JPS61186858A - Automatic analyzing instrument - Google Patents

Automatic analyzing instrument

Info

Publication number
JPS61186858A
JPS61186858A JP2750185A JP2750185A JPS61186858A JP S61186858 A JPS61186858 A JP S61186858A JP 2750185 A JP2750185 A JP 2750185A JP 2750185 A JP2750185 A JP 2750185A JP S61186858 A JPS61186858 A JP S61186858A
Authority
JP
Japan
Prior art keywords
sample
samples
automatic
analysis
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2750185A
Other languages
Japanese (ja)
Inventor
Naochika Ise
伊勢　直躬
Toshihiro Akama
赤間　敏寛
Akiteru Yoshioka
吉岡　明昭
Yutaka Dobashi
豊 土橋
Koji Igawa
井川　宏司
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP2750185A priority Critical patent/JPS61186858A/en
Publication of JPS61186858A publication Critical patent/JPS61186858A/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid

Abstract

PURPOSE:To improve processing capacity by determining the respective component contents per unit weight of sales or the respective component contents per unit number of the samples in an arithmetic part from the outputs from an automatic analyzing part using chromatography and automatic weighing part. CONSTITUTION:The total weight of the samples is measured by a balance 24 in the automatic weighing part 11 and the result of weighing is fed to a computer 28. The samples are then supplied to an automatic pulverizing and extracting device 14 of the automatic analyzing part 10 and the extraction liquid thereof is injected into the column 20 of a liquid chromatographic device 13 by which the liquid is automatically analyzed. The results of the analysis are integrated 18 and are outputted to the computer 28. The computer 28 determines the average weight per piece of the sample from the total weight of the samples and the number of the samples. The computer determines the content of each component per piece of the sample from the output from the integrator 18 and the number of the samples for one time, determines each content per unit weight of the samples from the output from the integrator 18 and the total weight of the samples and prints 27 the results of the calcula tion. The respective component contents are thus automatically determined without the tran scription of data and manual calculation, by which the processing capacity is improved and the generation of an error by the manual operation is prevented.

Description

【発明の詳細な説明】 産業上の利用分野 この発明は、クロマトグラフィを利用した自動分析装置
に関する。DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application This invention relates to an automatic analyzer using chromatography.

従来の技術およびその問題点 クロマトグラフィを利用した錠剤などの分析装置として
、液体クロマトグラフィ装置と、試料の自動粉砕抽出装
置と、抽出液の送液ポンプと、抽出液を液体クロマトグ
ラフィ装置に注入する自動注入装置と、液体クロマトグ
ラフィ装置の分析結果を積分する積分計とを備えたもの
が知られている。この装置を使用すれば、試料の粉砕、
抽出、注入、分析および分析結果の積分を自動的に行な
って、分析に使用した全試料中の各成分の含有量を求め
ることができる。試料の分析を行なう場合、全試料中の
各成分の含有量から試料単位重量当りの各成分の含有量
を求める必要があり、従来、これは次のような手作業に
より行なわれている。すなわち、分析に先立ち、天秤を
用いて所要個数の試料の総重量および分析に使用する試
料の重量をそれぞれ秤量し、その結果をデータシートに
記入しておく。Conventional technology and its problems Analyzers for tablets and other products using chromatography include liquid chromatography equipment, automatic sample crushing and extraction equipment, extract liquid delivery pumps, and automatic injection for injecting extract liquid into liquid chromatography equipment. A device is known that includes a device and an integrator that integrates the analysis results of the liquid chromatography device. Using this device, you can crush the sample,
Extraction, injection, analysis, and integration of analysis results can be performed automatically to determine the content of each component in all samples used for analysis. When analyzing a sample, it is necessary to determine the content of each component per unit weight of the sample from the content of each component in the entire sample, and conventionally this has been done manually as follows. That is, prior to analysis, the total weight of the required number of samples and the weight of the sample used for analysis are weighed using a balance, and the results are recorded on a data sheet.

