JPS61231461A - Apparatus for dripping specimen - Google Patents

Apparatus for dripping specimen

Info

Publication number
JPS61231461A
JPS61231461A JP7243185A JP7243185A JPS61231461A JP S61231461 A JPS61231461 A JP S61231461A JP 7243185 A JP7243185 A JP 7243185A JP 7243185 A JP7243185 A JP 7243185A JP S61231461 A JPS61231461 A JP S61231461A
Authority
JP
Japan
Prior art keywords
sample liquid
dripping
cup
holder member
air
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7243185A
Other languages
Japanese (ja)
Inventor
Fumio Sugaya
文雄 菅谷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Holdings Corp
Original Assignee
Fuji Photo Film Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Photo Film Co Ltd filed Critical Fuji Photo Film Co Ltd
Priority to JP7243185A priority Critical patent/JPS61231461A/en
Publication of JPS61231461A publication Critical patent/JPS61231461A/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

PURPOSE:To accurately perform chemical quantitative analysis, by mounting a dripping cup having a dripping chip part to an apparatus and detecting the size of the liquid droplet dripped from the dripping chip part to make the same proper. CONSTITUTION:A cup receiving member 26 is provided to the holder member 20 of a mount apparatus in an up-and-down movable manner. A dripping cup 10 having a dripping chip part 14 is received in the receiving member 26 and the dripping chip part 14 is protruded from the lower part of the receiving member 26. A cap member 30 is closed to hermetically close the dripping cup 10. Air is introduced into the dripping cup 10 from the vent hole 32 of the cap member 30 to pressurize said cup 10 and a liquid specimen is dripped from the dripping chip part 1. A light emitting diode 70 and an optical sensor 72 are provided to said dripping part to detect the size of a liquid droplet and the passage of air is controlled by the detection signal to make the size of the liquid droplet proper. Because the size of the liquid droplet is made proper by providing the liquid droplet detection means, quantitative analysis can be accurately and easily performed.

Description

【発明の詳細な説明】 （産業上の利用分野） 本発明は試料液点着装置、より詳細には特定の化学成分
を分析するための分析材料に分析用の試料液を点着供給
するための装置に関するものである。Detailed Description of the Invention (Industrial Application Field) The present invention is a sample liquid spotting device, more specifically, a device for spotting and supplying a sample liquid for analysis onto an analysis material for analyzing a specific chemical component. The invention relates to a device.

（従来の技術） 液体試料中の特定の化学成分を定性的もしくは定量的に
分析することは様々な産業分野において一般的に行なわ
れている操作である。特に血液や尿等、生物体液中の化
学成分または有形成分（例、赤血球、白血球、血小板等
）を定量分析することは生化学分野および臨床分野にお
いて極めて重要である。(Prior Art) Qualitative or quantitative analysis of specific chemical components in a liquid sample is a commonly performed operation in various industrial fields. In particular, quantitative analysis of chemical components or formed components (eg, red blood cells, white blood cells, platelets, etc.) in biological body fluids such as blood and urine is extremely important in the biochemical and clinical fields.

近年、試料液の小滴を点着供給するだけで該試料液中に
含まれている特定の化学成分または有形成分を定量分析
することのできるドライタイプの分析材料が開発され（
特公昭５３−２１６７７号、特開昭５５−１６４３５６
号、特開昭５６−９６２４５号、特開昭５６−９７８１
２号等に記載）、実用化されている。これらの分析材料
を用いると従来の湿式分析法に比して簡易かつ迅速に試
料液の分析を行なうことができるため、その使用は特に
数多くの検体を分析する必要のある医療機関、研究所等
において好ましいものである。また、特開昭５３−８１
２９２号、特開昭５８−１６１８６７号、特開昭５８−
２１５６６号等にはこのような分析材料を用いて分析を
行なうための化学分析装置が記載されている。In recent years, dry-type analytical materials have been developed that can quantitatively analyze specific chemical components or formed components contained in a sample liquid by simply applying small droplets of the sample liquid (
Japanese Patent Publication No. 53-21677, Japanese Patent Publication No. 55-164356
No., JP-A-56-96245, JP-A-56-9781
(described in No. 2, etc.) and has been put into practical use. Using these analytical materials, it is possible to analyze sample liquids more easily and quickly than conventional wet analysis methods, so their use is particularly important in medical institutions, laboratories, etc. that need to analyze a large number of samples. This is preferable. Also, JP-A-53-81
No. 292, JP-A-58-161867, JP-A-58-
No. 21566 and the like describe a chemical analysis device for performing analysis using such analysis materials.

