JPS61112026A - Carcinostatic agent - Google Patents

Abstract

PURPOSE:NINJIN-TO (a Chinese herb tea) composed of KANZO (root of Glycyrryhiza glabra), SHOKYO (rhizome of Zingiber officinale, JUTSU (rhizome of Atractylodes lancea) and NINJIN (rhizome of Panax ginseng) is used as a carcinostatic agent free from side effects. CONSTITUTION:NINJIN-TO is used as a carcinostatic agent. It has been found that NINJIN-TO used as a Chinese herb tea for the diseases such as acute or chronic digestive disorder has carcinostatic effect. For example, 3g of KANZO, 3g of SHOKYO, 3g of JUTSU and 3g of NINJIN are decocted with 600ccof water according to the traditional method to obtain 350cc of decoct, the dregs are removed, and the liquid is administered as a carcinostatic agent 3 times a day, or the liquid is used as a Chinese extract drug. The agent increases the survival ratio of ICR male mouse of Ehrlich ascites carcinoma. Furthermore, it has extremely low toxicity and high safety.

Description

[Detailed description of the invention] Industrial applications The present invention relates to anticancer agents.

Conventional technology The pharmacological mechanisms of the anticancer drugs currently in use are clear, and many of them have excellent anticancer effects, but on the other hand, they often act on normal cells and cause fatal side effects. . Therefore, the development of anticancer agents with fewer side effects is desired.

Problems to be Solved by the Invention The present invention provides an anticancer agent with few side effects.

Means to Solve the Problem The present inventors conducted research on the anticancer effects of various Chinese herbal formulas, and found that a Chinese herbal formula consisting of U' grass, Seikin, and AC1 ginseng, that is, ninjinto, has an anticancer effect. I discovered something. The present invention is based on this knowledge, and the present invention includes an anticancer agent comprising ninjinto. Ninjinto's constituent herbal medicines, amounts, extraction methods, etc. are described in classic Chinese herbal medicine prescriptions (Shokan Ron, Kinkan Yoro), and it is said that it is used for diseases such as acute and chronic gastrointestinal disorders, and that it has anticancer effects. There is something that was completely unknown before.

The carrot field follows the classics, 3 g of licorice, 3 g of fresh 'J', r
Boil 3g of L and 3g of carrots in 600cc of water to make 350cc.
It is also possible to remove the dregs and take it as an anti-cancer drug in three doses, but it is easier to take (()). For example, 3 parts by weight of licorice, 2 to 3 parts by weight of licorice, 1 part of 3 parts of ginseng, and 3 parts of ginseng are heated and extracted with 10 times the amount of water. ,
After passing through the filtration, it is dried to obtain a powdered ninjinto dried extract, which is an anticancer agent.Suitable excipients, adjuvants, etc. used in the formulation of Tsuwari are added to this to form a formulation l! ! Sozo') Powder according to 7Ij method,
It can be made into granules, tablets, capsules, etc.

A specific example of the production of the anticancer agent of the present invention is as follows.Specific Example 1 A mixed herbal medicine containing 3g of Tj et al. l Add 20 mQ of water and make 1
Extraction was carried out by heating at 100°C for an hour, the resulting extract was filtered, and then spray-tried to obtain 12 g of dry extract powder.
ji, r Two Inventions J) Effect The anticancer effect of the anticancer agent of the present invention will be explained by giving experimental examples.Experimental Example Animal used: ICR strain male mice.

■Tumor wound Ha: Tumors were passaged in ICR mice using Ehrlich ascites cancer cells (1+, i4+), ■Experimental method Ehrlich ascites cancer cells (hereinafter referred to as A C Tumor cells were collected from mice 8 days after transplantation with 2 × 10 cells (10.2 mρ/).
After 24 hours, the anticancer agent of the present invention obtained in Example 1 was added to mice at doses of +00.200 and 300 mg/kg.
The drug was dissolved in physiological saline and administered intraperitoneally once a day for 10 days at a dose of 100 mg. Conotrol was administered intraperitoneally at 0.25 mQ/kg per day in physiological saline that does not contain the anticancer drug of the present invention.C) The results are shown in Table 1.

Table 1: Physiology ['' Numbers below the average value are 1〒・
V - Indicates error.

As is clear from Table 1, the anticancer agent of the present invention increases the survival rate of mice, demonstrating its anticancer effect.

Next, we conducted an acute Af test on oral administration of the anticancer agent of the present invention in ddY type 111 mice and RiceF- (Wist) mice.
ar) Conducted using pheasant rats -) However, specific example 1
The anticancer agent of the present invention obtained by
Oral administration did not cause any deaths. 1'.

As described above, the anticancer agent of the present invention has extremely low flf and high safety. In addition, considering that ninjinto has been used as a herbal straw from ancient times to the present,
It is found that there are fewer side effects. Experimental data and acute in the present invention? ! f PJ: Exam J) Utilization 9・Thinking about,
Behavioral dosage of the anticancer agent of the present invention: Depending on age, body weight, and degree of disease, the usual adult dose of dry extract powder is 05 to 5 g. It is considered appropriate to take 5 doses three times a day, depending on the situation.

Next, examples will be shown and specifically explained, but the present invention is not limited thereto.

Example I 100 g of the drug produced according to Example 1 of Section E was added to 18 g of lactose.
9g and macanenium stearate tg, and this mixture was compressed into tablets with a tablet machine with a diameter of 20 mm.
Surasoku tablets weighing about 2.3 g are made, crushed in an alternator, sized, and sieved to obtain good granules of 20 to 50 mesh particles.

For the second granule, the dosage is 0.5 to 45 g depending on the symptoms.
(017~ as the dry extract powder weight of the anticancer agent of the present invention)
(equivalent to 155g) three times a day.

Example 2 100 g of the drug produced according to the above specific example 1 was mixed with 120 g of microcrystalline cell mouth and 5 ml of Macnenoum stearate.
This mixture was compressed into tablets using a single punching block to produce tablets with a diameter of 71iI11 and a weight of 225 mg. One tablet of the present invention contains 100 mg of the dried Jill cancer agent powder of the present invention. Take 2 to 16 tablets of the same amount three times a day depending on your symptoms.

Example 3 250 mg of the drug prepared according to the above-mentioned Example 1 was filled into hard capsules. This capsule can be taken in two doses depending on the symptoms.
~20 capsules divided into 1111 times a day.

Claims (1)

[Claims] Anticancer drug made from ninjinto