a long-term search for an artificial kidney, including the ability to quickly remove water and waste products. It offers many properties such as approach.

Therefore, the above effects of the present invention have been recognized by providing a new dialysis device for humans, and Dialysis machines retain the dialysis effectiveness of traditional machines, but they also dialyze blood outside the body. It avoids the problems associated with By doing so and regenerating the dialysate outside the body, the dialysate (not blood) is transferred to the body. Body fluids other than intravenous or arterial blood circulating in and out and for dialysis against dialysate and in non-confined areas of the body, such as near the intestines, intraperitoneally or within the rectum. The intestine is a living tissue common to the intestines, or is advantageously removed from the user, but is a waste product. dialysis using a piece of the user's own tissue that is grafted so that there is no fluid communication with the It is something to do.

Figure 7 Submission of translation of written amendment (Article 184-7, Paragraph 1 of the Patent Act) November 2, 1985. I-day 1. Display of patent application PCT/US85/[10522 2. Name of the invention Intracorporeal Dialysis Device with Wearable Extracorporeal Regeneration Device 6, Patent Applicant Address: 91103, California, USA. Pasadena.

East Union Street IJ-To 39 people Name: Research and Development ・Systems 5. Date of submission of written amendment June 25, 1985 Amended claims (1) Dialyze the stored dialysate against body fluids in the intestines, and simultaneously transfer the dialysate outside the body. A wearable device consisting of a means of regeneration that can be continuously manipulated within the body and regenerated outside the body. A dialysis machine that can.

(2) An intracorporeal hand placed in the intestine to accommodate normal dialysate for body fluid dialysis. stage; usually located outside the body in open communication with the intracorporeal means and contained within the extracorporeal chamber; extracorporeal chamber means having a semi-permeable wall for regenerating dialysate against a second dialysate; and pump means for exchanging regenerated dialysate with dialysate contained in the body chamber. A dialysis device that is wearable, can be operated continuously within the body, and can be regenerated outside the body; Device.

(3) The intracorporeal means is suitable for dialyzing body fluids against a dialysate contained therein. The wearable device according to claim 2, having a semi-transparent wall, which is continuously operated in the body. A dialysis device that can be manufactured and regenerated outside the body.

(4) The internal body means do not have internal fluid communication with the intestine but are composed of living tissues common to the intestine. The wearable device of claim 2, consisting of a portion of the intestine continuously A dialysis device that can be operated within the body and regenerated outside the body.

(5) further including a semipermeable wall structure related to body fluid dialysis in the intestinal portion defining the body chamber; Wearable as described in claim 4! , which can be continuously manipulated inside the body and reused outside the body. A dialysis machine that can keep you alive.

(6) Is the rectum part of the body bypassed by passing waste products through the body? The wearable device according to claim 2, comprising: The right dialysis machine can be regenerated outside the body.

(7) Claim 6 further includes a semi-permeable wall structure in the rectal portion related to body fluid dialysis. A dialysis device that is wearable, can be operated continuously in the body, and can be regenerated outside the body, as described in Place.

(8) A conduit for transferring used dialysate extending through the anus between the body chamber and the extracorporeal chamber. The wearable and continuously intracorporeal device of claim 7 further comprising a step. A dialysis device that can be produced and regenerated outside the body.

(9) second dialysate means for supplying dialysate suitable for regenerating the first dialysate; further comprising: a semi-permeable wall of the extracorporeal chamber dialyzing the first dialysate into the second dialysate supply means; and having an elongated configuration of the sump for removing excess water therefrom. Dialysis device that is wearable, can be operated continuously in the body, and can be regenerated outside the body, as described in .

(10) Means for regenerating the second dialysate, and separating excess water from the second dialysate. [The wearable and continuous wearable device according to claim 9, further comprising means for disposing of the wearable and continuous A dialysis device that can be operated inside the body and regenerated outside the body.

(11) further comprising means for attaching the extracorporeal chamber to the body, the attaching means supporting the device; wearable according to claim 2, including belt means suitable for carrying; A dialysis device that can be operated continuously inside the body and regenerated outside the body.

02 The extracorporeal chamber is a long and thin tube, and the second dialysis tube surrounds the tube. The wearable device of claim 10 further comprising an envelope containing a liquid. A dialysis device that can be operated continuously inside the body and regenerated outside the body.

Q31 The wearable device according to claim 2, wherein the regeneration means is responsive to dialysate exchange. A dialysis device that can be continuously operated within the body and regenerated outside the body.