そして、その試料の分析が終了したならば、分析結果と
その前の秤量結果を使用して、手作業により試料単位重
量当りの各成分の含有量を計算する。このように、従来
の分析装置では、分析結果の処理に手作業を必要とする
ため、能率が悪く、しかもデータの書写しや計算の際に
誤りが生じ易い。When the analysis of the sample is completed, the content of each component per unit weight of the sample is manually calculated using the analysis results and the previous weighing results. As described above, conventional analyzers require manual labor to process analysis results, which is inefficient and prone to errors when copying and calculating data.

この発明は、上記の問題を解決し、能率が良くて誤りの
生じにくい自動分析装置を提供することを目的とする。The object of the present invention is to solve the above problems and provide an automatic analyzer that is efficient and less likely to cause errors.

問題点を解決するための手段 この発明による自動分析装置は、試料をクロマトグラフ
ィにより分析して分析結果を出力する自動分析部と、試
料の重量を秤量して秤量結果を出力する自動秤量部と、
分析部および秤量部に接続されこれらの出力に基いて少
なくとも試料単位重量当りの各成分の含有量または少な
くとも試料単位個数当りの各成分の含有量を求める演算
部とを備えているものである。Means for Solving the Problems The automatic analyzer according to the present invention includes: an automatic analysis section that analyzes a sample by chromatography and outputs the analysis result; an automatic weighing section that weighs the sample and outputs the weighing result;
The apparatus is equipped with a calculation section that is connected to the analysis section and the weighing section and calculates the content of each component per unit weight of a sample or at least the content of each component per unit number of samples based on the outputs thereof.

実　　施　　例 図面は、錠剤などの自動分析装置の構成を概略的に示す
。この装置は、試料を液体クロマトグラフィにより分析
して分析結果を出力する自動分析部（１０）と、試料の
重量を秤量して秤量結果を出力する自動秤量部〈１１）
と、分析部（１０）および秤量部（１１）に接続されこ
れらの出力に基いて少なくとも試料単位重量当りの各成
分の含有量または少なくとも試料単位個数当りの各成分
の含有量を求める演算部（１２）とから構成されている
。The drawings schematically show the configuration of an automatic analyzer for tablets, etc. This device includes an automatic analysis section (10) that analyzes a sample by liquid chromatography and outputs the analysis result, and an automatic weighing section (11) that weighs the weight of the sample and outputs the weighing result.
and a calculation section connected to the analysis section (10) and the weighing section (11) and calculating the content of each component per unit weight of the sample or at least the content of each component per unit number of samples based on these outputs. 12).

分析部（１０）は、試料の粉砕、抽出、注入および分析
を自動的に行なうものであり、液体クロマトグラフィ装
置（１３）と、試料の自動粉砕抽出装置（１４）と、こ
れに接続された標準品注入装置（３１）と、フィルタ（
３２）を介して自動粉砕抽出装置（１４）に接続された
抽出液の送液ポンプ（１５）と、抽出液を液体クロマト
グラフィ装置（１３）に注入する自動注入装置（１６）
と、液体クロマトグラフィ装置（１３）の分析結果をク
ロマトグラムの形に記録する記録計（１７）と、液体ク
ロマトグラフィ装置（１３）の分析結果を積分して演算
部（１２）に出力する積分計（１８〉と、これらを制御
する制御装＠（１９）とから構成されている。液体クロ
マトグラフィ装置（１３）は、主に、カラム（２０）、
ポンプ（２１）および検出器（２２）より構成されてい
る。なお、分析部（１０）のこれら各部の構成は公知の
ものであるから、説明を省略する。従来と異なるのは、
積分計（１８）の出力がインタフェース（２３）を介し
て演算部（１２）に送られることである。The analysis section (10) automatically crushes, extracts, injects, and analyzes samples, and includes a liquid chromatography device (13), an automatic sample crushing and extraction device (14), and a standard connected to this. Product injection device (31) and filter (
an extract liquid feeding pump (15) connected to the automatic crushing extraction device (14) via a pulverizer (32); and an automatic injection device (16) for injecting the extract into the liquid chromatography device (13).
, a recorder (17) that records the analysis results of the liquid chromatography device (13) in the form of a chromatogram, and an integrator (17) that integrates the analysis results of the liquid chromatography device (13) and outputs it to the calculation section (12). 18> and a control device @ (19) that controls these.The liquid chromatography device (13) mainly consists of a column (20),
It consists of a pump (21) and a detector (22). Note that the configuration of each of these parts of the analysis section (10) is well known, so a description thereof will be omitted. What is different from the conventional
The output of the integrator (18) is sent to the calculation unit (12) via the interface (23).

