JPS6092846A - Packaging material - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides packaging materials, particularly for men) -A/ (analgesic, anti-inflammatory,
(anti-pruritic), stimulant V (local irritation, antiseptic sterilization), % salite V acid, methyl IL/sodon aromatic ester, hexacro V ethane, and other volatile components such as poultices, fragrances, and insecticides. , relates to a packaging material useful for use in pouches for hermetically packaging volatile drugs.

Conventionally, the constituent materials for volatile drug packaging pouches are generally polyethylene (or polypropylene), starting from the inner layer.
A laminated sheet is used in which film, aluminum foil, paper, and cellophane are laminated and integrated through a lubricating agent, but in pouches made of such sheet materials, polyethylene as the inner layer (M) is used. Polyethylene (or polypropylene) film has excellent tear strength, so it is difficult to tear when opened and easy to open. Polyethylene (or polypropylene) film has volatile components (e.g.
L-camphor) 1 is well absorbed, so the active ingredients of the volatile drug sealed in the sealed package are consumed by absorption during the storage period, making it difficult to achieve the desired medicinal effect, and furthermore, this technique Due to the volatile components absorbed in the process, delamination occurs at the interface between the inner layer of the polyethylene (or polypropylene) film and the aluminum foil, resulting in a decrease in storage stability.

The present inventor has conducted extensive research in order to eliminate all of these conventional drawbacks! As a result, the innermost layer of a laminated V-t like the
In particular, the present inventors have found that the above-mentioned conventional drawbacks can be completely eliminated when the fin is constructed from a thin layer of Carphoki νv group-modified polyvinyl V-fin, and has successfully completed the present invention.

That is, in the present invention, the inner surface of the thin metal layer is
0 power! Levoxy M group modified polyolefin layer? Formed.

Unilateral side, fibrous layer and high tensile modulus'! Is there a film to be made? It relates to a packaging material formed by sequentially laminating layers with each other in between.

In the present invention, the V-oxyl intergroup polyolefin layer that constitutes the innermost layer has excellent heat sealing properties similar to conventional polyethylene (or polypropylene). It can be used as a pouch constituent material without any problems.

The innermost layer of the packaging material of the present invention? As is clear from the graph shown in Figure 2, the constituting carboquine M-based polyolefin is extremely stable against volatile components such as l-ment-IV and d-ment-IV, and absorbs almost all of them. Not only does this significantly reduce the loss of active ingredients due to absorption, which occurs in conventional products, but it also exhibits excellent barrier resistance against volatile components, making it possible to prevent the inner surface of the thin metal 1. This eliminates the problem of delamination during storage, and improves the storage stability of volatile drugs during sealed packaging.

Furthermore, the carboquine μ-based polyolefin layer has a thin coating layer, which makes it difficult to use conventional polyethylene (
Even though it is made of the same polyolefin type as polypropylene or polypropylene, the tear resistance is significantly improved, and the tear resistance of the pouch can be made the same.

The present invention will be explained below based on an embodiment shown in the drawings.

In the present invention, the innermost layer of the packaging material is composed of a carpoki Vl'v-based polyolefin layer (1).

As the VIL/intergroup polyolefin, various known polymers having a V group naturally present in the olefin polymer can be used. Can be used, especially ■ Olefin polymers such as ethylene, propylene or butene and acrylic acid,
ev by copolymerizing one or more α,β-ethylenically unsaturated carboxylic acids such as methacrylic acid, itaconic acid, fumaric acid, maleic acid, and maleic anhydride.

or ■ Polyolefins such as polyethylene, polypropylene, ethylene-propylene copolymer, or polybutene graft-polymerized with one or more α,β-ethylenically unsaturated to bonic acids are not impregnated with volatile components. Excellent sealability and heat sealability.
Can be used for furi. In the 2-isopolymer, the ratio of σ, β-ethylenically unsaturated power to the bonic acid in the olefin polymer is preferably about 1 to 59 mo14.

Such a power M boxy V group-based polyolefin is dissolved and dispersed in a thread-based bath agent (for example, kerosene, toM ene, methi M ethyl V ketone, etc.), and is applied to gravure coating,
The inner surface of the thin metal layer (2) is coated using a known coating means such as reverse row 7 record to form the layer (1). If the film thickness of layer (1) is less than, for example, 297M2, it will affect the reliability of heat sealing between the coated surfaces when used indoors, and if it is less than 10 f/M, it will affect the packaging of volatile components. Since there is a risk of causing unfavorable results in absorption into the material, a change of about 2 to 10 f/M2 is preferable.