上述のように、このような分析材料を用いて試料液中に
含まれる特定成分の分析を行なうためには対象となる試
料液を分析材料に適量点着供給する必要があり、したが
って適当な試料液点着供給手段を用いることが望ましい
。As mentioned above, in order to analyze specific components contained in a sample liquid using such analytical materials, it is necessary to apply an appropriate amount of the target sample liquid onto the analytical material. Preferably, a liquid spot delivery means is used.

この際、特に試料液として生物体液を用いる場合には検
体（すなわち試料液）の採取から点着までの間になるべ
く検体が外気に触れないようにして蒸発、凝固、汚染等
による成分の変化を防ぐことが分析上好ましく、試料液
点着供給手段はこのような条件を満足することが望まし
い。また、臨床検査等においては１つの検体をそれぞれ
異なつた化学成分に反応する複数の分析材料に点着供給
することによって複数の化学成分を分析することが一般
的に行なわれているため、試料液点着供給手段はこのよ
うな操作に適したものであることが望ましい。さらに、
特に多数の検体を迅速に分析することが必要とされる場
合、試料液点着供給手段はある検体に他の検体が混入す
ることのないようなものとすることが望ましい。At this time, especially when using a biological body fluid as the sample liquid, try to prevent the sample from coming into contact with the outside air as much as possible from the time the sample (i.e. sample liquid) is collected to the time of spotting to prevent changes in components due to evaporation, coagulation, contamination, etc. It is preferable for analysis to prevent this, and it is desirable that the sample liquid spot supply means satisfy such conditions. In addition, in clinical tests, etc., it is common practice to analyze multiple chemical components by spot-feeding a single specimen to multiple analysis materials that react to different chemical components. It is desirable that the spot supply means be suitable for such operations. moreover,
Particularly when it is necessary to quickly analyze a large number of specimens, it is desirable that the sample liquid spot supply means be such that one specimen will not be mixed with another specimen.

しかしながら、上述のような条件を満足し、しかも簡便
に操作でき、かつ容易に製造することのできる試料液点
着供給手段は知られていないのが現状である。However, at present, there is no known sample liquid spot supply means that satisfies the above-mentioned conditions, can be easily operated, and is easily manufactured.

（発明の目的） 本発明は上述のような現状に鑑み、正確な定量化学分析
または正確な有形成分の定量分析が簡易迅速に行なえる
ように試料液を任意の分析材料に点着供給することがで
きる試料液点着装置を提供することをその目的とするも
のである。(Objective of the Invention) In view of the above-mentioned current situation, the present invention provides a method for spotting and supplying a sample liquid to any analysis material so that accurate quantitative chemical analysis or accurate quantitative analysis of formed components can be performed simply and quickly. The object of the present invention is to provide a sample liquid spotting device that can perform the following steps.

（発明の構成） 本発明による試料液点着装置は、カップ部材。(Structure of the invention) The sample liquid spotting device according to the present invention includes a cup member.

ホルダー部材、キャップ部材、空気供給手段、液滴検出
手段、および制御手段を備えてなるものである。カップ
部材は試料液および空気を導入するのに適した開口を上
端に有し、滴下チップ部を下端に有して試料液を保持す
るように構成されている。ホルダー部材は滴下チップ部
を下端から突出させるようにしてカップ部材を着脱自在
に収納するように構成されている。キャップ部材は通気
口を有してホルダー部材上に開閉自在に設けられ、その
閉鎖時にはホルダー部材と嵌合してカップ部材を密閉し
、通気口からカップ部材上端の開口に空気を供給するこ
とができるように構成されている。空気供給手段はこの
通気口と連通ずるように設けられている。液滴検出手段
はカップ部材内への空気の供給によって滴下チップ部下
端に形成される試料液液滴の大きさくサイズ）を検出し
、対応する検出信号を出力するようになっている。制御
手段はこの検出信号に基いて空気供給手段を制御するよ
うに設けられている。It comprises a holder member, a cap member, an air supply means, a droplet detection means, and a control means. The cup member has an opening at the upper end suitable for introducing the sample liquid and air, and a dripping tip at the lower end to hold the sample liquid. The holder member is configured to removably house the cup member with the dripping tip portion protruding from the lower end. The cap member has a vent and is provided on the holder member so as to be openable and closable, and when the cap member is closed, it is fitted with the holder member to seal the cup member, and air can be supplied from the vent to the opening at the upper end of the cup member. It is configured so that it can be done. Air supply means is provided to communicate with this vent. The droplet detection means detects the size of a sample liquid droplet formed at the lower end of the dropping tip by supplying air into the cup member, and outputs a corresponding detection signal. The control means is provided to control the air supply means based on this detection signal.

