JPS6145968B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a deodorant composition, and more particularly to a composition for reducing armpit odor. It is well known that the unpleasant odor produced in the axilla is due to bacterial decomposition of apocrine gland sweat. There are numerous products on the market to treat the problem of malodorous sweat, and the most common product forms are lotions, which are usually applied from a roll-on applicator, and aerosols. Many products contain ingredients that reduce the amount of sweat secreted; ie, these are antiperspirants. Most antiperspirants used are astringent aluminum compounds, and the use of aluminum hydroxychloride is very common. Astringent aluminum compounds also have a deodorizing effect on secreted sweat. The present invention relates to a composition having only a deodorizing effect,
That is, they do not obstruct the flow of sweat to any appreciable extent. The composition and mode of action of deodorizers can be found in the "Handbook".
of Non-Prescription Drugs”, 1973 edition, no.
209 pages, Griffenhagen (GB
Griffenhagen) and LL Hawkins
“Deodorants and
Discussed in the paper ``Antiperspirants''. This article presents the active ingredients used in many trade name deodorant products. Many explanations for the cause of unpleasant body odor state that it is caused by the bacterial breakdown of apocrine sweat (see, for example, Wells and Lubowe, "Cosmetics and the
Skin, p. 290, (1964)) and that a satisfactory deodorant product must contain an effective antimicrobial agent (Cosmetics Science and
Technology” 2nd edition, Volume 2 (1972) No. 400
page). Many practical products are based on the use of fungicides such as hexachlorophene and various quaternary ammonium compounds. However, methods to overcome body odor have been proposed in the past. For example, the use of ion exchange resins to adsorb odorants found in axillary sweat has been suggested (U.S. Pat. No. 2,653,902;
(1953), J.invest.Derm. 23 , 411 (1954), and J.Soc.Cosmet.Chemists. 7 , 256 (1956))
However, there are no commercially available products that use ion exchange resins as deodorizers (Cosmetics Science and
Technology”, 2nd edition, Volume 2, (1972), No.
403 pages). Another method consists of masking unpleasant body odors with pleasant gradients (“Formulation and
"Function of Cosmetics" by Dr.Jelinetsk
Stephen Jellinek) (1970), No. 291
page). The use of antibiotics has also been suggested (Cosmetics Science and Technology, Part 2).
Edition, Volume 2 (1972), p. 402). Other deodorizing compounds that have recently been suggested are calcium, aluminum, magnesium or zinc salts of unsaturated aliphatic hydroxycarboxylic acids having at least 17 carbon atoms, such as zinc ricinoleate (UK Patent Specification No. 1282889): Esters of aliphatic or cycloaliphatic alcohols having 1 to 6 carbon atoms and mono- or dibasic fatty acids having 2 to 4 carbon atoms (UK Patent Specification No. 1487293); C ₁ of certain alkanediphosphonic esters _-C6 alkyl ester (UK Patent Specification No. 1524167);
and the dimeric and trimeric zinc and magnesium salts of certain polycarboxylic acids, such as linoleic and linolenic acids (GB 2014453). As far as commercially available body deodorizers are concerned, these are primarily based on the use of disinfectants;
Continuous use of this agent is thought to be potentially damaging to the natural skin function (see GB Patent Specifications Nos. 1282889, 1487293, 1524167 and 2014453). It is an object of the present invention to provide novel deodorant compositions for reducing armpit odor in the form of lotions, gels or aerosols containing active ingredients that are neither astringents nor antibacterial agents. It is also an object to provide a composition having active ingredients capable of providing a deodorizing effect over a significant period of time, about 24 hours or more, and which is colorless, odorless and free of undesirable side effects. perspiration secretion, comprising a suspension of particulate deodorizing active substance in a carrier liquid or gel medium containing not more than 80% water by weight of the carrier medium, characterized in that the deodorant active ingredient according to the invention is zinc carbonate. Deodorant lotion, stick and aerosol compositions are provided for reducing body odor in the axilla without inhibiting body odor. It will be understood from the foregoing that the deodorant composition of the present invention is also different from antiperspirant compositions that have a deodorizing effect. The active ingredients of the composition according to the invention only have a deodorizing effect. Accordingly, the deodorant compositions of the present invention contain zinc, magnesium or aluminum oxides, hydroxides or carbonates to counteract the harmful corrosive effects of antiperspirant aluminum compounds on textiles. This is different from the aqueous antiperspirant composition described in US Pat. No. 2,350,047. The compositions of the present invention also differ from body powders or dusting powders which usually consist of a talc base and also contain other powdered ingredients such as magnesium carbonate (Harry's Cosmeticology).