秤量部（１１）は、３つの天秤（２４）を備えている。The weighing section (11) includes three balances (24).

そして、各天秤（２４）の出力は、インタフェース（２
５〉を介してプリンタ（２６）および演算部（１２）に
それぞれ送られる。The output of each balance (24) is then sent to the interface (2
5> to the printer (26) and the arithmetic unit (12).

演算部（１２）は、プリンタ（２７〉を備えた小型のコ
ンピュータ（２８）と、これに接続された２台のＣＲＴ
ディスプレイ装［（２９＞とから構成されている。The calculation unit (12) includes a small computer (28) equipped with a printer (27) and two CRTs connected to it.
It consists of a display device (29).

次に、上記の自動分析装置を用いて錠剤の分析を行なう
場合の操作、作動の１例を説明する。Next, an example of operation and operation when analyzing tablets using the above-mentioned automatic analyzer will be explained.

分析に先立ち、演算部（１２）のディスプレイ装置（２
９）のキーボードを使用して、実験番号、測定成分、試
料の虐待条件、１回の分析に使用する試料の個数などの
必要な情報をコンピュータ（２８）に入力して記憶させ
ておく。Prior to analysis, the display device (2) of the calculation section (12)
Using the keyboard in step 9), enter necessary information such as the experiment number, components to be measured, sample abuse conditions, and number of samples used in one analysis into the computer (28) and store them.

一方、１回分の試料を秤量部（１１）の天秤（２４〉に
供給し、その総重量を秤量する。この秤量結果は、天秤
（２４）から演算部（１２）のコンピュータ（２８）に
送られて、これに記憶される。On the other hand, one sample is supplied to the balance (24) of the weighing section (11) and its total weight is weighed.The weighing result is sent from the balance (24) to the computer (28) of the calculation section (12). and stored in this.

１回分の試料の秤量が終了したならば、この試料を全て
分析部（１０）の自動粉砕抽出装置（１４）に供給する
。自動粉砕抽出装置（１４）に供給された試料は自動的
に粉砕、抽出され、抽出液は、送液ポンプ（１５）によ
り、制御装置（１９）を経て自動注入装置（１６）に送
られ、これにより液体クロマトグラフィ装置（１３）の
カラム（２０）に注入される。液体クロマトグラフィ装
＠（１３）は、カラム（２０）に注入された抽出液を自
動的に分析し、その結果をりＯマドグラムの形で記録計
（１７）に記録するとともに積分計（１８）に出力する
。そして、積分計（１８）は、この分析結果を積分し、
その結果を演算部（１２）のコンピュータ（２８）に出
力する。After one sample has been weighed, all the samples are supplied to the automatic crushing and extraction device (14) of the analysis section (10). The sample supplied to the automatic crushing and extracting device (14) is automatically crushed and extracted, and the extract liquid is sent to the automatic injection device (16) via the control device (19) by the liquid sending pump (15). This injects it into the column (20) of the liquid chromatography device (13). The liquid chromatography device @ (13) automatically analyzes the extract injected into the column (20), records the results in the form of a magneticogram on the recorder (17), and also records the results on the integrator (18). Output. Then, the integrator (18) integrates this analysis result,
The result is output to the computer (28) of the calculation section (12).

演算部（１２）のコンピュータ（２８）は、まず、１回
分の試料の総重量と試料の個数から、試料１個の平均重
量を求める。また、分析部（１０）の積分計（１８）の
出力と１回分の試料の個数から、試料１個当りの各成分
の含有量を求めるとともに、積分計（１８）の出力と試
料の総重量から試料単位重坦当りの各成分の含有量を求
める。The computer (28) of the calculation unit (12) first calculates the average weight of one sample from the total weight of one batch of samples and the number of samples. In addition, the content of each component per sample is determined from the output of the integrator (18) of the analysis section (10) and the number of samples for one batch, and the output of the integrator (18) and the total weight of the sample are calculated. Find the content of each component per unit weight of the sample.

そして、これらの演算結果を全てプリンタ（２７）に出
力する。以上で１回の試料の分析が終了する。All of these calculation results are output to the printer (27). This completes one sample analysis.

