JPS61107935A - Enzyme granule and its coloration - Google Patents

Abstract

PURPOSE:To enable beautiful white coating without prohibiting the stability of enzyme, by adhering a fine powdery whitening agent and a fine powdery whitening aid to an enzyme granule in two layers or adhering a mixture of both of them thereto in one powdery layer. CONSTITUTION:An enzyme granule is at first coated with a fine powdery whitening aid being a whitening agent and subsequently coated with a fine powdery whitening agent such as titanium oxide. Or, the fine powdery whitening aid and a fine powdery whitening agent are mixed and beautiful white coating is applied to the enzyme granule by using the resulting mixture. As the whitening agent, TiO2 is used and, as the whitening aid, CaCO3, CaSO4, MgO, SiO2 or Al2O3 are used and both of them are used in a wt. ratio of about 5-70% and the total amount of both of them to the enzyme granule is about 2-20wt%. The particle size of the whitening agent is about 0.1-6.0mum and that of the whitening aid is about 0.03-5.0mum.

Description

[Detailed Description of the Invention] ITJl relates to a method for coloring enzyme granules.

6) It has been noted that excellent products can be obtained under mild conditions by using near-enzymes, and attention has been drawn from various fields. Also, by separating enzymes from the culture solution of whole organisms,
A) New substances can be obtained by performing various enzymatic reactions using enzymes, or excellent results can be obtained by using enzymes in place of the methods used up until now. The importance of enzymatic reactions has come to be recognized.

Currently, in addition to the various uses of enzymes, enzymes are also used in granular form for various purposes. Enzymes are known to be used in this field by granulating enzymes and using them as medicines, mixing them into detergents as so-called enzyme-containing detergents, and applying various enzymes to the food industry.

Many enzymes are active at relatively low temperatures and are sensitive to temperature, so they are often used at temperatures below 50''C.

Therefore, high temperatures must be avoided during production or use of the enzyme, and the granulation techniques used include the transfer granulation method, compression molding method, flow method, and spray drying method. Enzyme particles obtained in this way are used in any size between granules and micropellets, but in order to be used in combination with other agents, the size of the enzyme particles should be as uniform as possible. It is preferable to obtain something.

In other words, the enzyme granules obtained by granulation in this manner may be used directly or mixed with other granules, but they may be used without separation from other ingredients. It is necessary.

On the other hand, enzymes obtained by conventional manufacturing methods are usually light brown in color, and therefore, even if efforts are made to dilute or increase the amount of particles obtained by granulation using a white filler, there is a limit to their effectiveness. Therefore, whitening cannot be achieved, especially when enzymes are used in detergents, since the detergent grains themselves are white, the enzyme grains must also be colorless or colored in a beautiful way. However, as it is used for laundry, it is not desirable because it reduces its commercial value, and it also costs a lot because it costs a lot.

It is necessary to obtain beautiful enzyme granules at low cost.

Here, the present inventors have discovered that this problem can be solved by coating enzyme granules, particularly micropellets or granules, with a whitening agent.

That is, the inventors first coated the enzyme granules with a whitening agent as a whitening agent, and then coated titanium oxide thereon.
Alternatively, it has been found that a beautiful white coating can be applied to M;Ic granules by mixing the two components.

Since these surface layers are applied to enzyme granules, they do not impede the stability of the enzyme, and must disintegrate quickly in the stomach for use in medicines, etc., and are suitable for use in detergents, etc. In order to be used for this purpose, it is necessary to have the disintegrability to quickly disintegrate in water, and the granules obtained by coating must also have good fluidity and have a coating strength that prevents pulverization. etc. are required.

Therefore, TlO2 is used as a whitening agent that satisfies these requirements, and CaCOa, (:aSOa (including those with water of crystallization), MgO, 5iOq, Al2 are used as whitening auxiliaries.
Using O3 etc., the weight ratio of whitening agent and whitening aid is 5 to 70%.
The total amount of both to the enzyme granules in the ratio of 2 to 203]f
The amount is %. Regarding the weight ratio of the white agent and the white auxiliary agent, if the white auxiliary agent is less than 5%, the economic effect of the coloring agent is low, and the white auxiliary agent 7
If the amount of a colorant exceeds 5%, the whitening effect of the colorant is low, and the range of 5 to 70% is the suitable range for obtaining the effect of adding the whitening aid. The degree of whiteness is low, and if it exceeds 20%, the effect of increasing the amount of colorant relative to the whitening agent is low, and the appropriate amount for obtaining the whitening effect of the colorant is 2 to 20%.
It is.

The particle size of the whitening agent is 0.1 to 8. Qμ, preferably 0.5~
1. For θ, the particle size of the white auxiliary agent is 0.03 to 5.0 p, preferably 0.05 to 1.0 l.

As a binder, commonly used water-soluble resinous substances 1 such as pVA, f-lyethylene glycol, CMC, cellulose derivatives such as methylcellulose and hydroquinepropylcellulose, starches such as sodium alkinate and dextrin, and polypropylene glycol are used as binders. , a copolymer of polypropylene glycol and polyethylene/glycol, coconut oil fatty acid monoethanolamide, lauryl distillate monoethanolamide, stearic acid monoethanolamide, etc. are used. Among these, C as a cellulose conductor
MC, wax and 17 polyethylene/glycol 150
0.4000 and 8000 are particularly preferred.