(14) A port in which the means for exchanging the first dialysate is in open communication with the intracorporeal chamber and the extracorporeal chamber. The wearable device according to claim 13, comprising a pump, which can be continuously operated in the body. A dialysis device that can be used and regenerated outside the body.

Q9 further includes a second pump, the envelope surrounding the extracorporeal chamber and the second pump; the second dialysate for adding replenishment solids to the second dialysate during pumping by the pump; a second dialysate replenishment solids supply means in fluid communication with the dialysate; Items listed in scope 14 are wearable, can be continuously manipulated inside the body, and can be regenerated outside the body. A dialysis machine that can be used.

(1, e) A filter containing dialyzed filterable components from the first dialysate into the second dialysate. in fluid communication with the envelope for separating permeable components from the second dialysate. 16. The wearable and continuous method of claim 15, further comprising filtration means. A dialysis device that can be operated within the body and regenerated outside the body.

body fluid dialysis, semi-permeable, generally tubular body PS chamber that does not have internal communication with an artery: the body an extracorporeal chamber in continuous open communication with the inner chamber; exchanging a first dialysate between the intracorporeal chamber and the extracorporeal chamber; a pump for regenerating the first dialysate during passage through the extracorporeal chamber and means for returning to the internal chamber; wearable, continuously operable within the body, and A dialysis machine that can be regenerated using water.

α mark: The body chamber consists of a part of the large intestine and the small intestine, and this part is the same as the intestine from which it was removed. Although there is no fluid communication between the two parts, the claims The transparent material described in item 17 that is wearable, can be continuously manipulated inside the body, and can be regenerated outside the body. analysis equipment.

Oj such as defining an extensive dialysis interface with body fluids outside the user's veins and arteries. It has the dimensions and configuration and is integrated with the living tissue of the user's intestines, but It can be worn continuously, including internal body fluid dialysis without open contact, and can be used continuously in the body. A dialysis device that can be operated and regenerated outside the body.

■ More dimensions that define an extensive dialysis interface with body fluids outside the user's veins and arteries. The living tissue of the user's body, that is, the living tissue of the user's rectum, A body fluid defined by and having no internal open communication with the user's intestines. A dialysis device that is wearable, can be operated continuously inside the body, and can be regenerated outside the body. Place.

(21) To define an extensive dialysis interface with body fluids outside the user's veins and arteries. the user's rectum, which is of similar size and configuration and has no internal open communication with the user's intestines; a body fluid dialysis chamber defined by a closed semi-permeable wall located within the A dialysis device that can be used, operated continuously within the body, and regenerated outside the body.

CI'21 defined at least in part by the rectum and not communicating with the intestines; body fluid dialysis body chamber suitable for containing permeate in connection with body fluid dialysis; The extracorporeal chamber is in continuous open communication; the first dialysate is exchanged between the intracorporeal chamber and the extracorporeal chamber. a pump means for dialyzing a first dialysate in the extracorporeal chamber and returning it to the body chamber; a wearable, continuously operable internally, and A dialysis device that can be regenerated outside the body.

(To) A body defined by the rectum of the user, through which the rectal fluid is transferred from the inner rectal wall. Inner chamber; body fluid dialysis connection between the inner wall of the rectum and body fluid dialysis in open communication with the body chamber , an extracorporeal chamber consisting of a semi-permeable chamber; exchanging dialysate between the intracorporeal chamber and the extracorporeal chamber; means for regenerating the first dialysate in the extracorporeal chamber and transferring the first dialysate to the intracorporeal chamber, e.g. Wearable for humans with rectums bypassed by anoplasty, A dialysis device that can be operated continuously inside the body and regenerated outside the body.

04) The first Torimachi fluid is passed through the intestines in relation to body fluid dialysis, and the composition of the first dialysate is dialyzing the first dialysate against a second dialysate having a different temperature in a first dialysate regeneration relationship; Continuous body fluid dialysis methods in the body, including:

(c) internal chambers within the user's body without internal communication with the user's veins and arteries; further comprising arranging extracorporeal chambers outside the body and exchanging the first dialysate between these chambers; The internal chamber is in dialysis communication with body fluids within the body, and the external chamber is connected to a semipermeable membrane. and in dialysis communication with a second dialysate outside the body. Method.

(E) Defining a body chamber in communication with body fluids and dialysis using the user's body tissues. 26. The method of claim 25, further comprising:

(c) Select a part of the user's intestine, and use the part as living tissue that is common to the intestine. Connected without internal fluid communication to define a body chamber in communication with body fluids and dialysis. 27. The method of claim 26, further comprising:

CQ Select a part of the rectum separated from the user's intestines to define a body chamber, and further comprising introducing a first dialysate into the dialysate and anally withdrawing the Torimachi fluid; 1 The dialysate is diffused in dialysis contact with the rectal wall during introduction and withdrawal, claims The method according to item 26.