上記の自動分析装置の場合、標準品の分析を１回行なっ
たのち上記のような試料の分析を２回行ない、２回の分
析結果の平均をとる。そして、このような１回の標準品
の分析と２回の試料の分析を種々の試料について繰返し
て行なう。In the case of the above-mentioned automatic analyzer, the standard product is analyzed once, then the sample is analyzed twice as described above, and the results of the two analyzes are averaged. Then, such one analysis of the standard product and two analyzes of the sample are repeated for various samples.

そして、複数回の標準品の分析結果を平均し、この平均
値に基いて各試料の最終的な分析結果を出す。Then, the results of multiple analyzes of the standard product are averaged, and the final analysis results for each sample are determined based on this average value.

試料の粉砕、抽出は、手操作で行なってもよい。この場
合には、液体りＯマドグラフィ装置（１３）に市販の注
入装置（オートサンプラ）（３０）を接続し、これによ
り抽出液をカラム（２０）に注入する。また、この場合
には、分析に先立ら、天秤（２４）により所要個数の試
料の総重量を秤量してその結果をコンピュータ（２８〉
に記憶させるとともに、このときの試料の個数をディス
プレイ装置（２９）からコンピュータ〈２８）に入力し
て記憶させておく。そして、これらの試料を全て粉砕し
、その全部または一部を使用して分析を行なう。粉砕し
た試料を全部使用するときは、分析結果が前記と同様に
処理されて、試料１個当りの各成分の含有量と試料単位
重量当りの各成分の含有量が求められる。Grinding and extraction of the sample may be performed manually. In this case, a commercially available injection device (autosampler) (30) is connected to the liquid O-magnetography device (13), and the extract is thereby injected into the column (20). In this case, prior to analysis, the total weight of the required number of samples is weighed using a balance (24), and the results are transferred to a computer (28).
At the same time, the number of samples at this time is input from the display device (29) to the computer (28) and stored. Then, all of these samples are pulverized, and all or part of them are used for analysis. When using all of the pulverized samples, the analysis results are processed in the same manner as described above to determine the content of each component per sample and the content of each component per unit weight of the sample.

粉砕した試料の一部だけを使用するときは、天秤（２４
）により分析に使用する試料の重量を別に秤量して、そ
の結果をコンピュータ（２８）に記憶させておく。そし
て、コンピュータ（２８）は、積分計（１８）の出力と
分析に使用した試料の［１から試料単位重量当りの各成
分の含有量を求め、この結果と前記と同様にして求めた
試料１個の平均重量から試料１個当りの各成分の含有量
を求める。When using only a portion of the crushed sample, use a balance (24
) to separately weigh the weight of the sample used for analysis, and store the results in the computer (28). Then, the computer (28) calculates the content of each component per unit weight of the sample from the output of the integrator (18) and [1] of the sample used for analysis, and calculates the content of each component per unit weight of the sample and the sample 1 calculated in the same manner as above. The content of each component per sample is determined from the average weight of each sample.

発明の効果 この発明による自動分析装置は、試料をクロマトグラフ
ィにより分析して分析結果を出力する自動分析部（１０
）と、試料の重量を秤量して秤量結果を出力する自動秤
量部（１１）と、分析部（１０）および秤量部（１１）
に接続されこれらの出力に基いて少なくとも試料単位重
量当りの各成分の含有量または少なくとも試料単位個数
当りの各成分の含有量を求める演算部（１２）とを備え
ているので、データの書写しや手作業による計算を行な
わずに、自動的に試料単位重量当りの各成分の含有量ま
たは試料単位個数当りの各成分の含有量を求めることが
できる。このため、従来のものに比べて、処理能力が数
倍（たとえば３〜５倍）に向上し、誤りも生じにくい。Effects of the Invention The automatic analyzer according to the present invention has an automatic analysis section (10
), an automatic weighing section (11) that weighs the sample and outputs the weighing result, an analysis section (10), and a weighing section (11).
It is equipped with a calculation section (12) which is connected to and calculates at least the content of each component per unit weight of the sample or at least the content of each component per unit number of samples based on these outputs, so it is easy to copy the data. The content of each component per unit weight of a sample or the content of each component per unit number of samples can be automatically determined without manual calculation. Therefore, the processing capacity is improved several times (for example, 3 to 5 times) compared to the conventional one, and errors are less likely to occur.

