JPS6127045B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an insole (shoe insole) containing an antifungal agent that is a therapeutic agent for athlete's foot. More specifically, the present invention relates to an insole having a therapeutic effect on athlete's foot, in which a specific antifungal agent is mixed, dispersed, and coated in an organic polymer material molded into the insole.

Conventional athlete's foot medicines are applied to the affected area in the form of powder, liquid, or ointment, but the method of the present invention is a new type of drug delivery method in which the antifungal agent is applied to the foot using an insole as a base.

The present invention utilizes the phenomenon that when a low-molecular antifungal agent is mixed and dispersed in a polymeric material and molded, it gradually migrates over time and precipitates on the surface of the polymeric material. be. Industrially, this phenomenon is not preferred because it is associated with the problem of product quality deterioration. Therefore, various improvement methods have been proposed and put into practical use, such as mixing compatible organic substances, stabilizing the mixture by thorough mixing, and converting mixed low-molecular substances into polymers. . The present invention aims to provide a long-term drug release effect to the skin by actively utilizing the phenomenon of volatilization of low molecular weight substances.

As is well known, Trichophyton burrows within the epidermis, so in order to obtain a therapeutic effect by applying a drug to the skin surface, the drug must remain on the skin surface for a long time. As a result, the therapeutic drug is absorbed into the epidermis via sweat glands, sebum, etc., and the therapeutic effect appears. When the insole is used as a drug delivery base, the contact time with the skin is expected to be 7 to 8 hours during the day, so the contact time is sufficient.

Antifungal agents include halogenated phenols,
At least one antifungal agent selected from the group consisting of antibiotic, fatty acid, and naphthiomate antifungal agents is used.

Specific examples include 2,4,5-trichlorophenyl iodine propargyl ester, griseofulvin, 11-iodo-10-undecic acid, 2,4,6-tribromphenylcaproic acid ester, α-naphthyl- N-methyl-
Suitable examples include N-β-naphthylthionocarbamate, but the present invention is not limited thereto.

These antifungal agents are effective against organic polymeric substances.
Apply 0.01-5% (by weight). The greater the mixing amount, the higher the medicinal efficacy, but when fillers, dispersants, etc. and antibacterial agents are dispersed and mixed into organic molecular substances, the moldability
There is a limit of about 1%, and the practically appropriate concentration is 1 to 2%.
%.

Organic polymer substances include natural rubber, polyisoprene, polyurethane, polyacrylonitrile,
Examples include polyethylene glycol terephthalate, polystyrene, polyethylene, polypropylene, and the like. The properties necessary for an organic polymer material include moldability, thermal stability, thermoplasticity, strength to withstand physical and chemical use when used in insoles, toughness, and cold resistance. Is required.

Materials necessary for product manufacturing include fillers such as clay, magnesium carbonate, silicon oxide, calcium chloride, etc., which are used to improve the physical properties of organic polymer materials and reduce costs. It is preferable to mix 1 to 40% (by weight) into the material substrate.

In order to mix the antifungal agent and the organic polymer substance more efficiently and uniformly, the antifungal agent may be adsorbed onto an adsorbent such as activated clay or activated carbon and then mixed. Some of these adsorbents have the effect as the filler described above. It also has the effect of absorbing bad odors when used as an insole.

The method of mixing the organic polymeric material and the antifungal agent changes depending on the process of molding the insole from the organic polymeric material. An example of the coating method of the present invention will be described below.

In advance, a coarsely woven fabric, film, viscose sponge, or polyurethane foam is punched into an insole mold, and if necessary, the laminated insole described above is obtained.

By applying or dipping an antifungal agent dissolved in a solvent onto one or both sides of the insole, the insole can be impregnated with the agent. In the most preferred embodiment of this method, one or both sides of the insole is coated with a mixed solution consisting of a solvent, an organic polymeric substance soluble in the solvent, and an antifungal agent. After coating, the insole is dried to remove the solvent and obtain an insole with anti-athlete's foot effect.

As an example, a 10% acetone solution of cellulose acetate was prepared, and 2% of the weight of cellulose acetate was added to the solution.
of 11-iodo-10-undecylenic acid was dissolved.
This was poured into an insole-shaped iron mold with a depth of 5 mm and dried at 60°C for 1 hour. The insole containing the antifungal agent was removed from the mold and had a thickness of approximately 0.5 m.

Claims (1)

[Scope of Claims] 1. An insole mainly composed of an organic polymeric substance, which comprises 2,4,5-trichlorophenyl iodine propargyl ester, griseofulvin, 11-iodo-10-undecynic acid, 2,4,6
-Tribromphenylcaproic acid ester, α-
At least one antifungal agent selected from the group consisting of naphthyl-N-methyl-N-β-naphthylthionocarbamate is coated on the surface of the organic polymer material at a ratio of 0.01 to 5.0% (by weight). An insole. 2 An insole mainly composed of organic polymeric substances, with a total content of 0.01 to 5.0% of halogenated phenolic antifungal agents and naphthiomate antifungal agents.
An insole made by coating the surface of an organic polymer material in a proportion of (by weight).