本発明において「滴下チップ部」とは小量（数μ応〜数
十μ９Ｊ）の試料液を液滴として滴下することのできる
開口を有する細い筒状の先端部分を意味する。In the present invention, the "dropping tip section" means a thin cylindrical tip portion having an opening through which a small amount (several microns to several tens of microns 9 J) of sample liquid can be dropped as a droplet.

また、本発明において「試料液」とは任意の化学分析ま
たは有形成分分析工程において使用され得るあらゆる液
体試料を意味するものであり、単に分析すべき未知量の
化学成分または有形成分を含有する検体試料液のみなら
ず、既知量の化学成分を含有する対照試料として検量線
の作成あるいはボテンシオメトリックな分析に用いられ
る、いわゆる「参照液」および「標準液」をも含有する
ものである。Furthermore, in the present invention, the term "sample liquid" refers to any liquid sample that can be used in any chemical analysis or formed component analysis step, and simply contains an unknown amount of chemical components or formed components to be analyzed. It contains not only the specimen sample solution to be analyzed, but also the so-called ``reference solution'' and ``standard solution,'' which are used as control samples containing known amounts of chemical components to create a calibration curve or perform botensiometric analysis. .

（発明の効果） 本発明による試料液点着装置は試料液を保持するための
カップ部材がホルダー部材に着脱自在に収納されるよう
になっているため、試料液をカップ部材ごと廃棄したり
、交換することが可能であり、したがって異なった試料
液が互いに混入する危険がない。(Effects of the Invention) In the sample liquid spotting device according to the present invention, the cup member for holding the sample liquid is detachably housed in the holder member, so that the sample liquid can be disposed of together with the cup member. They can be exchanged, so there is no risk of different sample liquids contaminating each other.

また、カップ部材をホルダー部材に装着し、キャップ部
材を閉じるとカップ部材は空気供給用の通気口および滴
下チップ部先端の開口を除いて密閉されるため、外気の
影響を殆んど受けることなく確実に試料液をその内部に
保持することができる。そして、この際には空気供給手
段とカップ部材の開口とがキャップ部材の通気口を介し
て連通するようになっているため、空気供給手段を作動
させることによって試料液液滴を滴下チップ部先端に形
成することができ、しかも液滴検出手段と制御手段の作
用によって液滴の大きさくサイズ。In addition, when the cup member is attached to the holder member and the cap member is closed, the cup member is sealed except for the air supply vent and the opening at the tip of the dripping tip, so it is hardly affected by outside air. It is possible to reliably hold the sample liquid inside. In this case, since the air supply means and the opening of the cup member communicate with each other through the vent hole of the cap member, the sample liquid droplet is dropped at the tip of the tip by activating the air supply means. The size of the droplet can be increased by the action of the droplet detection means and the control means.

形状）を予め定めた体積とすることができる。さらに、
充分な山の試料液がカップ部材内に予め注入されている
場合には、制御された断続的な空気の供給とこれに連動
する検出手段の作動によって簡易迅速に複数の分析材料
に対して同一の試料液を点着供給することが可能である
。shape) can have a predetermined volume. moreover,
When a sufficient amount of sample liquid is injected into the cup member in advance, the same measurement can be performed on multiple analytical materials easily and quickly by controlling intermittent air supply and the operation of the detection means in conjunction with this. It is possible to drip-feed the sample solution.