【図面の簡単な説明】[Brief explanation of drawings]

図面はこの発明の実施例を示す自動分析装置の構成部で
ある。 （１０）・・・自動分析部、（１１）・・・自動秤量部
、（１２）・・・演算部、（１３）・・・液体クロマト
グラフィ装置、（１４〉・・・自動粉砕抽出装置、（１
５）・・・送液ポンプ、（１６）・・・自動注入装置、
（１８）・・・積分計、（１９〉・・・制御装置。 以上 外４名The drawings show the components of an automatic analyzer showing an embodiment of the present invention. (10)...Automatic analysis section, (11)...Automatic weighing section, (12)...Calculation section, (13)...Liquid chromatography device, (14>...Automatic crushing and extraction device, (1
5)...liquid pump, (16)...automatic injection device,
(18)... Integrator, (19>... Control device. 4 people other than the above)

Claims (4)

【特許請求の範囲】[Claims] （１）試料をクロマトグラフィにより分析して分析結果
を出力する自動分析部（１０）と、試料の重量を秤量し
て秤量結果を出力する自動秤量部（１１）と、分析部（
１０）および秤量部（１１）に接続されこれらの出力に
基いて少なくとも試料単位重量当りの各成分の含有量ま
たは少なくとも試料単位個数当りの各成分の含有量を求
める演算部（１２）とを備えている自動分析装置。(1) An automatic analysis section (10) that analyzes a sample by chromatography and outputs the analysis result, an automatic weighing section (11) that weighs the sample and outputs the weighing result, and an analysis section (
10) and a calculation section (12) connected to the weighing section (11) and calculating the content of each component per unit weight of a sample or at least the content of each component per unit number of samples based on these outputs. automated analysis equipment. （２）分析部（１０）が、液体クロマトグラフィにより
試料を分析するものである特許請求の範囲第１項に記載
の自動分析装置。(2) The automatic analyzer according to claim 1, wherein the analysis section (10) analyzes the sample by liquid chromatography. （３）分析部（１０）が、試料の粉砕、抽出、注入およ
び分析を自動的に行なうものである特許請求の範囲第２
項に記載の自動分析装置。(3) The second claim in which the analysis section (10) automatically crushes, extracts, injects and analyzes the sample.
Automatic analyzer as described in Section. （４）分析部（１０）が、液体クロマトグラフィ装置（
１３）と、試料の自動粉砕抽出装置（１４）と、抽出液
の送液ポンプ（１５）と、抽出液を液体クロマトグラフ
ィ装置（１３）に注入する自動注入装置（１６）と、液
体クロマトグラフィ装置（１３）の分析結果を積分して
演算部（１２）に出力する積分計（１８）と、これらを
制御する制御装置（１９）とを備えている特許請求の範
囲第３項に記載の自動分析装置。(4) The analysis section (10) has a liquid chromatography device (
13), an automatic sample pulverization and extraction device (14), an extract liquid sending pump (15), an automatic injection device (16) for injecting the extract into the liquid chromatography device (13), and a liquid chromatography device (13). 13) The automatic analysis according to claim 3, comprising an integrator (18) that integrates the analysis result and outputs it to the calculation unit (12), and a control device (19) that controls these. Device.
JP2750185A 1985-02-13 1985-02-13 Automatic analyzing instrument Pending JPS61186858A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2750185A JPS61186858A (en) 1985-02-13 1985-02-13 Automatic analyzing instrument

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2750185A JPS61186858A (en) 1985-02-13 1985-02-13 Automatic analyzing instrument

Publications (1)

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JPS61186858A true JPS61186858A (en) 1986-08-20

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JP2750185A Pending JPS61186858A (en) 1985-02-13 1985-02-13 Automatic analyzing instrument

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03239951A (en) * 1990-02-19 1991-10-25 Shimadzu Corp Method and apparatus for measuring powder sample by atomic absorption analysis method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03239951A (en) * 1990-02-19 1991-10-25 Shimadzu Corp Method and apparatus for measuring powder sample by atomic absorption analysis method

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