(To) A semi-permeable wall is interposed between the first dialysate and the rectal wall, so that the semi-permeable wall is directly Claim 2 further comprising dialyzing the body fluid against a first dialysate within the intestinal wall. The method described in Section 8.

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Claims (30)

[Claims] (1) Dialyze the stored dialysate against body fluids inside the body, and simultaneously transfer the dialysate outside the body. A wearable device consisting of a means of regeneration that can be continuously manipulated within the body and regenerated outside the body. A dialysis machine that can. (2) An intracorporeal hand placed inside the body to accommodate normal dialysate for body fluid dialysis. stage; usually located outside the body in open communication with the intracorporeal means and contained within the extracorporeal chamber; extracorporeal chamber means having a semi-permeable wall for regenerating dialysate against a second dialysate; and pump means for exchanging regenerated dialysate with dialysate contained in the body chamber. a wearable, continuously operable and regenerated outside the body dialysis device consisting of; Device. (3) The intracorporeal means is suitable for dialyzing body fluids against a dialysate contained therein. The wearable device according to claim 2, having a semi-transparent wall, A dialysis device that can be manufactured and regenerated outside the body. (4) The internal body means do not have internal fluid communication with the intestine but are composed of living tissues common to the intestine. claim 2, wherein the wearable and continuous portion of the intestine is A dialysis device that can be operated within the body and regenerated outside the body. (5) further including a semipermeable wall structure related to body fluid dialysis in the intestinal portion defining the body chamber; The device according to claim 4 is wearable, can be operated continuously inside the body, and can be reused outside the body. A dialysis machine that can keep you alive. (6) from the rectal region where the intracorporeal means are bypassed by passing waste products through the bypass; comprising a wearable device as claimed in claim 2, which can be continuously operated in the body and A dialysis machine that can be regenerated outside. (7) Claim 6 further includes a semi-permeable wall structure in the rectal portion related to body fluid dialysis. A dialysis device that is wearable, can be operated continuously in the body, and can be regenerated outside the body, as described in Place. (8) Conduit for transporting used dialysate extending through the anus between the internal and external chambers The wearable and continuously intracorporeal device of claim 7 further comprising a step. A dialysis device that can be produced and regenerated outside the body. (9) second dialysate means for supplying dialysate suitable for regenerating the first dialysate; further comprising: a semi-permeable wall of the extracorporeal chamber dialyzing the first dialysate into the second dialysate supply means; and having an elongated configuration for removing excess water therefrom. A dialysis device that is wearable, can be operated continuously in the body, and can be regenerated outside the body, as described in Place. (10) means for regenerating the second dialysate and separating excess water from the second dialysate; 10. The wearable and continuous method of claim 9, further comprising means for disposing of the wearable and continuously A dialysis device that can be operated within the body and regenerated outside the body. (11) further comprising means for attaching the extracorporeal chamber to the body, the attaching means supporting the device; wearable according to claim 2, including belt means suitable for carrying; A dialysis device that can be operated continuously inside the body and regenerated outside the body. (12) The extracorporeal chamber is an elongated tube, and the second dialysis chamber surrounds the tube. The wearable device of claim 10 further comprising an envelope containing a liquid. A dialysis device that can be operated continuously inside the body and regenerated outside the body. (13) The wearable according to claim 2, wherein the regeneration means is responsive to dialysate exchange. A dialysis device that can be continuously operated within the body and regenerated outside the body. (14) A port in which the means for exchanging the first dialysate is in open communication with the intracorporeal chamber and the extracorporeal chamber. the wearable and continuously operable in the body according to claim 13, comprising: A dialysis device that can be used and regenerated outside the body. (15) further comprising a second pump, the envelope surrounding the extracorporeal chamber and the second pump; the second dialysate for adding replenishment solids to the second dialysate during pumping; 2. A second dialysate replenishment solids supply means in fluid communication with the second dialysate. The scope of the invention is that it is wearable, can be continuously operated within the body, and can be regenerated outside the body. A dialysis machine that can. (16) Filtration containing dialyzed filterable components from the first dialysate into the second dialysate in fluid communication with the envelope for separating the possible components from the second dialysate. 