1. Waxes 1 such as PVA as a binder.

Cellulose derivatives such as CMC, methylcellulose, hydroxypropylcellulose, sodium alginate, starch such as dextrin, or a mixture thereof in a range of 1 to 2% by weight, polyethylene brecol, polypropylene glycol, polypropylene As an aqueous solution containing one or a mixture of glycol and polyethylene, a copolymer of glycol, coconut oil fatty acid monoethanolamide, lauric acid monoethanolamide, stearic acid monoethanol 7mide, etc. in a range of 1 to 20% by weight. used. Aqueous solutions in the range of 1-2% violet of cellulose derivatives and/or starches, or molten waxes may also be used. When the concentration is lower than the applicable range, the tackiness of the binder is low, and when the temperature is higher than the applicable range, the viscosity at room temperature becomes extremely high, making it difficult to handle the aqueous binder solution.

The use of molten wax has the characteristics that the operation time is short because it does not contain water, and there is no need to use water, and this method is particularly preferred as a coating method.

For coating the enzyme granules used in the present invention, it is also preferable to spray a coating liquid using a granulator that is normally used for coating granules; A stirrer granulator that has been used for this purpose is used. It is also possible to use a fluidized bed granulator. Coating is carried out at a temperature range of 35-90°C. IJt
In the granulator, an aqueous binder solution is used and the granule temperature is in the range of 35 to 60°C to prevent deterioration of the enzyme, and in the granulator, molten wax is used and coating is performed within the range of wax melting point ±10°C. be exposed.

The present invention will be explained below with reference to Examples.

Example 1 1.2 g+/m ) was coated, and Tie,
(particle size: 0.05 to 1.0 g) and a whitening aid were dispersed to form a powder, and the wax was cooled and solidified in a fluidized bed.

CaCO as brightening aid (a degree o, os ~0.ip)
A whiteness test was conducted using 3° Ca5O.2H20, N112S04 and the following results were obtained.

The powdering temperature was 62°C, the molten wax addition rate was 3.8%, and the whiteness Lm was measured with a colorimeter.

The stirring granulator used was model LMA-10 manufactured by Nara Kikai.

Example 2 was coated on granulated M elementary particles (particle size: 0.3 to 1.2 m/w), then a whitening aid was powdered, and TiO(
Particle size J-J~1.0L) was powdered.

Olli As a brightening aid (0.05 to 0.1 degrees A), gQ.

Using CaSO4.2H20 and Na2SO4, a whiteness test was conducted after cooling and consolidating the wax, and the following results were obtained.

Powdering was carried out at a temperature of 43°C and a molten wax addition rate of 3.7%.
Enzyme granules (particle size 0.3 to 1.2 m) are made by granulating an aqueous suspension in which i02 (particle size 0.3 to 0, sp>) and a white auxiliary agent (particle size 0.03 to 0.1 m) are dispersed. /m), and after drying, a white color test was conducted.

The composition of the spray liquid is as follows.

CMC (binder) 0.7 parts Polyethylene glycol + 500 (binder) 7.0 parts Whitening powder (mixture of TiO and whitening aid) 20.0
Department water
72.3 parts powder was added at a temperature of 46°C. Example 4 White auxiliary agent (
Spray an aqueous suspension in which particles (particle size 0.03 to 0.1 μ) are dispersed into granulated enzyme granules (particle size 0.3 to 1.2 m/m).
Then, a suspension 1 IpJ solution in which TlO2 (particle size: 0.3 to 0.5 mm) was further dispersed was sprayed onto the granules, and after drying, a white color test was conducted.

1st stage binder 0.5z Polyviny) It7) Lt': x-JL/
(PVA) 9.3% polyethylene glycol 40
0015, Ox white auxiliary 74.7% water 2nd stage binder 0.5$ and 16'P Sibu a pilse with 6-su(HPC
) 6.0 Abuse Polyethylene Glycol 400018・
O-Kan T' 02 75.5 with water powder is temperature 43℃ Procedural amendment (voluntary) January 17, 1980

Claims (1)

[Scope of Claims] (1) A method for coloring enzyme granules, which comprises applying a fine powder whitening agent and a fine powder whitening auxiliary agent in two layers or a mixture of both in one layer to enzyme granules. (2) Claim 1 in which the whitening agent is titanium dioxide
Enzyme granule coloring method described in section. (3) The enzyme granule coloring method according to claim 1, wherein the white auxiliary agent is calcium carbonate, magnesium oxide, or silicon oxide. (4) Any one of claims 1 to 3, in which a mixture of a whitening agent and a whitening aid in a weight ratio of 5 to 70% by weight is applied to the enzyme granules in an amount of 2 to 20% by weight. Enzyme granule coloring method described in Section. (5) The enzyme granule coloring method according to any one of claims 1 to 4, wherein the binder used for dusting is a liquid substance consisting of a waxy substance and/or water. (6) The enzyme granule coloring method according to any one of claims 1 to 5, wherein the powdering is carried out using a fluidized bed method or an agitating granulator. (7) The enzyme granule coloring method according to claim 6, wherein the dusting temperature is in the range of 35°C to 90°C. (8) The enzyme granule coloring method according to claims 1 to 4, wherein the whitening agent has a particle size of 0.1 to 6μ and the whitening aid has a particle size of 0.03 to 5μ. (3) Enzyme granules colored by the method described in any one of claims 1 to 8.