Revised by JB Willkinson (1973)
), p. 249). Magnesium carbonate is included in this preparation as a carrier for the fragrance (The Principles and Practice of Moderu
"Cosmetics" by RG Harry, 1st edition (1948) Volume 2, p. 183 and "Perfume
Cosmetics and Soaps” Pouchier (WA
Poucher) 2nd edition, (1925) Volume 1, No. 179
page). The deodorizing effect of talcum powders containing large surface area zinc carbonate as well as other powders with large surface areas is based solely on the adsorption properties of large surface area powders.
(1968), p. 416, an effective deodorizing powder cannot simply be obtained on this basis.
The ability to absorb and bind specific odorants is necessary and butylamine and ethyl mercaptan have been suggested as model compounds to assess the absorption potential of body deodorant actives (UK Patent Specification No.
No. 2014453). In fact, it has been suggested to add deodorants effective against body odor to powders containing a certain proportion of magnesium carbonate as mentioned by Fiedler (UK Patent Specifications Nos. 1,282,889 and 1,524,167). The deodorant composition of the invention may be in the form of a lotion, the carrier liquid for such products being usually a volatile alcohol, preferably ethanol or water and mixtures thereof, the amount of water preferably being Not more than 60% by weight of the carrier medium. Other suitable carrier liquids are well known to those skilled in the art. Deodorant lotions are typically applied to the skin from a roll-on applicator, but can be applied from other applicators. The liquid phase also usually includes an emollient to provide the desired skin feel and to help keep the deodorant actives on the skin. Isopropyl myristate or other fatty acid esters such as dibutyl phthalate and diisopropyl adipate are particularly suitable, but other substances well known to those skilled in the art, such as cetyl alcohol, can also be used. A thickening agent is desirably included to help maintain the deodorant powder in suspension in the lotion. Preferably hydrophobic clays or colloidal silica are used for this purpose. Hydrophobic clay is bentone,
For example, it is commercially available under the trade name Bentone-34 or Bentone-38. The preferred colloidal silica is
Aerosil200 (product name) and Cab-O-Sil M-5
(Product name) and other grade products. Also included are cellulose derivatives, such as hydroxypropylcellulose (eg Klucel M). Roll-on compositions according to the invention are typically 10-
Contains 30% deodorant active, 1-30% emollient, 0.5 to 5% suspension, the remainder consisting essentially of alcohol or hydroalcohol. The deodorant products of the present invention in gel form include the usual ingredients that provide a stick base in which the particulate deodorant active ingredients are dispersed. The base typically comprises an alcohol or other aqueous alcohol thickened to form a gel with sodium stearate or other hardeners. The gel preferably also contains substances that improve skin feel, such as glycerol. These compositions usually contain about 10 to 30% by weight of powdered deodorant active ingredient. The deodorant composition may also be in the form of an aerosol;
The composition is packaged in an aerosol container with a gaseous propellant. This aerosol composition is of the type in which a powder is suspended in a liquid vehicle containing a mixture of a carrier liquid and a liquefied gaseous propellant. Aerosol compositions of the powder suspension type are well known to those skilled in the art. Conventional carrier liquids and liquefied propellants can be used in the aerosol compositions of the present invention, along with conventional suspending agents that are often included in these products to aid in suspending the active powdered ingredients. In particular, the formulation of antiperspirant powder suspension aerosols is well known and the deodorant of the present invention can be prepared by replacing the powdered antiperspirant active ingredient of this product with a powder of the deodorant active compound. Product formulation is accomplished. An aerosol powder suspension product in which the active powder component is a deodorant is described in British Patent Specification No. 1476117. In the products described in this prior specification, the deodorant active is an alkali metal bicarbonate. The deodorizing product according to the invention is a powder of zinc carbonate and is disclosed in the British Patent Specification No.
It can be made by substituting the sodium bicarbonate in the example of No. 1476117. The amount of powdered deodorizer active present in the aerosol compositions of the invention varies over a wide range, but is usually within the range of 0.5 to 15% by weight of the composition. A preferred amount is about 1 to about 10%, especially 1.5 to 5% by weight of the aerosol composition. The deodorant powder desirably consists of particles of 100 microns or less in diameter, and preferably consists of particles of essentially 100 microns or less in diameter.
Consisting of particles having dimensions between 70 and 70 microns. The carrier liquid may be a non-volatile, non-hygroscopic liquid, for example as suggested in US Pat. No. 3,968,203. Carrier liquids with emollient properties are particularly useful and many of these are illustrated in GB 1393860. Particularly preferred are fatty acid esters such as diisopropyl myristate and those shown in US Pat. No. 4,045,548, such as dibutyl phthalate and diisopropyl adipate. Various other carrier liquids for powder suspension aerosols are described in U.S. Pat. No. 3,974,270, no.
