JPS6115650A - Oil-soluble liquid composition - Google Patents

Abstract

PURPOSE:To obtain an oil-soluble liquid composition capable of dissolving a large amount of lecithin in a fish oil, by compounding refined lecithin together with a vegetable oil or tocopherol in a fish oil. CONSTITUTION:Crude lecithin such as soybean lecithin is defatted with acetone or a hydrated acetone having a water-content of 10wt% and extracted with a 1-3C alcohol, and the alcohol is removed from the product to obtain refined lecithin. The objective composition contains (A) 20-70(wt)%, preferably 25-50% refined lecithin, (B) 10-60%, preferably 15-50% fish oil containing eicosapentaenoic acid or docosahexaenoic acid and (C) 20-60%, preferably 20-50% vegetable oil or tocopherol.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] This invention relates to a liquid oil-soluble composition containing lecithin and fish oil and used as a nutritional food.

[Conventional technology]

Lecithin such as soybean lecithin has its physiological activity, pharmacological action,
Because it has surface activity, it is attracting attention as an edible additive. On the other hand, eicosapentaenoic acid (hereinafter referred to as EP
Polyunsaturated fatty acids such as A) and docosahexaenoic acid (hereinafter referred to as DHA) have also attracted attention for their physiological activity, and foods containing lecithin and fish oil containing these have been proposed (for example, in Japanese Patent Application Laid-Open No. 1983-1982). No. 82070).

[Problem that the invention seeks to solve]

However, the solubility of lecithin in fish oil is low;
If a large amount of lecithin is blended with fish oil, a transparent liquid oil-soluble composition cannot be obtained, so there has conventionally been a problem that the proportion of lecithin in the composition can only be blended at 3 to 20% by weight.

[Means for solving problems]

This invention is intended to solve the above problems, and provides a liquid oil-soluble composition that can dissolve a large amount of lecithin in fish oil by blending purified lecithin with vegetable oil or tocopherol in fish oil. .

This invention consists of 20-70% by weight of purified lecithin extracted with 01-C3 alcohol after defatting crude lecithin with a solvent containing acetone, 10-60% by weight of fish oil containing eicosapentaenoic acid or docosahexaenoic acid, and vegetable oil or This is a liquid oil-soluble composition characterized by containing 20 to 60% by weight of tocopherol.

Purified lecithin is an extract obtained by degreasing crude lecithin such as commercially available soybean lecithin with a solvent containing acetone, and then dealcoholizing the soluble portion extracted with 01-C3 alcohol. The acetone-containing solvent may be acetone alone, or an acetone-containing solvent containing 10% by weight or less of water.

In the defatting method, crude lecithin is brought into contact with a solvent containing acetin at 0 to 15[deg.] C., the fat content is solubilized in the solvent, and defatted lecithin is obtained as a residual solid. It is not necessary to completely defatte, and a fat content of 10% by weight or less may remain.

The amount of crude lecithin brought into contact with the solvent containing acetone was 20
~40% by weight is preferred. By performing such degreasing, the next extraction with alcohol becomes possible.

As the alcohol for treating defatted lecithin, methanol, ethanol, n-propatool, 1so-propatool, etc. can be used. Treatment with alcohol involves contacting defatted lecithin with alcohol at room temperature to 50°C,
Soluble components are extracted into alcohol, and the extract is dealcoholized to produce purified lecithin. The amount of defatted lecithin brought into contact with alcohol is preferably 5 to 20% by weight.

By the above extraction, physiologically active substances such as phosphatidylcodylcholine (hereinafter referred to as PC) in defatted lecithin are extracted to the solution side, and components that become insoluble when blended with fish oil remain as solid components. Purified lecithin obtained by dealcoholizing the extract is soluble in fish oil and contains active ingredients in a concentrated state. However, since this purified lecithin is in the form of a hard paste 1 and has a high viscosity, it is difficult to dissolve it directly in fish oil, so it is dissolved in vegetable oil or tocopherol, which will be described later, and then incorporated into fish oil.

The blending ratio of the purified lecithin described above is 20 to 70% by weight, preferably 25 to 50% by weight. If it is less than 20% by weight, the effect of lecithin will be reduced, and if it exceeds 70% by weight, the effect of fish oil will be reduced and the viscosity will become too high, resulting in poor workability.

The fish oil contains EPA or (and) DHA, and particularly preferably contains EPAIO by weight or more and DHA by weight % or more. In addition to the fish oil itself, this fish oil also contains EPA or DHA, which is concentrated by wintering, solvent fractionation, column fractionation, fractional distillation, etc.
Contains highly concentrated oils.

The mixing ratio of fish oil is 10 to 60% by weight, preferably 15 to 60% by weight.
It is 50% by weight. If it is less than 10% by weight, the effect of fish oil will be reduced, and if it exceeds 60% by weight, the effect of lecithin will be reduced.

The vegetable oil is a vegetable liquid oil that preferably contains linoleic acid in an amount of 35% by weight or more, and examples of usable oil include wheat germ oil, olive oil, safflower oil, and soybean oil. Natural tocopherol can be used as tocopherol. Commercially available natural tocopherols usually contain vegetable oil and the parenthesized tocopherols dissolve purified lecithin well, so in this case,
There is no need to add vegetable oil separately. The blending ratio of vegetable oil or tocopherol is 20 to 60% by weight, preferably 2
It is 0 to 50% by weight. If it is less than 20% by weight, lecithin and fish oil cannot be transparently solubilized, and if it exceeds 60% by weight, the effect of the active ingredient will be reduced.

