JPS6129743B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a drug solution or blood container made of a soft thermoplastic resin sheet or film such as soft vinyl chloride resin. Collection of medicinal solutions or blood that has an encapsulation part to keep it in a dusty state;
Contains containers for storage or transfer.

In general, it has become common practice for medical solution or blood containers to be covered with plastic sheets, films, plastic tubes, molded products, etc. in order to keep the injection and discharge ports sterile or dust-free until just before use. ing.

For example, in Japanese Patent Application Laid-open No. 53-31390,
One end of the tube is melted and placed over the injection/discharge port, and in Japanese Utility Model Publication No. 19747, an injection molded envelope with a line of weakness is formed using an adhesive such as a solvent. , which is glued to the inlet/outlet. Furthermore, in Japanese Utility Model Publication No. 52-42639, in order to form a flap for opening in advance, a sheet-shaped molded product is thermally bonded to an envelope sheet, and then the injection and discharge ports are covered. be.

As shown in the above example, the inlet/outlet and its encapsulation are separate parts that are joined by insertion, solvent bonding, thermal bonding, or the like. In such a case, the manufacturing cost of the drug solution or blood container increases due to the increase in both the manufacturing process and the assembly and joining process of the parts, and the opportunity for contamination with microorganisms and dust, which is the most serious defect in the container, increases. increase

In view of the current situation, an object of the present invention is to provide a drug solution or blood container that can simplify the manufacturing process of the container and reduce the chance of contamination by microorganisms and dust.

In other words, it is a drug solution or blood container made of a sheet or film of a soft vinyl chloride resin, and the hollow cylindrical object constituting the injection/discharge port is made of a partially cross-linked polyester having a degree of cross-linking of 2 to 50% that can be heat-sealed to the bag body. The hollow cylindrical body is made of vinyl chloride resin, and has a diaphragm that blocks the contents of the container from the outside air, one end of which is welded to the main body of the container, and the other end that allows the hollow cylindrical body to be easily connected to the outside air. This container is characterized by having a thin wall so that it can be welded and sealed, and a notch-like cut or weakened part is provided in the welded and sealed part.

In FIGS. 1 and 2, a drug solution or blood container made of a sheet or film of a soft thermoplastic resin such as a soft vinyl chloride resin generally has one or several ports 2 for injecting or discharging the contents of the container. ,
The injection/discharge port 2 is provided with a diaphragm 6 for blocking the contents of the container from outside air, and is joined to the main container 1 at a welded portion 5. When puncturing a syringe needle, plastic needle, etc. to the injection/discharge port 2,
At least the inner surface of the joint on the outside air side of the inlet/outlet port 2, including the diaphragm 6, must be kept sterile and dust-free like the inner surface of the main container 1. For this reason, the injection/discharge port 2 is covered with a separately prepared covering body 3a made of a sheet, an extruded tube, or an injection molded product.

In the present invention, as illustrated in FIGS. 3-1, 2, and 3, the injection/discharge port 2 and its envelope 3b are molded as an integral hollow cylindrical body by injection molding or the like,
The basic feature is that after one end is joined to the main container 1 at the welding part 5, the other end is welded and sealed to obtain a drug solution or blood container that can keep the injection/discharge port clean.

In order to facilitate welding and sealing by heat sealing, ultrasonic sealing, high frequency sealing, etc., the envelope 3 is
It is preferable to mold it into a thin wall. In general, the wall thickness of the injection/discharge port 2 depends on the hardness of the material, but is 0.5 to 3 mm.
is preferable, and the thickness of the envelope 3b with respect to this is,
0.3 to 10% to 80% of the wall thickness of the injection/discharge port
1.5mm is preferred. Furthermore, in order to facilitate melt sealing, a notch 7 may be provided. Also, Figure 3-3
By forming the envelope 3b from the middle of the injection/discharge port 2, as illustrated in FIG.

It is preferable that the envelope 3b can be easily opened without using scissors or the like, and the present inventors have developed a molding material or molding method that can be bonded to the main container 1 and that has imparted tearability, or a shape that has imparted tearability. By using the present invention, it was possible to obtain a liquid medicine or blood container having an injection/discharge port 2 from which the envelope 3b could be easily opened or removed. Below, various examples will be further explained in detail.