以上述べたように本発明による試料液点着装置は正確な
化学分析または有形成分の定量分析が簡易迅速に行なえ
るように試料液を任意の分析材料に点着供給することの
できるものであり、そ・の・産業上の利用価値は極めて
高い。As described above, the sample liquid spotting device according to the present invention is capable of spotting and supplying a sample liquid to any analysis material so that accurate chemical analysis or quantitative analysis of formed components can be easily and quickly performed. Yes, its industrial value is extremely high.

（実施態様） 以下、図面を参照して本発明の実施態様を説明する。(Embodiment) Embodiments of the present invention will be described below with reference to the drawings.

第１図および第２図は本発明の一実施態様である試料液
点着装置のキャップ部材開放時および閉鎖時をそれぞれ
示す垂直断面図である。FIGS. 1 and 2 are vertical cross-sectional views showing the sample liquid spotting device according to an embodiment of the present invention when the cap member is opened and closed, respectively.

これらの図面に示す試料液点着装置ｔ（以下、単に［点
ｌＢ１１Ｊという）はカップ部材１０、ホルダー部材２
０およびキャップ部材３０を有している。カップ部材１
０の上端は開口１２を形成し、−下端は滴下チップ部１
４を形成している。ホルダー部材２０は基部２２とカッ
プ収納部材２６を有している。カップ収納部材２６は滴
下チップ部１４を下端から突出させるようにして、カッ
プ部材１０を着脱自在に収納するものであり、基部２２
の開口２４内にスプリング２８を介して弾性的かつ上下
可動に支持されている。キャップ部材３０は通気口３２
を有してホルダー部材２０の基部２２上に開閉自在に段
けら、れており、閉鎖時にはホルダー部材２０と嵌合し
てカップ部材１０を密閉し、通気口３２からカップ部材
１０の開口１２に空気を供給できるようになっている。The sample liquid spotting device t (hereinafter simply referred to as point 1B11J) shown in these drawings includes a cup member 10 and a holder member 2.
0 and a cap member 30. Cup member 1
The upper end of 0 forms the opening 12, and the lower end forms the dripping tip part 1.
4 is formed. The holder member 20 has a base 22 and a cup storage member 26. The cup storage member 26 is configured to removably store the cup member 10 with the dripping tip portion 14 protruding from the lower end.
It is elastically supported in an opening 24 via a spring 28 so as to be movable up and down. The cap member 30 has a ventilation hole 32
is provided on the base 22 of the holder member 20 so as to be openable and closable, and when closed, it fits with the holder member 20 to seal the cup member 10, and from the vent 32 to the opening 12 of the cup member 10. Air can be supplied.

通気口３２のジヨイント部３４はフレキシブルチューブ
４０を介してシリンダー５０と連通することができるよ
うになっており、ピストン５２をパルスモータ−６０に
よって駆動することにより、通気口３２に空気を供給す
ることができる。The joint portion 34 of the vent port 32 can communicate with the cylinder 50 via a flexible tube 40, and air can be supplied to the vent port 32 by driving the piston 52 with a pulse motor 60. I can do it.

試料液を開口１２から注入して内部に保持させたカップ
部材１０をカップ収納部材２６に装着し、キャップ部材
３０を閉じるとカップ部材１０およびカップ収納部材２
６と共にスプリング２８が付勢されるため、カップ部材
１０は開口１２をキャップ３０の下面に密着させ、かつ
滴下チップ部１４を下端から突出させた状態でホルダー
部材２０内に支持される。ここでパルスモータ−６０を
作動させてピストン５２を第２図矢印方向に移動すれば
フレキシブルチューブ４０゜ジヨイント部３４１通気口
３２を経由してカップ部材１０の開口１２に空気を供給
することができる。適当量または予め定めた体積の空気
を開口１２に供給することによって、滴下チップ部１４
の先端には予め定めた体積の試料液液滴が形成される。When the cup member 10 in which the sample liquid is injected through the opening 12 and held inside is attached to the cup storage member 26 and the cap member 30 is closed, the cup member 10 and the cup storage member 2 are removed.
6 as well as the spring 28, the cup member 10 is supported within the holder member 20 with the opening 12 in close contact with the lower surface of the cap 30 and the dripping tip portion 14 protruding from the lower end. If the pulse motor 60 is operated to move the piston 52 in the direction of the arrow in FIG. 2, air can be supplied to the opening 12 of the cup member 10 via the flexible tube 40° joint 341 and the vent 32. . By supplying an appropriate amount or predetermined volume of air to the opening 12, the dripping tip portion 14
A sample liquid droplet with a predetermined volume is formed at the tip of the sample.