The metal thin layer (2) is composed of a metal foil and a metal vapor deposited layer,
Its materials include Al, Cu%8n, 8b, Z
n, Mg.

Kn can be used as an example of these alloys. This thin metal layer (2) serves as a protective barrier layer for volatile components, and from the functional and manufacturing standpoints, for example, in the case of AV aluminum foil, the thickness is about 6 to 80 μm. What remains is a government system.

Adhesive agent (3) on one side of the pond of metal thin layer (2)? A fibrous layer (4) is confined therethrough. As the electrical connection means, for example, an extrusion lamination method using polyethylene (15 to 25 μm thick) or a known wet lamination method such as ethylene-vinyl acetate V emulsion (dry coating weight 1, θ to 8
．． O17M2) is applied. Does the fibrous layer (4) give the product strength and tearability? For example, paper, non-woven fabric, etc. can be used for the paper, and paper with a basis weight of 20 to 8017 M2 can be advantageously used from the viewpoint of stiffness and economical efficiency, such as pure white roll paper of 80 to 4097 M2.
Preferably.

On one side of the fibrous layer (4), glue (5)? Through,
High tensile modulus? The existing film (6) is ai[edited].

Polyethylene (15-30μ thick) is used as a means of attachment.
Extrusion lamination method etc. are applied. This film (6) has a protective layer (T) as the outermost layer, and is made of polyethylene terephthalate of 20 to 40μ, oriented polypropylene, and cellophane. Can be used to advantage.

The quality and performance test results of the product of the present invention and the comparative product are compared and shown below.

[Product of the present invention]

Cellophane (809/m2)/aN agent (polyethylene 80
p ) / Pure white roll paper (8017M2) / 1ift Mu MP-LJ-10 (manufactured by Toyo Morton Co., Ltd.) [Comparison product] Same as the product of the present invention except that the innermost layer is composed of polyethylene lye 2 rem (807z). The innermost polyethylene film L id and the anchor coating agent [
Urethane type, A D 885 A/F (100/6.
5) 0, 1817M2, manufactured by Toyo Ink Manufacturing Co., Ltd. Extrusion coated and formed fc
%.

〔Test method〕

Kitaki 2 types of packaging material Iio cm square pouch,
The inside is filled with volatile component-impregnated cloth (impregnated with l-menthol and dl-camphor) and sealed, and the tear resistance after packaging has increased.
Content retention and the degree of absorption of active ingredients into packaging materials were investigated. the result? Shown in Table 1.

In Table 1, ``amount of movable components in packaging materials and impregnated cloth'' refers to approximately 50 g of cloth containing 100 mg of dl-camph and 150 mg of l-menthol vt: 20 f' of I-thyl alcohol solution. dl-camphor and l- impregnated with jl, packaged and unsealed after aging, dl-camphor and l-
This is the result of menthol extraction and quantification using gas chromatography.

Table 1 As is clear from Table 1, the product of the present invention is superior in tearability and content retention compared to the comparative product, and as is clear from Figure 2, the active ingredient content during the storage period is lower. The absorption loss was small, and its excellent quality and performance were confirmed.

Furthermore, in the graph of Figure 2, Solid line: content of grape-active ingredients in cloth Broken line...Amount of active ingredient absorbed by packaging material White circle connection...Invention dl-camphor Shiroishi connection line...Invention l-mentors Black circle connection...comparison de-camphor Kurobishi connection...Comparison e-menthol

[Brief explanation of drawings]

Is Fig. 1 an embodiment of the present invention? Partially enlarged sectional view shown, 2nd
The figure is a graph showing a comparison of the amounts of active ingredients in packaging materials and impregnated cloth. 3) is a control agent, (4) is a fibrous layer, (5) is an iF agent, and (6) is a film having a high tensile modulus. [Below 1]

Claims (1)

[Claims] ■ A force of 2 to 109/m2 is formed on the inner surface of the thin metal layer, while a phoxyl-based polyolefin layer is formed on the outer surface.
Film ftWf having a fibrous layer and high tensile modulus: A packaging material formed by sequentially laminating layers with an intelligence agent interposed therebetween.