JPS609691B2 - Pack composition with striped tubes - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a pack composition in a striped tube, more specifically, a medicinal agent-containing component and a main base component having specific compositions and physical properties are placed in the shoulder and body of the striped tube, respectively. The present invention relates to a facial pack composition which is filled with a medicinal agent, which is stable, and which extrudes the medicinal agent-containing component in a striped manner on the main base component at the time of use.

The facial pack composition nourishes the skin, tightens the skin by giving it a feeling of tension when it is dry, and temporarily blocks the skin from the outside air, stimulating the skin's renewal and at the same time removing dirt from the skin. It has the effect of removing substances and excess fat, and its main base ingredients include a film-forming agent such as polyvinyl alcohol, a solvent such as ethanol, water, and if necessary, an inorganic powder, a skin nutrient, and a heat-retaining agent. Peel-oH type pack compositions, inorganic powders such as titanium oxide and besotonite, dispersants such as carboxymethyl cellulose sodium, water, and main base ingredients such as skin nutrients and heat insulating agents as necessary. Mud (mud)
There are pack-type pack compositions. These pack compositions are blended with medicinal agents such as vitamins and enzymes in order to enhance their effects. However, when these medicinal agents are directly incorporated into the pack composition, they are added to the main base of the pack composition. The solvent and highly polar components (hereinafter referred to as polar components)
In many cases, the activity decreases due to reaction with other substances, resulting in instability.

Therefore, by micro-encapsulating medicinal agents, for example,
When blending vitamin C as a medicinal agent, methods such as stabilizing it by esterification, or packaging the medicinal agent and the main base component separately and making them into a product by mixing them at the time of use are adopted. However, these methods have problems with dissolution from microcapsules, insufficient stabilization of the medicinal agent, and economical disadvantages due to separate packaging.

While conducting various studies in order to obtain a pack composition in which a medicinal agent is stably blended without such problems, the present inventors learned that the purpose could be achieved by using a striped tube, and thus completed the present invention. It was it.

In other words, striped tubes have traditionally been used in toothpastes, etc., mainly to improve the visual appearance during use [for example, in modern packaging (Mo
demPackagng) February 1961 issue, 98-1
00 and U.S. Pat. No. 2,918,199], there are various types, but basically, as shown in the attached striped tube partial vertical cross-sectional view, a hollow tube with a tube capital 1' and a hole 2 is used. 3 is inserted into the tube shoulder tube 41.The A component and the B component are filled in the body section 5 in a separate state.When the contents are pushed out, the B component is inserted into the hollow tube. At the same time, the A component is extruded through the hole 2 onto the B component in a striped manner. By changing the color tone of the A component and B component, the striped contents can be It is something that is pushed out.

Therefore, even if the medicinal agent is unstable when directly added to the composition, it can change the physical properties of the composition of ingredients A and B.
As component A, we use a system that contains little or no Hitake component that stably holds the medicinal agent and prevents the diffusion and mixing of the medicinal agent and component B. If component B is used as the main base component with a large amount, a composition containing a stable medicinal agent can be obtained.However, since component A is extruded from the striped tube in a striped manner on component B, is the size of the hole in the hollow tube, A
In addition to the quantitative ratio of both components A and B, the compatibility of both components is an important factor. There is a problem as to whether striped tubes can be used if the physical properties of both components are changed in order to stabilize the medicinal agent.

As a result of extensive research, the inventors have determined that the A component is an oil-based paste or W/O type emulsion cream, and the B component is an aqueous paste containing inorganic powder.The A component is a medicinal agent. We also found that by blending the main base component as component B, it was possible to obtain a pack composition that stably contained a medicinal agent that could be extruded from a striped tube in the form of cotton. The inorganic powder that exists in an undissolved dispersed state exhibits an adsorption effect on component A due to its adhesion and adsorption power due to its porosity, making it possible to extrude component A in a striped manner. This is thought to be due to the fact that the reaction between medicinal agents and polar ingredients can be minimized by creating an emulsified cream.The present invention was made based on this knowledge, and the present invention is based on this knowledge. Filling the shoulder and both ears of the tube with an aqueous paste-like main base component containing a medicinal agent-containing component and an inorganic powder in the form of a paste or cream based on a W/O type emulsion. The present invention provides a pack composition in a striped tube characterized by:

In the pack composition of the present invention, the medicinal agent can be separated from the main base component, especially its polar component, and incorporated into a stable system, so that the medicinal agent reacts with the polar component and its activity is increased. There are fewer problems such as deterioration, and there are no economical disadvantages associated with separate packaging.Furthermore, by incorporating oil-based ingredients, the smoothness and moisturizing of the skin are enhanced, and it is especially effective for beer-based products. The pain when removing the film, which is a problem with off-type packs, can be significantly reduced, and the film is also easy to remove, and when used,
The highly active medicinal agent-containing ingredients are extruded out in a striped pattern on top of the main base ingredient, improving the sensation and fully demonstrating the medicinal effect. It has advantages over pot packs. However,
The medicinal agents used in the pack composition of the present invention include vitamins, especially vitamin C, enzymes, especially protease,
Examples include lysozyme, which is incorporated into the following oil-based paste or W/O emulsion cream depending on its solubility or dispersibility.

○｝Oil-based paste Vegetable or animal fats and oils such as olive oil, castor oil, sesame oil, coconut oil, cottonseed oil, and lanolin; Waxes such as beeswax; Hydrocarbons such as liquid paraffin, petrolatum, squalene, and squalane Oils; ester oils such as isopropyl myristate, isopropyl no V remitate, inpropyl lanolate, acetylated lanolin, parserine oil; oleyl alcohol, with side chains such as 2-ethyl hexadecyl alcohol; Higher alcohols; mixtures of one or more oil components that are pasty to liquid at room temperature, such as silicone oil, and extruded to form a suitable base.

For example, a mixture of 20 to 60% liquid paraffin (weight %, same hereinafter), 5 to 40% lanolin, 1 to 10% olive oil, and 20 to 50% petrolatum is exemplified. ■W/O
In general, it is necessary to minimize the amount of substances such as water, lower alcohols, acids, bases, inorganic salts, and anionic or cationic surfactants in emulsion-based creams.
．． 5-5%, polyoxyethylene nonionic surfactant 1-5%, fatty acid ester nonionic surfactant 1-5
%, fatty acid ester 1-10%, higher alcohol 3-2
0%, hydrocarbon oil 20~40%, polyhydric alcohol 5~
20% and water 10-30%; alternatively, wax 0.5-10%, polyoxyethylene nonionic surfactant 1-5%, fatty acid ester nonionic surfactant 1-5%, fatty acid Ester 1~10%, fatty acid 1~
10%, higher alcohol 3-20%, hydrocarbon oil 20%
~40%, polyhydric alcohol 1-20% and water 10-3
An example is a system consisting of 0%.

If these medicinal agent-containing ingredients are mixed with a coloring agent such as ordinary dye, the medicinal agent-containing ingredients will stand out in stripes when the contents of the tube are extruded, which is aesthetically pleasing. may be blended.

Note that ○/W type emulsion creams with certain compositions can be extruded into stripes and can be used as medicinal agent-containing ingredients, but oil-based pastes or W/O type emulsion creams have a certain composition. Emulsified creams are better. The main base component of the present invention may be an aqueous paste containing inorganic powder and commonly used in bag compositions, and can be in either beer-off type or drop pack type. Inorganic powders used include titanium oxide, talc,
Zinc white, bentonite, calcium phosphate, calcium carbonate, magnesium carbonate, sodium sulfate, metal soap powder, etc. are included, and one or more of these can be used in an amount of 1 to 20% of the ingredients in the beer-off type. In the case of a drop pack type, it is preferably blended in an amount of 1 to 60%.
Note that when no inorganic powder is blended into the main base component, component A is extruded intermittently in the form of flocs, making it difficult to always extrude component A at a constant ratio. The striped tube used in the present invention is not particularly limited, and may be any commonly used striped tube. To produce the striped tube pack composition of the present invention, the medicinal agent-containing component and the main base component are are prepared separately, first filling the shoulder of the tube with the drug-containing component and then filling the chest with the main base component.

