JPS6140252A - N-carbamoylamino acid derivative - Google Patents

N-carbamoylamino acid derivative

Info

Publication number
JPS6140252A
JPS6140252A JP16338584A JP16338584A JPS6140252A JP S6140252 A JPS6140252 A JP S6140252A JP 16338584 A JP16338584 A JP 16338584A JP 16338584 A JP16338584 A JP 16338584A JP S6140252 A JPS6140252 A JP S6140252A
Authority
JP
Japan
Prior art keywords
acid derivative
expressed
formula
phosgene
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16338584A
Other versions
JPS6343383B2 (en
Inventor
Hiroshi Chuma
Yasuhiro Morisawa
Atsushi Tomonaga
Mikiro Yanaka
Original Assignee
Kureha Chem Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Chem Ind Co Ltd filed Critical Kureha Chem Ind Co Ltd
Priority to JP16338584A priority Critical patent/JPS6343383B2/ja
Publication of JPS6140252A publication Critical patent/JPS6140252A/en
Publication of JPS6343383B2 publication Critical patent/JPS6343383B2/ja
Application status is Expired legal-status Critical

Links

Abstract

NEW MATERIAL:N,N-[N-Methyl-N-(2-phenethyl-2-carboxyethyl)carbamoyl]-benzylalycine expressed by formula I, a salt or ester thereof.
USE: A hypotensor and/or a remedy for heat failure, having powerful inhibitory action on angiotensin converting enzymes.
PREPARATION: According to reaction formulae, a β-amino-acid derivative expressed by formula II is reacted with phosgene to produce an N-chlorocarbonylamino acid derivative, and the resultant product is reacted with an α-amino acid derivative expressed by formula III to obtain an N-carbamoylamino acid derivative. The resultant product is further hydrolized in a solvent such as hydrous methanol using an alkali such as NaOH or KOH to obtain the compound expressed by formula I. In said reaction, the phosgene is used in an equimolar amount or more, usually 1.5W15 times the molar amount of the compound expressed by formula II.
COPYRIGHT: (C)1986,JPO&Japio
JP16338584A 1984-08-02 1984-08-02 Expired JPS6343383B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16338584A JPS6343383B2 (en) 1984-08-02 1984-08-02

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16338584A JPS6343383B2 (en) 1984-08-02 1984-08-02

Publications (2)

Publication Number Publication Date
JPS6140252A true JPS6140252A (en) 1986-02-26
JPS6343383B2 JPS6343383B2 (en) 1988-08-30

Family

ID=15772880

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16338584A Expired JPS6343383B2 (en) 1984-08-02 1984-08-02

Country Status (1)

Country Link
JP (1) JPS6343383B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110667A (en) * 1990-03-26 1992-05-05 Minnesota Mining And Manufacturing Company Polymer composition imparting low surface energy
US5213743A (en) * 1986-06-24 1993-05-25 Goyo Paper Working Co., Ltd. Method of manufacturing release paper
WO1996018606A1 (en) * 1994-12-14 1996-06-20 Santen Pharmaceutical Co., Ltd. Novel 1,3-dialkylurea derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5213743A (en) * 1986-06-24 1993-05-25 Goyo Paper Working Co., Ltd. Method of manufacturing release paper
US5110667A (en) * 1990-03-26 1992-05-05 Minnesota Mining And Manufacturing Company Polymer composition imparting low surface energy
WO1996018606A1 (en) * 1994-12-14 1996-06-20 Santen Pharmaceutical Co., Ltd. Novel 1,3-dialkylurea derivatives
US5968980A (en) * 1994-12-14 1999-10-19 Santen Pharmaceutical Co., Ltd. 1,3-dialkylurea derivative

Also Published As

Publication number Publication date
JPS6343383B2 (en) 1988-08-30

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