No. 3949066, No. 3920807, No. 3833721 and No.
3833720 and British Patent Specification No. 1411547, no.
No. 1369872, No. 1341748, No. 1300260 and No.
It is suggested in No. 1476117. Volatile carrier liquids that can be used, such as ethanol, are also described in South African Patent Specification No. 75/3576 and the use of volatile silicones is described in British Patent No. 1467676. The weight ratio of deodorant active powder to carrier liquid can vary over a wide range, preferably from 0.01 to 3 parts per part by weight of carrier liquid.
0.04 to 1 part powder. The liquefied propellant may be a hydrocarbon, a halogenated hydrocarbon or a mixture thereof. Examples of materials suitable for use as propellants are given in the aforementioned patents and include trichlorofluoromethane, dichlorodifluoromethane, dichlorotetrafluoroethane, monochlorodifluoromethane, trichlorotrifluoroethane, propane, butane, 1,1-difluoroethane, Contains 1,1-difluoro-1-chloroethane, dichloromonofluoromethane, methylene chloride and isobutane, singly or in combination. Trichlorofluoromethane, dichlorodifluoromethane, dichlorotetrafluoroethane and isobutane, used alone or in mixtures, are preferred. It is common practice for aerosol powder spray compositions to include substances that assist in suspending the powder in the liquid vehicle. The substances prevent compaction of the powder and they also act as thickening or gelling agents for liquid vehicles. Hydrophobic clays and colloidal silicas are particularly suitable. Hydrophobic clays are Bentone, e.g. Bentone-34
or Bentone-38, and their use as suspending agents is disclosed in U.S. Pat.
It is described in many patent specifications including No. 3773683. Suitable colloidal silicas include Aerosil 200 (trade name) and Cab-O-Sil M-5 (trade name) and other grades. The use of hydrophobic clays and colloidal silica to suspend powders in the manufacture of aerosol deodorant sprays is disclosed in British Patent Specification No. 1476117
It is also listed in the issue. Recently it has been shown that the expression of perspiration on the skin can be limited without the use of astringent antiperspirants by the application of solid particulate hygroscopic polymers that have the ability to absorb an amount of water at least equal to their own weight. British Patent Specifications No. 1485373, No. 1501862 and No.
Disclosed in No. 2003730. This water-swellable absorbent polymer can be included in the deodorizing compositions of the above-described invention that utilize an anhydrous or substantially anhydrous carrier medium. Anionic polyelectrolyte absorbent materials are e.g. crosslinked etherified starches as described in German Patent Application No. 2702781 or US Pat. No. 4,117,222; US Pat. No. 3,589,364;
Sodium carboxymethyl cellulose cross-linked as described in U.S. Pat. No. 3,936,441 or No. 3,965,091; polyelectrolyte internally esterified as described in U.S. Pat. No. 3,678,031;
Starch-acrylonitrile graft copolymers as described in German Patent Application No. 3997484 or No. 3661815; or polyacrylates crosslinked with polyamide/epichlorohydrin materials as described in German Patent Application No. 2614662; or
It is a potassium salt of polyacrylic acid crosslinked with aluminum ions as described in No. 4090013. It is insoluble in water to an extent of at least 40% by weight. According to another aspect of the invention, a powder suspension type in which the powder is suspended in a liquid vehicle comprising a mixture of a liquid carrier and a liquid propellant, characterized in that the powder comprises a water-absorbing anionic polyelectrolyte and zinc carbonate. of aerosol products are provided. These aerosol compositions desirably contain from 0.5 to 15% by weight of water-absorbing anionic polyelectrolyte and from 0.5 to 15% by weight of deodorant active powder. This water-absorbing anionic polyelectrolyte can also be included in the anhydrous or substantially anhydrous lotion or gel-type deodorant products of the present invention. In this product the polyelectrolyte may be present in an amount of 10 to 30% by weight, preferably 15 to 25% by weight. Deodorant compositions according to the invention preferably also include fragrance, but also other optional minor ingredients. Fragrances are generally included in amounts within the range of 0.1 to 0.2% by weight. The invention is illustrated by the following examples, in which percentages are by weight. Approximately 24 times the deodorization test shown in the example
The following study was performed on a panel of human or more subjects over five consecutive days. Deodorization Test Day 1 After cleaning and drying the axilla, the operator applies a placebo aerosol product to each axilla (approximately 15 cm to 2
spraying). Next, give the panelists a clean shirt or blouse. Placebo % Isopropyl Myristate 1.0 Fragrance 0.44 Propellant 1 Same as in Example 1 up to 100.0 Day 2 Remove the panelists' shirts or blouses and raise their arms above their heads. Smell both armpits to determine which side has a stronger armpit odor and record a score indicating whether the right or left armpit has a stronger odor or whether this odor is equally strong. do. Panelists then evaluate their own axilla in the same manner. After these evaluations, the process from day 1 is repeated. Day 3: Repeat the odor evaluation from day 2. Repeat the washing and spraying of Day 1 again, but instead of applying the placebo, apply the test and control products. One preselected random group of panelists was given the test and control products in the left and right axilla, respectively, and the remaining panelists (a group of virtually identical size to the previous group) were given the right and Apply the test and control products respectively on the left side.