The filling ratio of both components depends on the size of the tube and the size of the hole in the hollow tube, but in order to push out the contents in a striped manner to the end, the weight ratio of the medicinal agent-containing component to the main base component should be 1. :5～
It is preferable to set it as the range of 1:30. As mentioned above,
The striped tube pack composition of the present invention allows the medicinal agent to be separated from the main base component and blended into a stable system, so that the medicinal agent does not react with the main base component and its activity decreases. There are fewer problems and there are no economical disadvantages associated with separate packaging.Furthermore, the combination of oil-based ingredients enhances the smoothness and moisturizing of the skin, making it especially suitable for beer-off type products. The pain when removing the film, which is a problem with packs, can be significantly reduced, the film is also easy to remove, and when used, the highly active medicinal agent is extruded onto the main base component in a cotton-like manner. It is extremely superior to conventional pack compositions, as it not only improves aesthetic appearance but also fully exhibits its medicinal effects and stimulates skin regeneration.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 Beer-off type pack composition Composition of ingredients containing medicinal agents % Liquid paraffin 47 Lanolin
10 olive oil
3 Vaseline
30 vitamin C
IO main base component composition % polyvinyl alcohol 7-power - Beau Paul 93
4 (New water-based synthetic polymer compound manufactured by B.F. Juodrich Chemical Co., USA) 1 Polyethylene glycol Titanium pentoxide
3-ethanol
15 water
69 According to these compositions, an oil-based paste-like medicinal agent-containing component and an aqueous-based paste-like main base component were prepared by a conventional method, and each was applied to the shoulder and body of the striped tube.
A pack composition in a striped tube was obtained by filling the composition in a weight ratio of medicinal agent-containing component to main base component of 1:9.

This pack composition was left at 40 oo to test the change in vitamin C over time. The test was conducted by adding vitamin CI% to a composition having the same composition as the main base ingredient as a control, and measuring the residual amount of vitamin C over each day using the iodine titration method (1st edition Cosmetic Raw Materials Standards, Supplement 0 Commentary 6 to The vitamin C content immediately after manufacture was determined by the modified method of Yakuji Nippo (Page 9, Yakuji Nippo).
This was done by calculating the residual rate (%) when it was set to 0%. The results are as follows. 400015 days
400,030 days Example 1 composition 91% 82% Control composition 55% 21% These results show that vitamin C is extremely stably blended in the striped tube pack composition of the present invention.

Example 2 Dropack type composition Composition of medicinal agent-containing ingredients % Aluminum stearate 1 Lanolitho
3 Polyoxyethylene sorbitan monostearate/Sorbitan monostearate 1 Cetanol 5 Liquid paraffin 34 Squalane
5 Sorbitol
5 polyethylene glycol 1000
Lysozyme trichloride 10 water
32 Main base component composition % Calcium hydrogen phosphate 35 Sodium carboxymethyl cellulose 10 Glycerin
10 water
45 According to these compositions, a W/O emulsion cream-like medicinal agent-containing component and an aqueous paste-like main base component were adjusted by a conventional method, and the medicinal agent-containing component was added to the shoulder and body of the striped tube, respectively. : Weight ratio of main base component 1:
9 to obtain a pack composition in a striped tube.

This pack composition was left at 40°C to test for daily changes in lysozyme chloride activity.

In the test, 2% lysozyme chloride was added to a composition having the same composition as the main base component as a control, and the enzyme activity over each day was measured using Micrococcus lysodictus (M.
Smoleri's method of measuring bacteriolytic activity against L$odejktic Satoshi) by absorbance
- Sunare sell, J. bact, volume 63, page 665 (
(1952)] was modified and measured, and the activity immediately after production was 1
This was done by calculating the residual activity rate (%) when it is set to 00%. The results are as follows. 40q015
Days: 400,030 days Example 2 Composition: 95% 87% Control Composition: 62% 34% From these results, it can be seen that lysozyme chloride is extremely stably blended in the striped tube pack composition of the present invention.