In addition to the above-mentioned essential components, the liquid oil-soluble composition of the present invention may contain up to 40% by weight of other components.

The liquid oil-soluble composition of the present invention is produced by dissolving purified lecithin in vegetable oil or tocopherol, and mixing this with fish oil to uniformly solubilize it. The resulting composition is a transparent liquid, has no turbidity, and has excellent cold resistance, and can be used as a food as it is or in encapsulation.

〔Effect of the invention〕

According to the present invention, since purified lecithin, fish oil, and vegetable oil or tocopherol are blended, a large amount of lecithin is blended with fish oil to solubilize it, thereby obtaining a liquid oil-soluble composition that is transparent, free of turbidity, and highly physiologically active. be able to.

〔Example〕

Experimental examples and examples will be described below.

Within each country, percentages are percentages by weight.

Experimental example Defatted lecithin obtained by defatting commercially available soybean lecithin with acetone (
PC 23%, other ingredients 74% (of which oil and fat 8%)
]) was brought into contact with alcohol and stirred at room temperature, and then
After heating to 40-50°C for 0 min and standing overnight, decantation and centrifugation (3000 rpm)
Table 1 shows the results divided into a soluble part and a precipitated part.

From the results in Table 1, it can be seen that most of the PC was extracted into the soluble part, and the other insoluble components remained in the precipitated part. It is also understood that butanol has a poor yield of soluble parts, and 4 to C3 alcohols, particularly methanol and ethanol, are preferable.

Example: 300ml of acetone for 200g of commercially available soybean lecithin
After repeating the process of contacting 2 and degreasing 4 times,
1800 ml of ethanol for 80 g of defatted lecithin
Extraction was carried out at room temperature by contacting the lecithin with 100% alcohol, and the extract was dealcoholized to obtain purified lecithin.

The above purified lecithin was added to wheat germ oil (containing 50% linoleic acid) or commercially available natural tocopherol (tocopherol 80%).
%, containing 20% vegetable oil), and this was dissolved in sardine oil (containing 20% vegetable oil).
A liquid oil-soluble composition was prepared by blending the composition with 25% EPA, 12% DHA, and 0.8% linoleic acid) or its concentrated oil (containing 2S% EPA, 13% DHA, and 1% linoleic acid).

Table 2 shows the components of the obtained composition and its appearance after being left at 20° C. for one month.

The viscosity of the composition of N[13 in Table 2 is 190 cPs at 60°C
, No., and No. 4 have a viscosity of 104 cPs, which is suitable for encapsulation. These compositions were encapsulated in 300 mg opal-type gelatin capsules and placed in a 50 mQ amber bottle.
Add 0 grains at a time with desiccant and heat at -5°C, O°C, 5°C.
The capsules were stored at 10°C, 20°C, and 40°C for 2 months, but the transparency of the capsules remained constant and the peroxide value of the composition was 3.
Changes in the content of EPA, linoleic acid, and tocopherol were within the measurement error range, ranging from 2 to 4.1 meq/kg.

(Overview 1) From the above results, Nα1-7 using purified lecithin
Both maintain a transparent appearance, but crude lecithin (Nα
8), the one using defatted lecithin (Nα9), and the one using no vegetable oil (Nα10), it can be seen that a transparent liquid oil-soluble composition cannot be obtained.

Agent: Patent Attorney Yanagi Hara Compiled Procedures/Written Amendment 1, Indication of the Case: Patent Application No. 136981 of 1982, 2, Name of the Invention: Liquid Oil-Soluble Composition 3, Relationship with the Person Making the Amendment: Address of Patent Applicant: Tokyo 1-10-1 Yurakucho, Chiyoda-ku, Tokyo Name (434) Nippon Oil & Fats Co., Ltd. Representative Teruji Ogawa 4, Agent Address: 105 Phone: 436-470
0 Address 3-15-8-6 Nishi-Shinbashi, Minato-ku, Tokyo Number of inventions increased by amendment 07 Target of amendment Column 88 for detailed explanation of the invention in the specification Contents of the amendment (1) Specification No. 4 In the fifth line from the bottom of the page, "zircozylcholine" is corrected to "zircoline j.

(2) On page 5, line 3, "difficult" is corrected to "difficult in terms of workability and requires a long time."

(3) On page 5, line 12, "this" is corrected to "used here."

Claims (4)

[Claims] (1) After defatting crude lecithin with a solvent containing acetone, 20 to 70% by weight of purified lecithin extracted with C_1 to C_3 alcohol, 10 to 60% by weight of fish oil containing eicosapentaenoic acid or docosahexaenoic acid, and vegetable oil or A liquid oil-soluble composition containing 20 to 60% by weight of tocopherol. (2) The liquid oil-soluble composition according to claim 1, wherein the acetone-containing solvent is acetone or an acetone water-containing solvent. (3) The liquid oil-soluble composition according to claim 1 or 2, wherein the crude lecithin is soybean lecithin. (4) The liquid oil-soluble composition according to any one of claims 1 to 3, wherein the purified lecithin is obtained by dealcoholizing an extract.