JPS61225106A - Dermatic agent for external use - Google Patents

Abstract

PURPOSE:To provide an external agent for skin, containing an anionic surfactant in combination with a specific hydroquinone glucoside, having suppressed skin irritation of anionic surfactant in the external agent for skin, and useful as cosmetic, medicinal drug, quasi-drug, etc. CONSTITUTION:The objective external agent for skin contains (A) one or more aniotic surfactants such as lauric acid slat, cocoylsulfuric acid slat, casein salt, etc., and (B) one or more hydroquinone glucosides of formula (R is pentose residue, hexose residue, amino sugar residue, uronic acid residue and their methylated group) (especially preferably hydroquinone-beta-D-glucoxide). The sum of the components A and B in the agent is preferably 0.1-30wt%, especially 6-20wt%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Fields of Application] The present invention relates to a composition in which the skin irritation of an anionic surfactant contained in the system is alleviated, and is applicable to cosmetics, pharmaceuticals,
The aim is to provide external skin preparations that are useful in the field of quasi-drugs.

[Prior Art] Surfactants are often blended into the base of external skin preparations as emulsifiers, solubilizers, dispersants, detergents, and the like. Among them, anionic surfactants have strong emulsifying power, solubilizing power, dispersing power, and detergent power.Furthermore, fatty acid alkali 7, which is a representative anionic surfactant, is the surfactant that has been used for the longest time. Because it feels good when used, it is frequently used, especially in the cosmetics field.

However, anionic surfactants have skin irritation properties and may cause skin disorders in some people. The concentration of surfactants in external skin preparations is relatively low, except for detergents, but now that the overall skin safety of external skin preparations has improved, anionic surfactants are It is also desired that the irritation properties be further improved.

[Problems to be Solved by the Invention] Therefore, the present inventors conducted intensive studies with the aim of further reducing the skin irritation caused by anionic surfactants in external skin preparations, and surprisingly found that The present inventors have discovered that this objective can be achieved by blending a specific hydroquinone glycoside with an anionic surfactant, and have completed the present invention.

[Means for Solving the Problems] That is, the present invention uses one or more anionic surfactants and one or more hydroquinone glycosides represented by the following general formula (1). It is a skin external preparation characterized by containing.

(In formula (1), R represents a pentose residue, a hexose residue, a deminosaccharide residue, a uronic acid residue, or a methylated product thereof.

) The present invention will be explained in detail below.

The anionic surfactants used in the present invention include all anionic surfactants commonly used in external skin preparations. Specific examples include fatty acid salts such as laurate, palmitate, oleate, stearate, isostearate, hehenate, abietate, and alkyl sulfates such as lauryl sulfate and cocoyl sulfate. Ester salts, alkyl ether sulfate ester salts such as POE lauryl sulfate and POE cocoyl sulfate, N-acyl sarcosine salts such as lauroyl male lucosine salts, N-
Fatty acid amide succinates such as myristoyl-N-methyl clarine salt, cocoyl methyl taurino salt, lauryl methyl tausonol salt, phosphate ester salts such as POE oleyl ether phosphate, POE stearyl ether phosphate, 2-ethyl hequinyl sulfosuccinate,
Sulfosuccinates such as monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, lauryl polypropylene glycol sulfosuccinate, alkyl hanzene sulfonates such as linear todecyl hanzene sulfonate, N-lauroyl glutamate, N-stearoyl N-acyl amino acid salts such as glutamate, N-myristoyl glutamate, N-balmitoyl aspartate, sulfated oils such as funnel oil, amidosuccinates such as lauroyl monoethanolamide succinate, or POE alkyl ethers. Carboxylate, P
Examples include OE alkyl allyl ether carboxylate, α-olefin sulfonate, fatty acid ester sulfonate, secondary alcohol sulfate ester salt, fatty acid alkylolamide sulfate ester salt, and caseinate.

The cations forming the above salts include sodium,
Alkali metals such as potassium, alkaline earth metals such as magnesium and calcium, amines such as jetanolamine and triethanolamine, basic amino acids such as lysine and arginine, as well as 2-amino-2-methylpropanol or ammonia, etc. can be given.

In the present invention, any one or more of these anionic surfactants may be selected and used. The amount of the cleaning agent is not particularly limited, but in general, the amount of cleaning material is 5 to 1.
00% by weight, and 0.1 to 2% by weight in other cases.

The hydroquinone glycoside used in the present invention is represented by general formula (1). To give you a specific example,
L-arabinose, D-arabinose, D-xylose, D-ribose, L-xylulose, L-lyxose,
Residues of pentose sugars such as D-ribulose, D-glucose,
Residues of hexose sugars such as D-galactose, L-galactose, D-mannose, D-talose, D-fructose, -sorbose, D-tagatose, D-psicose, D-glucosamine, D-galactosamine , sialic acid,
Residues of amino sugars such as aminouronic acid and muramic acid, D
Examples include uronic acid residues such as -glucuronic acid, D-galacturonic acid, D-mannuronic acid, L-iduronic acid, -guluronic acid, and methylated products thereof.