Example 3 Beer off-type pack composition Containing medicinal agent Composition % Beeswax
2 Polyoxyethylene sorbitan monooleate 1 Sorbitan monooleate
1 Stearic acid 1 Lanolin alcohol 5 Lanolin
2cetanol
5 Liquid paraffin 34
glycerin 3 vitamin C
20 water
26 Main base component composition
% polyvinyl alcohol
5 hydroxyethyl cellulose 0
．． 5 Pentonite 1 Calcium carbonate 1 Talc
2 Ethanol
10 water
80.5 According to these compositions, prepare a W/O emulsion cream-like medicinal agent-containing component and an aqueous paste-like main base component by a conventional method, and apply the medicinal agent to the shoulder and body of the striped tube, respectively. Ingredients: Weight ratio of main base component: 1
:9 to obtain a pack composition in a striped tube.

This pack composition was left at 40 qo, and vitamin CI% was added to a composition having the same composition as the main base component * as a control, and the change over time of vitamin C was tested in the same manner as in Example 1. did.

The results are as follows. 400015 days 400
030 days Example 3 Composition 89% 75% Control composition 51% 19% These results show that vitamin C is extremely stably blended in the striped tube pack composition of the present invention.

The following table shows the beer off-type pack composition (1) obtained in Example 1 and the commercially available beer off-type pack composition (0
) shows the results of a comparative evaluation of the usability using a panel test.

The panel test consisted of 50 female subjects (20-40 years old).
I went there.

Each subject first used one composition for two weeks, then stopped using the pack for one week, then used the other composition for two weeks, and evaluated each composition for each item in the table. . The average number of times one composition was used was 3.5 times, and each time the composition was applied to the face after washing the face, left for 10 to 18 minutes, and then removed after drying.

The evaluation for each item is: Good: 32 points, Fair: 1 point, Average:
The results were evaluated based on a score of 0 points, slightly poor: -1 point, and poor: -2 points, and the average score calculated by dividing the total score of each item by the number of subjects was compared. As is clear from these results, compared to conventional pack compositions, the pack composition of the present invention enhances the smoothness and moisturizing of the skin, causes significantly less pain when removing the film, and makes the film easier to remove. It turns out it's easy.

[Brief explanation of the drawing]

The drawing is a partial longitudinal sectional view of a striped tube. The symbols in the figure mean the following. 1: Tube neck, 2: Hole, 3: Hollow tube, 4: Tube shoulder, 5: Tube neck.

Claims (1)

[Scope of Claims] 1. In the pack composition, an oil-based or W/O type emulsion-based paste or cream-like medicinal agent-containing component and an aqueous-based paste-like main base component containing an inorganic powder,
A pack composition containing striped tubes, characterized in that the shoulder and body portions of the tubes are filled, respectively. 2 The weight ratio of the medicinal agent-containing component: the main base component is 1:5 to 1
:30. 3. The composition according to claim 1, wherein the medicinal agent-containing component is an oil-based paste. 4 Claim 3, which is a peel-off type composition
composition of the term. 5. The composition according to claim 4, wherein the main base component contains 1 to 20% by weight of inorganic powder. 6. The composition according to claim 3, which is a drop pack type composition. 7. The composition according to claim 6, wherein the main base component contains 1 to 60% by weight of inorganic powder. 8. The composition according to claim 1, wherein the medicinal agent-containing component is a W/O emulsion cream. 9 Claim 8, which is a peel-off type composition
composition of the term. 10. The composition of claim 9, wherein the main base component contains 1 to 20% by weight of inorganic powder. 11 Claim 8 which is a drop pack type composition
composition of the term. 12. The composition of claim 11, wherein the main base component contains 1 to 60% by weight of inorganic powder.