The side of the panelist to which the test product is applied is referred to as the test side and the side to which the control product is applied is referred to as the control side. Apply the test and control products in the same manner and in normal consumer usage. For aerosol products, apply in the same manner as for placebos. Day 4 Repeat the operations from day 3. Day 5 Repeat the evaluation done on day 2. A merit score for the test product is calculated from the scores obtained in the above test to indicate the magnitude of the difference in deodorizing effectiveness between the test product and the control product. Merit Score The merit score associated with the test product is given by the formula: 100/T(A-B-C+D), where A is the number of scores on the test side that has the stronger odor when the placebo is applied on both sides. be. B is the number of scores for the control side which has a stronger odor when the placebo is applied bilaterally. C is the number of scores on the test side that has a stronger odor when the test and control products are applied. D is the number of scores on the control side which has a stronger odor when the test and control products are applied. T is the total number of evaluations including those where the two sides are judged to be equal. This merit score is thus determined by the percentage decrease in observations on the test side with a stronger odor (100/T(A-C)) and the percentage increase in observations on the control side with a stronger odor (100/T(D)). -B)). This merit score therefore indicates the difference in efficacy between the test and control products. Significance Test If the distribution of placebo scores on days 2 and 3 are not significantly different at the 5% level, they are merged and the same is done for days 4 and 5; The merged scores for days 4 and 5 are then compared to the merged scores for days 2 and 3. All significance tests were performed by Komogorov-Smirnov analysis (see “Nonpardmetic
Statistics for the Behavioral Sciences,” International Student Edition, Siegel (S.
Siegel), pp. 127-136, published by McGraw-Hill Koeisha). Example 1 An aerosol deodorizer spray was prepared with the following composition: % Basic Zinc Carbonate 4.5 Isopropyl Myristate 6.0 Pyrogenic Silica (Aerosil 200) 0.45 Propellant Up to 100.0 The zinc carbonate has a particle size of 10 to 70 microns. . Its surface area was approximately 12 m ² /g. The propellant consisted of a mixture of equal weights of Propellant 11 (trichlorofluoromethane) and Propellant 12 (dichlorodichloromethane). The composition was prepared by first forming a suspension concentrate by blending and homogenizing all ingredients except the propellant. The concentrate was sealed with a suitable aerosol valve and placed in a container pressurized with propellant. The above product was tested in the deodorization test described above using a placebo product as a control. The product of the present invention has a merit score of 5% significance.
It had 43. Example 2 The following example illustrates an aerosol deodorizing spray of the present invention containing a particulate water-absorbing polymer. % basic zinc carbonate 1.5 Industrial methylated spirits 3.0 Hydrophobic granular soil (Bentone38) 0.3 Cetyl alcohol 0.5 Dipropylene glycol 0.3 Aqueous ethyl alcohol (92% alcohol)
0.15 Water-absorbing polymer 1.0 Isopropyl myristate 2.0 Propellant ¹ Same as Example ¹ up to 100.0. The water-absorbing polymer was commercially available from National Starch and Chemical Company under the trade name "Permasorb 30 Cosmetic Grade." It is a potassium salt of polyacrylic acid crosslinked with aluminum ions and is generally described in US Pat. No. 4,090,013. The composition was prepared by first combining isopropyl myristate, dipropylene glycol, cetyl alcohol, and Bentone-38 in a high shear mixer to form a gel. Aqueous ethanol was added to stiffen the gel while continuing to shear the mixture. The water-absorbing polymer was incorporated into the gel until a smooth cream was formed and the same was true for zinc carbonate. The final mixture along with technical methylated spirits was added to an aerosol container, which was sealed with an aerosol valve and pressurized with a propellant. Examples of other suitable water-absorbing polymers that can be used in place of the aforementioned polymers are crosslinked carboxymethyl starch, which is described in German Patent Application No. 2702781, commercially available from Sumitomo Chemical under the trade name Hydrogel S-50 cross-linked saponified copolymer of acrylic acid and vinyl ester, and XD-85701 from Dow Chemical Company.