16. The wearable, continuously body-carrying device of claim 15, further comprising filtration means. A dialysis device that can be operated inside the body and regenerated outside the body. (17) Resists deterioration due to exposure to the body, and undergoes body fluid dialysis within the user's body. body fluids that have an elongated configuration and no internal communication with veins or arteries an analytic, semi-permeable, generally tubular body chamber; an extracorporeal chamber in continuous open communication with the body chamber; a pump for exchanging a first dialysate between the intracorporeal chamber and the extracorporeal chamber; and the extracorporeal chamber. means for regenerating and returning the first dialysate to the body chamber during passage through the chamber; A dialysis device that can be used, operated continuously within the body, and regenerated outside the body. (18) The body chamber consists of a part of the large intestine or small intestine, and the part is the same as the intestine from which it was removed. A claim consisting of living tissue in common with, but not in internal fluid communication with, The device described in paragraph 17 is wearable, can be continuously operated within the body, and can be regenerated outside the body. Dialysis machine. (19) to define an extensive dialysis interface with body fluids outside the user's veins and arteries; sized and configured, and is integrated with the living tissue of the user's intestine; Can be worn continuously, including internal body fluid dialysis chambers that are not open to the body. A dialysis device that can be operated inside the body and regenerated outside the body. (20) to define an extensive dialysis interface with body fluids outside the user's veins and arteries; of the same size and configuration as the living tissue of the user's body, i.e. the user's rectum. A body fluid that is defined by tissue and has no internal open communication with the user's intestines. A transparent material that can be worn inside the body, can be continuously manipulated inside the body, and can be regenerated outside the body. analysis equipment. (21) to define an extensive dialysis interface with body fluids outside the user's veins and arteries; within the user's rectum, having the same dimensions and configuration and having no internal open communication with the user's intestines. A wearer containing a body fluid dialysis chamber defined by a closed semi-permeable wall located in the A dialysis device that can be operated continuously within the body and regenerated outside the body. (22) Defined at least in part by the rectum that does not communicate with the intestine and is permeable to body fluids. Body fluid dialysis body chamber suitable for storing dialysate for analysis; continuous open with the body chamber an extracorporeal chamber in communication; a port for exchanging a first dialysate between the intracorporeal chamber and the extracorporeal chamber; pumping means; and dialyzing the first dialysate in the extracorporeal chamber and returning it to the body chamber; a wearable, continuously operable internally and externally A dialysis machine that can be regenerated. (23) Defined by the user's rectum, allowing fluid to migrate from the inner rectal wall Body chamber: Body fluid dialysis that is in a body fluid dialysis relationship with the inner wall of the rectum and in open communication with the body chamber. an extracorporeal chamber consisting of a transcorporeal, semi-permeable chamber; for exchanging dialysate between the intracorporeal chamber and the extracorporeal chamber; and means for regenerating a first dialysate in the extracorporeal chamber and returning it to the intracorporeal chamber; means for continuing body fluid dialysis; e.g., by colostomy Wearable for humans with bypassed rectums and continuously in the body A dialysis device that can be operated and regenerated outside the body. (24) A first dialysate is passed through the body in connection with body fluid dialysis, and the composition of the first dialysate is dialyzing the first dialysate against a second dialysate having a different temperature in a first dialysate regeneration relationship; Continuous body fluid dialysis methods in the body, including: (25) internal chambers within the user's body without internal communication with the user's veins and arteries; , further comprising arranging extracorporeal chambers outside the body and exchanging the first dialysate between these chambers. , the intracorporeal chamber is in dialysis communication with body fluids within the body, and the extracorporeal chamber is a semipermeable membrane. and is in dialysis communication with a second dialysate outside the body. the method of. (26) Using the user's body tissue to define a body chamber in communication with body fluids and dialysis; 26. The method of claim 25, further comprising: (27) Select a part of the user's intestine, and use the part as a living tissue common to the intestine. to define a body chamber in which body fluids and dialysis are in communication with each other without internal fluid communication. 27. The method of claim 26, further comprising: (28) Select a part of the rectum separated from the user's intestines to define a body chamber; introducing a first dialysate into the dialysate and anally withdrawing the dialysate; The first dialysate is diffused in dialysis contact with the rectal wall during introduction and withdrawal. Scope of Claim 26. The method according to item 26. (29) A semi-permeable wall is interposed between the first dialysate and the rectal wall, so that the semi-permeable wall Claim 1 further comprising dialyzing the body fluid against a first dialysate within the rectal wall. The method according to item 28. (30) Dialyzing the dialysate stored in the body against body fluids, and at the same time dialyzing the dialysate outside the body. A dialysis method involving regenerating.