JPS6133009B2 - - Google Patents
Info
- Publication number
- JPS6133009B2 JPS6133009B2 JP51133956A JP13395676A JPS6133009B2 JP S6133009 B2 JPS6133009 B2 JP S6133009B2 JP 51133956 A JP51133956 A JP 51133956A JP 13395676 A JP13395676 A JP 13395676A JP S6133009 B2 JPS6133009 B2 JP S6133009B2
- Authority
- JP
- Japan
- Prior art keywords
- persimmon
- aqueous solution
- solution
- toxin
- cases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 235000011511 Diospyros Nutrition 0.000 claims description 40
- 244000236655 Diospyros kaki Species 0.000 claims description 40
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 9
- 231100000614 poison Toxicity 0.000 claims description 8
- 239000003440 toxic substance Substances 0.000 claims description 8
- 229960005486 vaccine Drugs 0.000 claims description 8
- 244000005700 microbiome Species 0.000 claims description 5
- 230000000415 inactivating effect Effects 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 description 20
- 230000000694 effects Effects 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 239000000203 mixture Substances 0.000 description 11
- 239000003053 toxin Substances 0.000 description 10
- 231100000765 toxin Toxicity 0.000 description 10
- 108700012359 toxins Proteins 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 9
- 238000001784 detoxification Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 229920001864 tannin Polymers 0.000 description 6
- 235000018553 tannin Nutrition 0.000 description 6
- 239000001648 tannin Substances 0.000 description 6
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 5
- 239000001263 FEMA 3042 Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 5
- 108010055044 Tetanus Toxin Proteins 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 210000000265 leukocyte Anatomy 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 5
- 229940033123 tannic acid Drugs 0.000 description 5
- 235000015523 tannic acid Nutrition 0.000 description 5
- 229920002258 tannic acid Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 229940118376 tetanus toxin Drugs 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 229940066827 pertussis vaccine Drugs 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 description 3
- 241000700198 Cavia Species 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003812 hydrophid venom Substances 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 231100000668 minimum lethal dose Toxicity 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 241000588832 Bordetella pertussis Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000723267 Diospyros Species 0.000 description 2
- 235000003385 Diospyros ebenum Nutrition 0.000 description 2
- 235000008597 Diospyros kaki Nutrition 0.000 description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 description 2
- 102000016607 Diphtheria Toxin Human genes 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 201000005702 Pertussis Diseases 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 101710092462 Alpha-hemolysin Proteins 0.000 description 1
- 101710197219 Alpha-toxin Proteins 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 241000588807 Bordetella Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000193449 Clostridium tetani Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241001175500 Diospyros ebenum Species 0.000 description 1
- 244000022372 Diospyros lotus Species 0.000 description 1
- 235000003333 Diospyros lotus Nutrition 0.000 description 1
- 241000792913 Ebenaceae Species 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 206010034650 Peritoneal adhesions Diseases 0.000 description 1
- 108010081690 Pertussis Toxin Proteins 0.000 description 1
- 101710124951 Phospholipase C Proteins 0.000 description 1
- 241000015864 Protobothrops flavoviridis Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 239000002776 alpha toxin Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 231100000776 exotoxin Toxicity 0.000 description 1
- 239000002095 exotoxin Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13395676A JPS5359023A (en) | 1976-11-08 | 1976-11-08 | Inactivation of toxins produced by microbials and attenuation of vaccines |
| US05/846,149 US4172126A (en) | 1976-11-08 | 1977-10-27 | Method for the inactivation of microbial toxins and attenuation of vaccines |
| GB45618/77A GB1548787A (en) | 1976-11-08 | 1977-11-02 | Method for the inactivation of microbial toxins and attenuation of vaccines |
| AU30414/77A AU511811B2 (en) | 1976-11-08 | 1977-11-07 | Inactivation of microbial toxins and attenuation of vaccines |
| ZA00776648A ZA776648B (en) | 1976-11-08 | 1977-11-07 | Method for the inactivation of microbial toxins and attenuation of vaccines |
| FR7733618A FR2370056A1 (fr) | 1976-11-08 | 1977-11-08 | Tannin provenant de fruits du genre diospyros, son procede de preparation et son application therapeutique |
| DE19772749961 DE2749961A1 (de) | 1976-11-08 | 1977-11-08 | Verfahren zur inaktivierung von mikrobischen toxinen und zur abschwaechung von vakzinen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13395676A JPS5359023A (en) | 1976-11-08 | 1976-11-08 | Inactivation of toxins produced by microbials and attenuation of vaccines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5359023A JPS5359023A (en) | 1978-05-27 |
| JPS6133009B2 true JPS6133009B2 (enrdf_load_stackoverflow) | 1986-07-31 |
Family
ID=15116998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13395676A Granted JPS5359023A (en) | 1976-11-08 | 1976-11-08 | Inactivation of toxins produced by microbials and attenuation of vaccines |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5359023A (enrdf_load_stackoverflow) |
| ZA (1) | ZA776648B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62215210A (ja) * | 1986-03-14 | 1987-09-21 | Sumitomo Electric Ind Ltd | 光コネクタ |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57146208U (enrdf_load_stackoverflow) * | 1981-03-04 | 1982-09-14 |
-
1976
- 1976-11-08 JP JP13395676A patent/JPS5359023A/ja active Granted
-
1977
- 1977-11-07 ZA ZA00776648A patent/ZA776648B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62215210A (ja) * | 1986-03-14 | 1987-09-21 | Sumitomo Electric Ind Ltd | 光コネクタ |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5359023A (en) | 1978-05-27 |
| ZA776648B (en) | 1978-09-27 |
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