Among these, the most preferred is where R is a residue of D-glucose, particularly hydroquinone with a β-bond of D-glucose, that is, hy-l-quinone-β-D-glucoside (-ship name: arbutin).

In the present invention, one or more of the above hydroquinone glycosides are arbitrarily selected and used, and the blending amount is 0.1 to 30% by weight, preferably 6%, based on the total amount of the skin external preparation.
~20% by weight.

External skin preparations that can be formulated with anionic surfactants and glycosides of ``Hy-l'' and ``roquinone'' are common external skin preparations, such as aqueous solution systems, solubilized systems, emulsification systems, powder dispersion systems, water-oil 2
It has a wide range of bases such as layer type, water-oil-powder three-layer type, etc., and can be used in basic cosmetics such as lotion, emulsion, cream, blowout, cleansing foam, makeup cosmetics such as lipstick, foundation, etc. In addition to cosmetics such as hair cosmetics such as shampoos, conditioners, and hair tonics, our products range from pharmaceuticals to quasi-drugs.

The skin external preparation of the present invention may contain humectants, thickeners, oils, preservatives, other surfactants, antioxidants, and sequestering agents, as necessary, to the extent that the effects of the present invention are not impaired. , ultraviolet absorbers, powders, drugs, colorants, fragrances, etc. can be added.

(The following is a blank space) [Effects of the Invention] Below, the skin irritation suppressing effect of the anionic surfactant possessed by the glycoside of hydroquinone according to the present invention will be shown.

In the experiment, sodium dotecyl sulfate, triethanolamine stearate, and monosodium N-lauroylglutamate were used as anionic surfactants, and each was individually dissolved in water-ethanol (water:ethanol-95:5).
A sample melted at the following concentration and 0 arbutin were added to the container.
．． The test was carried out using samples to which 5% by weight or 6% by weight had been added.

Table-1 Type of anionic surfactant Dissolved concentration (wt%) Sodium dotesyl sulfate 0.2 Table-2 A human body occlusion punch test was conducted using the above samples. The test subjects were 54 healthy adult women, and the application site was the forearm. Evaluations were made according to the following criteria, and the positive rate was calculated.

1 Judgment criteria - No reaction at all - Slight erythema erythema edema and papules in addition to edema + small blisters in addition to edema and papules →−), (+10+) were considered positive, and the percentage of the total number of 54 people was defined as the positive rate.

The results are shown in Table-3.

(Left below) Table 3 Sample No., Positive rate 1 31.5% 29.2 3 12.9 4 27.8 57.4 6 11.1 7 14.8 93.7 From the results in Table 3, this It is clear that arbutin according to the invention alleviates the skin irritation of anionic surfactants.

EXAMPLES Next, examples of the present invention will be shown. The present invention is not limited thereby.

Example 1 Emulsion A, stearic acid 2.5 cetanol 1.5 vaseline
5.0 Liquid paraffin 10.0
POE (10) Oleate 2.0 Propylparahen 0.1 Tocopheryl acetate
0.01 fragrance 0.2B
, polyethylene glycol 1500 3.0 triethanolamine 1.0 arbutin
1.0 Sodium hexametaphosphate 0.0
5 Oval ice making Heat and melt the components belonging to the remainder (manufacturing method) A (oil phase). Separately, the components belonging to B are mixed and melted and heated (aqueous phase). The oil phase was added to the water phase to emulsify it, and then cooled to obtain a milky lotion.

Example 2 Cleansing Foam A, Monosodium N-Lauroylglutamate 20.0 Sodium Cocoyl Methyl Tauride 104O POE (60) Hydrogenated Castor Oil 4.0 Lauric Acid
2.0 fragrance
0.5B, arbutin
1.0 Ice making remainder (manufacturing method) Example 1. According to.

Example 3 Sodium shampoo lauryl ether sulfate 10.0 Triethanolamine lauryl ether sulfate 10.0 Cocoyl diethanolamide 5.0 Hetaine lauryl dimethylaminoacetate 4.0 Citric acid 0.5 Trisodium edetate 0.1 Propylparahen
0.5 fragrance
0.3 Arbutin 10.0 Purified water Remaining components (manufacturing method) After heating, stirring and melting each component, a shampoo was obtained by cooling.

Example 4 Cream A, stearic acid 10.0 stearyl alcohol 4.0 butyl stearate
8.0 Glyceryl monostearate (self-emulsifying type) 2.0 Propylene glycol 3.0 Seikari
0.2 fragrance
0.2 Ethylparahen 0.0
5B, Arbutin 0.2 Hydroquinone β-D-arabinocyto 0.5 Purified water Remaining (manufacturing method) as in Example 1.

Examples 1 to 4 had good safety, excellent oral stability, and usability.

Claims (1)

[Claims] (1) An external preparation for skin, characterized by containing one or more anionic surfactants and one or more hydroquinone glycosides represented by the following general formula (I). ▲There are mathematical formulas, chemical formulas, tables, etc.▼・・・(I) (In formula (I), R is a pentose residue, a hexose residue, an amino sugar residue, a uronic acid residue, or their (Indicates methylated product.)