第２図に示すように、滴下チップ部１４先端に形成され
る試料液液滴の大きさくサイズ、形状）は発光ダイオー
ド（ＬＥＤ）７０およびコリメートレンズ７１とこれに
対応する光センサ−７２とからなる液滴検出手段によっ
て検出される。その検出信号は光センサ−７２から出力
され、増幅回路７４を経て判定回路７６に伝達される。As shown in FIG. 2, the size and shape of the sample liquid droplet formed at the tip of the dropping tip section 14 is controlled by a light emitting diode (LED) 70, a collimating lens 71, and a corresponding optical sensor 72. The liquid droplet is detected by a droplet detection means. The detection signal is output from the optical sensor 72 and transmitted to the determination circuit 76 via the amplifier circuit 74.

判定回路７６は調整回路７Ｂによって予め定められた値
と検出信号値とを比較することによって液滴が所定の大
きさくサイズ。The determination circuit 76 determines that the droplet has a predetermined size by comparing the detection signal value with a value predetermined by the adjustment circuit 7B.

形状）であるか否かを判定し、この判定結果を駆動回路
８０に出力する。駆動回路８０はこの判定結果に基き、
所定の大きさくサイズ、形状）の液滴を滴下チップ部１
４先端に形成するのに適当な量の空気をカップ１０内に
供給するべくピストン２２が運動するようにパルスモー
タ−６０を駆動する。shape), and outputs this determination result to the drive circuit 80. Based on this determination result, the drive circuit 80
The tip part 1 drops a droplet of a predetermined size and shape.
The pulse motor 60 is driven so that the piston 22 moves to supply the appropriate amount of air into the cup 10 to form the four tips.

滴下チップ部１４先端に所定の大きさの液滴が形成され
ると上述の液滴検出手段および各回路の働きによってパ
ルスモータ−６０は停止される。ここで点着装置および
分析材料１００を（第２図の点線で示すように）相対的
に垂直移動させて試料液液滴の界面を分析材料１００の
液点着部位の表面（展開層等の表面）または液点着孔に
接触させると液滴は滴下チップ部１４の先端から離れて
分析材料１００上に点着供給される。When a droplet of a predetermined size is formed at the tip of the dropping tip section 14, the pulse motor 60 is stopped by the operation of the droplet detection means and each circuit described above. Here, the spotting device and the analysis material 100 are moved relatively vertically (as shown by the dotted line in FIG. When the droplet comes into contact with the surface) or the liquid spotting hole, the droplet leaves the tip of the dropping tip section 14 and is spotted and supplied onto the analysis material 100.

カップ部材１０に充分な量の試料液が保持されている場
合には、この後さらに空気をカップ部材１０内に供給し
て新たな、予め定めた大きさくサイズ。If a sufficient amount of sample liquid is held in the cup member 10, air is further supplied into the cup member 10 to increase the size to a new predetermined size.

形状）の液滴を滴下チップ部１４先端に形成することに
よって複数の分析材料に対して連続的に試料液の点着供
給を行なうことも可能である。By forming droplets of the following shape at the tip of the dropping tip portion 14, it is also possible to continuously spot and supply sample liquid to a plurality of analysis materials.

所定の分析操作が終了した後、キャップ部材３゜を開く
とカップ収納部材２６はスプリング２８の伸張によって
第１図に示、すように再び上昇する。したがって、カッ
プ部材１０は残余試料液を保持したまま容易にホルダー
部材２０から取り出し、廃棄することができる。また複
数のカップ部材を予め用意しておけば、カップ部材の交
換によって異なる種類の試料液を簡易迅速に点着供給す
ることも可能である。After the predetermined analysis operation is completed, when the cap member 3° is opened, the cup storage member 26 is raised again as shown in FIG. 1 by the expansion of the spring 28. Therefore, the cup member 10 can be easily taken out from the holder member 20 and discarded while retaining the remaining sample liquid. Furthermore, if a plurality of cup members are prepared in advance, different types of sample liquids can be easily and quickly dispensed by replacing the cup members.

