JPS6087212A - Cleaning of denture - Google Patents

Abstract

PURPOSE:To eliminate the coloring or discoloration of the denture surface, to lyse and remove Candida, and to improve the hygienic state of the oral cavity, by using a lytic enzyme-type cleaning agent in combination with an alkali oxidation-type cleaning agent. CONSTITUTION:(A) A lytic enzyme-type cleaning agent composed of an enzymatic preparation having lytic action to Candida, especially a beta-1,3-glucanase preparation having excellent lytic and removing activity to Candida albicans is combined properly with (B) an alkali oxidation-type cleaning agent such as a perborate agent, hypochlorite agent, etc., and is used for the cleaning of a denture. The application frequency ratio of the component A to the component B (A:B) is preferably (1-60):1, especially (6-30):1. Usually, the agent A is used normally, and the agent B is used intermittently.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for cleaning dentures, and more particularly, the present invention relates to a method for cleaning dentures, and more specifically, the present invention relates to a method for cleaning dentures using a bacteriolytic enzyme type cleaning agent, that is, a Candida lytic enzyme preparation, and an alkaline oxidation type cleaning agent, that is, a strong alkaline tjl with a pH of 11 or higher. This relates to a cleaning method in which an oxidizing agent preparation that exhibits an oxidizing effect is appropriately combined with the oxidizing agent.

The main purpose of conventional denture cleaning methods was to improve the appearance of the denture by removing stains or discoloration on the surface of the denture caused by tobacco or tea stains. However, today, denture stains are understood from a microbiological perspective.
It has come to be recognized that denture stains are caused by microorganisms, particularly Candida albicans and its products, and that this bacterium is the causative agent of denture stomatitis. One thing became clear. It is known that Candida bacteria can cause angular stomatitis and can sometimes induce pulmonary candidiasis, and oral contamination caused by Candida bacteria has become a major problem in today's aging society. It came. Therefore, as a cleaning method for dentures, it is desirable to not only improve the external appearance but also dissolve and remove the Candida bacteria to improve oral hygiene.

As mentioned above, conventional cleaning methods are aimed at beautifying the appearance, and do not have the effect of dissolving and removing Candida bacteria, so they cannot be expected to have any effect on oral hygiene. For example, barborate agents and hypochloride agents, which are oxidizing agents that act in strong alkalinity with a pH of 11 or higher (herein referred to as alkaline oxidizing type cleaning agents), are effective in removing plaque and discoloration on the surface of dentures. Although it is extremely effective, it does not have the effect of removing Candida bacteria, and furthermore, it has a harmful effect on dentures due to λ・1, so it cannot be used continuously. 3 In view of the current situation, the present inventors have developed A lytic enzyme type cleaning agent containing Candida lytic enzyme, and the above-mentioned alkali oxidation type. It has been found that the purpose can be achieved by using the method in appropriate combination with a detergent.

However, according to the present invention, by using a bacteriolytic enzyme type cleaner and an alkaline oxidizing type cleaner in combination at an appropriate frequency, the appearance of dentures can be made beautiful, and Candida bacteria can be dissolved and removed to improve denture quality. It is possible to prevent stomatitis and maintain good oral hygiene.

The lytic enzyme type detergent used in the present invention can be arbitrarily selected from enzyme preparations having a Candida-dissolving action.
A denture cleaning composition containing β-1゜3-glucanase as an essential component previously provided by the present inventor (Patent Application No. 1 of 1982)
'6100) is optimal. This denture cleaning composition is a formulation of β-1,3-glucanase, which has an excellent dissolving and removing action against Candida albicans, together with various excipients, and even if used repeatedly, it will not cause damage to teeth. It is an excellent cleaning agent with no adverse effects.

Next, the alkaline oxidation type detergent used in the method of the present invention includes well-known perborate agents and hypochloride agents. In the method of the present invention, the lytic enzyme type detergent and the alkaline oxidation type detergent are used at an appropriate ratio, for example, the frequency of use of the lytic enzyme type detergent is -1:1 to 6.
0:1, especially 6:1 to 30:1. That is, normally, a lytic enzyme type cleaning agent is used continuously, and an alkaline oxidation type cleaning agent is used intermittently. Although the order of use is arbitrary, it is preferable to first remove plaque from the denture surface using an alkaline oxidation type cleaning agent.