It is a crosslinked acrylic polymer commercially available as Example 3 An aerosol deodorizer spray was made having the following composition. % Basic Zinc Carbonate 2.0 Isopropyl Myristate 3.0 Cetyl Alcohol 0.5 Aqueous Ethanol (92% Ethanol) 0.3 Hydrophobic Clay (Bentone-38) 0.6 Industrial Methylated Spirits 25.0 Propellant ¹ Same as in Example ¹ up to 100.0. This product was made by a method similar to that described above for the product of Example 2. Example 4 An aerosol deodorizer spray was made having the following composition. % Basic Zinc Carbonate 2.0 Isopropyl Myristate 2.0 Pyrogenic Silica (Aerogil 200) 0.4 Industrial Methylated Spirits 19.0 Water 52.25 Dimethyl Ether Up to 100.0 This product was made according to the procedure described in Example 1,
The final step is pressurization of the aerosol container with dimethyl ether propellant. Example 5 A deodorizer roll-on product was made having the following composition. % Chlorinated Zinc Carbonate 20.0 Isopropyl Myristate 20.0 Hydrophobic Clay (Bentone38) 2.0 Cetyl Alcohol 2.0 Aqueous Ethanol (92% Ethanol) 1.0 Industrial Methylated Spirits Up to 100.0% (trade name) and cetyl alcohol to form a gel to prepare a composition. While continuing to shear the mixture, aqueous ethanol was added to stiffen the gel. Zinc carbonate was then mixed into the gel until a smooth cream was formed. This mixture was then mixed with industrial methylated spirits and filled into a roll-on applicator. Example 6 This is a deodorizer product of the invention in stick form. % Basic zinc carbonate 20.0 Water-absorbing polymer ¹ 15.0 Sodium stearate 5.0 Glycerin 3.0 Ethylene glycol monoethyl ether
2.5 Industrial Methylated Spirits Same as in ^Example 2 up to 100.0. The compatibility of deodorizer actives and water-absorbing polymers can be determined by the following test. Compatibility test 0.1 for 1 g of water-absorbing polymer and 2 g of deodorant active substance
A slurry was prepared by adding 40ml of molar sodium chloride solution. The slurry thus formed was left to equilibrate for 1 h, after which the sample was transferred to a weighed sintered glass tube (weight W ₁ ), then placed in a centrifuge tube and subjected to MSE Super Minor Bench standard swing arm centrifugation. Centrifuged at 3000 rpm for 1.25 hours in a machine. The sintered tube was then reweighed (weight W ₂ ) and placed in a vacuum oven at 60° C. until dry to a constant (weight W ₃ ). The retention capacity of a polymer in the presence of a deodorizing active substance is expressed by the following formula: W ₂ -W ₃ /W ₃ -W ₁ The retention performance (RC ₂ ) of the polymer in the absence of deodorizer active is measured in a similar manner. In the presence of the deodorizer active substance, the effective absorbency (EA) of the polymer is 100×
It is given by RC ₁ /RC ₂ . Table 1 shows the retention capacity of the polymer shown in Example 1 in the presence of zinc carbonate as deodorizer active. The effective absorption value is also shown.

Table: The present invention therefore provides a formulation of a combination containing a perspiration-absorbing polymer and a non-sterilizing deodorizing active that provides a combination that exhibits both good deodorizing properties and relatively high absorbency. provide

Claims (1)

Claims: 1. A suspension of particulate deodorizing active material in a carrier liquid or gel medium containing up to 80% water by weight of the carrier medium, characterized in that the deodorizing active material is zinc carbonate. Deodorant lotion, stick and aerosol compositions for reducing body odor in the axilla without inhibiting sweat secretion. 2. A deodorizing composition according to claim 1, wherein zinc carbonate is present in an amount of 0.5 to 30% by weight. 3. A deodorizing composition according to claim 1 or 2, wherein the carrier medium is substantially anhydrous and the composition also comprises a water-absorbing anionic polyelectrolyte. 4. A deodorizing composition according to claim 3, wherein the water-absorbing polyelectrolyte amounts to 0.5 to 30% by weight of the composition. 5. A deodorizing composition according to any one of claims 1 to 4, which also normally comprises a gaseous propellant and is in the form of a deodorant spray. 6. Claim 1 in which the carrier liquid is lower alcoholic or aqueous and in the form of a lotion.
The deodorizing composition according to any one of Items to Item 4. 7. A deodorizing composition according to claim 6, which also contains a thickener and is packaged in a roll-on applicator.