なお、液滴検出手段は上記実施態様に示したような発光
ダイオードと光センサーの組合わせに限られるものでは
なく、例えば、レーザーダイオード、白熱電球、グロー
放電灯（ネオンランプ等）等の発光素子とフォトトラン
ジスタ、フォトダイオード、チャージ力プルドデバイス
（ｃＯＤ）。Note that the droplet detection means is not limited to the combination of a light emitting diode and a light sensor as shown in the above embodiments, but may also be a light emitting element such as a laser diode, an incandescent light bulb, or a glow discharge lamp (neon lamp, etc.). and phototransistors, photodiodes, and charge-force pulled devices (cOD).

ＭＯ８受光素子等の受光素子とを組合わせてなる光学的
手段、あるいは超音波発信素子と受信素子とを組合わせ
てなる（液滴検出の精度を高めるために音響レンズ等を
配置することもできる）超音波検出手段等を使用するこ
とができる。An optical means formed by combining a light receiving element such as an MO8 light receiving element, or a combination of an ultrasonic transmitting element and a receiving element (an acoustic lens etc. can also be arranged to improve the accuracy of droplet detection) ) Ultrasonic detection means etc. can be used.

【図面の簡単な説明】[Brief explanation of the drawing]

第１図は本発明の一実施態様である試料液点着装置をキ
ャップ部材を開放した状態で示す垂直断面図、 第２図は上記装置をキャップ部材を閉鎖した状態で示す
垂直断面図である。 １０・・・・・・カップ部材　　　　　　１２・・・開
　　　　口１４・・・・・・滴下チップ部　　　　　２
０・・・ホルダー部材２２・・・・・・基　　　　部　
　　　　２４・・・開　　　　口２６・・・・・・カッ
プ収納部材　　　　２Ｂ・・・スプリング３０・・・・
・・キャップ部材　　　　　３２・・・通　気　口４０
・・・・・・フレキシブルチューブ　５０・・・シリン
ダー５２・・・・・・ピストン ６０・・・・・・パルスモータ−７０・・・ＬＥＤ７１
・・・・・・コリメートレンズ　　　７２・・・光セン
サ−７４・・・・・・増幅回路　　　　　　　７６・・
・判定回路７８・・・・・・調整回路　　　　　　　８
０・・・駆動回路ｉｏｏ・・・分析材料FIG. 1 is a vertical sectional view showing a sample liquid spotting device according to an embodiment of the present invention with the cap member open, and FIG. 2 is a vertical sectional view showing the device with the cap member closed. . 10... Cup member 12... Opening 14... Dripping tip portion 2
0... Holder member 22... Base
24...Opening 26...Cup storage member 2B...Spring 30...
... Cap member 32 ... Ventilation port 40
...Flexible tube 50 ... Cylinder 52 ... Piston 60 ... Pulse motor 70 ... LED 71
... Collimator lens 72 ... Optical sensor -74 ... Amplification circuit 76 ...
・Judgment circuit 78...Adjustment circuit 8
0...Drive circuit ioo...Analysis material

Claims (5)