By cleaning dentures using the method of the present invention, denture users can be freed from denture stomatitis and can always use clean dentures comfortably.

The method of the present invention will be explained in more detail by giving formulation examples and usage examples below.

1 Bacterial Enzyme Type Cleaning Agent Zymolyase 5000' 10 parts Trypsin 30 parts Lactose 150 parts Potassium dihydrogen phosphate 16 parts Sodium hydrogen phosphate 12820 64 parts Crystalline cellulose -11 300 parts The above ingredients are thoroughly mixed and compressed using a suitable compression device such as a roller compactor to form a plate-like mass, which is then granulated using a suitable crusher or oscillator, and classified using a classifier such as a gyro shifter. Granules are obtained (dry-produced granules). Fine granules are obtained by changing the granulation conditions. The granules or fine granules thus obtained are divided into 0.5 to 2 g portions.

e Lytic enzyme type cleaning agent E-L jtJLPiL Z yIllolyase@5000 5 parts Alcalase 0 10 parts Lactose G, 39.5 parts Avicel 5 parts Magnesium stearate 0.5 parts Potassium dihydrogen phosphate 8 parts Sodium hydrogen phosphate 12H20- -1mu'' total 100
The above ingredients are thoroughly mixed and tablets of about 100 to 36-00 nu+ are made into tablets by direct compression method.

mU Alkali oxidation type cleaning agent spoon - Soil -■ (%) Sodium perborate, H2O2 7.0 Sodium dichloroisocyanonurate 7.0 Tris-1 helium phosphate anhydrous 54.0 Sodium-lium dodecyl sulfate 0 ．． 2 Huas]~Green 0.08 Pepa~Min1~Powder 0.4 Mannitol 11.32 i;too, 0% Mix the above ingredients and make granules by dry method using a conventional method. Separate the packaging. Furthermore, 1 granule of this
1 to 2.50 tablets per tablet.

1 Dashing tip Alkaline oxidation type cleaning agent [-1*m construction L Shiku 1] Ruisoshi) 7 Sodium nurate 18.5 Sodium perborate 820 7.0 Anhydrous phosphorus trisodium 59.0 PEG6000 0. 25 Sodium dodecyl sulfate 0. 2 2-Menthol 0.1 Mannitol 14.95 Total 100.0% The above ingredients are mixed and subjected to a dry process in a conventional manner to form granules and packaged into 1-3 g portions of pear. Further, the Hoko granules are compressed into tablets of 1 to 2.5 g.

Add 1 package or 1 tablet of each of the above formulations to 120 ml of water.
Soak the denture for 60 minutes or more and clean.

[Bio91] A maxillary denture user (65 years old, male) was given 6 packages of the lytic enzyme type detergent obtained in Formulation Example 1 and 1 package of the alkaline oxidation type detergent obtained in Formulation Example 3. The subjects were instructed to use an alkaline oxidation-type detergent on the first day, and to use a lytic enzyme-type detergent every day thereafter. In a bacteriological test conducted one week later, no bacteria were detected from the denture base (mucosal surface), where countless Candida bacteria had been present before use, and denture stomatitis was also found to have healed. Furthermore, there was no discoloration, and the appearance was beautiful and the feeling of use was significantly improved.

8 packages of the lytic enzyme type detergent obtained in Formulation Example 1 and 1 package of the alkaline oxidation type detergent obtained in Formulation Example 3 were administered to a right denture user (77 years old, male) on both the lower and lower sides of L-L. When used in the same order as in Example 1, an inspection after the usage period showed that
Candida was not detected and was observed before use. The L-part stomatitis had also healed.

In addition, the dentures became more shiny and food particles were less likely to adhere to them.

Patent applicant: Rohto Pharmaceutical Co., Ltd. Agent: Patent attorney: Aoyou and 1 other person 9-

Claims (4)

[Claims] (1) A method for cleaning dentures, which comprises using an appropriate combination of a bacteriolytic enzyme type cleaner and an alkaline oxidation type cleaner. (2) The cleaning method according to item 1, wherein the lytic enzyme type cleaning agent is a denture cleaning composition containing β-1,3-glucanase as an essential component. (3) The cleaning method according to item 1, wherein the alkali oxidation type cleaning agent is a perborate agent or a hypochloride agent. (4) The cleaning method according to item 1, wherein the ratio of the lytic enzyme type cleaner to the alkali oxidation type cleaner is 1:1 to 60:1.