Example 1 In Figures 4-1 and 2, the injection/discharge port 2 and the envelope 3b were formed using a soft polyvinyl chloride molding material made of partially crosslinked polyvinyl chloride having a degree of crosslinking of 2 to 50%. As shown in FIG. 3-1 and 2, after integrally molding and welding to the main container 1, the sealing part 4 is formed,
The injection/discharge port 2 was encapsulated. The sealing part 4 was provided with a notch-like cut 8, which served as an opening or a cutting start part.

Molding materials made of partially cross-linked polyvinyl chloride have low tear strength and are easily oriented in the flow direction of the resin, so they can be easily torn and their orientation is stable, making them easy to open. It was possible to obtain a blood or drug solution container having an extremely excellent injection/discharge port encapsulation.

Example 2 In FIG. 5, a soft polyvinyl chloride molding material made of polyvinyl chloride with an average degree of polymerization of 800 to 1500 is used as the material A of the injection/discharge port 2, and the encapsulating body 3b
Using a soft polyvinyl chloride molding material made of polyvinyl chloride with an average degree of polymerization of 2000 to 3000 as the side material B, the injection/discharge port 2 and the encapsulating body 3 are formed by injection molding.
b are integrally molded and welded to the main container 1,
By melt-sealing the other end, it was possible to obtain a blood or drug solution container having an envelope with an injection/discharge port that could be easily opened from the boundary between the two materials A and B.

Similarly, when the partially crosslinked polyvinyl chloride molding material described in Example 1 was used as material B, the same effect could be obtained.

Further, in this embodiment, material A and material B may be replaced.

In Examples 3 and 4 as well, the partially crosslinked polyvinyl chloride molding material described in Example 1 was used as the material for the injection and discharge ports.

Example 3 In FIG. 6, a thin weakened line 9 is formed between the injection/discharge port 2 of the drug solution or blood container and its envelope 3b.
is provided and integrally molded, and the weakened line 9 is used as an opening line. When unsealing, as shown in FIG. 6-1, the envelope 3b could be threaded or broken off near the sealing part 4.

In FIG. 6-2, the sealing portion 4 was formed including the line of weakness 9, and the seal could be torn open using the notch 8. In FIG. 6-3, a flap 10 was previously integrally molded near the line of weakness 9, and the seal could be easily opened by pulling the flap 10.

Embodiment 4 A rubber stopper may be required when a syringe needle, an infusion set, a blood collection set, a blood transfusion set, etc., is punctured and connected to the injection/discharge port of a drug solution or blood container.

In this embodiment, as shown in FIG. 7, a rubber stopper 11 is sealed and integrally molded inside the injection/discharge port 2, and a diaphragm 6 is formed to prevent the rubber stopper from coming into contact with the liquid inside. A protrusion 12 is formed to surround the stopper 11, and the injection/discharge port 2 and its envelope 3b are integrally molded.

This prevents rubber pieces from entering the liquid from the rubber stopper 11 and prevents foreign particles from increasing due to contact with the rubber. Since everything including the body is integrally molded in a single process, chances of contamination by microorganisms or dust can be minimized. The imparting of unsealability can be achieved using any of the methods described in Examples 1 to 3 described above.

[Brief explanation of the drawing]

FIG. 1 is an example of a conventionally known drug solution/blood container, FIG. 2 is an example of a cross section near the injection/discharge port of a conventionally known drug solution/blood container, and FIG. 3-1 is an example of a drug solution/blood container according to the present invention. An example of a cross section near the injection/discharge port of the container, 2 and 3 are other examples, and Fig. 4-1 and 2 are examples of the injection/discharge port in Embodiment 1 of the present invention.
FIG. 5 is an example of the injection/discharge port in Embodiment 2,
6-1, 2, and 3 are examples of the injection/discharge ports in the third embodiment, and FIG. 7 is an example of the injection/discharge ports in the fourth embodiment.

Claims (1)

[Claims] 1 Containers for drug solutions or blood made of sheets or films of soft vinyl chloride resin, which are used for injection and
A hollow cylindrical body constituting the outlet is made of a partially crosslinked polyvinyl chloride resin with a crosslinking degree of 2 to 50% that can be heat-sealed to the bag body, and the hollow cylindrical body is a diaphragm that blocks the contents of the container from outside air. One end is welded to the container body, and the other end is thinned so that the hollow cylindrical object can be easily welded and sealed, and a notch-shaped cut or a notch is formed in the welded and sealed part. A drug solution or blood container characterized by having a weakened portion.