【特許請求の範囲】[Claims] （１）（ａ）試料液および空気を導入するのに適した開
口を形成する上端と滴下チップ部を形成する下端とを有
し、前記試料液を保持するカップ部材、 （ｂ）前記滴下チップ部を下端から突出させるようにし
て前記カップ部材を着脱自在に収納するホルダー部材、 （ｃ）通気口を有して前記ホルダー部材上に開閉自在に
設けられ、その閉鎖時に前記ホルダー部材と嵌合して前
記カップ部材を密閉し、前記通気口から前記カップ部材
の開口に空気を供給することができるようになっている
キャップ部材、 （ｄ）前記通気口と連通する空気供給手段、（ｅ）前記
ホルダー部材に前記カップ部材が収納されている際に前
記滴下チップ部下端に形成される試料液液滴の大きさを
検出し、対応する検出信号を出力する液滴検出手段、お
よび （ｆ）前記検出信号に基いて前記空気供給手段を制御す
る制御手段からなることを特徴とする試料液点着装置。(1) (a) A cup member that holds the sample liquid and has an upper end that forms an opening suitable for introducing the sample liquid and air and a lower end that forms a dripping tip portion, (b) the dripping tip (c) a holder member that removably houses the cup member with a portion protruding from the lower end; (c) a holder member having a ventilation hole and provided on the holder member so as to be openable and closable, and fitting with the holder member when the holder member is closed; a cap member configured to seal the cup member and supply air from the vent to the opening of the cup member; (d) air supply means communicating with the vent; (e) (f) droplet detection means for detecting the size of a sample liquid droplet formed at the lower end of the dropping tip when the cup member is housed in the holder member and outputting a corresponding detection signal; A sample liquid spotting device comprising a control means for controlling the air supply means based on the detection signal. （２）前記検出手段が発光素子とこれに対応する光セン
サーとからなる特許請求の範囲第１項記載の試料液点着
装置。(2) The sample liquid spotting device according to claim 1, wherein the detection means comprises a light emitting element and a corresponding optical sensor. （３）前記発光素子が発光ダイオードもしくはレーザー
ダイオードである特許請求の範囲第２項記載の試料液点
着装置。(3) The sample liquid spotting device according to claim 2, wherein the light emitting element is a light emitting diode or a laser diode. （４）前記発光素子が白熱電球もしくはグロー放電灯で
ある特許請求の範囲第２項記載の試料液点着装置。(4) The sample liquid spotting device according to claim 2, wherein the light emitting element is an incandescent lamp or a glow discharge lamp. （５）前記検出手段が超音波発振素子とこれに対応する
受信素子からなる特許請求の範囲第１項記載の試料液点
着装置。(5) The sample liquid spotting device according to claim 1, wherein the detection means comprises an ultrasonic oscillation element and a corresponding receiving element.
JP7243185A 1985-04-05 1985-04-05 Apparatus for dripping specimen Pending JPS61231461A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7243185A JPS61231461A (en) 1985-04-05 1985-04-05 Apparatus for dripping specimen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7243185A JPS61231461A (en) 1985-04-05 1985-04-05 Apparatus for dripping specimen

Publications (1)

Publication Number Publication Date
JPS61231461A true JPS61231461A (en) 1986-10-15

Family

ID=13489098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7243185A Pending JPS61231461A (en) 1985-04-05 1985-04-05 Apparatus for dripping specimen

Country Status (1)

Country Link
JP (1) JPS61231461A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013012A1 (en) * 1989-04-25 1990-11-01 Kyoto Daiichi Kagaku Co., Ltd. Method of detecting operation condition of a micropipette
EP0641599A1 (en) * 1993-09-08 1995-03-08 Roche Diagnostics GmbH Method and device for measuring the volume of liquids
WO1996013726A1 (en) * 1994-10-31 1996-05-09 Abbott Laboratories Method and apparatus for dispense verification
EP1099941A1 (en) * 1999-11-09 2001-05-16 Tecan Schweiz AG Method for determining the weights of fluid units, weighing device as well as its use
EP2848306A1 (en) 2013-09-13 2015-03-18 Bruker Daltonik GmbH Dispenser system for mass spectrometric sample preparations

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013012A1 (en) * 1989-04-25 1990-11-01 Kyoto Daiichi Kagaku Co., Ltd. Method of detecting operation condition of a micropipette
EP0641599A1 (en) * 1993-09-08 1995-03-08 Roche Diagnostics GmbH Method and device for measuring the volume of liquids
WO1996013726A1 (en) * 1994-10-31 1996-05-09 Abbott Laboratories Method and apparatus for dispense verification
US5559339A (en) * 1994-10-31 1996-09-24 Abbott Laboratories Method and apparatus for verifying dispense of a fluid from a dispense nozzle
EP1202066A2 (en) * 1994-10-31 2002-05-02 Abbott Laboratories Method for dispense verification
EP1202066A3 (en) * 1994-10-31 2002-07-31 Abbott Laboratories Method for dispense verification
EP1099941A1 (en) * 1999-11-09 2001-05-16 Tecan Schweiz AG Method for determining the weights of fluid units, weighing device as well as its use
EP2848306A1 (en) 2013-09-13 2015-03-18 Bruker Daltonik GmbH Dispenser system for mass spectrometric sample preparations

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